Abstract：
:The purpose of this study was to assess possible central side-effects of sildenafil (Viagra) on attention and memory functions. Sildenafil and placebo were administered in young male subjects in a double-blind balanced cross-over design. Behavioral patterns and event-related brain potentials (ERP) were recorded in a spatial auditory attention and a visual word recognition task. While behavioral patterns did not reveal any overt effects of sildenafil, auditory ERPs were indicative of an enhanced ability to focus attention (amplitude enhancement of Nd-effect) and to select relevant target stimuli in the sildenafil condition (P3 component). In the memory task, CNS-effects of sildenafil were evident in a reduction of a negativity in the 150-250 ms range. No overt effects on behavior were observed. Nevertheless, the data reveal CNS-effects of sildenafil necessitating further studies.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Schultheiss D,Müller SV,Nager W,Stief CG,Schlote N,Jonas U,Asvestis C,Johannes S,Münte TFdoi
10.1007/pl00007092keywords:
subject
Has Abstractpub_date
2001-02-01 00:00:00pages
46-50issue
1eissn
0724-4983issn
1433-8726journal_volume
19pub_type
杂志文章abstract：OBJECTIVES:It has been reported that apoptosis of penile erectile tissue occurs after penile denervation, castration, and diabetes mellitus in animal studies. Aim of this study was to investigate apoptosis in corpora cavernosa of patients with organic erectile dysfunction (ED). METHODS:Cavernous biopsies were obtained...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0332-6
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:Data assessing the effectiveness of single-use flexible ureteropyeloscopy (FURS) are limited. This study evaluates and compares single-use FURS with conventional reusable FURS. METHODS:A systematic search using electronic databases (Pubmed and Embase) was performed for studies evaluating single-use FURS in the...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-017-2131-4
更新日期：2018-04-01 00:00:00
abstract：:With the advantages of constant availability, minimal loss of bowel, relative simplicity (no mesentery interfering with implantation, high mobility of the tube), minimized risk of stone formation (no use of staples), reliable continence (no leak point) and easy catheterization (longitudinal folds), this straightforwar...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s003450050059
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:Chronic inflammation has been considered a potential risk factor for prostate cancer. Toll-like receptors (TLRs) are important in the innate immune response to pathogens and in cross talk between innate immunity and adaptive immunity. In this study, sequence variants in the TLR4 gene were investigated to determ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0690-3
更新日期：2012-04-01 00:00:00
abstract：PURPOSES:To describe the differential tissue expression of tumor-associated trypsin inhibitor (TATI) in normal bladder urothelium, primary urothelial carcinoma of the bladder (UCB) and metastatic UCB and to assess the association of TATI expression with molecular markers commonly altered in UCB and clinical outcomes af...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0727-7
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:To evaluate the perioperative morbidity of PC-RPLND in two intermediate volume centers and to identify predictors of high morbidity. METHODS:Retrospective analysis of 124 patients treated with open PC-RPLND at two tertiary referral centers between 2001 and 2018. Perioperative morbidity was determined by analyz...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03229-5
更新日期：2020-05-05 00:00:00
abstract：:We are fortunate that our ability to diagnose the specific adrenal entities that mandate a surgical approach is extremely accurate. The combination of analytical methodology to measure the appropriate adrenocortical and medullary hormone production and the radiology techniques for localization are superb. The manageme...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050103
更新日期：1999-02-01 00:00:00
abstract：PURPOSE:The lack of precedent in transitioning from pediatric to adult care poses a challenge to providers for patients with spina bifida (SB). The purpose of this study was to summarize perceptions about best practices for the care of adult spina bifida patients. MATERIALS AND METHODS:A national survey was electronic...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02635-8
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:The perioperative and oncological outcomes of laparoscopic radical nephrectomy (LRN) for T1-T2 renal cell carcinoma (RCC) are well established. We aim to determine whether LRN is a comparable alternative to open radical nephrectomy (ORN) in the treatment of T3 RCC using a matched pair analysis study design. ME...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1280-y
更新日期：2015-01-01 00:00:00
abstract：:Mycophenolate mofetil (MM) is the ester derivative of mycophenolic acid (MPA), which exerts immunosuppressive activity by inhibiting de novo purine biosynthesis. Following animal models and pilot studies in human renal allograft recipients that confirmed MM's ability to prevent and half rejection episodes, 3 large mul...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00182076
更新日期：1996-01-01 00:00:00
abstract：INTRODUCTION:Peyronie's disease (PD) is a localized connective tissue disorder of the penile tunica albuginea (TA) with a still obscure etiopathology. Recent studies from our laboratory have demonstrated differences in Smad3 and Smad4 gene expression of PD-fibroblasts and non-PD-fibroblasts after stimulation with recom...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0320-x
更新日期：2009-02-01 00:00:00
abstract：PURPOSE:To perform a feasibility phase study of a panel of putative protein biomarkers and determine whether it can identify and predict tumor recurrence in patients with non-muscle-invasive bladder cancer (NMIBC) on follow-up. METHODS:We prospectively analyzed the urine of 152 patients previously treated for NMIBC. Q...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03188-x
更新日期：2020-04-06 00:00:00
abstract：PURPOSE:To present current evidence supporting the vessel sparing technique to reconstruct bulbar urethral strictures via primary anastomosis. METHODS:English literature review of presented series of transecting and non-transecting bulbar urethroplasty from 2000 to 2018. RESULTS:Since its introduction in 2007, vessel...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02867-8
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:Vesico-ureteral reflux (VUR) represents one of the most significant risk factors for acute pyelonephritis in children. Surgery is an important part of its management. Laparoscopic ureteric reimplantation using the Lich-Gregoir technique is an option for VUR. The aim of this study is to assess short- and medium-...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2064-y
更新日期：2017-11-01 00:00:00
abstract：:The purpose of the present study was to examine the outcome profiles of a large number of patients with locally advanced adenocarcinoma of the prostate following radical perineal prostatectomy (RPP) for clinically organ-confined disease. Of 1662 men who underwent RPP performed by a single surgeon between January 1972 ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s003459900100
更新日期：2000-06-01 00:00:00
abstract：:Urinary bladder cancer (UBC) is a common disease worldwide. At any point in time 2.7 million people have a history of UBC. The incidence of UBC varies over the world with highest rates in developed communities. But the burden of UBC will increase in less developed areas of the world. These changes can be attributed to...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0383-3
更新日期：2009-06-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVES:Standardization of hands-on training (HoT) has profoundly impacted the educational field in the last decade. To provide quality training sessions on a global scale, the European School of Urology Training group developed a teaching guide for tutors in 2015. Our study aims to understand wheth...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03161-8
更新日期：2020-03-21 00:00:00
abstract：PURPOSE:Complete urethral replacement using unseeded matrices has been proposed as a possible therapy in cases of congenital or acquired anomalies producing significant defects. Tissue regeneration involves fibrin deposition, re-epithelialization, and remodeling that are limited by the size of the defect. Scar formatio...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0316-6
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVES:Monopolar transurethral resection of the prostate (TURP) is the gold standard surgical treatment for bothersome moderate to severe lower urinary tract symptoms (LUTS) secondary to benign prostate obstruction. The aim of the study is to compare monopolar versus bipolar TURP focusing on operative and functiona...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-017-2023-7
更新日期：2017-10-01 00:00:00
abstract：PURPOSE:To compare prognostic performance of MSKCC and IMDC risk models in patients with synchronous mRCC. METHODS:Retrospective analysis of pre-therapeutic MSKCC and IMDC prognostic factors and outcomes in patients with synchronous mRCC treated at a single institute in the targeted therapy era was performed. Cytoredu...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1769-7
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVES:Adjuvant chemotherapy (ACT) is recommended for non-organ-confined bladder cancer (BCa) after radical cystectomy (RC) and pelvic lymph node dissection (PLND), but there are sparse data regarding its specific efficacy in patients with histological variants. The aim of our study was to evaluate the role of ACT ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03362-1
更新日期：2020-07-25 00:00:00
abstract：PURPOSE:To critically review and synthesize data of ureteroscopy (URS) in different circumstances that all urologists may encounter during everyday clinical practice, such as pregnancy, obesity, bleeding diathesis, renal stones larger than 2 cm, calyceal diverticula, and kidney malformations. METHODS:According to PRIS...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-014-1345-y
更新日期：2015-02-01 00:00:00
abstract：INTRODUCTION:Currently, osteoporosis research is rarely undertaken in males but an increase in male life expectancy in the company of hypogonadism suggests the necessity for potential therapeutic options. MATERIALS AND METHODS:In this study, the changes in bone structure under standardized testosterone- (T), raloxifen...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0373-5
更新日期：2009-08-01 00:00:00
abstract：PURPOSE:We sought to examine the literature reporting the effect of urinary tract infection (UTI) on non-schistosomiasis-related UBC (UBCNS) through a systematic review and meta-analysis. METHODS:A predefined study protocol was developed according to PRISMA. Medline and Scopus were searched for all studies investigati...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-018-2257-z
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVES:Androgen receptor (AR) action in benign and malignant tissue is potentiated by a number of co-regulatory proteins that may interact with one or more receptor domains. With improvement of research methodologies, it became possible to detect a number of co-activators whose expression is increased in prostate c...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-011-0797-6
更新日期：2012-06-01 00:00:00
abstract：PURPOSE:To investigate the effects of onabotulinum toxin type A (Onabot/A) intravesical injections on urinary and sexual function in a group of patients affected by multiple sclerosis (MS). METHODS:We enrolled 31 MS female patients with symptoms of overactive bladder and detrusor overactivity. All patients underwent u...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-015-1578-4
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:MicroRNAs (miRNAs) play an important role as regulators of gene expression in tumourigenesis by controlling many biological processes in growth, development, differentiation and apoptosis. Previous studies have shown an altered expression of specific miRNAs in clear cell renal cell carcinoma (ccRCC). But the fu...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0633-4
更新日期：2011-06-01 00:00:00
abstract：PURPOSE:The primary objective was to evaluate the effect of autologous muscle-derived cell (AMDC) injections on the urethral sphincter morphometry compared to placebo injections. Secondary aims were to explore the reduction of stress incontinence episode frequency (IEF) and factors associated with the efficacy of AMDC....
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03076-4
更新日期：2020-11-01 00:00:00
abstract：:One of the historic landmarks in urology is the first planned nephrectomy performed in 1869 by Gustav Simon of Heidelberg (1824-1877). In the history of medicine the reflections and considerations of the specialized surgeon reveal distinguished analyses of the "case" and, thus, the beginning of a modern scientific dis...
journal_title：World journal of urology
pub_type： 传,历史文章,杂志文章
doi：10.1007/s003450050125
更新日期：1999-06-01 00:00:00
abstract：:Small-intestinal submucosa (SIS) is a unique biomaterial that has been shown to induce tissue-specific regeneration in numerous organ systems. In the urinary tract, animal studies have demonstrated that SIS promotes functional bladder regeneration. Other preliminary studies have suggested that SIS may also be extremel...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/PL00007071
更新日期：2000-02-01 00:00:00
