当前位置： SCI文献检索 > WORLD JOURNAL OF UROLOGY期刊下所有文献 > Molecular predictors of response to PD-1/PD-L1 inhibition in urothelial cancer.

Molecular predictors of response to PD-1/PD-L1 inhibition in urothelial cancer.

Abstract：

INTRODUCTION:The survival of patients with metastatic urothelial cancer (mUC) is poor. During the last 40 years, chemotherapy was the predominant treatment modality for mUC. The discovery of the immune checkpoint inhibitors (ICI), especially the inhibitors of the programmed cell death 1 and its ligand (PD-1/PD-L1), has revolutionized cancer immunotherapy. The PD-1 and PD-L1 inhibitors provide a new and effective treatment option for patients with UC, particularly for patients with recurrence after platinum-based therapy and those who are ineligible for cisplatin. METHODS:A literature search on PubMed, ClinicalTrials.gov and selected annual congress abstracts was conducted in May 2018, using a combination of keywords, medical subject headings (MeSH) terms and free text incorporating urothelial bladder cancer; immunotherapy; immune checkpoint inhibition, biomarkers, PD1/PD-L1. RESULTS:Although some patients demonstrate complete and/or durable responses under ICI, the reliable prediction of response to ICI is not possible. In the clinical setting, physicians are not able to predict response to ICI in mUC and to adequately select patients who will benefit. Exploratory analysis of clinical trial data revealed that PD-L1 expression, tumor mutation burden, tumor-infiltrating lymphocytes and gene expression profiles might have some predictive and/or prognostic value in different patient populations. CONCLUSION:Validated robust biomarkers are still needed to overcome this hurdle to forecast response of ICI in UC patients.

journal_name

World J Urol

journal_title

World journal of urology

authors

Stühler V,Maas JM,Bochem J,da Costa IA,Todenhöfer T,Stenzl A,Bedke J

doi

10.1007/s00345-018-2538-6

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

1773-1784

issue

9

eissn

0724-4983

issn

1433-8726

pii

10.1007/s00345-018-2538-6

journal_volume

37

pub_type

杂志文章,评审

相关文献

WORLD JOURNAL OF UROLOGY文献大全
  • CHESS classification of bladder-outflow obstruction. A consequence in the discussion of current concepts.

    abstract：:The present discussion on the natural history, growth rate pathophysiology, morbidity, and possible treatment of benign prostatic hyperplasia (BPH) reinforces the need to objectify mechanical BPH-induced obstruction with pressure-flow study. Different methods for the quantification of BPH-induced obstruction exist and...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/BF00182667

    authors： Höfner K,Kramer AE,Tan HK,Krah H,Jonas U

    更新日期：1995-01-01 00:00:00

  • Long-term oncological outcomes in patients with limited nodal disease undergoing radical prostatectomy and pelvic lymph node dissection without adjuvant treatment.

    abstract：PURPOSE:This study aimed at analysing long-term oncologic outcomes in prostate cancer patients with limited nodal disease (1-2 positive lymph nodes) without adjuvant therapy after radical prostatectomy (RP). METHODS:We retrospectively analysed data of 209 pN1 patients who underwent RP between January 1998 and 2010 wit...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-017-2079-4

    authors： Mandel P,Rosenbaum C,Pompe RS,Steuber T,Salomon G,Chun FK,Graefen M,Huland H,Tilki D

    更新日期：2017-12-01 00:00:00

  • Androgen therapy with dehydroepiandrosterone.

    abstract：:The physiological role of dehydroepiandrosterone (DHEA) and DHEA sulphate (DHEAS) is poorly understood. It depends in a large part on their transformation into testosterone and estradiol. The capacity of DHEA as a neurosteroid, the recent discovery of putative specific DHEA receptors on endothelial and vascular smooth...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-003-0367-7

    authors： Buvat J

    更新日期：2003-11-01 00:00:00

  • Is electronic follow-up using a mobile phone application after mid-urethral sling placement feasible and efficient?

    abstract：PURPOSE:To assess and report the feasibility and efficacy of electronic follow-up in patients after mid-urethral sling (MUS) operation. METHODS:All 235 patients after MUS operation for stress urinary incontinence (SUI) were divided into the WeChat follow-up (WFU) and the outpatient follow-up (OFU) groups. Patients com...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-020-03245-5

    authors： Pan Y,Chen H,Chen H,Jin X,Zhu Y,Chen G

    更新日期：2020-05-19 00:00:00

  • Liquid chromatography-mass spectrometry identification of serum biomarkers for nocturia in aged men.

    abstract：PURPOSE:We aimed to investigate the association between nocturia and serum metabolites identified using metabolomics analysis. METHODS:This study enrolled 66 men aged 65-80 years, recruited from the outpatient department of a university hospital. The participants were stratified as follows: Nocturia group [45 men with...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02647-4

    authors： Kira S,Mitsui T,Miyamoto T,Ihara T,Nakagomi H,Hashimoto Y,Takamatsu H,Tanahashi M,Takeda M,Sawada N,Andersson KE,Takeda M

    更新日期：2019-10-01 00:00:00

  • Association between family history of prostate cancer and positive biopsies in a Brazilian screening program.

    abstract：PURPOSE:To test the association between family history of prostate cancer (FH) and prostate cancer (PCa) risk in a large screening program in Brazil, as no conclusive study has yet investigated this. METHODS:Between 2004 and 2007, 17,569 men were screened in 231 small municipalities using mobile screening units. Posit...

    journal_title：World journal of urology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00345-012-0904-3

    authors： Muller RL,Faria EF,Carvalhal GF,Reis RB,Mauad EC,Carvalho AL,Freedland SJ

    更新日期：2013-10-01 00:00:00

  • Necessity of differentiating small (

    abstract：PURPOSE:Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) provides reasonable performance in detecting significant cancers. Still, it is unclear about whether all PI-RADS 4 lesions show the same cancer detection rate (CDR) regardless of tumor size. The aim was to compare the CDRs of small (< 10 mm) and l...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02924-2

    authors： Park SY,Park BK

    更新日期：2020-06-01 00:00:00

  • The vacuum cleaner effect in minimally invasive percutaneous nephrolitholapaxy.

    abstract：INTRODUCTION:Percutaneous stone removal increasingly plays an important role among the different approaches of interventional stone therapy, particularly since the development of miniaturized instruments is resulting in lower morbidity for the patients. One major drawback of smaller instruments is the increased difficu...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-015-1541-4

    authors： Nicklas AP,Schilling D,Bader MJ,Herrmann TR,Nagele U,Training and Research in Urological Surgery and Technology (T.R.U.S.T.)-Group.

    更新日期：2015-11-01 00:00:00

  • Prostatitis: the role of antibiotic treatment.

    abstract：:The prostatitis syndrome is commonly found in urologic practice and is classified according to the NIDDK/NIH, in which bacterial prostatitis (acute and chronic) is distinguished from chronic pelvic pain syndrome (CPPS). In acute bacterial prostatitis (NIH category I), antibiotic treatment is mandatory and successful i...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-003-0333-4

    authors： Wagenlehner FM,Naber KG

    更新日期：2003-06-01 00:00:00

  • (18)F-choline PET/CT for early detection of metastases in biochemical recurrence following radical prostatectomy.

    abstract：PURPOSE:Salvage radiotherapy (SRT) for biochemical recurrence (BCR) following radical prostatectomy (RP) should if possible be added at a prostate-specific antigen (PSA) level of <1-2 ng/mL. The value of positron emission tomography combined with computed tomography (PET/CT) at such low PSA values is not defined. The p...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-015-1547-y

    authors： Kjölhede H,Ahlgren G,Almquist H,Liedberg F,Lyttkens K,Ohlsson T,Bratt O

    更新日期：2015-11-01 00:00:00

  • Long-term outcome of kidneys with initially poor drainage or no drainage following pyeloplasty.

    abstract：:Pyeloplasty for congenital ureteropelvic junction (UPJ) obstruction enjoys a 90-95% success rate. Although treatment of the failed pyeloplasty has been addressed in the literature, management of the poorly draining or nondraining renal unit in the immediate postoperative period has not received any attention. For this...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/BF00183119

    authors： Miyamoto KK,Mesrobian HG

    更新日期：1996-01-01 00:00:00

  • Oxytocin plasma levels in the systemic and cavernous blood of healthy males during different penile conditions.

    abstract：:It is well established that transmitters of the nonadrenergic-noncholinergic (NANC) system are involved in the control of sexual arousal and penile erection in healthy males. The proerectile activity of dopamine D1/D2 receptor agonist apomorphine-HCl (IXENSE, UPRIMA) involves oxytocinergic pathways descending from the...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-002-0300-5

    authors： Uckert S,Becker AJ,Ness BO,Stief CG,Scheller F,Knapp WH,Jonas U

    更新日期：2003-05-01 00:00:00

  • Factors predicting inguinal node metastasis in squamous cell cancer of penis.

    abstract：PURPOSE:To identify factors predicting the risk of inguinal metastasis in squamous cell carcinoma of the penis. The therapeutic advantages of early lymphadenectomy in squamous cell carcinoma of the penis must be counterbalanced against its post-operative morbidity. Loss to follow up is a major problem in developing cou...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-009-0421-1

    authors： Bhagat SK,Gopalakrishnan G,Kekre NS,Chacko NK,Kumar S,Manipadam MT,Samuel P

    更新日期：2010-02-01 00:00:00

  • Prostate-specific antigen kinetics after I125-brachytherapy for prostate adenocarcinoma.

    abstract：PURPOSE:To investigate a potential correlation between the achievement of a cut-off of nadir PSA (nPSA) after brachytherapy (BRT) with biochemical Disease-Free Survival (bDFS) and to define the rate of post-BRT PSA bounces. METHODS:Retrospective analysis was carried out in 105 consecutive patients affected with early-...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-012-0932-z

    authors： Guarneri A,Botticella A,Ragona R,Filippi AR,Munoz F,Casetta G,Gontero P,Tizzani A,Ricardi U

    更新日期：2013-04-01 00:00:00

  • Sky is no limit for ureteroscopy: extending the indications and special circumstances.

    abstract：PURPOSE:To critically review and synthesize data of ureteroscopy (URS) in different circumstances that all urologists may encounter during everyday clinical practice, such as pregnancy, obesity, bleeding diathesis, renal stones larger than 2 cm, calyceal diverticula, and kidney malformations. METHODS:According to PRIS...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-014-1345-y

    authors： Giusti G,Proietti S,Peschechera R,Taverna G,Sortino G,Cindolo L,Graziotti P

    更新日期：2015-02-01 00:00:00

  • Orchialgia after laproscopic renal surgery: a common problem with questionable etiology. Are there any predictors?

    abstract：PURPOSE:Orchialgia after laproscopic renal surgery has been rarely reported in literature, and gonadal vein ligation is considered the main etiology. Our objective was to study the incidence, intensity and to find out any specific factors that could lead to orchialgia. MATERIALS AND METHODS:All patients planned for la...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-012-0864-7

    authors： Srivastava A,Kapoor R,Srivastava A,Ansari MS,Singh M,Kapoor R

    更新日期：2013-10-01 00:00:00

  • The effectiveness of targeted relative to empiric prophylaxis on infectious complications after transrectal ultrasound-guided prostate biopsy: a meta-analysis.

    abstract：PURPOSE:Rectal culture screening for fluoroquinolone (FQ)-resistant Enterobacteriaceae before transrectal ultrasound guided prostate (TRUSPB) biopsy and targeted antibiotic prophylaxis (TAP) may decrease post-TRUSPB infection rates compared to empiric (EAP) regimens. The objective of this study was to evaluate the effe...

    journal_title：World journal of urology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00345-018-2217-7

    authors： Scott S,Harris PN,Williamson DA,Liss MA,Doi SAR,Roberts MJ

    更新日期：2018-07-01 00:00:00

  • Multiparametric ultrasound-targeted biopsy compares favorably to multiparametric MRI-transrectal ultrasound fusion-targeted biopsy on initial biopsy of men at risk for prostate cancer.

    abstract：PURPOSE:The purpose this study is to evaluate the efficacy of multiparametric ultrasound-targeted biopsies in patients undergoing initial biopsy of the prostate for the suspicion of prostate cancer. MATERIALS AND METHODS:A total of 167 patients who are biopsy naïve underwent multiparametric ultrasound-targeted biopsy ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-018-2187-9

    authors： Fulgham PF

    更新日期：2018-05-01 00:00:00

  • Extra-anatomical transobturator bypass graft for femoral artery involvement by metastatic carcinoma of the penis: report of five patients.

    abstract：OBJECTIVES:Squamous cell carcinoma (SCC) of the penis with inguinal lymph node involvement aggravates prognosis and can cause femoral artery bleeding, hemorrhagic shock and even death. The objective of this study is to describe the use of extra-anatomical transobturator bypass graft for femoral artery involvement by me...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-008-0282-z

    authors： Ferreira U,Reis LO,Ikari LY,da Silva W Jr,Matheus WE,Denardi F,Stopiglia RM,Menezes FH

    更新日期：2008-10-01 00:00:00

  • An antimicrobial prophylaxis protocol using rectal swab cultures for transrectal prostate biopsy.

    abstract：PURPOSE:To evaluate the benefit of an antimicrobial prophylaxis protocol using rectal swab cultures in patients undergoing transrectal ultrasound (TRUS)-guided prostate biopsy in our Veterans Affairs population. METHODS:Between June 1, 2013, and June 1, 2014, we implemented an antimicrobial prophylaxis protocol using ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-015-1571-y

    authors： Summers SJ,Patel DP,Hamilton BD,Presson AP,Fisher MA,Lowrance WT,Southwick AW

    更新日期：2015-12-01 00:00:00

  • Impact of sodium 18F-fluoride PET/CT, 18F-fluorocholine PET/CT and whole-body diffusion-weighted MRI on the management of patients with prostate cancer suspicious for metastasis: a prospective multicentre study.

    abstract：PURPOSE:To compare the impact of 18F-sodium-fluoride (NaF) PET/CT, 18F-fluorocholine (FCH) PET/CT and diffusion-weighted whole-body MRI (DW-MRI) on the management of patients with prostate cancer (PCa) suspicious for distant metastasis. METHODS:Prostate cancer patients were prospectively included between December 2011...

    journal_title：World journal of urology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00345-018-2547-5

    authors： Gauthé M,Aveline C,Lecouvet F,Michaud L,Rousseau C,Tassart M,Cussenot O,Talbot JN,Durand-Zaleski I

    更新日期：2019-08-01 00:00:00

  • Radical retropubic prostatectomy versus brachytherapy for low-risk prostatic cancer: a prospective study.

    abstract：OBJECTIVES:To compare the oncological and functional outcomes reported after radical retropubic prostatectomy (RRP) versus brachytherapy (BT) in the treatment of low-risk prostatic cancer (CaP). METHODS:Between May 1999 and October 2002, 200 patients (mean age 65.3 +/- 8.7) were enrolled and randomized into two groups...

    journal_title：World journal of urology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00345-009-0418-9

    authors： Giberti C,Chiono L,Gallo F,Schenone M,Gastaldi E

    更新日期：2009-10-01 00:00:00

  • Diet and prostate cancer prevention.

    abstract：PURPOSE:To evaluate the present human-based evidence that diet is related to the risk and outcome of prostate cancer. METHODS:Review of major case-control and cohort studies, and experimental trials evaluating the effect of diet or dietary constituents on the risk of prostate cancer. RESULTS:Although non-experimental...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-011-0810-0

    authors： Marshall JR

    更新日期：2012-04-01 00:00:00

  • Prospective comparison of short-term functional outcomes obtained after pure laparoscopic and robot-assisted laparoscopic sacrocolpopexy.

    abstract：OBJECTIVE:To prospectively compare short-term functional outcomes achieved by laparoscopic or robot-assisted sacrocolpopexy for pelvic organ prolapse. MATERIALS AND METHODS:We prospectively collected clinical and operative data over 24 months for female patients who underwent either pure laparoscopic sacrocolpopexy (L...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-011-0748-2

    authors： Seror J,Yates DR,Seringe E,Vaessen C,Bitker MO,Chartier-Kastler E,Rouprêt M

    更新日期：2012-06-01 00:00:00

  • Transrectal contrast enhanced ultrasound for diagnosis of prostate cancer.

    abstract：:The diagnosis of prostate cancer is based on histology. Prostate biopsies are obtained based on the triad of prostate specific antigen (PSA), digital rectal examination (DRE) and transrectal ultrasound. Because prostate biopsies still have a large percentage of negative outcomes, patient selection and biopsy direction...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-007-0189-0

    authors： Wink MH,de la Rosette JJ,Grimbergen CA,Wijkstra H

    更新日期：2007-08-01 00:00:00

  • Vimentin over-expression and carbonic anhydrase IX under-expression are independent predictors of recurrence, specific and overall survival in non-metastatic clear-cell renal carcinoma: a validation study.

    abstract：PURPOSE:Clinical outcomes prognostic markers are awaited in clear-cell renal carcinoma (ccRCC) to improve patient-tailored management and to assess six different markers' influence on clinical outcomes from ccRCC specimen and their incremental value combined with TNM staging. MATERIALS AND METHODS:This is a retrospect...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-016-1854-y

    authors： Ingels A,Hew M,Algaba F,de Boer OJ,van Moorselaar RJ,Horenblas S,Zondervan P,de la Rosette JJ,Pilar Laguna Pes M

    更新日期：2017-01-01 00:00:00

  • High hospital and surgeon volume and its impact on overall survival after radical cystectomy among patients with bladder cancer in Quebec.

    abstract：INTRODUCTION AND OBJECTIVES:Previous studies reported improved outcomes for bladder cancer patients who had radical cystectomy (RC) performed by surgeons and hospitals with high annual RC volumes. The objective of this study was to determine the effect of high hospital and surgeon volume on overall survival after RC fo...

    journal_title：World journal of urology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00345-014-1457-4

    authors： Santos F,Zakaria AS,Kassouf W,Tanguay S,Aprikian A

    更新日期：2015-09-01 00:00:00

  • Urinary BTA: indicator of bladder cancer or of hematuria.

    abstract：BACKGROUND:In this study, we investigated the influence of hematuria on the performance of the bladder tumor antigen (BTA) tests in a clinical cohort and in an experimental model. MATERIALS AND METHODS:Urine samples from a cohort of 126 subjects (64 with BCa and 62 controls) were analyzed by ELISA for hemoglobin and B...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-012-0935-9

    authors： Miyake M,Goodison S,Rizwani W,Ross S,Bart Grossman H,Rosser CJ

    更新日期：2012-12-01 00:00:00

  • A novel method of surgical instruction: international telementoring.

    abstract：:Telemedicine is the use of communication technologies to deliver health care. Telesurgical telementoring represents an advanced form of telemedicine, whereby an experienced surgeon can guide and teach practicing surgeons new operative techniques utilizing current video technology, medical robots, and high-band-width t...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s003450050082

    authors： Lee BR,Bishoff JT,Janetschek G,Bunyaratevej P,Kamolpronwijit W,Cadeddu JA,Ratchanon S,O'Kelley S,Kavoussi LR

    更新日期：1998-01-01 00:00:00

  • PSA kinetics following primary focal cryotherapy (hemiablation) in organ-confined prostate cancer patients.

    abstract：PURPOSE:We aim to evaluate prostate-specific antigen (PSA) trends in post-primary focal cryotherapy (PFC) patients. MATERIALS AND METHODS:This was an institutional review board-approved retrospective study of PFC patients from 2010 to 2015. Patients with at least one post-PFC PSA were included in the study. Biochemica...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-017-2130-5

    authors： Kongnyuy M,Islam S,Mbah AK,Halpern DM,Werneburg GT,Kosinski KE,Chen C,Habibian DJ,Schiff JT,Corcoran AT,Katz AE

    更新日期：2018-02-01 00:00:00