Abstract:
BACKGROUND:Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of preoperative circulating neutrophil-lymphocyte ratio (NLR) (known as a marker of SIR) in human primary bladder cancer (BC) undergoing radical cystectomy (RC) remains controversial. Hence, we performed this meta-analysis to better understand the role of preoperative circulating NLR in prognosis prediction for primary BC patients undergoing RC. METHODS:We searched PubMed, Embase and EBSCO to identify the studies and computed extracted data with STATA 12.0. RESULTS:A total of 11,945 patients with BC from 18 published studies were incorporated into this meta-analysis. We found that elevated NLR was significantly associated with decreased 3-year and 5-year overall survival (OS), 1-year, 3-year and 5-year recurrence-free survival (RFS), but not with 1-year or 10-year OS, or 10-year RFS in primary BC patients who underwent RC. The results also showed that neoadjuvant chemotherapy (NAC) had a significant impact on the negative prognostic effect of NLR. In addition, high NLR significantly correlated with unfavorable clinicopathological features of BC. CONCLUSION:Elevated preoperative circulating NLR leads to an unfavorable outcome in primary BC undergoing RC, especially in patients without NAC, implicating that it might be a valuable prognostic index for these patients.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Hu G,Xu F,Zhong K,Wang S,Xu Q,Huang L,Cheng Pdoi
10.1007/s00345-018-2593-zsubject
Has Abstractpub_date
2019-09-01 00:00:00pages
1817-1825issue
9eissn
0724-4983issn
1433-8726pii
10.1007/s00345-018-2593-zjournal_volume
37pub_type
杂志文章,meta分析abstract:PURPOSE:Prostate cancer (PCa) is the most common malignancy in men and the cause for the second most common cancer-related death in the western world. Despite ongoing development of novel approaches such as second generation androgen receptor targeted therapies, metastatic disease is still fatal. In PCa, immunotherapy ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03497-1
更新日期:2020-10-26 00:00:00
abstract:PURPOSE:Robotic radical cystectomy (RRC) has become a commonly utilised alternative to open radical cystectomy (ORC). We performed a systematic review and meta-analysis of RRC vs ORC focusing on perioperative outcomes and safety. METHODS:Medline, EMBASE and CENTRAL were searched from January 2000 to April 2020 followi...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-020-03385-8
更新日期:2020-07-30 00:00:00
abstract:INTRODUCTION:Recently, small renal masses (SRMs) (< or =4 cm) are found more frequently, especially in the elderly and co-morbid patients. Standard treatment for SRMs is nephron-sparing surgery (NSS). New techniques like energy ablation and surveillance have been introduced. MATERIALS AND METHODS:Overview of treatment...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-010-0516-8
更新日期:2010-06-01 00:00:00
abstract::The orthotopic neobladder has become the preferred method of handling the urinary tract after removal of the bladder in men and women. However, an improved quality of life compared to urinary diversion fails to be realized when voiding dysfunction arises. These difficulties with urination range from retention to incon...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s003450000146
更新日期:2000-10-01 00:00:00
abstract:PURPOSE:STAMPEDE arm H demonstrated a survival benefit for newly diagnosed prostate cancer (PCa) patients with low metastatic burden (LMB) who additionally received radiotherapy (RT) to the primary. However, it is unknown if radical prostatectomy (RP) may achieve equivalent results, since existing studies did neither i...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02950-0
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:To critically review and synthesize data of ureteroscopy (URS) in different circumstances that all urologists may encounter during everyday clinical practice, such as pregnancy, obesity, bleeding diathesis, renal stones larger than 2 cm, calyceal diverticula, and kidney malformations. METHODS:According to PRIS...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-014-1345-y
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:Data assessing the effectiveness of single-use flexible ureteropyeloscopy (FURS) are limited. This study evaluates and compares single-use FURS with conventional reusable FURS. METHODS:A systematic search using electronic databases (Pubmed and Embase) was performed for studies evaluating single-use FURS in the...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-017-2131-4
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:We hypothesized that a relevant number of patients with clinically high-risk prostate cancer (PCA) indeed harbor overall favorable tumor characteristics (OFTC) (i.e., pT2a-c and Gleason score ≤3 + 4 = 7 and pN0/X) and that in these patients radical prostatectomy (RP) alone is most likely curative. METHODS:Betw...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1274-9
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:In this study, we investigated the influence of hematuria on the performance of the bladder tumor antigen (BTA) tests in a clinical cohort and in an experimental model. MATERIALS AND METHODS:Urine samples from a cohort of 126 subjects (64 with BCa and 62 controls) were analyzed by ELISA for hemoglobin and B...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-0935-9
更新日期:2012-12-01 00:00:00
abstract::Percutaneous nephrolithotomy (PCNL) remains the treatment of choice for staghorn renal calculi. Many reports suggest that laparoscopy can be an alternative treatment for large renal stones. We wished to evaluate the role and feasibility of laparoscopic extended pyelolithotomy (REP) for treatment of staghorn calculi. T...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-006-0099-6
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:Recent studies demonstrated ongoing inverse stage migration in prostate cancer (PCa) patients towards more advanced and unfavorable tumors. The USPSTF grade D recommendation may impact this trend in North American patients. We assessed contemporary stage migration and treatment trends in a large North American ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2396-2
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of Adjustable Transobturator Male System (ATOMS) compared to male Readjustment Mechanical External (REMEEX) system for post-prostatectomy incontinence (PPI). MATERIAL AND METHODS:A systematic review and meta-analysis on adjustable device ATOMS compared to male REMEEX is pres...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03300-1
更新日期:2020-06-11 00:00:00
abstract:PURPOSE:We sought whether serum total testosterone (tT), estradiol (E2), tT/E2 ratio, and sex hormone-binding globulin (SHBG) significantly fluctuate throughout time in men with prostate cancer (PCa). METHODS:Circulating hormones were measured in a cohort of 631 candidates for radical prostatectomy. Hormone levels wer...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-1009-8
更新日期:2013-04-01 00:00:00
abstract::We report on 208 patients with locally advanced renal-cell carcinoma who received a surgical adjuvant vaccination with autologous, Newcastle disease virus (NDV)-modified, and lethally irradiated tumor cells in combination with low-dose recombinant interleukin-2 and interferon-alpha. The pathological stage was defined ...
journal_title:World journal of urology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00184874
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:To investigate the association between overactive bladder (OAB) and coronary artery disease (CAD) as demonstrated on coronary angiography in patients > 65 years. METHODS:The patients who were > 65 years completed an OAB-V8 form before undergoing coronary angiography at a tertiary care hospital. The presence of...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2098-1
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To analyse the surgical margins status of prostatic glands, resected by laparoscopic radical prostatectomy (LRP) for prostate cancer, and to correlate it with biochemical free survival rate (BFSR). METHODS:Data were collected prospectively from 405 patients undergoing LRP from 2000 to 2009 at a single institut...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0711-2
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:To evaluate the thermal effect of Ho:YAG laser lithotripsy in a standardized in vitro model via real-time temperature measurement. METHODS:Our model comprised a 20 ml test tube simulating the renal pelvis that was immersed in a 37 °C water bath. Two different laser fibers [FlexiFib (15-45 W), RigiFib 1000 (45-...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2303-x
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:It has been hypothesized that endothelial dysfunction and pelvic atherosclerosis may contribute to lower urinary tract symptoms (LUTS). We assessed the relationship between cardiovascular risk factors and LUTS severity in male patients presented to urology clinic. METHODS:It is a cross-sectional study on pat...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2432-2
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:To assess the feasibility, safety, and outcomes of an expedited One-Stop prostate cancer (PCa) diagnostic pathway. PATIENTS AND METHODS:We identified 370 consecutive patients who underwent multiparametric magnetic resonance imaging (mpMRI) and transrectal ultrasound fusion prostate biopsy (MRI/TRUS-PBx) from o...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02835-2
更新日期:2020-04-01 00:00:00
abstract::The aim of this study was to determine and compare the effects of both magnesium citrate and phytin on reducing urinary calcium excretion under high-calcium-diet conditions during single and combined treatments. An animal experiment was carried out over a period of 4 weeks in 35 male rats. Urinary calcium excretion wa...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF00184113
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND/AIM:The effects of printed educational material on cancer screening in women (Pap test and mammography) are well documented and confirmed by several studies. The aim of our study was to evaluate the impact of similar printed educational material on prostate cancer screening by PSA and DRE. MATERIAL AND METH...
journal_title:World journal of urology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00345-008-0258-z
更新日期:2008-08-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Previous studies reported improved outcomes for bladder cancer patients who had radical cystectomy (RC) performed by surgeons and hospitals with high annual RC volumes. The objective of this study was to determine the effect of high hospital and surgeon volume on overall survival after RC fo...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-014-1457-4
更新日期:2015-09-01 00:00:00
abstract:PURPOSE/OBJECTIVE(S):Recent in vitro and in vivo evidence has suggested that statin medications may have anticancer activity. We sought to determine whether statin use was associated with improved clinical outcome in men treated with brachytherapy for prostate cancer. MATERIALS/METHODS:A database of men with prostate ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1281-x
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To investigate pathological and oncological outcomes of obese patients who underwent robot-assisted radical prostatectomy (RARP) compared with laparoscopic radical prostatectomy (LRP) or open retropubic radical prostatectomy (RRP) since limited comparative data exist with regard to oncological and survival o...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-014-1326-1
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:To provide a comprehensive update of the joint consultation of the International Consultation on Urological Diseases (ICUD) for the diagnosis and management of non-urothelial cancer of the urinary bladder. METHODS:A detailed analysis of the literature was conducted reporting on the epidemiology, etiology, diag...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-018-2421-5
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:Recent lung cancer data have shown an association of XPA-210, a key peptide of thymidine kinase, with advanced disease. We thus assessed its proliferation status in primary (M0) and metastatic (M1) renal cell carcinoma (RCC). METHODS:Paraffin slides from 30 patients (mean age: 61.2 years; range: 42-84) with cl...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-010-0621-8
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:Taiwan is a highly endemic area for urothelial carcinoma (UC) and chronic kidney disease (CKD). We evaluate the gender effect on the relationship between renal outcome and clinical characteristics of CKD patients with UC. METHODS:The clinical and pathologic records of 404 patients were retrospectively analyzed...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0682-3
更新日期:2011-08-01 00:00:00
abstract::Upon feeling the urge to urinate, the urinary bladder contracts, the urethral sphincters relax and urine flows through the urethra. These actions are mediated by the micturition reflex. We investigated the hypothesis that vesical contraction is maintained by positive feedback through continuous flow of urine through t...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-003-0340-5
更新日期:2003-08-01 00:00:00
abstract:PURPOSE:Clinical outcomes prognostic markers are awaited in clear-cell renal carcinoma (ccRCC) to improve patient-tailored management and to assess six different markers' influence on clinical outcomes from ccRCC specimen and their incremental value combined with TNM staging. MATERIALS AND METHODS:This is a retrospect...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-016-1854-y
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:Often PIRADS 3 findings are usually followed up with further MRIs of the prostate. Current guidelines do not state an optimal interval between the initial MRI and the follow-up MRI. The aim of this study was to find out if PIRADS 3 lesions evolve over time and to determine how long the optimal interval between ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2135-0
更新日期:2018-03-01 00:00:00