Abstract：
PURPOSE:To investigate the effects of onabotulinum toxin type A (Onabot/A) intravesical injections on urinary and sexual function in a group of patients affected by multiple sclerosis (MS). METHODS:We enrolled 31 MS female patients with symptoms of overactive bladder and detrusor overactivity. All patients underwent urodynamics and were administered 3-day voiding diary, Incontinence Quality of Life (I-QoL) questionnaire, Female Sexual Function Index (FSFI) questionnaire, Hamilton Anxiety Rating Scale (HAM-A) and Hamilton Depression Rating Scale (HAM-D) before and 3 months after Onabot/A intravesical injection. RESULTS:Onabot/A injection significantly improved urinary symptoms as shown by the 3-day voiding diary, I-QoL questionnaire and the urodynamic variables. In addition, it also significantly improved sexual functioning in continent patients and psychological status as demonstrated by the increase in FSFI, HAM-A and HAM-D scores. CONCLUSIONS:The Onabot/A-induced positive effect on sexual dysfunction in our MS patients is likely due to an indirect effect exerted by the overall urological clinical improvement on sexual function at both the psychological and emotional levels. The positive effect exerted by Onabot/A on the anxiety and depression scale also suggests that urinary symptoms have a negative impact on the psychological status of the patients.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Giannantoni A,Proietti S,Giusti G,Gubbiotti M,Millefiorini E,Costantini E,Berardelli A,Conte Adoi
10.1007/s00345-015-1578-4subject
Has Abstractpub_date
2015-12-01 00:00:00pages
2095-101issue
12eissn
0724-4983issn
1433-8726pii
10.1007/s00345-015-1578-4journal_volume
33pub_type
临床试验,杂志文章abstract：:We are fortunate that our ability to diagnose the specific adrenal entities that mandate a surgical approach is extremely accurate. The combination of analytical methodology to measure the appropriate adrenocortical and medullary hormone production and the radiology techniques for localization are superb. The manageme...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050103
更新日期：1999-02-01 00:00:00
abstract：PURPOSE:To assess the effects of warm ischaemia time (WIT) on renal function after laparoscopic partial nephrectomy (LPN) for renal masses in patients with a normal contralateral kidney. METHODS:From October 2006 to December 2008, 53 patients treated with LPN were enrolled in this prospective study. Effective renal pl...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-011-0729-5
更新日期：2012-04-01 00:00:00
abstract：:The original article can be found online. ...
journal_title：World journal of urology
pub_type： 已发布勘误
doi：10.1007/s00345-020-03495-3
更新日期：2020-10-24 00:00:00
abstract：BACKGROUND:To introduce the detailed procedures of two innovative surgical options for pediatric buried penis and prospectively compare their efficacy and safety. METHODS:A single-center, non-randomized, prospective study was conducted at the Zhongnan Hospital of Wuhan University, where patients were operated on using...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2243-5
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:The mechanisms responsible for the pathogenesis of long-term renal damage induced by extracorporeal shock wave lithotripsy (ESWL) are not clear. The present study was designed to investigate the role of nuclear factor κB (NFκB) signal pathway in the pathogenesis of chronic shock wave-induced renal damage in rat...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0515-9
更新日期：2010-10-01 00:00:00
abstract：:Non-gonococcal urethritis (NGU) is conventionally treated with oral antibiotics. With this Phase II study, we investigated the action of a locally disinfecting substance, Instillagel, in symptomatic NGU. Instillation treatment was performed twice daily to 32 male patients with symptomatic NGU. To evaluate the therapeu...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-001-0236-1
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of preoperative circulating neutrophil-lymphocyte ratio (NLR) (known as a marker of SIR) in human primary bladder cancer (BC) undergoing radical cystectomy (RC) remains c...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-018-2593-z
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:It was our aim in this study to develop a technique that is rather simple, overcomes the problems of Devine and Horton glanuloplasty in patients with small glans, and is flexible to be tailored to any hypospadias surgery. METHODS:A total of 11 patients were included in this preliminary report. A triangular ski...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0386-0
更新日期：2009-10-01 00:00:00
abstract：:In multivariate analysis, GS of the regular prostatectomy specimen was the only statistically significant parameter for pT2R1 prostate cancer. ...
journal_title：World journal of urology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00345-020-03136-9
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:Testicular torsion is the most concerning underlying cause of acute scrotal pain that can lead to loss of the affected testicle. Whether a torted testicle can be salvaged surgically is directly affected by prompt presentation and diagnosis. This study aims to evaluate the awareness of testicular torsion amongst...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2269-8
更新日期：2018-09-01 00:00:00
abstract：INTRODUCTION:Natural orifice transluminal endoscopic surgery (NOTES) and laparoendoscopic single-site surgery (LESS) are the next steps in the evolution of laparoscopic surgery, promising reduced morbidity and improved cosmetic result. The inconsistent terminology initially used led to confusion. Understanding the tech...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-012-0899-9
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:To analyse the surgical margins status of prostatic glands, resected by laparoscopic radical prostatectomy (LRP) for prostate cancer, and to correlate it with biochemical free survival rate (BFSR). METHODS:Data were collected prospectively from 405 patients undergoing LRP from 2000 to 2009 at a single institut...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0711-2
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:We sought to examine the literature reporting the effect of urinary tract infection (UTI) on non-schistosomiasis-related UBC (UBCNS) through a systematic review and meta-analysis. METHODS:A predefined study protocol was developed according to PRISMA. Medline and Scopus were searched for all studies investigati...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-018-2257-z
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:Assess knowledge and awareness concerning human papillomavirus (HPV) infection, HPV-associated diseases, and the existence of a specific vaccine among non-HPV-screened Caucasian-European adults after the market introduction of HPV vaccines. METHODS:A cohort of 934 consecutive patients seeking their first medic...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1379-1
更新日期：2015-06-01 00:00:00
abstract：PURPOSE:Living donor nephrectomy is a high-stake procedure involving healthy individuals, therefore every effort should be made to define each patient's individualized risk and improve potential donors' information. The aim of this study was to evaluate the interest of the Mayo adhesive probability (MAP) score, an imag...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03513-4
更新日期：2020-11-11 00:00:00
abstract：PURPOSE:To evaluate the feasibility of measuring the intrapelvic pressure (IPP) during f-URS with a wire including a pressure sensor and to assess IPP profiles during the procedure. METHODS:Patients undergoing f-URS for stone disease were recruited. A wire with pressure sensor was placed in the renal cavities to measu...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03216-w
更新日期：2020-05-07 00:00:00
abstract：PURPOSE:This report presents our early experience at Cleveland Clinic replacing conventional ultrasound with a novel 29 MHz high-resolution micro-ultrasound system for both systematic sampling and real-time targeting of suspicious regions during prostate biopsy. The added value of micro-ultrasound and MRI over systemat...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02863-y
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:To evaluate the role of multiparametric magnetic resonance imaging (mpMRI) in Gleason score (GS) 3 + 4 prostate cancer (PCa) and evaluate independent factors in mpMRI that can predict GS upgrading, we compared the outcomes of GS upgrading group and GS non-upgrading group. PATIENTS AND METHODS:We analyzed th...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03421-7
更新日期：2020-08-31 00:00:00
abstract：:Expression and overexpression of the epidermal growth factor receptor (EGFR) have been described in several solid tumors including bladder, breast, colorectal, NSCLC, prostate, and ovarian cancers. In addition to gene amplification, point mutations within the kinase domain also occur. Previous reports indicate that th...
journal_title：World journal of urology
pub_type： 杂志文章,收录出版
doi：10.1007/s00345-007-0202-7
更新日期：2007-12-01 00:00:00
abstract：PURPOSE:XPA-210 is a proliferation marker derived from Thymidine kinase-1. It is of clinical significance in kidney, breast, and bladder cancer. There are no data available for XPA-210 in prostate cancer (PC). Herein, we aim to determine the clinical usefulness of XPA-210 in PC. MATERIALS AND METHODS:In a retrospectiv...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0768-y
更新日期：2012-08-01 00:00:00
abstract：:The landscape has dramatically changed for patients seeking treatment for rapid ejaculation. Previously, psychotherapy or behavioral treatment was considered to be the treatment of choice for this troubling sexual dysfunction. Since the early 1990s, an efficacious alternative treatment has emerged-the off-label admini...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-004-0489-6
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:We report on a 62-year-old gentleman presenting at our urological department with an advanced renal cell cancer of the right kidney (10 cm in diameter), with an extensive caval vein thrombus (level IV) and bilateral pulmonary metastases. Another suspicious lesion at the left hemithorax was radiologically des...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0955-5
更新日期：2014-02-01 00:00:00
abstract：:This review paper highlights the important health issue of orchialgia and the chronic pelvic pain syndrome. There are a number of specific and non-specific etiologies and different treatment options based on the sub-categorization of orchialgia. The focus of this article is on the specific etiologies of chronic orchia...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-013-1092-5
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:To examine the prevalence of lower urinary tract symptoms (LUTS) and the bother they impose in a population-based sample of adults in Brazil. METHODS:A cross-sectional population-based survey was conducted between September 2006 and January 2007 in the city of Salvador, Brazil. Cluster samples of representativ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1057-8
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:68Ga-PSMA Positron Emission Tomography/Computerized Tomography (PET/CT) has shown promising results for the detection of recurrent prostate cancer (RPCa). However, the diagnostic value of this method is yet to be validated. The aim of this study was to determine the influence of clinical and biochemical vari...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2460-y
更新日期：2019-05-01 00:00:00
abstract：:Noncontrast helical computed tomography (CT) has recently been found to be superior to excretory urography (IVU) in the evaluation of patients with suspected ureterolithiasis. Noncontrast helical CT does not require the use of intravenous contrast material with its associated cost and risk of adverse reactions and can...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050020
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:Combination therapy of male lower urinary tract symptoms with α(1)-adrenoceptor and muscarinic receptor antagonists attracts increasing interest. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca(2+) channels. Here, we have investigated whether propiverin...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0655-6
更新日期：2011-04-01 00:00:00
abstract：PURPOSE:To evaluate the 6-month effects of the recommended drug and light dosage in focal vascular-targeted photodynamic therapy (VTP) using TOOKAD(®) Soluble in patients with localized prostate cancer (LPCa). METHODS:We performed a pooled analysis of 117 men with LPCa, PSA <10 ng/mL, and Gleason score ≤ 7 (3 + 4), fr...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-015-1505-8
更新日期：2015-07-01 00:00:00
abstract：:The 30-45% failure rate after radical cystoprostatectomy mandates that we explore and optimize multimodal therapy to achieve better disease control in these patients. Cisplatin-based multi-agent combination chemotherapy has been used with success in metastatic disease and has therefore also been introduced in patients...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-006-0113-z
更新日期：2006-11-01 00:00:00
abstract：:The purpose of this study was to assess possible central side-effects of sildenafil (Viagra) on attention and memory functions. Sildenafil and placebo were administered in young male subjects in a double-blind balanced cross-over design. Behavioral patterns and event-related brain potentials (ERP) were recorded in a s...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/pl00007092
更新日期：2001-02-01 00:00:00
