Abstract：
PURPOSE:The mechanisms responsible for the pathogenesis of long-term renal damage induced by extracorporeal shock wave lithotripsy (ESWL) are not clear. The present study was designed to investigate the role of nuclear factor κB (NFκB) signal pathway in the pathogenesis of chronic shock wave-induced renal damage in rat model. MATERIALS AND METHODS:Adult male Sprague-Dawley rats were exposed to ESWL under the guidance of X-rays. On days 1, 3, 7, 35, and 105 postexposures to shock wave, the animals were killed to examine the changes in renal histology and functions, and NFκB activity. The expression of NFκB-dependent fibrogenic genes was also analyzed. Pyrrolidine dithiocarbamate (PDTC), a specific NFκB inhibitor, was used to further investigate the involvement of NFκB. RESULTS:The applied shock wave caused a transient decline in renal function and induced chronic morphological changes such as tubular injury and interstitial fibrosis. NFκB was significantly activated in renal cortex. PDTC had little or no effects on the shock-wave-induced transient renal damage, but attenuated the long-term renal lesions associated with NFκB activation. In addition, the shock wave exposure also up-regulated the expression of transforming growth factor-β1 (TGF-β1), which was also blocked by PDTC. CONCLUSION:NFκB plays an important role in the progression of shock-wave- induced long-term renal damage in rat model.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Li X,Xue Y,He D,Chen X,Zhang Ldoi
10.1007/s00345-010-0515-9subject
Has Abstractpub_date
2010-10-01 00:00:00pages
657-62issue
5eissn
0724-4983issn
1433-8726journal_volume
28pub_type
杂志文章abstract：PURPOSE:It was our aim in this study to develop a technique that is rather simple, overcomes the problems of Devine and Horton glanuloplasty in patients with small glans, and is flexible to be tailored to any hypospadias surgery. METHODS:A total of 11 patients were included in this preliminary report. A triangular ski...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0386-0
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abstract：:The landscape has dramatically changed for patients seeking treatment for rapid ejaculation. Previously, psychotherapy or behavioral treatment was considered to be the treatment of choice for this troubling sexual dysfunction. Since the early 1990s, an efficacious alternative treatment has emerged-the off-label admini...
journal_title：World journal of urology
pub_type： 杂志文章,评审
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journal_title：World journal of urology
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journal_title：World journal of urology
pub_type： 杂志文章
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journal_title：World journal of urology
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journal_title：World journal of urology
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journal_title：World journal of urology
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journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
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更新日期：2015-09-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
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journal_title：World journal of urology
pub_type： 临床试验,杂志文章
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journal_title：World journal of urology
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更新日期：1996-01-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,meta分析
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journal_title：World journal of urology
pub_type： 杂志文章
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journal_title：World journal of urology
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journal_title：World journal of urology
pub_type： 杂志文章,评审
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更新日期：2018-10-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s003450050082
更新日期：1998-01-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
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更新日期：2016-07-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0891-4
更新日期：2013-08-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
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journal_title：World journal of urology
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journal_title：World journal of urology
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journal_title：World journal of urology
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journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
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更新日期：2013-12-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
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更新日期：2013-04-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
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更新日期：2013-10-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：World journal of urology
pub_type： 杂志文章,评审
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journal_title：World journal of urology
pub_type： 杂志文章
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更新日期：2011-06-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
