Abstract:
PURPOSE:To assess the performance of EAU risk classification in PCa patients according to the biopsy pathway (standard versus MRI guided) and to develop a new, more accurate, targeted biopsy (TB)-based classification. MATERIALS AND METHODS:We included 1345 patients consecutively operated by radical prostatectomy (RP) since 2014, when MRI and TB were introduced in the diagnostic pathway. Patients underwent systematic biopsy (SB) only (n = 819) or SB and TB (n = 526) prior to RP during the same time period. Pathological and biochemical outcomes were compared between PCa men undergoing SB (SB cohort) and a combination of TB and SB (TB cohort). Kaplan-Meier and Cox regression models were used to assess biochemical recurrence-free survival (RFS). RESULTS:Both cohorts were comparable regarding final pathology and RFS (p = 0.538). The EAU risk classification accurately predicted outcomes in SB cohort, but did not significantly separate low from intermediate risk in TB cohort (p = 0.791). In TB cohort, the new proposed three-group risk classification significantly improved the recurrence risk prediction compared with the EAU risk classification: HR 4 (versus HR 1.2, p = 0.009) for intermediate, and HR 15 (versus HR 6.5, p < 0.001) in high-risk groups, respectively. A fourth group defining very high-risk cases (≥ T2c clinical stage or grade group 5) was also proposed. CONCLUSIONS:The new classification integrating TB findings we propose meaningfully improves the recurrence prediction after surgery in patients undergoing a TB-based diagnostic pathway, compared with standard EAU risk classification which is still relevant for patients undergoing only SB. External validation is needed.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Ploussard G,Manceau C,Beauval JB,Lesourd M,Almeras C,Gautier JR,Loison G,Salin A,Soulié M,Tollon C,Malavaud B,Roumiguié Mdoi
10.1007/s00345-019-03053-6subject
Has Abstractpub_date
2020-10-01 00:00:00pages
2493-2500issue
10eissn
0724-4983issn
1433-8726pii
10.1007/s00345-019-03053-6journal_volume
38pub_type
杂志文章abstract::Prostate carcinoma (PCa) displays a wide variety of genetic alterations, versatile expression profiles as well as cell surface markers. Despite this heterogeneity, a common treatment for advanced PCa is androgen deprivation therapy (ADT). ADT targets the androgen receptor-a member of the nuclear receptor superfamily-w...
journal_title:World journal of urology
pub_type: 杂志文章,评审
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journal_title:World journal of urology
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journal_title:World journal of urology
pub_type: 杂志文章,meta分析
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journal_title:World journal of urology
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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journal_title:World journal of urology
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journal_title:World journal of urology
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journal_title:World journal of urology
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journal_title:World journal of urology
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pub_type: 杂志文章
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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journal_title:World journal of urology
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journal_title:World journal of urology
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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journal_title:World journal of urology
pub_type: 临床试验,杂志文章
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journal_title:World journal of urology
pub_type: 杂志文章
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03333-6
更新日期:2020-07-04 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
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更新日期:2008-08-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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更新日期:2020-10-26 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,随机对照试验
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更新日期:2006-02-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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更新日期:2013-08-01 00:00:00