Abstract：
PURPOSE:Chronic inflammation has been considered a potential risk factor for prostate cancer. Toll-like receptors (TLRs) are important in the innate immune response to pathogens and in cross talk between innate immunity and adaptive immunity. In this study, sequence variants in the TLR4 gene were investigated to determine whether they were associated with prostate cancer risk in a Korean cohort. METHODS:An association study between 11 single-nucleotide polymorphisms (SNPs) of the TLR4 gene and prostate cancer was performed in 463 Korean male subjects including 240 prostate cancer patients and 223 healthy controls. SNPs were genotyped using the TaqMan assay, and their association with the risk of prostate cancer was evaluated using logistic regression analysis. RESULTS:The statistical analysis revealed that one SNP at the 3'UTR (rs11536889) showed significant association with the risk of prostate cancer (P (corr) = 0.005, OR = 1.81). One common haplotype (ht2) was also significantly associated with the risk of prostate cancer (P (corr) = 0.009, OR = 1.77). However, further analysis showed no association between any of the SNPs and prostate cancer prognostic factors such as the Gleason score or tumor stage. CONCLUSIONS:The findings of this study suggest that polymorphisms of the TLR4 gene might be associated with the risk of prostate cancer in Korean men.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Kim HJ,Bae JS,Chang IH,Kim KD,Lee J,Shin HD,Lee JY,Kim WJ,Kim W,Myung SCdoi
10.1007/s00345-011-0690-3subject
Has Abstractpub_date
2012-04-01 00:00:00pages
225-32issue
2eissn
0724-4983issn
1433-8726journal_volume
30pub_type
杂志文章abstract：CONTEXT:The majority of prostate cancer diagnoses are facilitated by testing serum Prostate Specific Antigen (PSA) levels. Despite this, there are limitations to the diagnostic accuracy of PSA. Consideration of patient demographic factors and biochemical adjuncts to PSA may improve prostate cancer risk stratification. ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03392-9
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abstract：:In 90 patients treated with laser prostatectomy using the Urolase (n = 50) or Ultraline (n = 40) laser fiber, the fiber-tip durability was investigated. In general the Urolase fiber tips were less damaged than the Ultraline fiber tips. At visual inspection, 62% of the Urolase fiber tips were graded as minimally damage...
journal_title：World journal of urology
pub_type： 杂志文章
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abstract：:The purpose of this study was to assess possible central side-effects of sildenafil (Viagra) on attention and memory functions. Sildenafil and placebo were administered in young male subjects in a double-blind balanced cross-over design. Behavioral patterns and event-related brain potentials (ERP) were recorded in a s...
journal_title：World journal of urology
pub_type： 杂志文章
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更新日期：2001-02-01 00:00:00
abstract：:To understand alterations to the urokinase system that may occur in progressively metastatic prostate cancer cells, we assessed urokinase plasminogen activator receptor (uPAR) expression, in vitro motility towards vitronectin, urokinase plasminogen activator (uPA)-induced growth and growth factor regulation of uPAR ex...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0395-3
更新日期：2004-04-01 00:00:00
abstract：PURPOSE:To critically review and synthesize data of ureteroscopy (URS) in different circumstances that all urologists may encounter during everyday clinical practice, such as pregnancy, obesity, bleeding diathesis, renal stones larger than 2 cm, calyceal diverticula, and kidney malformations. METHODS:According to PRIS...
journal_title：World journal of urology
pub_type： 杂志文章,评审
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abstract：:Robotic surgery was started in the Department of Urology, Hospital Kuala Lumpur, in April 2004. We present our experience in developing the program and report the results of our first 50 cases of robotic radical prostatectomy. A three-arm da Vinci robotic system was installed in our hospital in March 2004. Prior to in...
journal_title：World journal of urology
pub_type： 杂志文章
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abstract：BACKGROUND:Previous study compared limited number of parameters post the treatment of cold knife and laser urethrotomy for urethral stricture and controversy about the superiority of those two techniques still remains. This study aims to update the evidence and provide better clinical guidance. METHOD:We systematicall...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
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abstract：PURPOSE:Given that the tumor-promoting inflammation has been previously established in squamous cell carcinoma of the bladder but its contribution to development of urothelial carcinoma (UC) still remains elusive, our aim was to study changes in expression and activity of inflammation-mediating NF-κB and STAT3 transcri...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1237-1
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abstract：:The treatment of clinically locally advanced prostate cancer (cT3-4) is subject to controversies. Patients with lymph node metastases as well as patients with overstaged localized and thus curable disease fall into this category. Radical prostatectomy, external beam radiotherapy and early or deferred hormonal therapy ...
journal_title：World journal of urology
pub_type： 杂志文章,评审
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abstract：PURPOSE:Testicular torsion is the most concerning underlying cause of acute scrotal pain that can lead to loss of the affected testicle. Whether a torted testicle can be salvaged surgically is directly affected by prompt presentation and diagnosis. This study aims to evaluate the awareness of testicular torsion amongst...
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-007-0208-1
更新日期：2007-12-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
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journal_title：World journal of urology
pub_type： 临床试验,杂志文章,随机对照试验
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abstract：BACKGROUND:The significance of a positive UroVysion FISH assay is uncertain in patients with normal cystoscopy. This multicenter study evaluates the clinical significance of a positive FISH assay in patients with no visible tumor and excluding those with a positive cytology. METHODS:A multi-institutional, retrospectiv...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
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更新日期：2015-09-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0768-y
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVES:Squamous cell carcinoma (SCC) of the penis with inguinal lymph node involvement aggravates prognosis and can cause femoral artery bleeding, hemorrhagic shock and even death. The objective of this study is to describe the use of extra-anatomical transobturator bypass graft for femoral artery involvement by me...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0282-z
更新日期：2008-10-01 00:00:00
abstract：PURPOSE:To compare the impact of 18F-sodium-fluoride (NaF) PET/CT, 18F-fluorocholine (FCH) PET/CT and diffusion-weighted whole-body MRI (DW-MRI) on the management of patients with prostate cancer (PCa) suspicious for distant metastasis. METHODS:Prostate cancer patients were prospectively included between December 2011...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-018-2547-5
更新日期：2019-08-01 00:00:00
abstract：PURPOSE:To evaluate the role of adrenergic and nitrergic signaling on ureteric peristaltic frequency and contraction force in vivo using a large animal model. METHODS:Twelve female pigs (72 ± 4 kg) were chronically instrumented with an electronic pressure-monitoring catheter in the right ureter. Nephrostomy, cystostom...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1663-8
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abstract：:Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF alpha) are two closely related peptides that interact with cell-surface epidermal growth factor receptors (EGFR) to induce receptor tyrosine phosphorylation and activation of intracellular signal-transduction pathways. EGF appears to be the predom...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00185972
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abstract：:Expression and overexpression of the epidermal growth factor receptor (EGFR) have been described in several solid tumors including bladder, breast, colorectal, NSCLC, prostate, and ovarian cancers. In addition to gene amplification, point mutations within the kinase domain also occur. Previous reports indicate that th...
journal_title：World journal of urology
pub_type： 杂志文章,收录出版
doi：10.1007/s00345-007-0202-7
更新日期：2007-12-01 00:00:00
abstract：PURPOSE:Management of prostate cancer following radiation therapy remains challenging, especially for younger men or those with life expectancy greater than 10 years. We outline the efficacy, safety and adequacy of radical prostatectomy for the treatment of radiorecurrent localized prostate cancer. METHODS:A systemati...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-013-1029-z
更新日期：2013-12-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2187-9
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:To introduce the detailed procedures of two innovative surgical options for pediatric buried penis and prospectively compare their efficacy and safety. METHODS:A single-center, non-randomized, prospective study was conducted at the Zhongnan Hospital of Wuhan University, where patients were operated on using...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2243-5
更新日期：2018-08-01 00:00:00
abstract：INTRODUCTION:Erectile dysfunction (ED) and cardiovascular disease (CVD) share a great number of common risk factors. There is growing evidence that aldosterone, an independent CVD risk factor, is associated with ED. AIMS:The purpose of this study was to determine the relationship between plasma aldosterone and erectil...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1723-0
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Upper tract urothelial carcinoma (UTUC) is a rare and heterogeneous disease. Several clinical and biological prognostic factors have been identified in multi-institutional collaborative works with the aim of helping decision-making in pursuit of tailored individual patient care. This review provides an overv...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-016-1826-2
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVES:To evaluate the impact of age, stone size, location, radiolucency, extraction of stone fragments, size of ureteroscope and presence and degree of hydronephrosis on the efficacy and safety of holmium:YAG (Ho:YAG) laser lithotripsy in the ureteroscopic treatment of ureteral stones in children. METHODS:Between...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1152-x
更新日期：2014-08-01 00:00:00
abstract：PURPOSE:Metastatic renal cell carcinoma (mRCC) represents a significant and rising burden of disease, with rapidly evolving treatment modalities. The role of cytoreductive nephrectomy (CN) is controversial in this setting. As such, London Cancer has pursued a multidisciplinary team (MDT) approach when assessing suitabi...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03107-0
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:We aim to evaluate prostate-specific antigen (PSA) trends in post-primary focal cryotherapy (PFC) patients. MATERIALS AND METHODS:This was an institutional review board-approved retrospective study of PFC patients from 2010 to 2015. Patients with at least one post-PFC PSA were included in the study. Biochemica...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2130-5
更新日期：2018-02-01 00:00:00
abstract：:The purpose of this study was to assess the ability of [(18)F]FDG-PET, CT/MRI and serum tumor marker (TM) to predict the viability of residual masses after high-dose chemotherapy (HD-Ctx) in patients with metastatic germ cell tumors (GCT). In a prospective study, 60 residual tumors in 28 GCT patients were classified a...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0392-6
更新日期：2004-06-01 00:00:00
abstract：PURPOSE:To evaluate the feasibility of measuring the intrapelvic pressure (IPP) during f-URS with a wire including a pressure sensor and to assess IPP profiles during the procedure. METHODS:Patients undergoing f-URS for stone disease were recruited. A wire with pressure sensor was placed in the renal cavities to measu...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03216-w
更新日期：2020-05-07 00:00:00
