Abstract：
PURPOSE:To evaluate the diagnostic potential of choline measurements by in vivo magnetic resonance spectroscopy (MR spectroscopy) for diagnosis of renal masses. METHODS:Twenty-eight patients with 29 renal lesions underwent prospectively preoperative 3 T MR spectroscopy of renal masses before diagnostic tissue confirmation. A respiratory-triggered single-voxel MR spectroscopy was performed in these masses using the point-resolved spectroscopy (TR, 2,000 ms, TE, 135 ms) sequence. The spectra were analyzed for choline resonances at 3.23 ppm, which were normalized by the noise outside the diagnostic range of the spectra. Image and spectra analyses were conducted blinded to all patient-related data. Histological results of the surgical resection or image-guided biopsy specimen were defined as the standard of reference. Appropriate statistical tests were used. RESULTS:Seventeen lesions were histopathologically malignant, and 12 lesions were benign. Mean choline SNR in malignant lesions was 2.9 and 1.33 in benign lesions (P = 0.019). ROC analysis revealed an area under the curve of 0.721 and SE 0.0763 with a P value of 0.0038. A Cho SNR ≥2 as cutoff for malignancy resulted in a sensitivity and specificity of 52.9 % (95 % CI 27.8-77.0 %) and 91.7 % (61.5-99.8 %), respectively. Although not significant, choline was observed more regularly in G3 (4 out of 5) compared with G2 (5 out of 12) RCC (P > 0.05). CONCLUSIONS:We could demonstrate the potential role of in vivo MR spectroscopy as a tool for differentiating benign from malignant masses with a high positive predictive value of 90 %. Furthermore, choline may be a biomarker of RCC aggressiveness.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Sevcenco S,Krssak M,Javor D,Ponhold L,Kuehhas FE,Fajkovic H,Haitel A,Shariat SF,Baltzer PAdoi
10.1007/s00345-014-1272-ysubject
Has Abstractpub_date
2015-01-01 00:00:00pages
17-23issue
1eissn
0724-4983issn
1433-8726journal_volume
33pub_type
杂志文章abstract：INTRODUCTION:The current pool of organs available for transplantation does not cover requirements, for this reason non-standard risk donors need to be incorporated into the pool. In this way, donors with small renal tumour are considered for transplantation after bench tumour excision. The aim of our study was to analy...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03463-x
更新日期：2020-09-30 00:00:00
abstract：OBJECTIVES:Robotic radical prostatectomy claims optimal oncologic results, minimal morbidity and best outcomes of urinary continence and erection function. Potential benefits concerning side effects and complications compared to open radical prostatectomy are analysed. METHODS:Out of 450 robotic radical prostatectomie...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析,多中心研究
doi：10.1007/s00345-008-0287-7
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVES:Objective characterization of renal mass anatomy facilitates treatment selection and prediction of surgical outcomes. We investigated R.E.N.A.L nephrometry score (NS) efficacy in predicting outcomes after minimally invasive nephron-sparing surgery (MINSS). METHODS:A total of 250 patients with 252 renal mass...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0876-3
更新日期：2013-10-01 00:00:00
abstract：:To understand alterations to the urokinase system that may occur in progressively metastatic prostate cancer cells, we assessed urokinase plasminogen activator receptor (uPAR) expression, in vitro motility towards vitronectin, urokinase plasminogen activator (uPA)-induced growth and growth factor regulation of uPAR ex...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0395-3
更新日期：2004-04-01 00:00:00
abstract：OBJECTIVES:It has been reported that apoptosis of penile erectile tissue occurs after penile denervation, castration, and diabetes mellitus in animal studies. Aim of this study was to investigate apoptosis in corpora cavernosa of patients with organic erectile dysfunction (ED). METHODS:Cavernous biopsies were obtained...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0332-6
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:Decreased vitamin D levels have been associated with prostate cancer, but it is unclear whether this association is causal. A functional single-nucleotide polymorphism (SNP) in the group-specific component (GC) gene (T > G, rs2282679) has been associated with 25-hydroxy (25-OH) vitamin D and 1.25 dihydroxy (1.2...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-015-1646-9
更新日期：2016-04-01 00:00:00
abstract：:The cost of urethral catheterisation injury (UCI) is significant, but the true incidence of patient care error is difficult to establish in the absence of specific hospital codes recording difficult urethral catheterisation (DUC) and UCI. For many years urologists are familiar passing a non-traumatic hydrophilic guide...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2499-9
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:Cabazitaxel, a semi-synthetic taxane of the third generation, inhibits prostate cancer (PC) cell growth by affecting the microtubule architecture. Since cabazitaxel has also been demonstrated to inhibit androgen receptor (AR) functionality, AR and AR-associated heat shock protein (HSP) expressions in the presen...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2615-x
更新日期：2019-10-01 00:00:00
abstract：:The aim of this study was to determine the long-term clinical efficacy and complications of neuromodulation with a unilateral sacral foramen electrode in 36 patients with chronic voiding dysfunction. Following a positive effect of a percutaneous nerve evaluation test, patients underwent open surgery. A permanent elect...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s003450050074
更新日期：1998-01-01 00:00:00
abstract：:The results of changing treatment modalities in 690 consecutive patients with low stages nonseminomatous germ-cell tumors (NSGCT) of the testis were analyzed. Overall, 120 patients (17.4%) suffered relapses, and 25 (3.6%) died of cancer after a follow-up period ranging from 2 to 20 years. The indications for primary (...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00192265
更新日期：1994-01-01 00:00:00
abstract：INTRODUCTION:Recently, small renal masses (SRMs) (< or =4 cm) are found more frequently, especially in the elderly and co-morbid patients. Standard treatment for SRMs is nephron-sparing surgery (NSS). New techniques like energy ablation and surveillance have been introduced. MATERIALS AND METHODS:Overview of treatment...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-010-0516-8
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:68Ga-PSMA Positron Emission Tomography/Computerized Tomography (PET/CT) has shown promising results for the detection of recurrent prostate cancer (RPCa). However, the diagnostic value of this method is yet to be validated. The aim of this study was to determine the influence of clinical and biochemical vari...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2460-y
更新日期：2019-05-01 00:00:00
abstract：PURPOSE:To test the hypothesis that cytoreductive nephrectomy (CN) improves overall survival (OS) of patients with synchronous metastatic renal cell carcinoma (mRCC), who subsequently receive targeted therapies (TT). METHODS:We identified 261 patients who received TT for synchronous mRCC with or without prior CN. To a...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2154-x
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVES:Adjuvant chemotherapy (ACT) is recommended for non-organ-confined bladder cancer (BCa) after radical cystectomy (RC) and pelvic lymph node dissection (PLND), but there are sparse data regarding its specific efficacy in patients with histological variants. The aim of our study was to evaluate the role of ACT ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03362-1
更新日期：2020-07-25 00:00:00
abstract：:Nephrolithiasis is a highly prevalent disease worldwide with rates ranging from 7 to 13% in North America, 5-9% in Europe, and 1-5% in Asia. Due to high rates of new and recurrent stones, management of stones is expensive and the disease has a high level of acute and chronic morbidity. The goal of this study is to rev...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-017-2008-6
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:Accurate puncture of the renal collecting system is crucial to the success of percutaneous nephrolithotomy and presents a technical challenge for urologists. Here, we introduced the Surgical Approach Visualization and Navigation (SAVN) system, a novel navigation system to assist puncture and reduce intraoperati...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2496-z
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:Assess knowledge and awareness concerning human papillomavirus (HPV) infection, HPV-associated diseases, and the existence of a specific vaccine among non-HPV-screened Caucasian-European adults after the market introduction of HPV vaccines. METHODS:A cohort of 934 consecutive patients seeking their first medic...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1379-1
更新日期：2015-06-01 00:00:00
abstract：PURPOSE:To explore the role of prostate biopsy core length on prediction of index tumor clinical significance and localization on radical prostatectomy (RP) and time to recurrence, hypothesizing 10-, 10-12-, or > 12-mm minimum core as potential biopsy quality control. METHODS:Assessed 2424 prostate biopsy cores and co...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2242-6
更新日期：2018-07-01 00:00:00
abstract：:The aim of this study was to determine and compare the effects of both magnesium citrate and phytin on reducing urinary calcium excretion under high-calcium-diet conditions during single and combined treatments. An animal experiment was carried out over a period of 4 weeks in 35 male rats. Urinary calcium excretion wa...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00184113
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:To identify factors predicting the risk of inguinal metastasis in squamous cell carcinoma of the penis. The therapeutic advantages of early lymphadenectomy in squamous cell carcinoma of the penis must be counterbalanced against its post-operative morbidity. Loss to follow up is a major problem in developing cou...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0421-1
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:Lymph node dissection (LND) is not routinely performed during radical nephroureterectomy (RNU) in upper tract urothelial carcinomas (UTUC), and its clinical relevance is unclear. The purpose of the present study was to evaluate the impact of LND on clinical outcomes in a large multicenter series of RNU for UTUC...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-011-0705-0
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:To evaluate temporary double J ureteric stenting (TDJS) as a test to diagnose ureteropelvic junction obstruction (UPJO) in equivocal cases. MATERIALS AND METHODS:One hundred and nine consecutive adult patients with loin pain and ipsilateral equivocal UPJO (EqUPJO) on radioisotope diuretic renogram (RDR) were e...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0464-3
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:To evaluate whether the rate of Gleason score (GS) upgrade on final pathology, the rate of positive surgical margins (PSM) and the rate of biochemical recurrence (BCR) after radical prostatectomy (RP) were different if prostate biopsy (PB) was graded by community pathologists (CP) as compared to specialized uro...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1788-4
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:For better understanding of urogenital tuberculosis (UGTB), its clinical spectrum and characteristic features need to be evaluated. MATERIALS AND METHODS:One hundred and forty-two cases of UGTB patients were analyzed retrospectively. We considered age, gender, symptoms, and diagnostic procedures. RESULTS:The ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02767-x
更新日期：2020-01-01 00:00:00
abstract：:Orthotopic urinary diversion via the Kock ileal neobladder is the preferred form of bladder reconstruction in men and, now, in women undergoing cystectomy at the University of Southern California. Through June of 1993, 266 men were diverted in this fashion. There were 3 perioperative mortalities (1.1%); early complica...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF01836343
更新日期：1996-01-01 00:00:00
abstract：:Robotic surgery was started in the Department of Urology, Hospital Kuala Lumpur, in April 2004. We present our experience in developing the program and report the results of our first 50 cases of robotic radical prostatectomy. A three-arm da Vinci robotic system was installed in our hospital in March 2004. Prior to in...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-006-0069-z
更新日期：2006-06-01 00:00:00
abstract：INTRODUCTION:Urinary incontinence in men after radical prostatectomy affects strongly quality of life. If conservative treatment fails, surgical treatment consists of implantable devices. If the requirement of manual dexterity in the artificial sphincter is to be avoided, the ProACT system offers a readjustable system,...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2483-4
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVES:To compare the oncological and functional outcomes reported after radical retropubic prostatectomy (RRP) versus brachytherapy (BT) in the treatment of low-risk prostatic cancer (CaP). METHODS:Between May 1999 and October 2002, 200 patients (mean age 65.3 +/- 8.7) were enrolled and randomized into two groups...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-009-0418-9
更新日期：2009-10-01 00:00:00
abstract：PURPOSE:We aim to analyze the efficacy of different focus sizes and the influence of pulse pressure (intensity) during shock wave lithotripsy (SWL) in terms of stone fragmentation. METHODS:Combination of three focal sizes (F1 = 2 mm, F2 = 4 mm, F3 = 8 mm) and 11 output pressure settings (intensity 10-20) of a piezoele...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-03069-y
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVES:To evaluate retrospectively the objective and subjective parameters in 42 male patients who underwent bone anchored sub-urethral sling positioning (BAUS) for SUI (stress urinary incontinence) due to ISD (intrinsic sphincter deficiency). METHODS:Patients with SUI due to radical retropubic prostatectomy (36 p...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-007-0222-3
更新日期：2008-04-01 00:00:00
