Abstract：
PURPOSE:Decreased vitamin D levels have been associated with prostate cancer, but it is unclear whether this association is causal. A functional single-nucleotide polymorphism (SNP) in the group-specific component (GC) gene (T > G, rs2282679) has been associated with 25-hydroxy (25-OH) vitamin D and 1.25 dihydroxy (1.25-OH2) vitamin D levels. METHODS:To examine the hypothesized inverse relationship between vitamin D status and prostate cancer, we studied the association between this SNP and prostate cancer outcome in the prospective PROCAGENE study comprising 702 prostate cancer patients with a median follow-up of 82 months. RESULTS:GC rs2282679 genotypes were not associated with biochemical recurrence [hazard ratios (HR) 0.91, 95 % confidence interval (CI) 0.73-1.12; p = 0.36], development of metastases (HR 1.20, 95 % CI 0.88-1.63; p = 0.25) or overall survival (HR 1.10; 95 % CI 0.84-1.43; p = 0.50). CONCLUSIONS:A causal role of vitamin D status, as reflected by GC rs2282679 genotype, in disease progression and mortality in prostate cancer patients is unlikely.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Trummer O,Langsenlehner U,Krenn-Pilko S,Pieber TR,Obermayer-Pietsch B,Gerger A,Renner W,Langsenlehner Tdoi
10.1007/s00345-015-1646-9subject
Has Abstractpub_date
2016-04-01 00:00:00pages
607-11issue
4eissn
0724-4983issn
1433-8726pii
10.1007/s00345-015-1646-9journal_volume
34pub_type
杂志文章,随机对照试验abstract：PURPOSE:To investigate the effects of onabotulinum toxin type A (Onabot/A) intravesical injections on urinary and sexual function in a group of patients affected by multiple sclerosis (MS). METHODS:We enrolled 31 MS female patients with symptoms of overactive bladder and detrusor overactivity. All patients underwent u...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-015-1578-4
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVES:To understand how prioritization of treatment attributes and treatment choice varies by patient characteristics, we sought to specifically determine how demographic variables affect patient treatment preference. PATIENTS AND METHODS:Male patients with urethral stricture disease participated in a choice-base...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2066-9
更新日期：2017-11-01 00:00:00
abstract：OBJECTIVES:To evaluate the impact of age, stone size, location, radiolucency, extraction of stone fragments, size of ureteroscope and presence and degree of hydronephrosis on the efficacy and safety of holmium:YAG (Ho:YAG) laser lithotripsy in the ureteroscopic treatment of ureteral stones in children. METHODS:Between...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1152-x
更新日期：2014-08-01 00:00:00
abstract：:The author presents the life and achievements of Johann von Mikulicz-Radecki and his contribution to European and world surgery. Mikulicz was born in Czernowitz, then a part of the Austro-Hungarian Empire. He was educated in numerous Austrian schools and graduated at Vienna University in 1875. In 1880 he became surgeo...
journal_title：World journal of urology
pub_type： 传,历史文章
doi：10.1007/s00345-007-0227-y
更新日期：2008-02-01 00:00:00
abstract：:Pyeloplasty for congenital ureteropelvic junction (UPJ) obstruction enjoys a 90-95% success rate. Although treatment of the failed pyeloplasty has been addressed in the literature, management of the poorly draining or nondraining renal unit in the immediate postoperative period has not received any attention. For this...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00183119
更新日期：1996-01-01 00:00:00
abstract：PURPOSE:The international meeting on reconstructive Urology (IMORU) is a live surgery event (LSE) where expert surgeons perform various reconstructive surgeries. To evaluate patient safety, an extended follow-up of the complications of two subsequent IMORU meetings were gathered. Also, a detailed survey concerning the ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02666-1
更新日期：2019-11-01 00:00:00
abstract：PURPOSE:Prostate cancer (PCa) is the most common malignancy in men and the cause for the second most common cancer-related death in the western world. Despite ongoing development of novel approaches such as second generation androgen receptor targeted therapies, metastatic disease is still fatal. In PCa, immunotherapy ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03497-1
更新日期：2020-10-26 00:00:00
abstract：:Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF alpha) are two closely related peptides that interact with cell-surface epidermal growth factor receptors (EGFR) to induce receptor tyrosine phosphorylation and activation of intracellular signal-transduction pathways. EGF appears to be the predom...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00185972
更新日期：1995-01-01 00:00:00
abstract：:Percutaneous nephrolithotomy (PCNL) remains the treatment of choice for staghorn renal calculi. Many reports suggest that laparoscopy can be an alternative treatment for large renal stones. We wished to evaluate the role and feasibility of laparoscopic extended pyelolithotomy (REP) for treatment of staghorn calculi. T...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-006-0099-6
更新日期：2006-06-01 00:00:00
abstract：PURPOSE:To investigate the impact of gender differences on treatment success, intraoperative and postoperative complications in patients undergoing ureteroscopy (URS). MATERIALS AND METHODS:A prospectively maintained database of 927 consecutively performed ureteroscopies on solitary ureteral stones in four different c...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-014-1435-x
更新日期：2015-09-01 00:00:00
abstract：:Non-gonococcal urethritis (NGU) is conventionally treated with oral antibiotics. With this Phase II study, we investigated the action of a locally disinfecting substance, Instillagel, in symptomatic NGU. Instillation treatment was performed twice daily to 32 male patients with symptomatic NGU. To evaluate the therapeu...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-001-0236-1
更新日期：2002-05-01 00:00:00
abstract：PURPOSE:To perform a feasibility phase study of a panel of putative protein biomarkers and determine whether it can identify and predict tumor recurrence in patients with non-muscle-invasive bladder cancer (NMIBC) on follow-up. METHODS:We prospectively analyzed the urine of 152 patients previously treated for NMIBC. Q...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03188-x
更新日期：2020-04-06 00:00:00
abstract：PURPOSE:Current systemic treatment of targeted therapies, namely the vascular endothelial growth factor-antibody (VEGF-AB), VEGF receptor tyrosine kinase inhibitor (TKI) and mammalian target of rapamycin (mTOR) inhibitors, have improved progression-free survival and replaced non-specific immunotherapy with cytokines in...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-016-1868-5
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:To determine retrospectively the perioperative management and outcome of transurethral prostate/bladder surgery (TURP, TURB) and transrectal prostate biopsy in hemophiliacs. METHODS:Thirty-seven hemophilic patients underwent TURP (12 patients), TURB (13 patients), or transrectal prostate biopsy (12 patients) w...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0988-9
更新日期：2013-06-01 00:00:00
abstract：INTRODUCTION:Herein, current developments in open and minimally invasive renal surgery are presented. MATERIALS AND METHODS:This also includes considerations on the appropriate indication for the two surgical procedures in small renal tumours, locally advanced disease (>pT2), complicated renal tumours as well as cytor...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0238-3
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVES:Squamous cell carcinoma (SCC) of the penis with inguinal lymph node involvement aggravates prognosis and can cause femoral artery bleeding, hemorrhagic shock and even death. The objective of this study is to describe the use of extra-anatomical transobturator bypass graft for femoral artery involvement by me...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0282-z
更新日期：2008-10-01 00:00:00
abstract：:Genital skin loss results from a heterogeneous group of traumatic and infectious processes. Removal of all devitalized tissue is necessary prior to reconstructive surgery; hyperbaric oxygen may help in the management of necrotizing infections. Defect coverage depends more on the remaining genital skin than on the etio...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050115
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVES:To evaluate the diagnostic value of 12 core biopsy versus sextant biopsy at different prostatic-specific antigen densities (PSAD). METHODS:We retrospectively analyzed the records of 1,463 patients who underwent transrectal ultrasound-guided prostate biopsies at our institution. 995 patients underwent 12 cor...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-008-0264-1
更新日期：2008-08-01 00:00:00
abstract：:The surgical complications encountered in 478 patients who underwent primary retroperitoneal lymph-node dissection for clinical stage A and B nonseminomatous testicular cancer during the period ranging from 1982 to 1992 were reviewed. There were 54 complications in 51 patients (10.6%), and there was no surgery-related...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00192272
更新日期：1994-01-01 00:00:00
abstract：:Tissue engineering, long a matter of myth and dream throughout the history of medicine, is now a practical reality. A wide spectrum of biological materials are used in the field of urology to treat disease and to overcome human disabilities, including tissue grafts and organ transplantation. Laboratory-engineered biop...
journal_title：World journal of urology
pub_type： 历史文章,杂志文章
doi：10.1007/s003450050015
更新日期：2000-02-01 00:00:00
abstract：:We report on a 17-year-old white woman with multiple bilateral renal angiomyolipomas (AMLs) in the absence of tuberous sclerosis. Multiple hyperdense lesions were detected in both kidneys by sonography. A computed tomography (CT) scan confirmed mainly fatty tissue. Sparing as much functional tissue as possible, eight ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-001-0242-3
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:The Grade Group (GG) classification is recommended by guidelines as a reliable prognostic factor of prostate cancer. However, most studies have been performed on the Caucasian population. Our objective was to validate GG classification as a safe way to classify intermediate- and high-risk patients with African ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02931-3
更新日期：2020-06-01 00:00:00
abstract：:Successful management of transitional-cell carcinoma of the urinary bladder is greatly dependent upon regular surveillance and early detection of persistent or recurrent carcinoma. The development of a highly sensitive urinary test for the detection of transitional-cell carcinoma of the bladder could have a dramatic i...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF02201981
更新日期：1997-01-01 00:00:00
abstract：INTRODUCTION:Recently, small renal masses (SRMs) (< or =4 cm) are found more frequently, especially in the elderly and co-morbid patients. Standard treatment for SRMs is nephron-sparing surgery (NSS). New techniques like energy ablation and surveillance have been introduced. MATERIALS AND METHODS:Overview of treatment...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-010-0516-8
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:Chronic inflammation has been considered a potential risk factor for prostate cancer. Toll-like receptors (TLRs) are important in the innate immune response to pathogens and in cross talk between innate immunity and adaptive immunity. In this study, sequence variants in the TLR4 gene were investigated to determ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0690-3
更新日期：2012-04-01 00:00:00
abstract：:Our objectives were to ascertain the tolerability and efficacy of trospium chloride in doses of 20 mg twice daily for long-term therapy (52 weeks) in patients with urge syndrome. The trial comprised a total of 358 patients with urge syndrome or urge incontinence. After randomisation in the ratio of 3:1, participants w...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/s00345-003-0321-8
更新日期：2003-05-01 00:00:00
abstract：:The postnatal management of prenatally detected hydronephrosis mainly involves a close follow-up with ultrasound, renal isotopic scan and URO-MRI. In some cases, there is an indication for either a pyeloplasty or, more exceptionally, nephrectomy of a non-functioning obstructed kidney. In this chapter, we review the in...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-004-0458-0
更新日期：2004-12-01 00:00:00
abstract：PURPOSE:Digital low-dosage, linear slot scanning radiography (Lodox®) is an imaging modality that can emit down to one-tenth the radiation of conventional X-ray systems. We prospectively evaluated Lodox® as a diagnostic imaging modality in patients with ureterolithiasis. METHODS:Conventional kidney-ureter-bladder (KUB...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02803-w
更新日期：2020-04-01 00:00:00
abstract：:This paper provides an overview of the scientific and practical aspects of assessing health-related quality of life (HRQL). The paper provides a brief overview of developments in the field and then discusses the definition of HRQL. The different types of HRQL measure available to researchers are described, with specif...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050132
更新日期：1999-08-01 00:00:00
abstract：BACKGROUND:Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of preoperative circulating neutrophil-lymphocyte ratio (NLR) (known as a marker of SIR) in human primary bladder cancer (BC) undergoing radical cystectomy (RC) remains c...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-018-2593-z
更新日期：2019-09-01 00:00:00
