Abstract：
PURPOSE:Investigate the short-term effect of sildenafil on microcirculation, especially the velocity, the pattern of the flow and the recruitment of the leukocyte in postcapillaries. METHODS:In male Sprague-Dawley rats, the microcirculatory consequences of 60 min experimental testicular torsion, followed by 240 min of reperfusion, were examined. Using fluorescence intravital microscopy, changes in red blood cell velocity in post-capillary venules and rolling as well as adhesion of leukocytes in the postcapillary venules were examined before the torsion and every hour during the reperfusion period. Sildenafil was given 10 min prior to reperfusion (iv 0.7 mg/kg, n = 6), while control animals received saline vehicle (n = 5). RESULTS:The characteristic flow motion disappeared in the affected testicular during the torsion. Red blood cell velocity values were dramatically decreased (by > 50%) and both rolling and adhesion of leukocytes increased during the reperfusion phase. Sildenafil treatment resulted in significantly higher red blood cell velocity values during the entire reperfusion period, but exerted only a temporary positive effect on the plost-ischaemic leukocyte-endothelial interactions. CONCLUSIONS:Intraoperative administration of sildenafil during surgical detorsion may provide marked testicular microperfusion benefits, but failed to influence the overall leukocyte-driven microcirculatory inflammatory reactions.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Oroszi M,Szabó A,Fehér ÁM,Deák G,Bajory Zdoi
10.1007/s00345-018-2340-5subject
Has Abstractpub_date
2018-12-01 00:00:00pages
2081-2087issue
12eissn
0724-4983issn
1433-8726pii
10.1007/s00345-018-2340-5journal_volume
36pub_type
杂志文章abstract：INTRODUCTION:The survival of patients with metastatic urothelial cancer (mUC) is poor. During the last 40 years, chemotherapy was the predominant treatment modality for mUC. The discovery of the immune checkpoint inhibitors (ICI), especially the inhibitors of the programmed cell death 1 and its ligand (PD-1/PD-L1), has...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-018-2538-6
更新日期：2019-09-01 00:00:00
abstract：:The original article can be found online. ...
journal_title：World journal of urology
pub_type： 已发布勘误
doi：10.1007/s00345-020-03495-3
更新日期：2020-10-24 00:00:00
abstract：PURPOSE:For better understanding of urogenital tuberculosis (UGTB), its clinical spectrum and characteristic features need to be evaluated. MATERIALS AND METHODS:One hundred and forty-two cases of UGTB patients were analyzed retrospectively. We considered age, gender, symptoms, and diagnostic procedures. RESULTS:The ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02767-x
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:The challenges in providing urologic care across borders and in resource-constrained settings are poorly understood. We sought to better characterize the impediments to the delivery of urological care in low- and middle-income countries (LMICs) compared to high-income countries (HICs). METHODS:A 70 question on...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03101-6
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:Neurogenic bladder due to spinal cord injury has significant consequences for patients' health and quality of life. Regular surveillance is required to assess the status of the upper and lower urinary lower urinary tracts and prevent their deterioration. In this review, we examine surveillance techniques in neu...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-018-2345-0
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:The aim of this study was to assess the impact of experience on the outcome of image fusion-guided prostate biopsies performed by urologists working at a high-volume medical center. METHODS:The first 210 consecutive fusion biopsies were analyzed following installation of the software-based biopsy platform Arte...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2605-z
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Previous study compared limited number of parameters post the treatment of cold knife and laser urethrotomy for urethral stricture and controversy about the superiority of those two techniques still remains. This study aims to update the evidence and provide better clinical guidance. METHOD:We systematicall...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-019-02729-3
更新日期：2019-12-01 00:00:00
abstract：:One of the historic landmarks in urology is the first planned nephrectomy performed in 1869 by Gustav Simon of Heidelberg (1824-1877). In the history of medicine the reflections and considerations of the specialized surgeon reveal distinguished analyses of the "case" and, thus, the beginning of a modern scientific dis...
journal_title：World journal of urology
pub_type： 传,历史文章,杂志文章
doi：10.1007/s003450050125
更新日期：1999-06-01 00:00:00
abstract：PURPOSE:To provide a comprehensive update of the joint consultation of the International Consultation on Urological Diseases (ICUD) for the diagnosis and management of non-urothelial cancer of the urinary bladder. METHODS:A detailed analysis of the literature was conducted reporting on the epidemiology, etiology, diag...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-018-2421-5
更新日期：2019-01-01 00:00:00
abstract：:Contemporary literature regarding the management of neobladder-vaginal fistula and stress urinary incontinence following radical cystectomy and neobladder reconstruction in women is reviewed in this article. Neobladder-vaginal fistula is uncommon but mandates meticulous repair. Compared to the native bladder, the wall...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-005-0013-7
更新日期：2005-09-01 00:00:00
abstract：PURPOSE:Low amplitude rhythmic contractions (LARC) occur in detrusor smooth muscle and may play a role in storage disorders such as overactive bladder and detrusor overactivity. The purpose of this study was to determine whether LARC frequencies identified in vitro from strips of human urinary bladder tissue correlate ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1994-0
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:To compare serial changes of postoperative storage symptoms between PVP and HoLEP, and to identify the predictors influencing postoperative improvement of storage symptoms. METHODS:A total of 486 men (PVP group: 213 cases; HoLEP group: 273 cases), in whom 12-month follow-up data were available, were included i...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1424-0
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:To evaluate contemporary international trends in the implementation of minimally invasive adrenalectomy and to assess contemporary outcomes of different minimally invasive techniques performed at urologic centers worldwide. METHODS:A retrospective multinational multicenter study of patients who underwent min...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-016-1791-9
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:In mid-2007, we introduced a new risk-stratified follow-up programme (FUP) for surgically treated localized renal cell carcinoma. After inclusion, the patients have been followed prospectively. In this study, we present the results in regard to stratification, completeness of the FUP and recurrences. METHODS:T...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1796-4
更新日期：2016-08-01 00:00:00
abstract：:Renal cystic disease, ranging from simple cysts to autosomal dominant polycystic kidney disease (ADPKD), can lead to significant complications such as pain, hypertension, infection, upper urinary tract obstruction, and even renal failure. For patients with preserved renal function, laparoscopic ablation of renal cysts...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/pl00007076
更新日期：2000-09-01 00:00:00
abstract：PURPOSE:We sought whether serum total testosterone (tT), estradiol (E2), tT/E2 ratio, and sex hormone-binding globulin (SHBG) significantly fluctuate throughout time in men with prostate cancer (PCa). METHODS:Circulating hormones were measured in a cohort of 631 candidates for radical prostatectomy. Hormone levels wer...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-1009-8
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:To evaluate the diagnostic potential of choline measurements by in vivo magnetic resonance spectroscopy (MR spectroscopy) for diagnosis of renal masses. METHODS:Twenty-eight patients with 29 renal lesions underwent prospectively preoperative 3 T MR spectroscopy of renal masses before diagnostic tissue confirma...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1272-y
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:The purpose this study is to evaluate the efficacy of multiparametric ultrasound-targeted biopsies in patients undergoing initial biopsy of the prostate for the suspicion of prostate cancer. MATERIALS AND METHODS:A total of 167 patients who are biopsy naïve underwent multiparametric ultrasound-targeted biopsy ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2187-9
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:Management of prostate cancer following radiation therapy remains challenging, especially for younger men or those with life expectancy greater than 10 years. We outline the efficacy, safety and adequacy of radical prostatectomy for the treatment of radiorecurrent localized prostate cancer. METHODS:A systemati...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-013-1029-z
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:Urinary cytology (C) and cystoscopy remain the gold standard for the detection and screening of bladder cancer (BC). In this prospective study, we analyzed whether baseline C, ImmunoCyt (I), BTA Stat (B), hemoglobin dipstick (H), and NMP22 BladderChek (N) can predict recurrence and progression. METHODS:Urinary...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-016-1795-5
更新日期：2016-10-01 00:00:00
abstract：INTRODUCTION:Natural orifice transluminal endoscopic surgery (NOTES) and laparoendoscopic single-site surgery (LESS) are the next steps in the evolution of laparoscopic surgery, promising reduced morbidity and improved cosmetic result. The inconsistent terminology initially used led to confusion. Understanding the tech...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-012-0899-9
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:To describe the clinical characteristics of struvite stones and determine the preoperative predictors of sepsis in struvite patients undergoing percutaneous nephrolithotomy (PCNL). METHODS:A retrospective study of patients who underwent PCNL between April 2011 and March 2018 was performed. The data of the stru...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02748-0
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:Peyronie's disease (PD) is a localized connective tissue disorder of the penile tunica albuginea (TA) with a still obscure etiopathology. Recent studies from our laboratory have demonstrated differences in Smad3 and Smad4 gene expression of PD-fibroblasts and non-PD-fibroblasts after stimulation with recom...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0320-x
更新日期：2009-02-01 00:00:00
abstract：PURPOSE:As silodosin 8 mg, used for treating BPH, is known to cause absence of sperms in the ejaculate, its potential as an on-demand, reversible, nonhormonal oral contraceptive for males was assessed in this pilot study. METHODS:In this randomized, double-blind, placebo-controlled pilot study, healthy, sexually activ...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-019-02806-7
更新日期：2020-03-01 00:00:00
abstract：:Gastrin releasing peptide (GRP) is a neuropeptide that has been suggested to play a role in the development of some malignancies. Our aim was: (1) to identify the expression of GRP in cancerous prostate glands, and (2) to correlate its expression to various pathological parameters and to the patient's clinical outcome...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0339-y
更新日期：2003-08-01 00:00:00
abstract：PURPOSE:There are sparse data describing outcomes of bone-only oligometastatic prostate cancer in comparison with lymph node disease treated with stereotactic body radiotherapy (SBRT). The primary aim of this study was to report progression-free survival (PFS) data for patients with bone-only disease. Influence of horm...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02873-w
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:To evaluate whether the rate of Gleason score (GS) upgrade on final pathology, the rate of positive surgical margins (PSM) and the rate of biochemical recurrence (BCR) after radical prostatectomy (RP) were different if prostate biopsy (PB) was graded by community pathologists (CP) as compared to specialized uro...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1788-4
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Imaging of the urinary tract and its surrounding tissue still remains challenging, since standard imaging in the urological operation room consists of fluoroscopy and plain X-rays. The combination of a ceiling-mounted X-ray system and a new urological intervention table now allows cross-sectional imaging and...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0951-9
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:High-quality leadership and chairing skills are vital for good performance in multidisciplinary tumor boards (MTBs), but no instruments currently exist for assessing and improving these skills. OBJECTIVE:To construct and validate a robust instrument for assessment of MTB leading and chairing skills. DESIGN...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2255-1
更新日期：2018-07-01 00:00:00
abstract：:Pyeloplasty for congenital ureteropelvic junction (UPJ) obstruction enjoys a 90-95% success rate. Although treatment of the failed pyeloplasty has been addressed in the literature, management of the poorly draining or nondraining renal unit in the immediate postoperative period has not received any attention. For this...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00183119
更新日期：1996-01-01 00:00:00
