Abstract：
PURPOSE:During rejection, leukocytes are recruited from the peripheral circulation into the graft leading to the damage of endothelial cells, capillary perfusion failure and graft loss. Chemokines play a pivotal role in the recruitment of leukocytes to the endothelium. Viral macrophage inflammatory protein-II (vMIP-II), a human herpes virus-8 DNA-encoded protein, is a broad-spectrum chemokine antagonist. The aim of the study was to prove the beneficial activity of vMIP-II treatment on acute rat kidney allograft damage. METHODS:Heterotopic rat kidney transplantation was performed in the Fischer 344 to Lewis transplantation model and animals were treated with vMIP-II (2 x 15 microg or 100 microg/day) for 7 days. Rejection-induced damage was analyzed by histology, and microcirculatory changes within the graft were analyzed by in vivo microscopy. RESULTS:Viral macrophage inflammatory protein-II significantly improved acute glomerular damage and tubulointerstitial inflammation and lowered the extent of vascular and tubulointerstitial damage of the treated allografts. Functional microcirculation of peritubular capillaries was significantly improved in vivo, and the firm adherence of leukocytes was significantly reduced by vMIP-II treatment. CONCLUSIONS:The administration of the broad-spectrum antagonist vMIP-II improved acute renal allograft damage, mainly by a reduction in leukocyte recruitment with a subsequently improved renal cortical microcirculation in vivo.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Bedke J,Stojanovic T,Kiss E,Behnes CL,Proudfoot AE,Gröne HJdoi
10.1007/s00345-010-0556-0subject
Has Abstractpub_date
2010-08-01 00:00:00pages
537-42issue
4eissn
0724-4983issn
1433-8726journal_volume
28pub_type
杂志文章abstract：OBJECTIVES:To compare the oncological and functional outcomes reported after radical retropubic prostatectomy (RRP) versus brachytherapy (BT) in the treatment of low-risk prostatic cancer (CaP). METHODS:Between May 1999 and October 2002, 200 patients (mean age 65.3 +/- 8.7) were enrolled and randomized into two groups...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-009-0418-9
更新日期：2009-10-01 00:00:00
abstract：:A Persian Gulf War veteran presented to the University Neuro-Urology service for management of severe chronic perineal pain. The overall physical and neurological exam was unremarkable. However, the rectal exam and the urodynamic study revealed a severe pelvic floor dysfunction. A neuro-behavioral approach is recommen...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/pl00007098
更新日期：2001-06-01 00:00:00
abstract：:One of the historic landmarks in urology is the first planned nephrectomy performed in 1869 by Gustav Simon of Heidelberg (1824-1877). In the history of medicine the reflections and considerations of the specialized surgeon reveal distinguished analyses of the "case" and, thus, the beginning of a modern scientific dis...
journal_title：World journal of urology
pub_type： 传,历史文章,杂志文章
doi：10.1007/s003450050125
更新日期：1999-06-01 00:00:00
abstract：PURPOSE:This study evaluated the baseline patient characteristics associated with the time to biochemical progression and overall survival in patients who participated in a phase II trial on zoledronic acid combined with the initial androgen-deprivation therapy for treatment-naïve bone-metastatic prostate cancer. METH...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-014-1431-1
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:To perform a feasibility phase study of a panel of putative protein biomarkers and determine whether it can identify and predict tumor recurrence in patients with non-muscle-invasive bladder cancer (NMIBC) on follow-up. METHODS:We prospectively analyzed the urine of 152 patients previously treated for NMIBC. Q...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03188-x
更新日期：2020-04-06 00:00:00
abstract：BACKGROUND:Recently, the American Urogynecologic Society and Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction released position statements on the use of mid-urethral slings. The statement offers that the polypropylene mesh mid-urethral sling (retropubic and transobturator) is now the recogni...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-015-1600-x
更新日期：2015-09-01 00:00:00
abstract：:The nuclear factor of kappa beta (NF-kappaB) transcription factor regulates the transcription of numerous genes including that of interleukin 6 (IL-6). The IL-6 acts as an autocrine and paracrine growth factor of androgen-independent prostate cancer. An aberrant expression of the IL-6 gene and an increase in IL-6 expr...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-007-0175-6
更新日期：2007-10-01 00:00:00
abstract：:Contemporary literature regarding the management of neobladder-vaginal fistula and stress urinary incontinence following radical cystectomy and neobladder reconstruction in women is reviewed in this article. Neobladder-vaginal fistula is uncommon but mandates meticulous repair. Compared to the native bladder, the wall...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-005-0013-7
更新日期：2005-09-01 00:00:00
abstract：:The aim of this article is to describe the current ultrasound (US) contrast agents employed in the characterization of renal tumors and to report our experience in the use of a contrast-specific ultrasound technique pulse inversion harmonic imaging (PIHI).A total of 23 renal masses were prospectively evaluated by conv...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-004-0410-3
更新日期：2004-11-01 00:00:00
abstract：PURPOSE:To systematically analyze the impact of prophylactic abdominal or retroperitoneal drain placement or omission in uro-oncologic surgery. METHODS:This systematic review follows the Cochrane recommendations and was conducted in line with the PRISMA and the AMSTAR-II criteria. A comprehensive database search inclu...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02978-2
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVES:To evaluate the impact of age, stone size, location, radiolucency, extraction of stone fragments, size of ureteroscope and presence and degree of hydronephrosis on the efficacy and safety of holmium:YAG (Ho:YAG) laser lithotripsy in the ureteroscopic treatment of ureteral stones in children. METHODS:Between...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1152-x
更新日期：2014-08-01 00:00:00
abstract：PURPOSE:To evaluate the association between the plant-based content of diet and serum testosterone levels in men from the national health and nutrition examination survey (NHANES) database. MATERIALS AND METHODS:Data on demographics, diet, and testosterone levels was acquired from the NHANES database. Using the food f...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03276-y
更新日期：2020-05-28 00:00:00
abstract：OBJECTIVES:We reviewed our patients with pathologic T3b renal cell carcinoma (RCC) to determine which factors influenced survival in this high risk patient group. METHODS:From April 1988 to August 2006, 722 patients underwent nephrectomy for RCC at Vanderbilt University. 128 patients (17%) had T3b disease by 2002 AJCC...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0358-9
更新日期：2009-02-01 00:00:00
abstract：PURPOSE:Metastatic renal cell carcinoma (mRCC) represents a significant and rising burden of disease, with rapidly evolving treatment modalities. The role of cytoreductive nephrectomy (CN) is controversial in this setting. As such, London Cancer has pursued a multidisciplinary team (MDT) approach when assessing suitabi...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03107-0
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVES:It has been reported that apoptosis of penile erectile tissue occurs after penile denervation, castration, and diabetes mellitus in animal studies. Aim of this study was to investigate apoptosis in corpora cavernosa of patients with organic erectile dysfunction (ED). METHODS:Cavernous biopsies were obtained...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0332-6
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:To evaluate renal function and to identify factors associated with renal dysfunction in the elective indications setting of nephron-sparing surgery (NSS). METHODS:We retrospectively reviewed operative data and glomerular filtration rate (GFR) of 519 patients treated by NSS in an elective indications setting be...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-014-1292-7
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:A paucity of data exists on the insignificant disease potentially suitable for active surveillance (AS) among men with intermediate-risk prostate cancer (PCa). We tried to identify pathologically insignificant disease and its preoperative predictors in men who underwent radical prostatectomy (RP) for intermedia...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1413-3
更新日期：2014-12-01 00:00:00
abstract：:The 30-45% failure rate after radical cystoprostatectomy mandates that we explore and optimize multimodal therapy to achieve better disease control in these patients. Cisplatin-based multi-agent combination chemotherapy has been used with success in metastatic disease and has therefore also been introduced in patients...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-006-0113-z
更新日期：2006-11-01 00:00:00
abstract：:The development of human benign prostatic hyperplasia (BPH) clearly requires a combination of testicular androgens and the ageing process. Although the role of androgens as the causative factor for human benign prostatic hyperplasia is debated, they undoubtedly play, at least, a permissive role. The principal prostati...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-002-0248-5
更新日期：2002-04-01 00:00:00
abstract：INTRODUCTION:The survival of patients with metastatic urothelial cancer (mUC) is poor. During the last 40 years, chemotherapy was the predominant treatment modality for mUC. The discovery of the immune checkpoint inhibitors (ICI), especially the inhibitors of the programmed cell death 1 and its ligand (PD-1/PD-L1), has...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-018-2538-6
更新日期：2019-09-01 00:00:00
abstract：:Nephrolithiasis is a highly prevalent disease worldwide with rates ranging from 7 to 13% in North America, 5-9% in Europe, and 1-5% in Asia. Due to high rates of new and recurrent stones, management of stones is expensive and the disease has a high level of acute and chronic morbidity. The goal of this study is to rev...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-017-2008-6
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:Current systemic treatment of targeted therapies, namely the vascular endothelial growth factor-antibody (VEGF-AB), VEGF receptor tyrosine kinase inhibitor (TKI) and mammalian target of rapamycin (mTOR) inhibitors, have improved progression-free survival and replaced non-specific immunotherapy with cytokines in...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-016-1868-5
更新日期：2017-02-01 00:00:00
abstract：:Although anejaculation is a relatively uncommon occurrence in the general population, over 12,000 new cases are reported annually. Anejaculation may result from spinal cord injury (SCI), retroperitoneal lymph node dissection (RPLND), diabetes mellitis, transverse myelitis, multiple sclerosis, or psychogenic disorders....
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00182035
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:To assess and report the feasibility and efficacy of electronic follow-up in patients after mid-urethral sling (MUS) operation. METHODS:All 235 patients after MUS operation for stress urinary incontinence (SUI) were divided into the WeChat follow-up (WFU) and the outpatient follow-up (OFU) groups. Patients com...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03245-5
更新日期：2020-05-19 00:00:00
abstract：OBJECTIVE:To provide appropriate evidence for treatment planning of patients with an impacted proximal ureteral stones ≥1.5 cm in size, by analyzing the therapeutic outcomes for those undergoing minimally invasive percutaneous antegrade ureterolithotripsy and retrograde ureterolithotripsy. PATIENTS AND METHODS:From Se...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-013-1026-2
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:To review the recent advances in terms of surgical technique and new robotic platforms applied to radical perineal prostatectomy (RPP). METHODS:A literature review was performed focusing on original articles on perineal prostatectomy searching via Medline/Pubmed and Embase. The entire spectrum was covered such...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-019-03004-1
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVES:Squamous cell carcinoma (SCC) of the penis with inguinal lymph node involvement aggravates prognosis and can cause femoral artery bleeding, hemorrhagic shock and even death. The objective of this study is to describe the use of extra-anatomical transobturator bypass graft for femoral artery involvement by me...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0282-z
更新日期：2008-10-01 00:00:00
abstract：PURPOSE/OBJECTIVE(S):Recent in vitro and in vivo evidence has suggested that statin medications may have anticancer activity. We sought to determine whether statin use was associated with improved clinical outcome in men treated with brachytherapy for prostate cancer. MATERIALS/METHODS:A database of men with prostate ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1281-x
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:To describe results of a simplified technique to configure the vesicourethral anastomosis and to restore posterior musculofascial plate during laparoscopic radical prostatectomy with a "single knot-single running" suture. METHODS:Between December 2006 and 2009, a conventional Van Velthoven anastomosis (group A...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-012-0840-2
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:To compare the impact of 18F-sodium-fluoride (NaF) PET/CT, 18F-fluorocholine (FCH) PET/CT and diffusion-weighted whole-body MRI (DW-MRI) on the management of patients with prostate cancer (PCa) suspicious for distant metastasis. METHODS:Prostate cancer patients were prospectively included between December 2011...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-018-2547-5
更新日期：2019-08-01 00:00:00
