Abstract:
:The treatment options for patients with advanced prostate cancer are limited. Because of recent advances in the understanding of the molecular biology of prostate cancer, the accessibility of the prostate for injection, and the availability of gene promotors that allow tissue-specific expression of therapeutic gene products, gene therapy for prostate cancer has realized significant achievements in recent years. What once belonged to the realm of basic science is now entering the domain of phase II clinical trials. In this review, current results and future directions in prostate gene therapy at the University of California, Los Angeles, are discussed.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Pantuck AJ,Zisman A,Belldegrun ASdoi
10.1007/s003450050187keywords:
subject
Has Abstractpub_date
2000-04-01 00:00:00pages
143-7issue
2eissn
0724-4983issn
1433-8726journal_volume
18pub_type
杂志文章,评审abstract:PURPOSE:Partial nephrectomy (PN) outcomes may be better at academic institutions than at non-academic centers. Peer-review, sub-specialized practice profile, higher individual surgeon and institutional caseload may explain this observation. To the best of our knowledge, the role of institutional academic affiliation ha...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0759-z
更新日期:2012-08-01 00:00:00
abstract:INTRODUCTION:The conservative management of upper tract urothelial carcinoma (UTUC) has historically been offered to patients with imperative indications. The recent International Consultation on Urologic Diseases (ICUD) publication on UTUC stratified treatment allocations based on high- and low-risk groups. This repor...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-016-1859-6
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Chronic inflammation has been considered a potential risk factor for prostate cancer. Toll-like receptors (TLRs) are important in the innate immune response to pathogens and in cross talk between innate immunity and adaptive immunity. In this study, sequence variants in the TLR4 gene were investigated to determ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0690-3
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVES:To compare the oncological and functional outcomes reported after radical retropubic prostatectomy (RRP) versus brachytherapy (BT) in the treatment of low-risk prostatic cancer (CaP). METHODS:Between May 1999 and October 2002, 200 patients (mean age 65.3 +/- 8.7) were enrolled and randomized into two groups...
journal_title:World journal of urology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00345-009-0418-9
更新日期:2009-10-01 00:00:00
abstract:PURPOSE:To compare the perioperative relative renal function and determine predictors of deterioration and recovery of separate renal function in patients with renal stones >10 mm and who underwent mini-percutaneous nephrolithotomy or retrograde intra-renal surgery. PATIENTS AND METHODS:A main stone >10 mm or stones g...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1653-x
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Upper tract urothelial carcinoma (UTUC) is a rare and heterogeneous disease. Several clinical and biological prognostic factors have been identified in multi-institutional collaborative works with the aim of helping decision-making in pursuit of tailored individual patient care. This review provides an overv...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-016-1826-2
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:To explore the role of prostate biopsy core length on prediction of index tumor clinical significance and localization on radical prostatectomy (RP) and time to recurrence, hypothesizing 10-, 10-12-, or > 12-mm minimum core as potential biopsy quality control. METHODS:Assessed 2424 prostate biopsy cores and co...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2242-6
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:Treatment options for antimuscarinic refractory neurogenic detrusor overactivity (NDO) are botulinum toxin type A injections (BTX-A) and augmentation cystoplasty (AC). We estimated initial and cumulative 5-year costs of these treatments. MATERIALS AND METHODS:Base case is an individual with antimuscarinic refr...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-010-0618-3
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVES:Androgen receptor (AR) action in benign and malignant tissue is potentiated by a number of co-regulatory proteins that may interact with one or more receptor domains. With improvement of research methodologies, it became possible to detect a number of co-activators whose expression is increased in prostate c...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-011-0797-6
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVES:The objective of our study was to study trainees' feedback and rating of models for training transurethral resection of bladder lesions (TURBT) and prostate (TURP) during simulation. METHODS:The study was performed during the ''Transurethral resection (TUR) module" at the boot camp held in 2019. Prior to th...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03559-4
更新日期:2021-01-04 00:00:00
abstract:OBJECTIVE:To compare efficacy and safety between superior calyceal access and inferior calyceal access for pelvic and/or lower calyceal renal stones. METHODS:Consecutive patients presenting with Pelvic and/or inferior calyceal renal calculi were allocated to the superior calyceal access (group 1) or inferior calyceal ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03409-3
更新日期:2020-08-31 00:00:00
abstract::The diagnosis of prostate cancer (PCa) can be challenging due to the limited performance of current diagnostic tests, including PSA, digital rectal examination and transrectal conventional US. Multiparametric MRI has improved PCa diagnosis and is recommended prior to biopsy; however, mp-MRI does miss a substantial num...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03193-0
更新日期:2020-04-18 00:00:00
abstract:PURPOSE:Testicular torsion is the most concerning underlying cause of acute scrotal pain that can lead to loss of the affected testicle. Whether a torted testicle can be salvaged surgically is directly affected by prompt presentation and diagnosis. This study aims to evaluate the awareness of testicular torsion amongst...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2269-8
更新日期:2018-09-01 00:00:00
abstract::The original article can be found online. ...
journal_title:World journal of urology
pub_type: 已发布勘误
doi:10.1007/s00345-020-03495-3
更新日期:2020-10-24 00:00:00
abstract::We report on 208 patients with locally advanced renal-cell carcinoma who received a surgical adjuvant vaccination with autologous, Newcastle disease virus (NDV)-modified, and lethally irradiated tumor cells in combination with low-dose recombinant interleukin-2 and interferon-alpha. The pathological stage was defined ...
journal_title:World journal of urology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00184874
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:The use of a ureteral access sheath (UAS) during flexible retrograde intrarenal surgery (RIRS) has become increasingly popular. Our aim was to evaluate the accessibility of a new UAS device, allowing the transformation of the working guidewire into a safety guidewire. METHODS:A prospective, multicenter study w...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-013-1094-3
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:To analyze and compare preoperative patient characteristics and postoperative results in men with stress urinary incontinence (SUI) selected for an adjustable male sling system or an artificial urinary sphincter (AUS) in a large, contemporary, multi-institutional patient cohort. METHODS:658 male patients who u...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2523-0
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To examine the effect of marital status and gender on stage at diagnosis, tumor grade, treatment type and cancer specific mortality (CSM) in patients with localized renal cell carcinoma (RCC). METHODS:Within Surveillance, Epidemiology, and End Results registry (2001-2013), we identified 57,700 patients with T1...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2082-9
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:Combination therapy of male lower urinary tract symptoms with α(1)-adrenoceptor and muscarinic receptor antagonists attracts increasing interest. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca(2+) channels. Here, we have investigated whether propiverin...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0655-6
更新日期:2011-04-01 00:00:00
abstract::Nephrolithiasis is a highly prevalent disease worldwide with rates ranging from 7 to 13% in North America, 5-9% in Europe, and 1-5% in Asia. Due to high rates of new and recurrent stones, management of stones is expensive and the disease has a high level of acute and chronic morbidity. The goal of this study is to rev...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-017-2008-6
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To evaluate the present human-based evidence that diet is related to the risk and outcome of prostate cancer. METHODS:Review of major case-control and cohort studies, and experimental trials evaluating the effect of diet or dietary constituents on the risk of prostate cancer. RESULTS:Although non-experimental...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-011-0810-0
更新日期:2012-04-01 00:00:00
abstract:INTRODUCTION:Muscle-invasive bladder cancer (MIBC) is an aggressive disease for which treatment strategies are continuously evolving. We characterized trends in treatment modalities for MIBC from 2004 to 2013 (the "pre-immunotherapy era") and identified predictors of receiving the current standard of care treatment: ne...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2371-y
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:Following its introduction in 1980, shock wave lithotripsy (SWL) rapidly emerged as the first-line treatment for the majority of patients with urolithiasis. Millions of SWL therapies have since been performed worldwide, and nowadays, SWL still remains to be the least invasive therapy modality for urinary s...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-014-1369-3
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:Adjuvant chemotherapy (ACT) is recommended for non-organ-confined bladder cancer (BCa) after radical cystectomy (RC) and pelvic lymph node dissection (PLND), but there are sparse data regarding its specific efficacy in patients with histological variants. The aim of our study was to evaluate the role of ACT ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03362-1
更新日期:2020-07-25 00:00:00
abstract::A low-pressure reservoir for urine is created by antimesenteric splitting and side-to-side anastomosis of the rectosigmoid, the expectation being to obtain better continence rates and better protection of the upper tract than are achievable by ureterosigmoidostomy. Between 1990 and August 1993 the procedure was perfor...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF00182560
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:During rejection, leukocytes are recruited from the peripheral circulation into the graft leading to the damage of endothelial cells, capillary perfusion failure and graft loss. Chemokines play a pivotal role in the recruitment of leukocytes to the endothelium. Viral macrophage inflammatory protein-II (vMIP-II)...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-010-0556-0
更新日期:2010-08-01 00:00:00
abstract::The aim of this article is to describe the current ultrasound (US) contrast agents employed in the characterization of renal tumors and to report our experience in the use of a contrast-specific ultrasound technique pulse inversion harmonic imaging (PIHI).A total of 23 renal masses were prospectively evaluated by conv...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-004-0410-3
更新日期:2004-11-01 00:00:00
abstract:PURPOSE:Data assessing the effectiveness of single-use flexible ureteropyeloscopy (FURS) are limited. This study evaluates and compares single-use FURS with conventional reusable FURS. METHODS:A systematic search using electronic databases (Pubmed and Embase) was performed for studies evaluating single-use FURS in the...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-017-2131-4
更新日期:2018-04-01 00:00:00
abstract::Due to its unique biological behavior, late relapse (LR) of testicular cancer has recently been described as an own tumor entity. It is currently defined as tumor recurrence more than 2 years after complete remission following primary treatment including chemotherapy. The incidence ranges from 2 to 6%, with a median r...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-004-0397-9
更新日期:2004-04-01 00:00:00
abstract:PURPOSE:Several disease characteristics have been identified as potential predictors for pathological node involvement (pN+) following radical cystectomy (RC). However, these have not been assessed in patients treated with neoadjuvant chemotherapy (NAC). We endeavored to assess factors predicting adverse pathology in c...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-015-1667-4
更新日期:2016-05-01 00:00:00