The prognostic role of preoperative circulating neutrophil-lymphocyte ratio in primary bladder cancer patients undergoing radical cystectomy: a meta-analysis.

Abstract:

BACKGROUND:Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of preoperative circulating neutrophil-lymphocyte ratio (NLR) (known as a marker of SIR) in human primary bladder cancer (BC) undergoing radical cystectomy (RC) remains controversial. Hence, we performed this meta-analysis to better understand the role of preoperative circulating NLR in prognosis prediction for primary BC patients undergoing RC. METHODS:We searched PubMed, Embase and EBSCO to identify the studies and computed extracted data with STATA 12.0. RESULTS:A total of 11,945 patients with BC from 18 published studies were incorporated into this meta-analysis. We found that elevated NLR was significantly associated with decreased 3-year and 5-year overall survival (OS), 1-year, 3-year and 5-year recurrence-free survival (RFS), but not with 1-year or 10-year OS, or 10-year RFS in primary BC patients who underwent RC. The results also showed that neoadjuvant chemotherapy (NAC) had a significant impact on the negative prognostic effect of NLR. In addition, high NLR significantly correlated with unfavorable clinicopathological features of BC. CONCLUSION:Elevated preoperative circulating NLR leads to an unfavorable outcome in primary BC undergoing RC, especially in patients without NAC, implicating that it might be a valuable prognostic index for these patients.

journal_name

World J Urol

journal_title

World journal of urology

authors

Hu G,Xu F,Zhong K,Wang S,Xu Q,Huang L,Cheng P

doi

10.1007/s00345-018-2593-z

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

1817-1825

issue

9

eissn

0724-4983

issn

1433-8726

pii

10.1007/s00345-018-2593-z

journal_volume

37

pub_type

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