Abstract:
:It is well established that transmitters of the nonadrenergic-noncholinergic (NANC) system are involved in the control of sexual arousal and penile erection in healthy males. The proerectile activity of dopamine D1/D2 receptor agonist apomorphine-HCl (IXENSE, UPRIMA) involves oxytocinergic pathways descending from the hypothalamus to the brain stem and spinal autonomic centers. Although it has been demonstrated that injection of oxytocin into the paraventricular nucleus and the hippocampus produces penile erection in rats, the significance of the peptide in the control of sexual arousal and penile erection in man has been, up until now, only poorly evaluated. The present study was undertaken to determine whether oxytocin (OT) plasma levels alter in the systemic and cavernous blood of healthy males under different penile conditions (flaccidity, tumescence, rigidity, detumescence). Twenty-five healthy adult males were exposed to visual and tactile erotic stimuli in order to elicit penile tumescence and rigid erection. Blood was taken from the corpus cavernosum (CC) and the cubital vein (CV) during penile flaccidity, tumescence, rigidity and detumescence. Following extraction from plasma aliqouts, oxytocin was measured by means of a radioimmunoassay. An increase was observed in the mean OT plasma levels in the systemic and cavernous blood when the flaccid penis became tumescent (CC: from 66.7+/-34 to 75+/-44 pg/ml; CV: from 71+/-41 to 79+/-49.5 pg/ml). From tumescence to rigidity, OT further rose in the cavernous blood (to 81+/-58 pg/ml), whereas it remained unaltered in the systemic circulation. During detumescence, oxytocin plasma levels dropped in the cavernous but again increased in the systemic blood (to 94+/-49 pg/ml). Our results support the hypothesis of a pivotal role of OT in the mechanism of male sexual arousal and penile erection and provide a rationale for the use of apomorphine in the treatment of erectile dysfunction.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Uckert S,Becker AJ,Ness BO,Stief CG,Scheller F,Knapp WH,Jonas Udoi
10.1007/s00345-002-0300-5keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
323-6issue
6eissn
0724-4983issn
1433-8726journal_volume
20pub_type
杂志文章abstract:PURPOSE:To investigate the inhibitory effects of electrical stimulation of sacral dorsal root ganglion (DRG) on bladder activity under non-nociceptive and nociceptive bladder conditions in cats. MATERIALS AND METHODS:12 cats were divided into non-nociceptive and nociceptive groups. Saline was used to distend the bladd...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2198-6
更新日期:2018-05-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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abstract::Telemedicine is the use of communication technologies to deliver health care. Telesurgical telementoring represents an advanced form of telemedicine, whereby an experienced surgeon can guide and teach practicing surgeons new operative techniques utilizing current video technology, medical robots, and high-band-width t...
journal_title:World journal of urology
pub_type: 杂志文章
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2074-9
更新日期:2017-12-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1220-2
更新日期:2014-12-01 00:00:00
abstract::The aim of this article is to describe the current ultrasound (US) contrast agents employed in the characterization of renal tumors and to report our experience in the use of a contrast-specific ultrasound technique pulse inversion harmonic imaging (PIHI).A total of 23 renal masses were prospectively evaluated by conv...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-004-0410-3
更新日期:2004-11-01 00:00:00
abstract::Local recurrent prostate cancer after radical treatment is found in the majority of men with a rising PSA. Salvage treatment procedures for recurrent disease, such as radiation therapy and ablative procedures, can provide long-term responses in well-selected cases. Prostate magnetic resonance imaging (MRI) allows diag...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-019-02677-y
更新日期:2019-08-01 00:00:00
abstract::There is a definite need for an effective and reversible form of male contraception, both for maintaining a stable population in industrial countries and for diminishing population growth in developing countries. It has been agreed upon that contraception is an essential component of reproductive health for men and wo...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-003-0369-5
更新日期:2003-11-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-0876-3
更新日期:2013-10-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF00182667
更新日期:1995-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2366-8
更新日期:2019-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 临床试验,杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-010-0621-8
更新日期:2011-12-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-018-2429-x
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:This study aims to determine whether intra-network and inter-network brain connectivities are altered using an independent component analysis (ICA). METHODS:Resting-state functional MRI (rs-fMRI) data were acquired from 26 patients with OAB and 28 healthy controls (HC). Eleven resting-state networks (RSNs) wer...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02838-z
更新日期:2020-04-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-008-0264-1
更新日期:2008-08-01 00:00:00
abstract:PURPOSE:To review the etiology and pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS:A literature review for the years 1985-2012 was performed using the MEDLINE database of the United States National Library of Medicine. RESULTS:The evidence for ongoing infection in men with CP/CPPS ...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-013-1061-z
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:Urinary cytology (C) and cystoscopy remain the gold standard for the detection and screening of bladder cancer (BC). In this prospective study, we analyzed whether baseline C, ImmunoCyt (I), BTA Stat (B), hemoglobin dipstick (H), and NMP22 BladderChek (N) can predict recurrence and progression. METHODS:Urinary...
journal_title:World journal of urology
pub_type: 临床试验,杂志文章
doi:10.1007/s00345-016-1795-5
更新日期:2016-10-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1044-0
更新日期:2013-12-01 00:00:00
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journal_title:World journal of urology
pub_type: 历史文章,杂志文章
doi:10.1007/s003450050015
更新日期:2000-02-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s003450100218
更新日期:2001-08-01 00:00:00
abstract::Nephrolithiasis is a highly prevalent disease worldwide with rates ranging from 7 to 13% in North America, 5-9% in Europe, and 1-5% in Asia. Due to high rates of new and recurrent stones, management of stones is expensive and the disease has a high level of acute and chronic morbidity. The goal of this study is to rev...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-017-2008-6
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:Changes in the management of minimally invasive oncologic renal surgery have introduced ablative therapies as the most recent advancement in minimally invasive technology. METHODS:The current evidence-based medicine on the topic of laparoscopic (LCA) and percutaneous (PCA) renal cryoablation was gathered ...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-010-0552-4
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:Bladder perforation is the second most common complication during transurethral resection of bladder tumours. It is unknown whether perforation affects the natural history of the tumour through cell seeding. The aim of this study was to study the impact of perforation on the oncologic outcomes of bladder car...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1197-x
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To compare the efficiency and safety of suctioning ureteral access sheath (UAS) and traditional UAS during flexible ureteroscopy (FURS) for treatment of renal stones. METHODS:Between January 2015 and December 2017, 165 patients who had renal stones successfully underwent FURS with suctioning UAS created by con...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2455-8
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:Taiwan is a highly endemic area for urothelial carcinoma (UC) and chronic kidney disease (CKD). We evaluate the gender effect on the relationship between renal outcome and clinical characteristics of CKD patients with UC. METHODS:The clinical and pathologic records of 404 patients were retrospectively analyzed...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0682-3
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Prognoses for intermediate-risk prostate cancer (PCa) remain heterogeneous. Improved substratification could optimize treatment and monitoring strategies. The objective was to validate this subclassification in a radical prostatectomy (RP) series. METHODS:Between 2000 and 2011, 4038 patients who underwent R...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-016-1979-z
更新日期:2017-08-01 00:00:00
abstract::This article reviews the definition, incidence, pathological characteristics and natural history of low risk localised prostate cancer. Low risk disease is typically defined as clinical stage T1/T2a, biopsy Gleason score =6, PSA < 10. This risk classification has provided a useful system for reporting of outcomes an...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-008-0277-9
更新日期:2008-10-01 00:00:00
abstract:PURPOSE:To determine whether individual and/or cumulative components of metabolic syndrome (obesity, hypertension, dyslipidemia, and hyperglycemia) are associated with pathologic features of kidney cancer. PATIENTS AND METHODS:A review of our kidney tumor database identified 462 patients who underwent partial or radic...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-016-1850-2
更新日期:2017-01-01 00:00:00