Abstract：
:Many human tumors such as bladder carcinoma that are initially responsive to chemotherapy eventually fail to respond to treatment. For most drugs, dose escalation that may be required for a cure cannot be achieved because sensitive tissues such as bone marrow limit cytotoxic therapy. Approaches to prevent or circumvent myelosuppression are therefore a high priority of research on dose intensification protocols. One such strategy is to protect bone marrow cells by virtue of expression of the multidrug-resistance (MDR1) gene encoding for P-glycoprotein. In our first set of experiments, we transplanted bone marrow cells derived from transgenic mice that constitutively express MDR1 to lethally irradiated recipients (n = 36). From 6 weeks to 10 months after the transplant, all animals contained MDR1 DNA in spleen and bone marrow specimens as indicated by Southern-blot analysis and expressed MDR1 RNA in bone marrow samples as detected by slot-blot analysis. In addition, these animals were resistant to the myelosuppressive effect of doxorubicin, daunomycin, taxol, vinblastine, vincristine, etoposide, and actinomycin D, whereas control animals that were reconstituted with normal bone marrow reacted with a significant decrease in their white blood counts. In a second set of experiments, we retrovirally transfected a construct consisting of a murine long-terminal repeat (LTR) promoter and the human MDR1 gene into CD34-positive bone marrow stem cells from rhesus monkeys using the same technique as in the ongoing clinical ADA gene-therapy protocol. Upon transplantation, high-level and long-lasting expression of the human MDR1 gene was observed in recipient monkeys.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
World J Uroljournal_title
World journal of urologyauthors
Mickisch GH,Schroeder FHdoi
10.1007/BF00184246subject
Has Abstractpub_date
1994-01-01 00:00:00pages
104-11issue
2eissn
0724-4983issn
1433-8726journal_volume
12pub_type
杂志文章,评审abstract：PURPOSE:We hypothesized that a relevant number of patients with clinically high-risk prostate cancer (PCA) indeed harbor overall favorable tumor characteristics (OFTC) (i.e., pT2a-c and Gleason score ≤3 + 4 = 7 and pN0/X) and that in these patients radical prostatectomy (RP) alone is most likely curative. METHODS:Betw...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1274-9
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:To compare prognostic performance of MSKCC and IMDC risk models in patients with synchronous mRCC. METHODS:Retrospective analysis of pre-therapeutic MSKCC and IMDC prognostic factors and outcomes in patients with synchronous mRCC treated at a single institute in the targeted therapy era was performed. Cytoredu...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1769-7
更新日期：2016-08-01 00:00:00
abstract：:We investigated a possible relationship between brefeldin A (BFA), an antibiotic, and cathepsin D (Cat.D), a lysosomal protease, in prostate cancer proliferation. Effects of BFA (30 ng/ml) were examined on the growth of three human prostatic cancer cell lines, PC-3, DU-145, and LNCaP cells. Its effect on Cat.D in thes...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/pl00007099
更新日期：2001-08-01 00:00:00
abstract：:This study was designed to evaluate the impact of lower-energy transurethral microwave thermotherapy (TUMT) on quality of life (QoL) and quality of sexual function (QSF) in patients with benign prostatic hyperplasia (BPH). A total of 216 patients with BPH received lower-energy TUMT treatment (Prostasoft 2.0) and were ...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s003450050042
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:Robotic radical cystectomy (RRC) has become a commonly utilised alternative to open radical cystectomy (ORC). We performed a systematic review and meta-analysis of RRC vs ORC focusing on perioperative outcomes and safety. METHODS:Medline, EMBASE and CENTRAL were searched from January 2000 to April 2020 followi...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-020-03385-8
更新日期：2020-07-30 00:00:00
abstract：INTRODUCTION:Following its introduction in 1980, shock wave lithotripsy (SWL) rapidly emerged as the first-line treatment for the majority of patients with urolithiasis. Millions of SWL therapies have since been performed worldwide, and nowadays, SWL still remains to be the least invasive therapy modality for urinary s...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-014-1369-3
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Dhat syndrome (DS) consists of vague somatic symptoms and at times sexual dysfunction which the patient falsely attributes to involuntary emissions of semen outside of sexual relations. OBJECTIVE:Describe and analyse the occurrences of DS in patients attending the clinic and clarify the existence of this co...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0911-4
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:To evaluate the diagnostic and staging ability of multiparametric MRI (mpMRI) compared to radical prostatectomy (RP) specimens after dissemination of this technology to several centres. mpMRI is an evolving technique aiming to improve upon the diagnostic sensitivity of prostate biopsy for the diagnosis of prost...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1960-x
更新日期：2017-06-01 00:00:00
abstract：PURPOSE:Robotic partial nephrectomy (RPN) is a minimally-invasive technique used to treat renal tumors. A clinical pathway and prospective research protocol (AMBU-REIN) were specifically set up to establish and assess the routine use of day-case RPN. METHODS:The AMBU-REIN study was conducted in the framework of the Fr...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03283-z
更新日期：2020-06-08 00:00:00
abstract：INTRODUCTION:Currently, osteoporosis research is rarely undertaken in males but an increase in male life expectancy in the company of hypogonadism suggests the necessity for potential therapeutic options. MATERIALS AND METHODS:In this study, the changes in bone structure under standardized testosterone- (T), raloxifen...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0373-5
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVES:Objective characterization of renal mass anatomy facilitates treatment selection and prediction of surgical outcomes. We investigated R.E.N.A.L nephrometry score (NS) efficacy in predicting outcomes after minimally invasive nephron-sparing surgery (MINSS). METHODS:A total of 250 patients with 252 renal mass...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0876-3
更新日期：2013-10-01 00:00:00
abstract：:We report on 208 patients with locally advanced renal-cell carcinoma who received a surgical adjuvant vaccination with autologous, Newcastle disease virus (NDV)-modified, and lethally irradiated tumor cells in combination with low-dose recombinant interleukin-2 and interferon-alpha. The pathological stage was defined ...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00184874
更新日期：1995-01-01 00:00:00
abstract：:This paper provides an overview of the scientific and practical aspects of assessing health-related quality of life (HRQL). The paper provides a brief overview of developments in the field and then discusses the definition of HRQL. The different types of HRQL measure available to researchers are described, with specif...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050132
更新日期：1999-08-01 00:00:00
abstract：:The author presents the life and achievements of Johann von Mikulicz-Radecki and his contribution to European and world surgery. Mikulicz was born in Czernowitz, then a part of the Austro-Hungarian Empire. He was educated in numerous Austrian schools and graduated at Vienna University in 1875. In 1880 he became surgeo...
journal_title：World journal of urology
pub_type： 传,历史文章
doi：10.1007/s00345-007-0227-y
更新日期：2008-02-01 00:00:00
abstract：PURPOSE:The primary objective was to evaluate the effect of autologous muscle-derived cell (AMDC) injections on the urethral sphincter morphometry compared to placebo injections. Secondary aims were to explore the reduction of stress incontinence episode frequency (IEF) and factors associated with the efficacy of AMDC....
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03076-4
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVES:It has been reported that apoptosis of penile erectile tissue occurs after penile denervation, castration, and diabetes mellitus in animal studies. Aim of this study was to investigate apoptosis in corpora cavernosa of patients with organic erectile dysfunction (ED). METHODS:Cavernous biopsies were obtained...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0332-6
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:As silodosin 8 mg, used for treating BPH, is known to cause absence of sperms in the ejaculate, its potential as an on-demand, reversible, nonhormonal oral contraceptive for males was assessed in this pilot study. METHODS:In this randomized, double-blind, placebo-controlled pilot study, healthy, sexually activ...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-019-02806-7
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:To evaluate the benefit of an antimicrobial prophylaxis protocol using rectal swab cultures in patients undergoing transrectal ultrasound (TRUS)-guided prostate biopsy in our Veterans Affairs population. METHODS:Between June 1, 2013, and June 1, 2014, we implemented an antimicrobial prophylaxis protocol using ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1571-y
更新日期：2015-12-01 00:00:00
abstract：:It has been brought to our attention that the first sentence of the Conclusion in the original publication [1] is incorrect. We have removed this sentence and the correct version can be found in this Erratum. ...
journal_title：World journal of urology
pub_type： 已发布勘误
doi：10.1007/s00345-019-02929-x
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:To examine the prevalence of lower urinary tract symptoms (LUTS) and the bother they impose in a population-based sample of adults in Brazil. METHODS:A cross-sectional population-based survey was conducted between September 2006 and January 2007 in the city of Salvador, Brazil. Cluster samples of representativ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1057-8
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:To evaluate for the first time the prognostic significance of female invasive patterns in stage pT4a urothelial carcinoma of the bladder in a large series of women undergoing anterior pelvic exenteration. PATIENTS AND METHODS:Our series comprised of 92 female patients in total of whom 87 with known invasion pa...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-014-1308-3
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:To prospectively compare short-term functional outcomes achieved by laparoscopic or robot-assisted sacrocolpopexy for pelvic organ prolapse. MATERIALS AND METHODS:We prospectively collected clinical and operative data over 24 months for female patients who underwent either pure laparoscopic sacrocolpopexy (L...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0748-2
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Individualized risk-adapted algorithms in prostate cancer (PCa) diagnosis using predictive prebiopsy variables in addition to prostate-specific antigen value may result in a considerable reduction of unnecessary systematic biopsies. Multi-parametric magnetic resonance imaging (mpMRI) has emerged ...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-019-02707-9
更新日期：2020-03-01 00:00:00
abstract：INTRODUCTION:Obesity may be a risk factor for kidney donors to develop reduced renal function. The Framingham heart study suggested that visceral adipose tissue (VAT) confers a more adverse metabolic profile compared with subcutaneous adipose tissue (SAT). Asians tend to have a higher VAT composition and it is unclear ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2566-2
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:Accurate puncture of the renal collecting system is crucial to the success of percutaneous nephrolithotomy and presents a technical challenge for urologists. Here, we introduced the Surgical Approach Visualization and Navigation (SAVN) system, a novel navigation system to assist puncture and reduce intraoperati...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2496-z
更新日期：2019-06-01 00:00:00
abstract：:Ileal conduits have long been accepted as a standard method for urinary diversion, but conventional ileal conduits are not always suitable for patients whose ureters are for the greater part compromised by neoplasm or preoperative irradiation, resulting in a shortening of the ureters. Bowel migration into the large ca...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s003450050092
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:To evaluate the role of multiparametric magnetic resonance imaging (mpMRI) in Gleason score (GS) 3 + 4 prostate cancer (PCa) and evaluate independent factors in mpMRI that can predict GS upgrading, we compared the outcomes of GS upgrading group and GS non-upgrading group. PATIENTS AND METHODS:We analyzed th...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03421-7
更新日期：2020-08-31 00:00:00
abstract：PURPOSE:To assess oncologic outcomes after salvage radiotherapy (SRT) without androgen deprivation therapy (ADT) in patients with persistently detectable PSA after radical prostatectomy (RT). METHODS:Two hundred and one patients who failed to achieve an undetectable PSA received SRT without ADT. The primary endpoint w...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-013-1214-0
更新日期：2014-10-01 00:00:00
abstract：:Telemedicine is the use of communication technologies to deliver health care. Telesurgical telementoring represents an advanced form of telemedicine, whereby an experienced surgeon can guide and teach practicing surgeons new operative techniques utilizing current video technology, medical robots, and high-band-width t...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s003450050082
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVES:Recent advances have led to the use of magnetic resonance imaging (MRI) alone or with fusion to transrectal ultrasound (TRUS) images for guiding biopsy of the prostate. Our group sought to develop consensus recommendations regarding MRI-guided prostate biopsy based on currently available literature and exper...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-018-2374-8
更新日期：2019-03-01 00:00:00
