Abstract:
BACKGROUND:Numerous recent studies have shown that concomitant carcinoma in situ (CIS) can be closely associated with the prognosis of patients with bladder cancer (BCa). However, the prognostic value of CIS in BCa is still not conclusive. Hence, we performed a systematic review and meta-analysis to explore the association between CIS and clinicopathological features and the prognostic value for BCa following radical cystectomy. METHODS:We performed this study in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Relevant studies were systematically collected from PubMed, EMBASE, and Web of Science, with an expiration date of August 2018. Hazard ratios and 95% confidence intervals (CIs) were pooled to assess the intensity of association. All data were analyzed by Stata 12.0. Moreover, heterogeneity and publication bias were determined, and sensitivity analysis was performed to examine whether the findings of the meta-analysis were robust. RESULTS:A total of 18,845 patients from 24 studies were included in the analysis. Our results indicated that CIS has no significant correlation with cancer-specific mortality (CSM) (pooled HR = 0.97, 95% CI 0.93-1.00, p = 0.059), overall mortality (OM) (pooled HR = 0.93, 95% CI 0.85-1.01, p = 0.076), overall survival (OS) (pooled HR = 1.04, 95% CI 0.96-1.12, p = 0.386), cancer-specific survival (CSS) (pooled HR = 1.06, 95% CI 0.97-1.16, p = 0.186), recurrence-free survival (RFS) (HR = 1.05, 95% CI 0.99-1.11, p = 0.098) or recurrence (pooled HR = 1.04, 95% CI 0.98-1.11, p = 0.212) in BCa patients. In addition, CIS was not correlated with gender (male vs. female, OR = 1.00, 95% CI 0.74-1.34, p = 0.978), pathological stage (III/IV vs. I/II: OR = 0.74, 95% CI 0.50-1.10, p = 0.132), tumor grade (1/2 vs. 3: OR = 3.38, 95% CI 0.73-15.65, p = 0.119), soft tissue surgical margin (STSM) (+ vs. - : OR = 1.20, 95% CI 0.97-1.48, p = 0.093) or lymphovascular invasion (LVI) (+ vs. - : OR = 0.92, 95% CI 0.62-1.38, p = 0.702),but was closely related to adjuvant chemotherapy (ACT) (yes vs. no, OR = 1.17, 95% CI 1.03-1.32, p = 0.019). Furthermore, these findings were demonstrated to be reliable by our sensitivity and subgroup analysis. CONCLUSIONS:The prognostic value of CIS in BCa remains inconclusive in patients submitted to RC. Our data indicated that CIS may have no significant correlation with the prognosis and clinicopathological parameters of BCa patients, and also may not be applied to risk stratification or individualized therapy in BCa patients. Further research should be conducted to confirm our findings.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Zhang L,Wu B,Zha Z,Zhao H,Yuan J,Jiang Ydoi
10.1007/s00345-019-02738-2subject
Has Abstractpub_date
2020-01-01 00:00:00pages
129-142issue
1eissn
0724-4983issn
1433-8726pii
10.1007/s00345-019-02738-2journal_volume
38pub_type
杂志文章,meta分析abstract:PURPOSE:To evaluate the diagnostic potential of choline measurements by in vivo magnetic resonance spectroscopy (MR spectroscopy) for diagnosis of renal masses. METHODS:Twenty-eight patients with 29 renal lesions underwent prospectively preoperative 3 T MR spectroscopy of renal masses before diagnostic tissue confirma...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1272-y
更新日期:2015-01-01 00:00:00
abstract::The treatment of clinically locally advanced prostate cancer (cT3-4) is subject to controversies. Patients with lymph node metastases as well as patients with overstaged localized and thus curable disease fall into this category. Radical prostatectomy, external beam radiotherapy and early or deferred hormonal therapy ...
journal_title:World journal of urology
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doi:10.1007/s00345-007-0158-7
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abstract::Local recurrent prostate cancer after radical treatment is found in the majority of men with a rising PSA. Salvage treatment procedures for recurrent disease, such as radiation therapy and ablative procedures, can provide long-term responses in well-selected cases. Prostate magnetic resonance imaging (MRI) allows diag...
journal_title:World journal of urology
pub_type: 杂志文章,评审
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abstract:PURPOSE:The aim of this study is to review the current literature that reports outcomes of Peyronie's disease (PD) reconstructive surgery using the collagen fleece TachoSil® (Baxter, CA, USA), a novel graft that has self-adhesive properties and gained popularity in recent years. METHODS:A literature review was perform...
journal_title:World journal of urology
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abstract::A Persian Gulf War veteran presented to the University Neuro-Urology service for management of severe chronic perineal pain. The overall physical and neurological exam was unremarkable. However, the rectal exam and the urodynamic study revealed a severe pelvic floor dysfunction. A neuro-behavioral approach is recommen...
journal_title:World journal of urology
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journal_title:World journal of urology
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journal_title:World journal of urology
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journal_title:World journal of urology
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1007/s00345-020-03349-y
更新日期:2020-07-12 00:00:00
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journal_title:World journal of urology
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更新日期:1994-01-01 00:00:00
abstract:: ...
journal_title:World journal of urology
pub_type: 社论
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更新日期:2019-02-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03101-6
更新日期:2020-11-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-0951-9
更新日期:2014-02-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF00182064
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2274-y
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journal_title:World journal of urology
pub_type: 历史文章,杂志文章
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更新日期:2000-02-01 00:00:00
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journal_title:World journal of urology
pub_type: 临床试验,杂志文章
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journal_title:World journal of urology
pub_type: 杂志文章,meta分析
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journal_title:World journal of urology
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journal_title:World journal of urology
pub_type: 杂志文章
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journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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更新日期:2003-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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更新日期:2008-10-01 00:00:00