Abstract:
OBJECTIVE:Radiation for tumors arising in the pelvis has been utilized for over a 100 years. Adverse effects (AEs) of radiotherapy (RT) continue to accumulate with time and are reported to show decades after treatment. The benefit of RT for pelvic tumors is well described as is their acute AEs. Late AEs are less well described. The burden of treatment for the late AEs is large given the high utilization of RT. REVIEW:For prostate cancer, 37% of patients will receive radiation during the first 6 months after diagnosis. Low-and high-grade AEs are reported to occur in 20-43 and 5-13%, respectively, with a median follow-up of ~60 months. For bladder cancer, the grade 2 and grade 3 late AEs occur in 18-27 and 6-17% with a median follow-up of 29-76 months. For cervical cancer, the risk of low-grade AEs following radiation can be as high as 28%. High-grade AEs occur in about 8% at 3 years and 14.4% at 20 years or ~0.34% per year. Radiation AEs appear to be less common or at least less well studied after radiation for rectal and endometrial cancers. CONCLUSION:Properly delineating the rate of long-term AEs after pelvic RT is instrumental to counseling patients about their options for cancer treatment. Further studies are needed that are powered to specifically evaluate long-term AEs.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Elliott SP,Malaeb BSdoi
10.1007/s00345-010-0603-xsubject
Has Abstractpub_date
2011-02-01 00:00:00pages
35-41issue
1eissn
0724-4983issn
1433-8726journal_volume
29pub_type
杂志文章,评审abstract:PURPOSE:The aim of the study is to evaluate the impact of having a nadir and persistently detectable ultrasensitive prostate-specific antigen (uPSA) between 0.01 and 0.1 ng/ml post-robot-assisted radical prostatectomy (RARP), on future biochemical recurrence (BCR). METHODS:We conducted a retrospective analysis of a pr...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03367-w
更新日期:2020-07-21 00:00:00
abstract:PURPOSE:Often PIRADS 3 findings are usually followed up with further MRIs of the prostate. Current guidelines do not state an optimal interval between the initial MRI and the follow-up MRI. The aim of this study was to find out if PIRADS 3 lesions evolve over time and to determine how long the optimal interval between ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2135-0
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:Urethroplasty is the most effective treatment method for anterior urethral strictures, which constitute an important health concern for males. This study aims to investigate factors that may predict treatment failure following urethroplasty for anterior urethral strictures and evaluate outcomes of different ure...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-03014-z
更新日期:2020-09-01 00:00:00
abstract::Orthotopic urinary diversion via the Kock ileal neobladder is the preferred form of bladder reconstruction in men and, now, in women undergoing cystectomy at the University of Southern California. Through June of 1993, 266 men were diverted in this fashion. There were 3 perioperative mortalities (1.1%); early complica...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF01836343
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Previous studies reported improved outcomes for bladder cancer patients who had radical cystectomy (RC) performed by surgeons and hospitals with high annual RC volumes. The objective of this study was to determine the effect of high hospital and surgeon volume on overall survival after RC fo...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-014-1457-4
更新日期:2015-09-01 00:00:00
abstract::Gastrin releasing peptide (GRP) is a neuropeptide that has been suggested to play a role in the development of some malignancies. Our aim was: (1) to identify the expression of GRP in cancerous prostate glands, and (2) to correlate its expression to various pathological parameters and to the patient's clinical outcome...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-003-0339-y
更新日期:2003-08-01 00:00:00
abstract:PURPOSE:The introduction of collagenase Clostridium histolyticum (CCH) has revolutionized the treatment of Peyronie's disease. The efficacy of this therapy has been well demonstrated and the safety profile is favorable. However, post-injection complications are poorly characterized and management of these complications...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-019-02817-4
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:Robotic partial nephrectomy (RPN) is a minimally-invasive technique used to treat renal tumors. A clinical pathway and prospective research protocol (AMBU-REIN) were specifically set up to establish and assess the routine use of day-case RPN. METHODS:The AMBU-REIN study was conducted in the framework of the Fr...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03283-z
更新日期:2020-06-08 00:00:00
abstract::Due to its unique biological behavior, late relapse (LR) of testicular cancer has recently been described as an own tumor entity. It is currently defined as tumor recurrence more than 2 years after complete remission following primary treatment including chemotherapy. The incidence ranges from 2 to 6%, with a median r...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-004-0397-9
更新日期:2004-04-01 00:00:00
abstract::The aim of this study was to determine the long-term clinical efficacy and complications of neuromodulation with a unilateral sacral foramen electrode in 36 patients with chronic voiding dysfunction. Following a positive effect of a percutaneous nerve evaluation test, patients underwent open surgery. A permanent elect...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s003450050074
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:To investigate, if and how omitting gadolinium-based contrast agents (GBCA) and dynamic contrast-enhanced imaging (DCE) influences diagnostic accuracy and tumor detection rates of prostate MRI. METHODS:In this retrospective study, 236 patients were included. The results of biparametric (bpMRI) and multiparamet...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2428-y
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:Different enhanced recovery after surgery (ERAS) protocols (EP) for radical cystectomy (RC) have been published. Protocols highly differ in number of included items and specific measures. MATERIALS AND METHODS:A systematic review and meta-analysis on EPs in RC were performed using the databases MedLine, Cochra...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03133-y
更新日期:2020-12-01 00:00:00
abstract::Animal models are at the centre of laboratory bladder cancer (BC) research and at the same time, the bridge to the clinic. A new and very promising therapeutical approach is to silence abnormally up-regulated genes in cancer, through small interfering RNA (siRNA) molecules. Therapeutic use and success of siRNAs will l...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-009-0374-4
更新日期:2009-06-01 00:00:00
abstract::The nuclear factor of kappa beta (NF-kappaB) transcription factor regulates the transcription of numerous genes including that of interleukin 6 (IL-6). The IL-6 acts as an autocrine and paracrine growth factor of androgen-independent prostate cancer. An aberrant expression of the IL-6 gene and an increase in IL-6 expr...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-007-0175-6
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To analyse whether the reported differences in nodal yield at pelvic lymph node dissection (PLND) for bladder cancer, between two hospitals, are reflected in the survival rates. PATIENTS AND METHODS:We assessed follow-up data of all 174 patients (mean age: 62.7, median follow-up: 3 years) who underwent PLND ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-0916-z
更新日期:2013-10-01 00:00:00
abstract::Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF alpha) are two closely related peptides that interact with cell-surface epidermal growth factor receptors (EGFR) to induce receptor tyrosine phosphorylation and activation of intracellular signal-transduction pathways. EGF appears to be the predom...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/BF00185972
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:To evaluate the perioperative morbidity of PC-RPLND in two intermediate volume centers and to identify predictors of high morbidity. METHODS:Retrospective analysis of 124 patients treated with open PC-RPLND at two tertiary referral centers between 2001 and 2018. Perioperative morbidity was determined by analyz...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03229-5
更新日期:2020-05-05 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of WX-G250, a chimeric monoclonal antibody that binds to carboxy anhydrase IX, combined with low-dose interferon-alpha (LD-IFNα) in patients with progressive metastatic renal cell carcinoma (mRCC). PATIENTS AND METHODS:Thirty-one patients, nephrectomized for the primary tumo...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-010-0570-2
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:The international meeting on reconstructive Urology (IMORU) is a live surgery event (LSE) where expert surgeons perform various reconstructive surgeries. To evaluate patient safety, an extended follow-up of the complications of two subsequent IMORU meetings were gathered. Also, a detailed survey concerning the ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02666-1
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Asymptomatic bacteriuria is common in diabetic women. Treatment of asymptomatic bacteriuria is not beneficial, but the natural history of the microbiology of asymptomatic bacteriuria has not been well described. OBJECTIVE:To describe the microbiological outcomes of bacteriuria in diabetic women with untreat...
journal_title:World journal of urology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00345-005-0042-2
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:To characterize testosterone profile changes over time in a cohort of prostate cancer (PCa) patients managed with active surveillance (AS) and to assess its correlation with the initial disease characteristics and further progression. METHODS:We conducted retrospective chart review of PCa patients managed w...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2270-2
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the factors affecting the lower urinary tract symptoms (LUTS) related quality of life (QoL) score. METHODS:This retrospective study analyzed 29,123 men who underwent health check-ups from January 2007 to July 2011 at a single institution. Those patients who completed th...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2052-2
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of Adjustable Transobturator Male System (ATOMS) compared to male Readjustment Mechanical External (REMEEX) system for post-prostatectomy incontinence (PPI). MATERIAL AND METHODS:A systematic review and meta-analysis on adjustable device ATOMS compared to male REMEEX is pres...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03300-1
更新日期:2020-06-11 00:00:00
abstract:PURPOSE:To characterize the clinical and pathologic staging of patients with urothelial carcinoma (UC) in bladder diverticula (BD) after undergoing radical cystectomy (RC) and determine the impact of UCBD on recurrence and survival. METHODS:We reviewed our institutional database of patients who underwent RC for UC (19...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1472-5
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:Although the role of lymph node dissection (LND) is well defined in many urological settings, uncertainty regarding need for LND still exists for patients with renal cell carcinoma (RCC). The aim of the current review is to highlight the rationale for performing or omitting LND at the time of renal surgery. ME...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-016-1886-3
更新日期:2017-04-01 00:00:00
abstract::The effects of pelvic floor muscle contraction on rectal and vesical function were studied in 19 healthy volunteers with the aim of shedding light on some of the hitherto vague aspects of the mechanisms involved in micturition and defecation and their disorders. Rectal and vesical pressures were recorded during pubore...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s003450100218
更新日期:2001-08-01 00:00:00
abstract::A basic understanding of the mediators and related mechanisms involved in the genital physiology of the female sexual response, and, in particular, the physiology of arousal, is paramount for the clinical practitioner whose medical knowledge and practice pertain to female sexual dysfunction. Familiarity with establish...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-002-0271-6
更新日期:2002-06-01 00:00:00
abstract:PURPOSE:To test the association between family history of prostate cancer (FH) and prostate cancer (PCa) risk in a large screening program in Brazil, as no conclusive study has yet investigated this. METHODS:Between 2004 and 2007, 17,569 men were screened in 231 small municipalities using mobile screening units. Posit...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-012-0904-3
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:To investigate a potential correlation between the achievement of a cut-off of nadir PSA (nPSA) after brachytherapy (BRT) with biochemical Disease-Free Survival (bDFS) and to define the rate of post-BRT PSA bounces. METHODS:Retrospective analysis was carried out in 105 consecutive patients affected with early-...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-0932-z
更新日期:2013-04-01 00:00:00
abstract::Tissue engineering, long a matter of myth and dream throughout the history of medicine, is now a practical reality. A wide spectrum of biological materials are used in the field of urology to treat disease and to overcome human disabilities, including tissue grafts and organ transplantation. Laboratory-engineered biop...
journal_title:World journal of urology
pub_type: 历史文章,杂志文章
doi:10.1007/s003450050015
更新日期:2000-02-01 00:00:00