当前位置： SCI文献检索 > WORLD JOURNAL OF UROLOGY期刊下所有文献 > A single mitochondrial DNA deletion accurately detects significant prostate cancer in men in the PSA 'grey zone'.

A single mitochondrial DNA deletion accurately detects significant prostate cancer in men in the PSA 'grey zone'.

Abstract：

PURPOSE:To determine the clinical performance of a blood-based test for clinically significant (CS) prostate cancer (PCa) (grade group ≥ 2) intended for use in men with prostate serum antigen levels in the 'grey zone' (PSA < 10 ng/ml). The test quantifies a previously described 3.4 kb mitochondrial DNA (mtDNA) deletion. METHODS:In a first prospective study of an MRI-guided re-biopsy population (n = 126), the 3.4 kb deletion and 18S rRNA gene were amplified from plasma. A diagnostic threshold was selected from the coordinates of the receiver operating characteristic curve and tested in a second population of men who were (n = 92) biopsy naïve when the mtDNA deletion was assayed and for whom those diagnosed with cancer on initial biopsy were treated with radical prostatectomy. RESULTS:The 3.4 kb deletion was a good predictor of CS PCa in the image-guided re-biopsy population [AUC 0.84, (95% CI 0.73-0.95)] and the selected threshold corresponded to a sensitivity of 87% [95% CI, 70-96%], specificity of 68% [95% CI, 47-85%] and negative predictive value (NPV) of 97%. Applying this threshold to the second population showed this deletion to be a strong predictor of CS cancer [AUC 0.98, (95% CI 0.94-1.02)], independent of PSA or age [sensitivity 100% (95% CI, 93-100%), specificity 90% (95%CI 73-98%) and NPV 100%]. CONCLUSION:The 3.4 kb deletion in plasma is an accurate predictor of CS cancer for men in the PSA 'grey zone'. Used in advance of biopsy for improved patient selection, this deletion may reduce the number of biopsies needed to diagnose CS prostate cancers.

journal_name

World J Urol

journal_title

World journal of urology

authors

Creed J,Klotz L,Harbottle A,Maggrah A,Reguly B,George A,Gnanapragasm V

doi

10.1007/s00345-017-2152-z

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

341-348

issue

3

eissn

0724-4983

issn

1433-8726

pii

10.1007/s00345-017-2152-z

journal_volume

36

pub_type

杂志文章

相关文献

WORLD JOURNAL OF UROLOGY文献大全
  • Voiding dysfunction in the orthotopic neobladder.

    abstract：:The orthotopic neobladder has become the preferred method of handling the urinary tract after removal of the bladder in men and women. However, an improved quality of life compared to urinary diversion fails to be realized when voiding dysfunction arises. These difficulties with urination range from retention to incon...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s003450000146

    authors： Steers WD

    更新日期：2000-10-01 00:00:00

  • Dhat syndrome, an emergent condition within urology in Spain.

    abstract：BACKGROUND:Dhat syndrome (DS) consists of vague somatic symptoms and at times sexual dysfunction which the patient falsely attributes to involuntary emissions of semen outside of sexual relations. OBJECTIVE:Describe and analyse the occurrences of DS in patients attending the clinic and clarify the existence of this co...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-012-0911-4

    authors： Menéndez V,Fernández-Suárez A,Placer J,García-Linares M,Tarragon S,Liso E

    更新日期：2013-08-01 00:00:00

  • Impact of using 29 MHz high-resolution micro-ultrasound in real-time targeting of transrectal prostate biopsies: initial experience.

    abstract：PURPOSE:This report presents our early experience at Cleveland Clinic replacing conventional ultrasound with a novel 29 MHz high-resolution micro-ultrasound system for both systematic sampling and real-time targeting of suspicious regions during prostate biopsy. The added value of micro-ultrasound and MRI over systemat...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02863-y

    authors： Abouassaly R,Klein EA,El-Shefai A,Stephenson A

    更新日期：2020-05-01 00:00:00

  • Impact of novel techniques on minimally invasive adrenal surgery: trends and outcomes from a contemporary international large series in urology.

    abstract：OBJECTIVE:To evaluate contemporary international trends in the implementation of minimally invasive adrenalectomy and to assess contemporary outcomes of different minimally invasive techniques performed at urologic centers worldwide. METHODS:A retrospective multinational multicenter study of patients who underwent min...

    journal_title：World journal of urology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00345-016-1791-9

    authors： Pavan N,Autorino R,Lee H,Porpiglia F,Sun Y,Greco F,Jeff Chueh S,Han DH,Cindolo L,Ferro M,Chen X,Branco A,Fornara P,Liao CH,Miyajima A,Kyriazis I,Puglisi M,Fiori C,Yang B,Fei G,Altieri V,Jeong BC,Berardinelli F

    更新日期：2016-10-01 00:00:00

  • Optimizing male fertility: oxidative stress and the use of antioxidants.

    abstract：PURPOSE:Management of male infertility is always a difficult task, with pathophysiology and available treatments often poorly understood. The purpose of this review was to summarize current evidence regarding the use of protective agents against reactive oxygen species (ROS), such as antioxidants that may be useful in ...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-019-02656-3

    authors： Cardoso JP,Cocuzza M,Elterman D

    更新日期：2019-06-01 00:00:00

  • Clinically high-risk prostate cancer patients comprise a relevant number of cancers with overall favorable tumor characteristics.

    abstract：PURPOSE:We hypothesized that a relevant number of patients with clinically high-risk prostate cancer (PCA) indeed harbor overall favorable tumor characteristics (OFTC) (i.e., pT2a-c and Gleason score ≤3 + 4 = 7 and pN0/X) and that in these patients radical prostatectomy (RP) alone is most likely curative. METHODS:Betw...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-014-1274-9

    authors： Musch M,Pluemer J,Roggenbuck U,Klevecka V,Kroepfl D

    更新日期：2015-01-01 00:00:00

  • Robotic kidney transplantation: one year after the beginning.

    abstract：INTRODUCTION:Kidney transplantation (KT) is the preferred treatment for patients with end-stage renal disease (ESRD). To reduce the morbidity of the open surgery, a robotic-assisted approach has been recently introduced. Our aim is to evaluate surgical and functional results on 17 cases of robotic-assisted kidney trans...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-017-2006-8

    authors： Breda A,Territo A,Gausa L,Rodríguez-Faba O,Caffaratti J,de León JP,Guirado L,Facundo C,Guazzieri M,Guttilla A,Villavicencio H

    更新日期：2017-10-01 00:00:00

  • Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma.

    abstract：PURPOSE:MicroRNAs (miRNAs) play an important role as regulators of gene expression in tumourigenesis by controlling many biological processes in growth, development, differentiation and apoptosis. Previous studies have shown an altered expression of specific miRNAs in clear cell renal cell carcinoma (ccRCC). But the fu...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-010-0633-4

    authors： Heinzelmann J,Henning B,Sanjmyatav J,Posorski N,Steiner T,Wunderlich H,Gajda MR,Junker K

    更新日期：2011-06-01 00:00:00

  • Histologic characterization of the post-radiation urethral stenosis in men treated for prostate cancer.

    abstract：PURPOSE:To evaluate histological changes in stenotic urethral tissue post-radiation therapy. Treatment of prostate cancer by radiation therapy carries a risk of off-target injury to the membranous urethra causing urethral stenosis. Limited characterization of post-radiation urethral stenosis exists in the literature. W...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-03031-y

    authors： Hughes M,Caza T,Li G,Daugherty M,Blakley S,Nikolavsky D

    更新日期：2020-09-01 00:00:00

  • Low amplitude rhythmic contraction frequency in human detrusor strips correlates with phasic intravesical pressure waves.

    abstract：PURPOSE:Low amplitude rhythmic contractions (LARC) occur in detrusor smooth muscle and may play a role in storage disorders such as overactive bladder and detrusor overactivity. The purpose of this study was to determine whether LARC frequencies identified in vitro from strips of human urinary bladder tissue correlate ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-016-1994-0

    authors： Colhoun AF,Speich JE,Cooley LF,Bell ED 3rd,Barbee RW,Guruli G,Ratz PH,Klausner AP

    更新日期：2017-08-01 00:00:00

  • The effects of testosterone on the cavernous tissue and erectile function.

    abstract：:A review of the current literature is conducted to explore the developmental aspects, animal and human experiences and the effects of pharmacological manipulation to explain the role androgens play in sexual function with special emphasis on erectile function and the erectile tissue. This review reveals that androgens...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/BF01275152

    authors： Shabsigh R

    更新日期：1997-01-01 00:00:00

  • Impact of sodium 18F-fluoride PET/CT, 18F-fluorocholine PET/CT and whole-body diffusion-weighted MRI on the management of patients with prostate cancer suspicious for metastasis: a prospective multicentre study.

    abstract：PURPOSE:To compare the impact of 18F-sodium-fluoride (NaF) PET/CT, 18F-fluorocholine (FCH) PET/CT and diffusion-weighted whole-body MRI (DW-MRI) on the management of patients with prostate cancer (PCa) suspicious for distant metastasis. METHODS:Prostate cancer patients were prospectively included between December 2011...

    journal_title：World journal of urology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00345-018-2547-5

    authors： Gauthé M,Aveline C,Lecouvet F,Michaud L,Rousseau C,Tassart M,Cussenot O,Talbot JN,Durand-Zaleski I

    更新日期：2019-08-01 00:00:00

  • Prospective evaluation of a urinary biomarker panel to detect and predict recurrence of non-muscle-invasive bladder cancer.

    abstract：PURPOSE:To perform a feasibility phase study of a panel of putative protein biomarkers and determine whether it can identify and predict tumor recurrence in patients with non-muscle-invasive bladder cancer (NMIBC) on follow-up. METHODS:We prospectively analyzed the urine of 152 patients previously treated for NMIBC. Q...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-020-03188-x

    authors： Srougi V,Reis ST,Viana N,Gallucci FP,Leite KR,Srougi M,Nahas WC

    更新日期：2020-04-06 00:00:00

  • OnabotulinumtoxinA intradetrusorial injections improve sexual function in female patients affected by multiple sclerosis: preliminary results.

    abstract：PURPOSE:To investigate the effects of onabotulinum toxin type A (Onabot/A) intravesical injections on urinary and sexual function in a group of patients affected by multiple sclerosis (MS). METHODS:We enrolled 31 MS female patients with symptoms of overactive bladder and detrusor overactivity. All patients underwent u...

    journal_title：World journal of urology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00345-015-1578-4

    authors： Giannantoni A,Proietti S,Giusti G,Gubbiotti M,Millefiorini E,Costantini E,Berardelli A,Conte A

    更新日期：2015-12-01 00:00:00

  • Risk factors affecting post-pubertal high serum follicle-stimulating hormone in patients with hypospadias.

    abstract：PURPOSE:The factors affecting spermatogenesis in adulthood in patients with hypospadias (HS) are not clearly understood. In the present study, risk factors affecting post-pubertal high serum follicle-stimulating hormone (FSH) were evaluated in patients with HS. MATERIALS AND METHODS:Among those with a history of HS su...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02687-w

    authors： Moriya K,Nakamura M,Kon M,Nishimura Y,Kanno Y,Kitta T,Shinohara N

    更新日期：2019-12-01 00:00:00

  • Insertion of double J stent as a therapeutic test in management of adults presenting with loin pain and equivocal ureteropelvic junction obstruction.

    abstract：PURPOSE:To evaluate temporary double J ureteric stenting (TDJS) as a test to diagnose ureteropelvic junction obstruction (UPJO) in equivocal cases. MATERIALS AND METHODS:One hundred and nine consecutive adult patients with loin pain and ipsilateral equivocal UPJO (EqUPJO) on radioisotope diuretic renogram (RDR) were e...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-009-0464-3

    authors： Osman T,Fawaz K,Abdelmaksoud A,Eltahawy I,Safa W,El Zayat T,El Sadek D,El Halaby R

    更新日期：2010-06-01 00:00:00

  • Management of small renal masses: a review.

    abstract：INTRODUCTION:Recently, small renal masses (SRMs) (< or =4 cm) are found more frequently, especially in the elderly and co-morbid patients. Standard treatment for SRMs is nephron-sparing surgery (NSS). New techniques like energy ablation and surveillance have been introduced. MATERIALS AND METHODS:Overview of treatment...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-010-0516-8

    authors： Remzi M,Javadli E,Ozsoy M

    更新日期：2010-06-01 00:00:00

  • Contemporary pathologic characteristics and oncologic outcomes of prostate cancers missed by 6- and 12-core biopsy and diagnosed with a 21-core biopsy protocol.

    abstract：PURPOSE:To assess the pathological and the oncologic outcomes of the prostate cancer (PCa) missed by 6- and 12-core biopsy protocols by using a reference 21-core scheme. MATERIALS AND METHODS:Between 2001 and 2009, all patients who had PCa detected in an initial 21-core TRUS biopsy scheme and were treated by a radical...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-011-0800-2

    authors： Ouzaid I,Xylinas E,Campeggi A,Hoznek A,Vordos D,Abbou CC,Vacherot F,Salomon L,de la Taille A,Ploussard G

    更新日期：2013-08-01 00:00:00

  • XPA-210: a new proliferation marker to characterize tumor biology and progression of renal cell carcinoma.

    abstract：PURPOSE:Recent lung cancer data have shown an association of XPA-210, a key peptide of thymidine kinase, with advanced disease. We thus assessed its proliferation status in primary (M0) and metastatic (M1) renal cell carcinoma (RCC). METHODS:Paraffin slides from 30 patients (mean age: 61.2 years; range: 42-84) with cl...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-010-0621-8

    authors： Gakis G,Hennenlotter J,Scharpf M,Hevler J,Schilling D,Kuehs U,Stenzl A,Schwentner C

    更新日期：2011-12-01 00:00:00

  • Prostatic peripheral nerve distribution may impact the functional outcome of nerve-sparing prostatectomy.

    abstract：PURPOSE:To study microscopic patterns of remaining peripheral nerves (PN) after nerve-sparing (NS) radical prostatectomy (RP) and possible consequences for nerve preparation. METHODS:Specimens from 27 patients (7 = non-NSRP, 20 = unilateral NS) were examined. Sections were investigated for PN content by immunoassaying...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-011-0791-z

    authors： Amend B,Hennenlotter J,Kuehs U,Laible I,Anastasiadis A,Schilling D,Stenzl A,Sievert KD

    更新日期：2013-04-01 00:00:00

  • Immunotherapy in prostate cancer: new horizon of hurdles and hopes.

    abstract：PURPOSE:Prostate cancer (PCa) is the most common malignancy in men and the cause for the second most common cancer-related death in the western world. Despite ongoing development of novel approaches such as second generation androgen receptor targeted therapies, metastatic disease is still fatal. In PCa, immunotherapy ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-020-03497-1

    authors： Tsaur I,Brandt MP,Juengel E,Manceau C,Ploussard G

    更新日期：2020-10-26 00:00:00

  • Hypertension is the primary component of metabolic syndrome associated with pathologic features of kidney cancer.

    abstract：PURPOSE:To determine whether individual and/or cumulative components of metabolic syndrome (obesity, hypertension, dyslipidemia, and hyperglycemia) are associated with pathologic features of kidney cancer. PATIENTS AND METHODS:A review of our kidney tumor database identified 462 patients who underwent partial or radic...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-016-1850-2

    authors： Kocher NJ,Rjepaj C,Robyak H,Lehman E,Raman JD

    更新日期：2017-01-01 00:00:00

  • Late relapse of testicular cancer.

    abstract：:Due to its unique biological behavior, late relapse (LR) of testicular cancer has recently been described as an own tumor entity. It is currently defined as tumor recurrence more than 2 years after complete remission following primary treatment including chemotherapy. The incidence ranges from 2 to 6%, with a median r...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-004-0397-9

    authors： Lipphardt ME,Albers P

    更新日期：2004-04-01 00:00:00

  • Persistent cancer in postchemotherapy retroperitoneal lymph-node dissection: outcome analysis.

    abstract：:Surgery following chemotherapy for treatment of metastatic testis cancer is reserved for partial remissions with localized tumors considered resectable. After primary chemotherapy, about 90% will have teratoma or necrosis and only 10% will have cancer. The concept of two cycles of post operative chemotherapy in this s...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/BF00185671

    authors： Donohue JP,Fox EP,Williams SD,Loehrer PJ,Ulbright TM,Einhorn LH,Weathers TD

    更新日期：1994-01-01 00:00:00

  • Novel laser positioning navigation to aid puncture during percutaneous nephrolithotomy: a preliminary report.

    abstract：PURPOSE:Accurate puncture of the renal collecting system is crucial to the success of percutaneous nephrolithotomy and presents a technical challenge for urologists. Here, we introduced the Surgical Approach Visualization and Navigation (SAVN) system, a novel navigation system to assist puncture and reduce intraoperati...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-018-2496-z

    authors： Wu J,Zhou P,Luo X,Hao Z,Lu C,Zhang H,Zhou T,Xu S

    更新日期：2019-06-01 00:00:00

  • Clinical significance of urothelial carcinoma ambiguous for muscularis propria invasion on initial transurethral resection of bladder tumor.

    abstract：PURPOSE:To evaluate the clinical significance of invasive urothelial carcinoma that is ambiguous for muscularis propria invasion on initial transurethral resection of bladder tumor (TURBT). METHODS:All consecutive in-house TURBTs with invasive urothelial carcinoma from 1999 to 2017 that underwent radical cystectomy (R...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02782-y

    authors： Hassan O,Murati Amador B,Lombardo KA,Salles D,Cuello F,Marwaha AS,Daniels MJ,Kates M,Bivalacqua TJ,Matoso A

    更新日期：2020-02-01 00:00:00

  • Analysis of the impact of adherent perirenal fat on peri-operative outcomes of robotic partial nephrectomy.

    abstract：INTRODUCTION:Adherent perirenal fat (APF) can be defined as inflammatory fat sticking to renal parenchyma, whose dissection is difficult and makes it troublesome to expose the tumour. Our objective was to evaluate the impact of APF on the technical difficulty of robot-assisted partial nephrectomy (RPN). PATIENTS AND M...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-015-1500-0

    authors： Khene ZE,Peyronnet B,Mathieu R,Fardoun T,Verhoest G,Bensalah K

    更新日期：2015-11-01 00:00:00

  • Quality of leadership in multidisciplinary cancer tumor boards: development and evaluation of a leadership assessment instrument (ATLAS).

    abstract：BACKGROUND:High-quality leadership and chairing skills are vital for good performance in multidisciplinary tumor boards (MTBs), but no instruments currently exist for assessing and improving these skills. OBJECTIVE:To construct and validate a robust instrument for assessment of MTB leading and chairing skills. DESIGN...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-018-2255-1

    authors： Jalil R,Soukup T,Akhter W,Sevdalis N,Green JSA

    更新日期：2018-07-01 00:00:00

  • Development and validation of nomograms to predict the recovery of urinary continence after radical prostatectomy: comparisons between immediate, early, and late continence.

    abstract：PURPOSE:Few studies have been conducted on the serial evaluation of predictors for recovery of urinary continence (RC) after radical prostatectomy (RP) among same cohort. We developed and validated nomograms to predict immediate (≤1), early (≤3), and late (≤12 months) RC from a contemporary series and compared each nom...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-013-1127-y

    authors： Jeong SJ,Yeon JS,Lee JK,Cha WH,Jeong JW,Lee BK,Lee SC,Jeong CW,Kim JH,Hong SK,Byun SS,Lee SE

    更新日期：2014-04-01 00:00:00

  • Does educational printed material manage to change compliance with prostate cancer screening?

    abstract：BACKGROUND/AIM:The effects of printed educational material on cancer screening in women (Pap test and mammography) are well documented and confirmed by several studies. The aim of our study was to evaluate the impact of similar printed educational material on prostate cancer screening by PSA and DRE. MATERIAL AND METH...

    journal_title：World journal of urology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00345-008-0258-z

    authors： Stamatiou K,Skolarikos A,Heretis I,Papadimitriou V,Alevizos A,Ilias G,Karanasiou V,Mariolis A,Sofras F

    更新日期：2008-08-01 00:00:00