Abstract：
PURPOSE:There are sparse data describing outcomes of bone-only oligometastatic prostate cancer in comparison with lymph node disease treated with stereotactic body radiotherapy (SBRT). The primary aim of this study was to report progression-free survival (PFS) data for patients with bone-only disease. Influence of hormone sensitivity and androgen deprivation therapy use was also assessed. METHODS:This is a single-centre retrospective cohort study. Hormone-sensitive and castrate-resistant patients with oligometastatic (≤ 3) bone-only prostate cancer treated with SBRT were included. Data were collected using electronic records. Kaplan-Meier survivor function, log rank test, as well as Cox regression were used to calculate PFS and overall survival. RESULTS:In total, 51 patients with 64 bone metastases treated with SBRT were included. Nine patients were castrate resistant and 42 patient's hormone sensitive at the time of SBRT. Median follow-up was 23 months. Median PFS was 24 months in hormone-sensitive patients and 3 months in castrate-resistant patients. No patients experienced grade 3 or 4 toxicities. There were three in-field recurrences. CONCLUSIONS:In this study, patients with bone oligometastatic disease showed potential benefit from SBRT with a median PFS of 11 months. Hormone-sensitive patients showed the greatest benefit, with results similar to that published for oligometastatic pelvic nodal disease treated with SBRT. Prospective randomised control trials are needed to determine the survival benefit of SBRT in oligometastatic bone-only prostate cancer and to determine prognostic indicators.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Patel PH,Chaw CL,Tree AC,Sharabiani M,van As NJdoi
10.1007/s00345-019-02873-wsubject
Has Abstractpub_date
2019-12-01 00:00:00pages
2615-2621issue
12eissn
0724-4983issn
1433-8726pii
10.1007/s00345-019-02873-wjournal_volume
37pub_type
杂志文章abstract：BACKGROUND:Chronic intraprostatic inflammation is suspected to play a major role in the pathogenesis of prostate cancer (PCa). Polymorphisms in interleukin-10 (IL-10), a key anti-inflammatory cytokine gene can influence immune response and immune evasion of tumor cells. Its role as an anti-metastatic molecule is also w...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0361-1
更新日期：2009-06-01 00:00:00
abstract：INTRODUCTION:Adherent perirenal fat (APF) can be defined as inflammatory fat sticking to renal parenchyma, whose dissection is difficult and makes it troublesome to expose the tumour. Our objective was to evaluate the impact of APF on the technical difficulty of robot-assisted partial nephrectomy (RPN). PATIENTS AND M...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1500-0
更新日期：2015-11-01 00:00:00
abstract：PURPOSE:Assess knowledge and awareness concerning human papillomavirus (HPV) infection, HPV-associated diseases, and the existence of a specific vaccine among non-HPV-screened Caucasian-European adults after the market introduction of HPV vaccines. METHODS:A cohort of 934 consecutive patients seeking their first medic...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1379-1
更新日期：2015-06-01 00:00:00
abstract：:Robotic surgery was started in the Department of Urology, Hospital Kuala Lumpur, in April 2004. We present our experience in developing the program and report the results of our first 50 cases of robotic radical prostatectomy. A three-arm da Vinci robotic system was installed in our hospital in March 2004. Prior to in...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-006-0069-z
更新日期：2006-06-01 00:00:00
abstract：PURPOSE:Patients with end-stage renal disease (ESRD) have an increased risk of developing renal cell carcinoma (RCC). This retrospective study compared clinical and pathological outcomes of RCC occurring in native kidneys of patients with ESRD (whether they underwent kidney transplantation or not) with those of renal t...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1248-y
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:The aim of the study is to evaluate the impact of having a nadir and persistently detectable ultrasensitive prostate-specific antigen (uPSA) between 0.01 and 0.1 ng/ml post-robot-assisted radical prostatectomy (RARP), on future biochemical recurrence (BCR). METHODS:We conducted a retrospective analysis of a pr...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03367-w
更新日期：2020-07-21 00:00:00
abstract：PURPOSE:To assess whether real-time elastography-targeted biopsy (RTE-bx) is superior to the standard systematic transrectal ultrasound (TRUS)-guided biopsy in predicting subsequent prostate cancer (PCa) rates in patients with initially negative biopsy and to specifically reveal differences in the occurrence of high-gr...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2178-x
更新日期：2018-04-01 00:00:00
abstract：:This study was designed to evaluate the impact of lower-energy transurethral microwave thermotherapy (TUMT) on quality of life (QoL) and quality of sexual function (QSF) in patients with benign prostatic hyperplasia (BPH). A total of 216 patients with BPH received lower-energy TUMT treatment (Prostasoft 2.0) and were ...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s003450050042
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:To evaluate the association between the plant-based content of diet and serum testosterone levels in men from the national health and nutrition examination survey (NHANES) database. MATERIALS AND METHODS:Data on demographics, diet, and testosterone levels was acquired from the NHANES database. Using the food f...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03276-y
更新日期：2020-05-28 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1241-5
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:Despite the increasing number of studies confirming the importance of neoadjuvant chemotherapy (NC) in patients before radical cystectomy (RC) for bladder cancer (BCa), NC remains underused. The aim of our study was to develop a nomogram predicting the cancer-specific mortality (CSM) of patients who underwent R...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-015-1640-2
更新日期：2016-02-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1644-y
更新日期：2016-04-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2243-5
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Asymptomatic bacteriuria is common in diabetic women. Treatment of asymptomatic bacteriuria is not beneficial, but the natural history of the microbiology of asymptomatic bacteriuria has not been well described. OBJECTIVE:To describe the microbiological outcomes of bacteriuria in diabetic women with untreat...
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pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-005-0042-2
更新日期：2006-02-01 00:00:00
abstract：:Despite several new urine markers urinary cytology remains the gold standard for the non-invasive detection of bladder carcinoma. The use of monoclonal antibodies against tumor associated antigens offers a promising approach to improve urinary cytology. The aim of this study was to compare fluorescence immunocytology ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0390-8
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVES:Monopolar transurethral resection of the prostate (TURP) is the gold standard surgical treatment for bothersome moderate to severe lower urinary tract symptoms (LUTS) secondary to benign prostate obstruction. The aim of the study is to compare monopolar versus bipolar TURP focusing on operative and functiona...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-017-2023-7
更新日期：2017-10-01 00:00:00
abstract：PURPOSE:To report our experience with pelvic reconstructive surgery with transobturator mesh implants in elderly women. MATERIALS AND METHODS:A total of 32 women aged >75 years with pelvic organ prolapse receiving anterior and/or posterior repair using transobturator mesh implants were included. Concomitant mid-urethr...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0863-8
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:In this study, we investigated the influence of hematuria on the performance of the bladder tumor antigen (BTA) tests in a clinical cohort and in an experimental model. MATERIALS AND METHODS:Urine samples from a cohort of 126 subjects (64 with BCa and 62 controls) were analyzed by ELISA for hemoglobin and B...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0935-9
更新日期：2012-12-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1281-x
更新日期：2015-01-01 00:00:00
abstract：:Reconstruction of long anterior urethral strictures that cannot be excised and reanastomosed remains controversial. We critically reviewed the literature on free-graft and pedicled skin-flap urethroplasty to determine the optimal method of repair. Overall, free grafts were successful in 84.3% of cases and flaps, in 85...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050048
更新日期：1998-01-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00182560
更新日期：1996-01-01 00:00:00
abstract：:Although anejaculation is a relatively uncommon occurrence in the general population, over 12,000 new cases are reported annually. Anejaculation may result from spinal cord injury (SCI), retroperitoneal lymph node dissection (RPLND), diabetes mellitis, transverse myelitis, multiple sclerosis, or psychogenic disorders....
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00182035
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:To determine the clinical performance of a blood-based test for clinically significant (CS) prostate cancer (PCa) (grade group ≥ 2) intended for use in men with prostate serum antigen levels in the 'grey zone' (PSA < 10 ng/ml). The test quantifies a previously described 3.4 kb mitochondrial DNA (mtDNA) deletion...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2152-z
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:This study aimed to identify non-neoplastic pathologic changes in partial nephrectomy specimens of patients without a known history of medical comorbidities. Routine analysis of this tissue may allow the clinician to identify subclinical renal disease. METHODS:We retrospectively reviewed our database of patien...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0720-1
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:We aim to analyze the efficacy of different focus sizes and the influence of pulse pressure (intensity) during shock wave lithotripsy (SWL) in terms of stone fragmentation. METHODS:Combination of three focal sizes (F1 = 2 mm, F2 = 4 mm, F3 = 8 mm) and 11 output pressure settings (intensity 10-20) of a piezoele...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-03069-y
更新日期：2020-10-01 00:00:00
abstract：:This paper provides an overview of the scientific and practical aspects of assessing health-related quality of life (HRQL). The paper provides a brief overview of developments in the field and then discusses the definition of HRQL. The different types of HRQL measure available to researchers are described, with specif...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050132
更新日期：1999-08-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0916-z
更新日期：2013-10-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0486-x
更新日期：2010-10-01 00:00:00
abstract：INTRODUCTION:Urinary incontinence in men after radical prostatectomy affects strongly quality of life. If conservative treatment fails, surgical treatment consists of implantable devices. If the requirement of manual dexterity in the artificial sphincter is to be avoided, the ProACT system offers a readjustable system,...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2483-4
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:To describe the clinical characteristics of struvite stones and determine the preoperative predictors of sepsis in struvite patients undergoing percutaneous nephrolithotomy (PCNL). METHODS:A retrospective study of patients who underwent PCNL between April 2011 and March 2018 was performed. The data of the stru...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02748-0
更新日期：2020-01-01 00:00:00
