当前位置： SCI文献检索 > WORLD JOURNAL OF UROLOGY期刊下所有文献 > Time-dependent up-regulation of neuronal 5-hydroxytryptamine binding sites in the detrusor of a rabbit model of partial bladder outlet obstruction.

Time-dependent up-regulation of neuronal 5-hydroxytryptamine binding sites in the detrusor of a rabbit model of partial bladder outlet obstruction.

Abstract：

:Serotonin (5-hydroxytryptamine; 5-HT), a vasoactive bioamine with potent contractile activity, is thought to act indirectly in the urinary bladder by the stimulation of its presynaptic receptors. This results in the release of acetylcholine (ACh), which then acts on muscarinic receptors to produce bladder contractility. Bladder outlet obstruction (BOO) can lead to detrusor instability associated with denervation supersensitivity to ACh. Using a rabbit model of partial BOO, we investigated whether there were any associated changes in the neuronal 5-HT binding sites. Partial BOO was induced in adult male New Zealand White rabbits. Sham-operated age-matched rabbits acted as controls. After 1, 3 and 6 weeks the urinary bladders were excised. Detrusor sections were incubated with [(3)H]-5-HT. Autoradiographs were generated and analysed densitometrically. The presence of nerves was detected using immunohistochemistry with NF200. Autoradiography demonstrated a time-dependent, significant (P < 0.0001) up-regulation of [(3)H]-5-HT binding sites in the detrusor smooth muscle after the induction of BOO. Immunohistochemistry confirmed that the [(3)H]-5-HT binding sites were neuronal. In the rabbit model of partial BOO there was a significant time-dependent up-regulation of neuronal [(3)H]-5-HT binding sites in the detrusor. This change may influence 5-HT-mediated ACh release, resulting in increased bladder contractility. This, in turn, may play a role in detrusor instability associated with denervation post-junctional supersensitivity. These results provide a possible rationale for further investigation into the use of 5-HT antagonists in the treatment of detrusor instability associated with BOO.

journal_name

World J Urol

journal_title

World journal of urology

authors

Khan MA,Dashwood MR,Thompson CS,Mumtaz FH,Morgan RJ,Mikhailidis DP

doi

10.1007/s003450050142

keywords:

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

255-60

issue

5

eissn

0724-4983

issn

1433-8726

pii

90170255.345

journal_volume

17

pub_type

杂志文章

相关文献

WORLD JOURNAL OF UROLOGY文献大全
  • PSA kinetics following primary focal cryotherapy (hemiablation) in organ-confined prostate cancer patients.

    abstract：PURPOSE:We aim to evaluate prostate-specific antigen (PSA) trends in post-primary focal cryotherapy (PFC) patients. MATERIALS AND METHODS:This was an institutional review board-approved retrospective study of PFC patients from 2010 to 2015. Patients with at least one post-PFC PSA were included in the study. Biochemica...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-017-2130-5

    authors： Kongnyuy M,Islam S,Mbah AK,Halpern DM,Werneburg GT,Kosinski KE,Chen C,Habibian DJ,Schiff JT,Corcoran AT,Katz AE

    更新日期：2018-02-01 00:00:00

  • Stress incontinence surgery at the time of prolapse surgery: mandatory or forbidden?

    abstract：INTRODUCTION:Concomitant anti-incontinence surgery at the time of prolapse repair has been a long-debated topic. Still today, there remains no clear answer to this question, although in recent years the literature has become more robust with the addition of more randomized controlled trials. The lifetime risk for women...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-015-1591-7

    authors： King AB,Goldman HB

    更新日期：2015-09-01 00:00:00

  • Update of the ICUD-SIU consultation on upper tract urothelial carcinoma 2016: treatment of low-risk upper tract urothelial carcinoma.

    abstract：INTRODUCTION:The conservative management of upper tract urothelial carcinoma (UTUC) has historically been offered to patients with imperative indications. The recent International Consultation on Urologic Diseases (ICUD) publication on UTUC stratified treatment allocations based on high- and low-risk groups. This repor...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-016-1859-6

    authors： Mandalapu RS,Remzi M,de Reijke TM,Margulis V,Palou J,Kapoor A,Yossepowitch O,Coleman J,Traxer O,Anderson JK,Catto J,de la Rosette J,O'Brien T,Zlotta A,Matin SF

    更新日期：2017-03-01 00:00:00

  • Molecular predictors of response to PD-1/PD-L1 inhibition in urothelial cancer.

    abstract：INTRODUCTION:The survival of patients with metastatic urothelial cancer (mUC) is poor. During the last 40 years, chemotherapy was the predominant treatment modality for mUC. The discovery of the immune checkpoint inhibitors (ICI), especially the inhibitors of the programmed cell death 1 and its ligand (PD-1/PD-L1), has...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-018-2538-6

    authors： Stühler V,Maas JM,Bochem J,da Costa IA,Todenhöfer T,Stenzl A,Bedke J

    更新日期：2019-09-01 00:00:00

  • Is a wider angle of the membranous urethra associated with incontinence after radical prostatectomy?

    abstract：PURPOSE:To investigate whether differences in the anatomy and dynamics of the pelvic floor (PF) in patients after radical prostatectomy (RP) depicted on magnetic resonance imaging (MRI) are associated with continence status. METHODS:In the prospective designed study, 24 patients with post-prostatectomy stress urinary ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-014-1241-5

    authors： Soljanik I,Bauer RM,Becker AJ,Stief CG,Gozzi C,Solyanik O,Brocker KA,Kirchhoff SM

    更新日期：2014-12-01 00:00:00

  • Decreased accuracy of the prostate cancer EAU risk group classification in the era of imaging-guided diagnostic pathway: proposal for a new classification based on MRI-targeted biopsies and early oncologic outcomes after surgery.

    abstract：PURPOSE:To assess the performance of EAU risk classification in PCa patients according to the biopsy pathway (standard versus MRI guided) and to develop a new, more accurate, targeted biopsy (TB)-based classification. MATERIALS AND METHODS:We included 1345 patients consecutively operated by radical prostatectomy (RP) ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-03053-6

    authors： Ploussard G,Manceau C,Beauval JB,Lesourd M,Almeras C,Gautier JR,Loison G,Salin A,Soulié M,Tollon C,Malavaud B,Roumiguié M

    更新日期：2020-10-01 00:00:00

  • Mechanisms of tumor invasion and metastasis.

    abstract：:Metastasis is the cascade of events involved in the transition of a malignancy from a localized tumor to the establishment of a distant foci. In this review we define the known stages and the factors involved. The multiplicity of steps involved allows many opportunities for therapeutic intervention. Current research h...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/BF00186891

    authors： Lawrence JA,Steeg PS

    更新日期：1996-01-01 00:00:00

  • The electrified catheter. Role in sterilizing urine and decreasing bacteriuria.

    abstract：:A catheter was designed to decrease the incidence of catheter-induced urinary infections. A randomized, controlled study was performed to assess its safety and efficacy. The study comprised 24 patients subjected to hemorrhoidectomy. The criteria for entry were a preoperative urinary pathogen count below 10(5) colony-f...

    journal_title：World journal of urology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00211417

    authors： Shafik A

    更新日期：1993-01-01 00:00:00

  • Clinical and therapeutic factors associated with adverse pathological outcomes in clinically node-negative patients treated with neoadjuvant cisplatin-based chemotherapy and radical cystectomy.

    abstract：PURPOSE:Several disease characteristics have been identified as potential predictors for pathological node involvement (pN+) following radical cystectomy (RC). However, these have not been assessed in patients treated with neoadjuvant chemotherapy (NAC). We endeavored to assess factors predicting adverse pathology in c...

    journal_title：World journal of urology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00345-015-1667-4

    authors： Zargar-Shoshtari K,Zargar H,Dinney CP,Ercole CE,Sharma P,Kovac E,Grivas PD,Stephenson AJ,Shah JB,Black PC,Spiess PE

    更新日期：2016-05-01 00:00:00

  • From laboratory expertise to clinical practice: multidrug-resistance-based gene therapy becomes available for urologists.

    abstract：:Many human tumors such as bladder carcinoma that are initially responsive to chemotherapy eventually fail to respond to treatment. For most drugs, dose escalation that may be required for a cure cannot be achieved because sensitive tissues such as bone marrow limit cytotoxic therapy. Approaches to prevent or circumven...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/BF00184246

    authors： Mickisch GH,Schroeder FH

    更新日期：1994-01-01 00:00:00

  • High spatial correlation in brain connectivity between micturition and resting states within bladder-related networks using 7 T MRI in multiple sclerosis women with voiding dysfunction.

    abstract：BACKGROUND:Several studies have reported brain activations and functional connectivity (FC) during micturition using functional magnetic resonance imaging (fMRI) and concurrent urodynamics (UDS) testing. However, due to the invasive nature of UDS procedure, non-invasive resting-state fMRI is being explored as a potenti...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-021-03599-4

    authors： Shi Z,Tran K,Karmonik C,Boone T,Khavari R

    更新日期：2021-01-29 00:00:00

  • Oxytocin plasma levels in the systemic and cavernous blood of healthy males during different penile conditions.

    abstract：:It is well established that transmitters of the nonadrenergic-noncholinergic (NANC) system are involved in the control of sexual arousal and penile erection in healthy males. The proerectile activity of dopamine D1/D2 receptor agonist apomorphine-HCl (IXENSE, UPRIMA) involves oxytocinergic pathways descending from the...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-002-0300-5

    authors： Uckert S,Becker AJ,Ness BO,Stief CG,Scheller F,Knapp WH,Jonas U

    更新日期：2003-05-01 00:00:00

  • Can the ice-water test predict the outcome of intradetrusor injections of botulinum toxin in patients with neurogenic bladder dysfunction?

    abstract：:The aim of this project was to evaluate the ice-water test as a predictor of the response to intradetrusor botulinum toxin injection in patients with neurogenic detrusor overactivity. We retrospectively evaluated the urodynamic parameters in 22 patients with neurogenic bladder dysfunction and positive ice-water test. ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-007-0208-1

    authors： Huwyler M,Schurch B,Knapp PA,Reitz A

    更新日期：2007-12-01 00:00:00

  • Stereotactic body radiotherapy for bone oligometastatic disease in prostate cancer.

    abstract：PURPOSE:There are sparse data describing outcomes of bone-only oligometastatic prostate cancer in comparison with lymph node disease treated with stereotactic body radiotherapy (SBRT). The primary aim of this study was to report progression-free survival (PFS) data for patients with bone-only disease. Influence of horm...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02873-w

    authors： Patel PH,Chaw CL,Tree AC,Sharabiani M,van As NJ

    更新日期：2019-12-01 00:00:00

  • Marital status and gender affect stage, tumor grade, treatment type and cancer specific mortality in T1-2 N0 M0 renal cell carcinoma.

    abstract：PURPOSE:To examine the effect of marital status and gender on stage at diagnosis, tumor grade, treatment type and cancer specific mortality (CSM) in patients with localized renal cell carcinoma (RCC). METHODS:Within Surveillance, Epidemiology, and End Results registry (2001-2013), we identified 57,700 patients with T1...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-017-2082-9

    authors： Marchioni M,Martel T,Bandini M,Pompe RS,Tian Z,Kapoor A,Cindolo L,Autorino R,Briganti A,Shariat SF,Schips L,Karakiewicz PI

    更新日期：2017-12-01 00:00:00

  • Long-term urinary adverse effects of pelvic radiotherapy.

    abstract：OBJECTIVE:Radiation for tumors arising in the pelvis has been utilized for over a 100 years. Adverse effects (AEs) of radiotherapy (RT) continue to accumulate with time and are reported to show decades after treatment. The benefit of RT for pelvic tumors is well described as is their acute AEs. Late AEs are less well d...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-010-0603-x

    authors： Elliott SP,Malaeb BS

    更新日期：2011-02-01 00:00:00

  • Advances in robotic surgery for pediatric ureteropelvic junction obstruction and vesicoureteral reflux: history, present, and future.

    abstract：PURPOSE:The introduction of robotic surgical technology into urological reconstruction, particularly pediatrics, has introduced new horizons for reducing the morbidity and enhancing the efficacy of surgical repair of congenital conditions in children. In reviewing the evolution of pediatric urological applications of r...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02753-3

    authors： Satyanarayan A,Peters CA

    更新日期：2020-08-01 00:00:00

  • Five compelling UTI questions after kidney transplant.

    abstract：PURPOSE:Urinary tract infection (UTI) is the most common bacterial infection among infectious complications in kidney transplant recipients (KTR). After transplantation, infections can result from surgical complications, donor-derived infections, pre-existing recipient infections, and nosocomial infections. Post-transp...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-020-03173-4

    authors： Aydın S,Patil A,Desai M,Simforoosh N

    更新日期：2020-11-01 00:00:00

  • Concomitant carcinoma in situ may not be a prognostic factor for patients with bladder cancer following radical cystectomy: a PRISMA-compliant systematic review and meta-analysis.

    abstract：BACKGROUND:Numerous recent studies have shown that concomitant carcinoma in situ (CIS) can be closely associated with the prognosis of patients with bladder cancer (BCa). However, the prognostic value of CIS in BCa is still not conclusive. Hence, we performed a systematic review and meta-analysis to explore the associa...

    journal_title：World journal of urology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00345-019-02738-2

    authors： Zhang L,Wu B,Zha Z,Zhao H,Yuan J,Jiang Y

    更新日期：2020-01-01 00:00:00

  • Evolution and simplified terminology of natural orifice transluminal endoscopic surgery (NOTES), laparoendoscopic single-site surgery (LESS), and mini-laparoscopy (ML).

    abstract：INTRODUCTION:Natural orifice transluminal endoscopic surgery (NOTES) and laparoendoscopic single-site surgery (LESS) are the next steps in the evolution of laparoscopic surgery, promising reduced morbidity and improved cosmetic result. The inconsistent terminology initially used led to confusion. Understanding the tech...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-012-0899-9

    authors： Georgiou AN,Rassweiler J,Herrmann TR,Stolzenburg JU,Liatsikos EN,Do EM,Kallidonis P,de la Teille A,van Velthoven R,Burchardt M

    更新日期：2012-10-01 00:00:00

  • The surgeon and his intention: Gustav Simon (1824-1876), his first planned nephrectomy and further contributions to urology.

    abstract：:One of the historic landmarks in urology is the first planned nephrectomy performed in 1869 by Gustav Simon of Heidelberg (1824-1877). In the history of medicine the reflections and considerations of the specialized surgeon reveal distinguished analyses of the "case" and, thus, the beginning of a modern scientific dis...

    journal_title：World journal of urology

    pub_type： 传,历史文章,杂志文章

    doi：10.1007/s003450050125

    authors： Moll F,Rathert P

    更新日期：1999-06-01 00:00:00

  • Current controversies in anterior urethral stricture repair: free-graft versus pedicled skin-flap reconstruction.

    abstract：:Reconstruction of long anterior urethral strictures that cannot be excised and reanastomosed remains controversial. We critically reviewed the literature on free-graft and pedicled skin-flap urethroplasty to determine the optimal method of repair. Overall, free grafts were successful in 84.3% of cases and flaps, in 85...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s003450050048

    authors： Wessells H,McAninch JW

    更新日期：1998-01-01 00:00:00

  • The prognostic role of preoperative circulating neutrophil-lymphocyte ratio in primary bladder cancer patients undergoing radical cystectomy: a meta-analysis.

    abstract：BACKGROUND:Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of preoperative circulating neutrophil-lymphocyte ratio (NLR) (known as a marker of SIR) in human primary bladder cancer (BC) undergoing radical cystectomy (RC) remains c...

    journal_title：World journal of urology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00345-018-2593-z

    authors： Hu G,Xu F,Zhong K,Wang S,Xu Q,Huang L,Cheng P

    更新日期：2019-09-01 00:00:00

  • Male contraception: mechanical, hormonal and non-hormonal methods.

    abstract：:There is a definite need for an effective and reversible form of male contraception, both for maintaining a stable population in industrial countries and for diminishing population growth in developing countries. It has been agreed upon that contraception is an essential component of reproductive health for men and wo...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-003-0369-5

    authors： Weber RF,Dohle GR

    更新日期：2003-11-01 00:00:00

  • Consistent and significant improvement of nighttime voiding frequency (nocturia) with silodosin in men with LUTS suggestive of BPH: pooled analysis of three randomized, placebo-controlled, double-blind phase III studies.

    abstract：OBJECTIVES:Nocturia is prevalent and bothersome in men with lower urinary tract symptoms suggestive of BPH (LUTS/BPH). α-Adrenoceptor antagonists without subtype selectivity have inconsistently shown significant effects on nocturia in these patients. We explored the effects of the α1A-adrenoceptor subtype-selective ant...

    journal_title：World journal of urology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00345-013-1228-7

    authors： Eisenhardt A,Schneider T,Cruz F,Oelke M

    更新日期：2014-10-01 00:00:00

  • Voiding dysfunction in the orthotopic neobladder.

    abstract：:The orthotopic neobladder has become the preferred method of handling the urinary tract after removal of the bladder in men and women. However, an improved quality of life compared to urinary diversion fails to be realized when voiding dysfunction arises. These difficulties with urination range from retention to incon...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s003450000146

    authors： Steers WD

    更新日期：2000-10-01 00:00:00

  • Development of robotic program: an Asian experience.

    abstract：:Robotic surgery was started in the Department of Urology, Hospital Kuala Lumpur, in April 2004. We present our experience in developing the program and report the results of our first 50 cases of robotic radical prostatectomy. A three-arm da Vinci robotic system was installed in our hospital in March 2004. Prior to in...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-006-0069-z

    authors： Sahabudin RM,Arni T,Ashani N,Arumuga K,Rajenthran S,Murali S,Patel V,Hemal A,Menon M

    更新日期：2006-06-01 00:00:00

  • Correction to: Tissue engineering of the urethra: where are we in 2019?

    abstract：:It has been brought to our attention that the first sentence of the Conclusion in the original publication [1] is incorrect. We have removed this sentence and the correct version can be found in this Erratum. ...

    journal_title：World journal of urology

    pub_type： 已发布勘误

    doi：10.1007/s00345-019-02929-x

    authors： Chapple C

    更新日期：2020-09-01 00:00:00

  • The use of hemostatic agents does not prevent hemorrhagic complications of robotic partial nephrectomy.

    abstract：PURPOSE:To assess the impact of HA on robotic PN (RPN) outcomes. METHODS:We retrospectively analyzed data from patients who underwent RPN in eight centers between 2009 and 2013. Hemorrhagic complications were defined as the occurrence of a pseudoaneurysm, arteriovenous fistula or hematoma requiring transfusion. Patien...

    journal_title：World journal of urology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00345-015-1537-0

    authors： Peyronnet B,Oger E,Khene Z,Verhoest G,Mathieu R,Roumiguié M,Beauval JB,Pradere B,Masson-Lecomte A,Vaessen C,Baumert H,Bernhard JC,Doumerc N,Droupy S,Bruyere F,De La Taille A,Roupret M,Bensalah K

    更新日期：2015-11-01 00:00:00

  • Sky is no limit for ureteroscopy: extending the indications and special circumstances.

    abstract：PURPOSE:To critically review and synthesize data of ureteroscopy (URS) in different circumstances that all urologists may encounter during everyday clinical practice, such as pregnancy, obesity, bleeding diathesis, renal stones larger than 2 cm, calyceal diverticula, and kidney malformations. METHODS:According to PRIS...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-014-1345-y

    authors： Giusti G,Proietti S,Peschechera R,Taverna G,Sortino G,Cindolo L,Graziotti P

    更新日期：2015-02-01 00:00:00