Abstract：
:To understand alterations to the urokinase system that may occur in progressively metastatic prostate cancer cells, we assessed urokinase plasminogen activator receptor (uPAR) expression, in vitro motility towards vitronectin, urokinase plasminogen activator (uPA)-induced growth and growth factor regulation of uPAR expression in three cell lines--PC-3 and two derivatives from secondary metastases, PC-3M and PC-3MM2. DU-145 and Tsu-Pr1 cells were included for comparative purposes. uPAR expression increases with metastatic passage in these cell lines and accompanies increased growth and motility responses in the presence of uPA. Growth factors TGFbeta1 and IGF-1 induce uPAR in all three prostate cancer lines; however, PC-3M and PC-3MM2 cells also respond to bFGF. Of the cell lines tested, PC-3MM2 most uniformly respond to added TGFbeta1, IGF-1 and bFGF. These results show that in two progressive derivatives from repeated metastasis of PC-3 cells, constitutive and growth factor-induced uPAR expression is enhanced. This increased uPAR facilitates the properties of growth and motility.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Forbes K,Gillette K,Kelley LA,Sehgal Idoi
10.1007/s00345-003-0395-3keywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
67-71issue
1eissn
0724-4983issn
1433-8726journal_volume
22pub_type
杂志文章abstract：:Gastrin releasing peptide (GRP) is a neuropeptide that has been suggested to play a role in the development of some malignancies. Our aim was: (1) to identify the expression of GRP in cancerous prostate glands, and (2) to correlate its expression to various pathological parameters and to the patient's clinical outcome...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0339-y
更新日期：2003-08-01 00:00:00
abstract：PURPOSE:MicroRNAs (miRNAs) play an important role as regulators of gene expression in tumourigenesis by controlling many biological processes in growth, development, differentiation and apoptosis. Previous studies have shown an altered expression of specific miRNAs in clear cell renal cell carcinoma (ccRCC). But the fu...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0633-4
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVES:Squamous cell carcinoma (SCC) of the penis with inguinal lymph node involvement aggravates prognosis and can cause femoral artery bleeding, hemorrhagic shock and even death. The objective of this study is to describe the use of extra-anatomical transobturator bypass graft for femoral artery involvement by me...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0282-z
更新日期：2008-10-01 00:00:00
abstract：PURPOSE:To report survival outcomes of patients treated surgically for sarcomatoid-variant renal cell carcinomas (sRCC) and to assess whether the underlying histologic subtype is an independent predictor of outcome. METHODS:One hundred and fifty-one patients underwent surgery at a referral center between 1991 and 2014...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1644-y
更新日期：2016-04-01 00:00:00
abstract：INTRODUCTION:Herein, current developments in open and minimally invasive renal surgery are presented. MATERIALS AND METHODS:This also includes considerations on the appropriate indication for the two surgical procedures in small renal tumours, locally advanced disease (>pT2), complicated renal tumours as well as cytor...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0238-3
更新日期：2008-04-01 00:00:00
abstract：PURPOSE:The purpose of the study is to introduce our experience of a modified single-port minilaparoscopic technique for the treatment of pediatric hydrocele. METHODS:Between June 2008 and May 2012, 279 boys (115 communicating hydrocele and 164 "non-communicating" hydrocele, diagnosis based on preoperative physical ex...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1259-8
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:Clinical outcomes prognostic markers are awaited in clear-cell renal carcinoma (ccRCC) to improve patient-tailored management and to assess six different markers' influence on clinical outcomes from ccRCC specimen and their incremental value combined with TNM staging. MATERIALS AND METHODS:This is a retrospect...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1854-y
更新日期：2017-01-01 00:00:00
abstract：:Despite several new urine markers urinary cytology remains the gold standard for the non-invasive detection of bladder carcinoma. The use of monoclonal antibodies against tumor associated antigens offers a promising approach to improve urinary cytology. The aim of this study was to compare fluorescence immunocytology ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0390-8
更新日期：2004-06-01 00:00:00
abstract：:We report on 208 patients with locally advanced renal-cell carcinoma who received a surgical adjuvant vaccination with autologous, Newcastle disease virus (NDV)-modified, and lethally irradiated tumor cells in combination with low-dose recombinant interleukin-2 and interferon-alpha. The pathological stage was defined ...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00184874
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:To assess the efficacy and safety of Adjustable Transobturator Male System (ATOMS) compared to male Readjustment Mechanical External (REMEEX) system for post-prostatectomy incontinence (PPI). MATERIAL AND METHODS:A systematic review and meta-analysis on adjustable device ATOMS compared to male REMEEX is pres...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03300-1
更新日期：2020-06-11 00:00:00
abstract：PURPOSE:Robotic radical cystectomy (RRC) has become a commonly utilised alternative to open radical cystectomy (ORC). We performed a systematic review and meta-analysis of RRC vs ORC focusing on perioperative outcomes and safety. METHODS:Medline, EMBASE and CENTRAL were searched from January 2000 to April 2020 followi...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-020-03385-8
更新日期：2020-07-30 00:00:00
abstract：PURPOSE:Patients presenting with prostate gland sizes greater than 200 cc pose a unique surgical challenge to both patients and surgeons. The objective of this study is to critically assess the efficacy and risks associated with performing holmium laser enucleation of the prostate (HoLEP) on glands ≥ 200 cc. MATERIALS...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03156-5
更新日期：2020-03-23 00:00:00
abstract：:The funding number was incorrect in the original published article. The correct funding number should read as follows. ...
journal_title：World journal of urology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00345-018-2289-4
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:To assess the long-term patient-reported outcomes following TO-TVT as a secondary continence procedure in women with recurrent stress urinary incontinence (R-SUI). METHODS:A secondary analysis of the 9-year follow-up of the E-TOT study was performed: 341 women with predominant SUI symptoms were randomised to u...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-016-1969-1
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:To assess the oncological safety of laparoscopic procedures for the management of urothelial carcinomas of the urinary tract. METHODS:Data on laparoscopic management of urothelial carcinomas in the literature were analysed using MEDLINE and by matching the following keywords: urological malignancies, upper t...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-008-0349-x
更新日期：2009-02-01 00:00:00
abstract：PURPOSE:To propose a new coating to silicone implants using Manganese dioxide. We present bacterial adhesion and proliferation when implants are challenged with Escherichia coli. METHODS:Coated and control silicon implants were placed in two independent subcutaneous pouches in the dorsum of Wistar rats. After skin clo...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02856-x
更新日期：2020-03-01 00:00:00
abstract：:The landscape has dramatically changed for patients seeking treatment for rapid ejaculation. Previously, psychotherapy or behavioral treatment was considered to be the treatment of choice for this troubling sexual dysfunction. Since the early 1990s, an efficacious alternative treatment has emerged-the off-label admini...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-004-0489-6
更新日期：2005-06-01 00:00:00
abstract：PURPOSE:To examine phosphodiesterase type 5 (PDE5) expression in the anterior fibromuscular stroma (AFMS) of the prostate. Although PDE5 expression was identified in the human prostate, differences in PDE5 expression in intra-prostatic regions are unknown. The AFMS in the prostate has peculiar innervations that could c...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03095-1
更新日期：2020-11-01 00:00:00
abstract：:Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF alpha) are two closely related peptides that interact with cell-surface epidermal growth factor receptors (EGFR) to induce receptor tyrosine phosphorylation and activation of intracellular signal-transduction pathways. EGF appears to be the predom...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00185972
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:During rejection, leukocytes are recruited from the peripheral circulation into the graft leading to the damage of endothelial cells, capillary perfusion failure and graft loss. Chemokines play a pivotal role in the recruitment of leukocytes to the endothelium. Viral macrophage inflammatory protein-II (vMIP-II)...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0556-0
更新日期：2010-08-01 00:00:00
abstract：PURPOSE:To determine whether individual and/or cumulative components of metabolic syndrome (obesity, hypertension, dyslipidemia, and hyperglycemia) are associated with pathologic features of kidney cancer. PATIENTS AND METHODS:A review of our kidney tumor database identified 462 patients who underwent partial or radic...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1850-2
更新日期：2017-01-01 00:00:00
abstract：:The purpose of the present study was to examine the outcome profiles of a large number of patients with locally advanced adenocarcinoma of the prostate following radical perineal prostatectomy (RPP) for clinically organ-confined disease. Of 1662 men who underwent RPP performed by a single surgeon between January 1972 ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s003459900100
更新日期：2000-06-01 00:00:00
abstract：PURPOSE:Complete urethral replacement using unseeded matrices has been proposed as a possible therapy in cases of congenital or acquired anomalies producing significant defects. Tissue regeneration involves fibrin deposition, re-epithelialization, and remodeling that are limited by the size of the defect. Scar formatio...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0316-6
更新日期：2008-08-01 00:00:00
abstract：:This article reviews the definition, incidence, pathological characteristics and natural history of low risk localised prostate cancer. Low risk disease is typically defined as clinical stage T1/T2a, biopsy Gleason score
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-008-0277-9
更新日期：2008-10-01 00:00:00
abstract：PURPOSE:STAMPEDE arm H demonstrated a survival benefit for newly diagnosed prostate cancer (PCa) patients with low metastatic burden (LMB) who additionally received radiotherapy (RT) to the primary. However, it is unknown if radical prostatectomy (RP) may achieve equivalent results, since existing studies did neither i...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02950-0
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:In the present study, we aimed to evaluate the sexual function in patients with multiple sclerosis (MS) who were examined in two subgroups and compare the results to the control group with a validated questionnaire. METHODS:A total of 23 consecutive female MS patients divided into groups with relapsing-remitti...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0891-4
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:To introduce the detailed procedures of two innovative surgical options for pediatric buried penis and prospectively compare their efficacy and safety. METHODS:A single-center, non-randomized, prospective study was conducted at the Zhongnan Hospital of Wuhan University, where patients were operated on using...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2243-5
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:Oxidative stress is believed to be one of the important etiologies in carcinogenesis that has not been systemically investigated in urothelial carcinoma (UC). Through data mining from a published transcriptomic database of UC of urinary bladders (UBUCs) (GSE31684), glutathione peroxidase 2 (GPX2) was identified...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1522-7
更新日期：2015-11-01 00:00:00
abstract：PURPOSE:To evaluate whether the rate of Gleason score (GS) upgrade on final pathology, the rate of positive surgical margins (PSM) and the rate of biochemical recurrence (BCR) after radical prostatectomy (RP) were different if prostate biopsy (PB) was graded by community pathologists (CP) as compared to specialized uro...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1788-4
更新日期：2016-10-01 00:00:00
abstract：:Although anejaculation is a relatively uncommon occurrence in the general population, over 12,000 new cases are reported annually. Anejaculation may result from spinal cord injury (SCI), retroperitoneal lymph node dissection (RPLND), diabetes mellitis, transverse myelitis, multiple sclerosis, or psychogenic disorders....
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00182035
更新日期：1993-01-01 00:00:00
