Abstract：
OBJECTIVES:Androgen receptor (AR) action in benign and malignant tissue is potentiated by a number of co-regulatory proteins that may interact with one or more receptor domains. With improvement of research methodologies, it became possible to detect a number of co-activators whose expression is increased in prostate cancer tissue. METHODS:Manuscripts describing prostate cancer-relevant regulation of cellular events by co-activators are selected and summarized. RESULTS:AR co-activators may regulate histone modification, proteasomal degradation, chaperones, sumoylation, chromatin remodeling, and cytoskeleton. Some of them (TIF-2) are up-regulated by androgens, whereas the expression of others increases during androgen ablation (p300, CBP, and Tip60). Most co-factors are important for the stimulation of cellular proliferation, although in some cases (ART-27), they act as tumor suppressors and are deleted in prostate cancer tissue. In addition to stimulating AR, some co-activators suppress apoptosis in prostate cancer cells that do not express the AR (p300 and SRC-3). It was recently shown that the inhibition of p300 slows down proliferation, stimulates apoptosis, and inhibits migration and invasion. CONCLUSIONS:Co-factors whose down-regulation results in the alterations of multiple cellular functions may be valid targets for novel therapies in advanced prostate cancer.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Culig Z,Santer FRdoi
10.1007/s00345-011-0797-6subject
Has Abstractpub_date
2012-06-01 00:00:00pages
297-302issue
3eissn
0724-4983issn
1433-8726journal_volume
30pub_type
杂志文章,评审abstract：:We evaluated the quality of micturition in patients with orthotopic neobladder replacement. In the present study, 58 patients who had undergone orthotopic neobladder replacement following cystectomy were enrolled. The quality of micturition was evaluated by means of uroflowmetry, a self-administered questionnaire and ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s003450000156
更新日期：2000-12-01 00:00:00
abstract：PURPOSE:To assess whether real-time elastography-targeted biopsy (RTE-bx) is superior to the standard systematic transrectal ultrasound (TRUS)-guided biopsy in predicting subsequent prostate cancer (PCa) rates in patients with initially negative biopsy and to specifically reveal differences in the occurrence of high-gr...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2178-x
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:Digital low-dosage, linear slot scanning radiography (Lodox®) is an imaging modality that can emit down to one-tenth the radiation of conventional X-ray systems. We prospectively evaluated Lodox® as a diagnostic imaging modality in patients with ureterolithiasis. METHODS:Conventional kidney-ureter-bladder (KUB...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02803-w
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:We sought to examine the literature reporting the effect of urinary tract infection (UTI) on non-schistosomiasis-related UBC (UBCNS) through a systematic review and meta-analysis. METHODS:A predefined study protocol was developed according to PRISMA. Medline and Scopus were searched for all studies investigati...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-018-2257-z
更新日期：2018-08-01 00:00:00
abstract：:Non-gonococcal urethritis (NGU) is conventionally treated with oral antibiotics. With this Phase II study, we investigated the action of a locally disinfecting substance, Instillagel, in symptomatic NGU. Instillation treatment was performed twice daily to 32 male patients with symptomatic NGU. To evaluate the therapeu...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-001-0236-1
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:Several studies have reported brain activations and functional connectivity (FC) during micturition using functional magnetic resonance imaging (fMRI) and concurrent urodynamics (UDS) testing. However, due to the invasive nature of UDS procedure, non-invasive resting-state fMRI is being explored as a potenti...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-021-03599-4
更新日期：2021-01-29 00:00:00
abstract：PURPOSE:To assess the pathological and the oncologic outcomes of the prostate cancer (PCa) missed by 6- and 12-core biopsy protocols by using a reference 21-core scheme. MATERIALS AND METHODS:Between 2001 and 2009, all patients who had PCa detected in an initial 21-core TRUS biopsy scheme and were treated by a radical...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0800-2
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:This study aimed at analysing long-term oncologic outcomes in prostate cancer patients with limited nodal disease (1-2 positive lymph nodes) without adjuvant therapy after radical prostatectomy (RP). METHODS:We retrospectively analysed data of 209 pN1 patients who underwent RP between January 1998 and 2010 wit...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2079-4
更新日期：2017-12-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-001-0242-3
更新日期：2002-09-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02838-z
更新日期：2020-04-01 00:00:00
abstract：INTRODUCTION:Natural orifice transluminal endoscopic surgery (NOTES) and laparoendoscopic single-site surgery (LESS) are the next steps in the evolution of laparoscopic surgery, promising reduced morbidity and improved cosmetic result. The inconsistent terminology initially used led to confusion. Understanding the tech...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-012-0899-9
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:To investigate the spontaneous clearance rates of remnant particles following miniaturized percutaneous nephrolithotomy (mini-PCNL) and retrograde intrarenal surgery (RIRS). METHODS:Among 624 patients who underwent mini-PCNL or RIRS at our institution from 2011 to 2015, we collected data of 247 patients with 2...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1807-5
更新日期：2016-11-01 00:00:00
abstract：PURPOSE:To assess long-term clinical and oncological outcome in women undergoing radical cystectomy and ileal neobladder reconstruction for invasive bladder cancer. METHODS:From 1995 to 2010, a total of 121 women with clinically organ-confined urothelial carcinoma underwent radical cystectomy with an orthotopic ileal ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0837-x
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:To critically review and synthesize data of ureteroscopy (URS) in different circumstances that all urologists may encounter during everyday clinical practice, such as pregnancy, obesity, bleeding diathesis, renal stones larger than 2 cm, calyceal diverticula, and kidney malformations. METHODS:According to PRIS...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-014-1345-y
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:To propose a new coating to silicone implants using Manganese dioxide. We present bacterial adhesion and proliferation when implants are challenged with Escherichia coli. METHODS:Coated and control silicon implants were placed in two independent subcutaneous pouches in the dorsum of Wistar rats. After skin clo...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02856-x
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:To assess the effects of warm ischaemia time (WIT) on renal function after laparoscopic partial nephrectomy (LPN) for renal masses in patients with a normal contralateral kidney. METHODS:From October 2006 to December 2008, 53 patients treated with LPN were enrolled in this prospective study. Effective renal pl...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-011-0729-5
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:Erectile dysfunction (ED) is an early sign of vascular dysfunction. Studies have reported a correlation between arterial stiffness and cardiovascular events. The objective of this study was to evaluate the association among different criteria for assessing arterial stiffness and cardiovascular risk factors in E...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0486-x
更新日期：2010-10-01 00:00:00
abstract：:The field of tissue engineering has developed in phases: initially researchers searched for "inert" biomaterials to act solely as replacement structures in the body. Then, they explored biodegradable scaffolds--both naturally derived and synthetic--for the temporary support of growing tissues. Now, a third phase of ti...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-008-0273-0
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:Data assessing the effectiveness of single-use flexible ureteropyeloscopy (FURS) are limited. This study evaluates and compares single-use FURS with conventional reusable FURS. METHODS:A systematic search using electronic databases (Pubmed and Embase) was performed for studies evaluating single-use FURS in the...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-017-2131-4
更新日期：2018-04-01 00:00:00
abstract：INTRODUCTION:Obesity may be a risk factor for kidney donors to develop reduced renal function. The Framingham heart study suggested that visceral adipose tissue (VAT) confers a more adverse metabolic profile compared with subcutaneous adipose tissue (SAT). Asians tend to have a higher VAT composition and it is unclear ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2566-2
更新日期：2019-10-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0618-3
更新日期：2011-02-01 00:00:00
abstract：:This paper provides an overview of the scientific and practical aspects of assessing health-related quality of life (HRQL). The paper provides a brief overview of developments in the field and then discusses the definition of HRQL. The different types of HRQL measure available to researchers are described, with specif...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050132
更新日期：1999-08-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0361-1
更新日期：2009-06-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00182035
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:To assess oncologic outcomes after salvage radiotherapy (SRT) without androgen deprivation therapy (ADT) in patients with persistently detectable PSA after radical prostatectomy (RT). METHODS:Two hundred and one patients who failed to achieve an undetectable PSA received SRT without ADT. The primary endpoint w...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-013-1214-0
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:Robotic partial nephrectomy (RPN) is a minimally-invasive technique used to treat renal tumors. A clinical pathway and prospective research protocol (AMBU-REIN) were specifically set up to establish and assess the routine use of day-case RPN. METHODS:The AMBU-REIN study was conducted in the framework of the Fr...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03283-z
更新日期：2020-06-08 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2389-1
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:The prostate-specific antigen density (PSAD) helps distinguish between benign prostatic hyperplasia (BPH) and prostate cancer. Accurate prostate volume (PV) assessment is necessary for PSAD calculation and both BPH diagnosis and treatment response monitoring; therefore, accurate PV measurement is increasingly b...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1220-2
更新日期：2014-12-01 00:00:00
abstract：:To evaluate the diagnostic efficacy of transrectal ultrasound (TRUS)-guided biopsy of the prostatic fossa in men with biochemical relapse following radical retropubic prostatectomy (RP). Thirty patients, with detectable prostate specific antigen (PSA) and negative imaging for metastases after RP, were evaluated for lo...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-007-0167-6
更新日期：2007-06-01 00:00:00
abstract：:Genital skin loss results from a heterogeneous group of traumatic and infectious processes. Removal of all devitalized tissue is necessary prior to reconstructive surgery; hyperbaric oxygen may help in the management of necrotizing infections. Defect coverage depends more on the remaining genital skin than on the etio...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050115
更新日期：1999-04-01 00:00:00
