Abstract:
PURPOSE:To determine whether individual and/or cumulative components of metabolic syndrome (obesity, hypertension, dyslipidemia, and hyperglycemia) are associated with pathologic features of kidney cancer. PATIENTS AND METHODS:A review of our kidney tumor database identified 462 patients who underwent partial or radical nephrectomy for renal cell carcinoma. The NCEP ATP-III criteria were used to define metabolic syndrome (MetS). Linear fixed effects modeling and ordinal logistic regression examined the relationship between MetS (individual and cumulative components) and pathologic characteristics. RESULTS:Two hundred and seventy-eight men and 184 women with a median age of 58 years, BMI of 31 kg/m2, tumor size of 3.7 cm, and nephrometry score of 6 were included. Ninety-seven (21 %) patients met NCEP ATP-III criteria for MetS. Hypertension was the only individual component of MetS associated with pathologic features of kidney cancer including increased tumor size [geometric mean ratio 1.17 (1.05-1.32), P = 0.03], higher tumor grade [OR 1.49 (1.03-2.17), P = 0.04], increasing nephrometry score [OR 1.77 (1.28-2.48), P = 0.001], and non-clear cell histology [OR 1.42 (1.01-2.02), P = 0.05]. Furthermore, combinations of MetS components were associated with increased tumor grade (P = 0.02), tumor stage (P = 0.02), nephrometry score (P ≤ 0.001), and non-clear cell histology (P = 0.02), only when hypertension was included. CONCLUSION:MetS is composed of four risk factors each implicated in carcinogenesis. We identified hypertension as the primary component associated with specific pathologic features of kidney cancer. Further studies are necessary to elucidate whether the effect of hypertension is a function of severity and/or chronicity.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Kocher NJ,Rjepaj C,Robyak H,Lehman E,Raman JDdoi
10.1007/s00345-016-1850-2subject
Has Abstractpub_date
2017-01-01 00:00:00pages
67-72issue
1eissn
0724-4983issn
1433-8726pii
10.1007/s00345-016-1850-2journal_volume
35pub_type
杂志文章abstract:PURPOSE:The perioperative and oncological outcomes of laparoscopic radical nephrectomy (LRN) for T1-T2 renal cell carcinoma (RCC) are well established. We aim to determine whether LRN is a comparable alternative to open radical nephrectomy (ORN) in the treatment of T3 RCC using a matched pair analysis study design. ME...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1280-y
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Erectile dysfunction (ED) and cardiovascular disease (CVD) share a great number of common risk factors. There is growing evidence that aldosterone, an independent CVD risk factor, is associated with ED. AIMS:The purpose of this study was to determine the relationship between plasma aldosterone and erectil...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1723-0
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:Previous studies examining the management of urinary tract infections (UTI) showed marked variability in the economical burden of care, with a tenfold increase in costs when patients require admission to the hospital. We sought to examine the patient and emergency department (ED) characteristics associated with...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-013-1167-3
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Upper tract urothelial carcinoma (UTUC) is a rare and heterogeneous disease. Several clinical and biological prognostic factors have been identified in multi-institutional collaborative works with the aim of helping decision-making in pursuit of tailored individual patient care. This review provides an overv...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-016-1826-2
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:To determine the clinical performance of a blood-based test for clinically significant (CS) prostate cancer (PCa) (grade group ≥ 2) intended for use in men with prostate serum antigen levels in the 'grey zone' (PSA < 10 ng/ml). The test quantifies a previously described 3.4 kb mitochondrial DNA (mtDNA) deletion...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2152-z
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:Holmium laser enucleation of the prostate (HoLEP) has become a popular alternative to TURP for desobstructive prostate surgery. The prevalence of incidental prostate cancer (iPCa) during surgery varies depending on many preoperative factors. To evaluate whether the surgical procedure itself (HoLEP vs. TURP) inf...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2353-0
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:The international meeting on reconstructive Urology (IMORU) is a live surgery event (LSE) where expert surgeons perform various reconstructive surgeries. To evaluate patient safety, an extended follow-up of the complications of two subsequent IMORU meetings were gathered. Also, a detailed survey concerning the ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02666-1
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:We reviewed our patients with pathologic T3b renal cell carcinoma (RCC) to determine which factors influenced survival in this high risk patient group. METHODS:From April 1988 to August 2006, 722 patients underwent nephrectomy for RCC at Vanderbilt University. 128 patients (17%) had T3b disease by 2002 AJCC...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-008-0358-9
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:To report the surgical outcomes of laparoscopic radical cystectomy (LRC) with extracorporeal orthotopic ileal neobladder (OIN) in patients with muscle-invasive urothelial carcinoma of the bladder (UCB). MATERIALS AND METHODS:Between October 2009 and December 2011, 37 patients with muscle-invasive UCB underw...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1122-3
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:To assess oncologic outcomes after salvage radiotherapy (SRT) without androgen deprivation therapy (ADT) in patients with persistently detectable PSA after radical prostatectomy (RT). METHODS:Two hundred and one patients who failed to achieve an undetectable PSA received SRT without ADT. The primary endpoint w...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-013-1214-0
更新日期:2014-10-01 00:00:00
abstract::The author presents the life and achievements of Johann von Mikulicz-Radecki and his contribution to European and world surgery. Mikulicz was born in Czernowitz, then a part of the Austro-Hungarian Empire. He was educated in numerous Austrian schools and graduated at Vienna University in 1875. In 1880 he became surgeo...
journal_title:World journal of urology
pub_type: 传,历史文章
doi:10.1007/s00345-007-0227-y
更新日期:2008-02-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of WX-G250, a chimeric monoclonal antibody that binds to carboxy anhydrase IX, combined with low-dose interferon-alpha (LD-IFNα) in patients with progressive metastatic renal cell carcinoma (mRCC). PATIENTS AND METHODS:Thirty-one patients, nephrectomized for the primary tumo...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-010-0570-2
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:To evaluate the present human-based evidence that diet is related to the risk and outcome of prostate cancer. METHODS:Review of major case-control and cohort studies, and experimental trials evaluating the effect of diet or dietary constituents on the risk of prostate cancer. RESULTS:Although non-experimental...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-011-0810-0
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:To assess the performance of EAU risk classification in PCa patients according to the biopsy pathway (standard versus MRI guided) and to develop a new, more accurate, targeted biopsy (TB)-based classification. MATERIALS AND METHODS:We included 1345 patients consecutively operated by radical prostatectomy (RP) ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-03053-6
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:To reach standardized terminology in focal therapy (FT) for prostate cancer (PCa). METHODS:A four-stage modified Delphi consensus project was undertaken among a panel of international experts in the field of FT for PCa. Data on terminology in FT was collected from the panel by three rounds of online questionna...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-016-1782-x
更新日期:2016-10-01 00:00:00
abstract::Vesicoureteral reflux (VUR) represents one of the most significant risk factors for acute pyelonephritis in children. The current indications for the surgical correction of VUR depend on the presence or absence of renal scars. If no scars are present, primary ureteral reimplantation is only indicated in high-grade bil...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-004-0408-x
更新日期:2004-06-01 00:00:00
abstract:PURPOSE:We aimed to explore the knowledge, attitudes, and practices towards prostate cancer (PCa) risk factors and prevention amongst men living in the southern Italian peninsula. METHODS:We retrospectively reviewed data collected during free preventive visits carried out by the Prevention and Research in Oncology (PR...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2074-9
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To explore efficacy and safety of Botulinum Neurotoxin Type A (BoNT-A) prostatic injection in patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperperplasia. MATERIALS AND METHODS:A phase 3 multicenter open-labeled study randomised patients to receive BoNT-A prostatic injection or o...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00345-018-2193-y
更新日期:2018-06-01 00:00:00
abstract::The surgical complications encountered in 478 patients who underwent primary retroperitoneal lymph-node dissection for clinical stage A and B nonseminomatous testicular cancer during the period ranging from 1982 to 1992 were reviewed. There were 54 complications in 51 patients (10.6%), and there was no surgery-related...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF00192272
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:Currently, osteoporosis research is rarely undertaken in males but an increase in male life expectancy in the company of hypogonadism suggests the necessity for potential therapeutic options. MATERIALS AND METHODS:In this study, the changes in bone structure under standardized testosterone- (T), raloxifen...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-009-0373-5
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:To evaluate the diagnostic and staging ability of multiparametric MRI (mpMRI) compared to radical prostatectomy (RP) specimens after dissemination of this technology to several centres. mpMRI is an evolving technique aiming to improve upon the diagnostic sensitivity of prostate biopsy for the diagnosis of prost...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-016-1960-x
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:High-quality leadership and chairing skills are vital for good performance in multidisciplinary tumor boards (MTBs), but no instruments currently exist for assessing and improving these skills. OBJECTIVE:To construct and validate a robust instrument for assessment of MTB leading and chairing skills. DESIGN...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2255-1
更新日期:2018-07-01 00:00:00
abstract::The treatment options for patients with advanced prostate cancer are limited. Because of recent advances in the understanding of the molecular biology of prostate cancer, the accessibility of the prostate for injection, and the availability of gene promotors that allow tissue-specific expression of therapeutic gene pr...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s003450050187
更新日期:2000-04-01 00:00:00
abstract::A catheter was designed to decrease the incidence of catheter-induced urinary infections. A randomized, controlled study was performed to assess its safety and efficacy. The study comprised 24 patients subjected to hemorrhoidectomy. The criteria for entry were a preoperative urinary pathogen count below 10(5) colony-f...
journal_title:World journal of urology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00211417
更新日期:1993-01-01 00:00:00
abstract::Despite several new urine markers urinary cytology remains the gold standard for the non-invasive detection of bladder carcinoma. The use of monoclonal antibodies against tumor associated antigens offers a promising approach to improve urinary cytology. The aim of this study was to compare fluorescence immunocytology ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-003-0390-8
更新日期:2004-06-01 00:00:00
abstract::The widespread use of measurement of prostate-specific antigen for prostate cancer screening has led to a dramatic increase in the number of transrectal biopsies. Although transrectal ultrasound-guided prostate biopsy is the gold standard in the diagnosis of prostate cancer, the strategies for initial and repeat biops...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-007-0151-1
更新日期:2007-03-01 00:00:00
abstract:PURPOSE:Combination therapy of male lower urinary tract symptoms with α(1)-adrenoceptor and muscarinic receptor antagonists attracts increasing interest. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca(2+) channels. Here, we have investigated whether propiverin...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0655-6
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:To evaluate temporary double J ureteric stenting (TDJS) as a test to diagnose ureteropelvic junction obstruction (UPJO) in equivocal cases. MATERIALS AND METHODS:One hundred and nine consecutive adult patients with loin pain and ipsilateral equivocal UPJO (EqUPJO) on radioisotope diuretic renogram (RDR) were e...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-009-0464-3
更新日期:2010-06-01 00:00:00
abstract::The development of human benign prostatic hyperplasia (BPH) clearly requires a combination of testicular androgens and the ageing process. Although the role of androgens as the causative factor for human benign prostatic hyperplasia is debated, they undoubtedly play, at least, a permissive role. The principal prostati...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-002-0248-5
更新日期:2002-04-01 00:00:00
abstract:PURPOSE:Low amplitude rhythmic contractions (LARC) occur in detrusor smooth muscle and may play a role in storage disorders such as overactive bladder and detrusor overactivity. The purpose of this study was to determine whether LARC frequencies identified in vitro from strips of human urinary bladder tissue correlate ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-016-1994-0
更新日期:2017-08-01 00:00:00