Abstract：
:There is a definite need for an effective and reversible form of male contraception, both for maintaining a stable population in industrial countries and for diminishing population growth in developing countries. It has been agreed upon that contraception is an essential component of reproductive health for men and women (the Weimar Manifesto on Male Contraception). The development of new, effective methods of male contraception has been identified as a high priority by the WHO Task Force on methods of regulation of male fertility. Hormonal male contraception is based on suppression of gondotrophins and substitution of testosterone in order to maintain male sexual function and bone mineralisation and to prevent muscle waist. For complete interruption of spermatogenesis, an adequate suppression of intratesticular testosterone production is needed. Various contraceptive regimens have been developed and tested, including testosterone monotherapy, androgen/progestin combinations, testosterone with GnRH analogs, and selective androgen and progestin receptor modulators. The combination of testosterone with progestogen is currently the most promising approach to hormonal male contraception. Also, several non-hormonal approaches to male contraception are promising and may offer the foundation for developing new male contraceptives.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Weber RF,Dohle GRdoi
10.1007/s00345-003-0369-5keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
338-40issue
5eissn
0724-4983issn
1433-8726journal_volume
21pub_type
杂志文章abstract：:To evaluate the diagnostic efficacy of transrectal ultrasound (TRUS)-guided biopsy of the prostatic fossa in men with biochemical relapse following radical retropubic prostatectomy (RP). Thirty patients, with detectable prostate specific antigen (PSA) and negative imaging for metastases after RP, were evaluated for lo...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-007-0167-6
更新日期：2007-06-01 00:00:00
abstract：INTRODUCTION:Percutaneous stone removal increasingly plays an important role among the different approaches of interventional stone therapy, particularly since the development of miniaturized instruments is resulting in lower morbidity for the patients. One major drawback of smaller instruments is the increased difficu...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1541-4
更新日期：2015-11-01 00:00:00
abstract：PURPOSE:To compare long-term functional outcomes after robotic vs. retropubic RP for patients with localized prostate cancer in routine care. METHODS:"HAROW" was a large German noninterventional health services research study that prospectively evaluated the treatment of patients with localized prostate cancer (≤ T2c)...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02956-8
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:The introduction of collagenase Clostridium histolyticum (CCH) has revolutionized the treatment of Peyronie's disease. The efficacy of this therapy has been well demonstrated and the safety profile is favorable. However, post-injection complications are poorly characterized and management of these complications...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-019-02817-4
更新日期：2020-02-01 00:00:00
abstract：PURPOSE:Partial nephrectomy (PN) outcomes may be better at academic institutions than at non-academic centers. Peer-review, sub-specialized practice profile, higher individual surgeon and institutional caseload may explain this observation. To the best of our knowledge, the role of institutional academic affiliation ha...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0759-z
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:Urethroplasty is the most effective treatment method for anterior urethral strictures, which constitute an important health concern for males. This study aims to investigate factors that may predict treatment failure following urethroplasty for anterior urethral strictures and evaluate outcomes of different ure...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-03014-z
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:Given that the tumor-promoting inflammation has been previously established in squamous cell carcinoma of the bladder but its contribution to development of urothelial carcinoma (UC) still remains elusive, our aim was to study changes in expression and activity of inflammation-mediating NF-κB and STAT3 transcri...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1237-1
更新日期：2014-12-01 00:00:00
abstract：:The treatment of clinically locally advanced prostate cancer (cT3-4) is subject to controversies. Patients with lymph node metastases as well as patients with overstaged localized and thus curable disease fall into this category. Radical prostatectomy, external beam radiotherapy and early or deferred hormonal therapy ...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-007-0158-7
更新日期：2007-04-01 00:00:00
abstract：:The landscape has dramatically changed for patients seeking treatment for rapid ejaculation. Previously, psychotherapy or behavioral treatment was considered to be the treatment of choice for this troubling sexual dysfunction. Since the early 1990s, an efficacious alternative treatment has emerged-the off-label admini...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-004-0489-6
更新日期：2005-06-01 00:00:00
abstract：PURPOSE:To explore the role of prostate biopsy core length on prediction of index tumor clinical significance and localization on radical prostatectomy (RP) and time to recurrence, hypothesizing 10-, 10-12-, or > 12-mm minimum core as potential biopsy quality control. METHODS:Assessed 2424 prostate biopsy cores and co...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2242-6
更新日期：2018-07-01 00:00:00
abstract：PURPOSE:The purpose this study is to evaluate the efficacy of multiparametric ultrasound-targeted biopsies in patients undergoing initial biopsy of the prostate for the suspicion of prostate cancer. MATERIALS AND METHODS:A total of 167 patients who are biopsy naïve underwent multiparametric ultrasound-targeted biopsy ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2187-9
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:The use of a ureteral access sheath (UAS) during flexible retrograde intrarenal surgery (RIRS) has become increasingly popular. Our aim was to evaluate the accessibility of a new UAS device, allowing the transformation of the working guidewire into a safety guidewire. METHODS:A prospective, multicenter study w...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-013-1094-3
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:To evaluate the role of multiparametric magnetic resonance imaging (mpMRI) in Gleason score (GS) 3 + 4 prostate cancer (PCa) and evaluate independent factors in mpMRI that can predict GS upgrading, we compared the outcomes of GS upgrading group and GS non-upgrading group. PATIENTS AND METHODS:We analyzed th...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03421-7
更新日期：2020-08-31 00:00:00
abstract：:Reconstruction of long anterior urethral strictures that cannot be excised and reanastomosed remains controversial. We critically reviewed the literature on free-graft and pedicled skin-flap urethroplasty to determine the optimal method of repair. Overall, free grafts were successful in 84.3% of cases and flaps, in 85...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050048
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:To study microscopic patterns of remaining peripheral nerves (PN) after nerve-sparing (NS) radical prostatectomy (RP) and possible consequences for nerve preparation. METHODS:Specimens from 27 patients (7 = non-NSRP, 20 = unilateral NS) were examined. Sections were investigated for PN content by immunoassaying...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0791-z
更新日期：2013-04-01 00:00:00
abstract：:The most important phosphates involved in urinary stone disease are carbonate apatite, brushite, and struvite. Overall, phosphate stones account for 12-20% of all stones, with a downward trend for struvite and an increase in carbonate apatite being observed in the last decade. The physicochemical basis for the formati...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050152
更新日期：1999-10-01 00:00:00
abstract：:Serotonin (5-hydroxytryptamine; 5-HT), a vasoactive bioamine with potent contractile activity, is thought to act indirectly in the urinary bladder by the stimulation of its presynaptic receptors. This results in the release of acetylcholine (ACh), which then acts on muscarinic receptors to produce bladder contractilit...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s003450050142
更新日期：1999-10-01 00:00:00
abstract：PURPOSE:Previous studies of the cell cycle progression (CCP) score in surgical specimens of prostate cancer (PCa) in patients treated by radical prostatectomy (RP) demonstrated significant association with time to biochemical recurrence (BCR). In this study, we compared the ability of the CCP score and the expression o...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-018-2290-y
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:Patients and their families utilize online resources when dealing with a diagnosis of bladder cancer. Many patients have questions regarding clinical management options. Online research forums may help researchers and providers identify research areas of interest. Our objective was to review online forums and i...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2479-0
更新日期：2019-06-01 00:00:00
abstract：:We investigated a possible relationship between brefeldin A (BFA), an antibiotic, and cathepsin D (Cat.D), a lysosomal protease, in prostate cancer proliferation. Effects of BFA (30 ng/ml) were examined on the growth of three human prostatic cancer cell lines, PC-3, DU-145, and LNCaP cells. Its effect on Cat.D in thes...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/pl00007099
更新日期：2001-08-01 00:00:00
abstract：:Sacral nerve modulation (SNM) is an effective way to treat non-neurogenic dysfunctions of pelvic organs. For over 20 years, this technique has been used for the treatment of overactive bladder, urinary retention, pelvic pain and even more recently, fecal incontinence and constipation. The objective of the study is to ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-007-0204-5
更新日期：2007-12-01 00:00:00
abstract：:Vesicoureteral reflux (VUR) represents one of the most significant risk factors for acute pyelonephritis in children. The current indications for the surgical correction of VUR depend on the presence or absence of renal scars. If no scars are present, primary ureteral reimplantation is only indicated in high-grade bil...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-004-0408-x
更新日期：2004-06-01 00:00:00
abstract：PURPOSE:Management of prostate cancer following radiation therapy remains challenging, especially for younger men or those with life expectancy greater than 10 years. We outline the efficacy, safety and adequacy of radical prostatectomy for the treatment of radiorecurrent localized prostate cancer. METHODS:A systemati...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-013-1029-z
更新日期：2013-12-01 00:00:00
abstract：:Small-intestinal submucosa (SIS) is a unique biomaterial that has been shown to induce tissue-specific regeneration in numerous organ systems. In the urinary tract, animal studies have demonstrated that SIS promotes functional bladder regeneration. Other preliminary studies have suggested that SIS may also be extremel...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/PL00007071
更新日期：2000-02-01 00:00:00
abstract：PURPOSE:To investigate the association between overactive bladder (OAB) and coronary artery disease (CAD) as demonstrated on coronary angiography in patients > 65 years. METHODS:The patients who were > 65 years completed an OAB-V8 form before undergoing coronary angiography at a tertiary care hospital. The presence of...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2098-1
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:For the treatment of persistent post-prostatectomy incontinence (PPI), several surgical treatment options including male slings are available. In 2010, the second generation of the retrourethral male sling Advance, AdVanceXP, was introduced. Aim of the study was to examine in a prospective multicentre study the...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-015-1731-0
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:Management of male infertility is always a difficult task, with pathophysiology and available treatments often poorly understood. The purpose of this review was to summarize current evidence regarding the use of protective agents against reactive oxygen species (ROS), such as antioxidants that may be useful in ...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-019-02656-3
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:To assess the impact of prolonged catheterization time on 1-week (short-term), 3-month (intermediate-term) and 1-year (long-term) UC. METHODS:Between 2008 and 2015, 6918 men underwent RP by four high-volume surgeons. Exclusion criteria were baseline urinary incontinence (UI) and radiotherapy prior or within 12...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2274-y
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:Donor and recipient gender influence on post-transplant kidney and patient survival is still controversial, and the literature data do not present unanimous conclusions. The aim of this study was to evaluate the effect of gender disparities between donor and recipient in 963 kidney transplants performed at our ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1137-9
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:To highlight a new imaging acquisition protocol during (18)F-fluorocholine PET/CT in patients with biochemical recurrence after RP. METHODS:A total of 146 patients with PSA levels between 0.2 and 1 ng/ml with negative conventional imaging who did not receive salvage treatment were prospectively enrolled. Imagi...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1481-z
更新日期：2015-10-01 00:00:00
