Abstract:
PURPOSE:We sought whether serum total testosterone (tT), estradiol (E2), tT/E2 ratio, and sex hormone-binding globulin (SHBG) significantly fluctuate throughout time in men with prostate cancer (PCa). METHODS:Circulating hormones were measured in a cohort of 631 candidates for radical prostatectomy. Hormone levels were analyzed according to either patient age, stratified into quartiles, or body mass index (BMI). Linear regression analyses tested the association between sex steroids and continuously coded patient age and BMI values. RESULTS:No significant differences were found among age quartiles regarding serum tT levels and tT/E2 ratio. Conversely, E2 and SHBG levels significantly increased throughout time (all, p ≤ 0.001). Total T did not linearly change according to continuously coded patient age; in contrast, E2 and SHBG linearly increased (all, p ≤ 0.001), whereas tT/E2 decreased (p = 0.016) with aging. Rate of hypogonadism significantly increased with aging (p = 0.04). Total T, T/E2 ratio, and SHBG linearly decreased along with BMI increases (all p ≤ 0.02), whereas serum E2 did not significantly change. Rate of hypogonadism significantly increased with BMI increases (p < 0.001). CONCLUSIONS:In contrast with longitudinal studies in the general male population, these data indirectly suggest that serum tT levels could be stable over time in PCa patients. This finding led to formulation of a "time-dependency theory", which postulates that the endocrine biology of prostate tissue is dependent on the exposure time at a given concentration of sex steroid, which, in turn, fluctuates throughout the lifespan of the individual.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Salonia A,Abdollah F,Capitanio U,Suardi N,Gallina A,Castagna G,Clementi MC,Briganti A,Rigatti P,Montorsi Fdoi
10.1007/s00345-012-1009-8subject
Has Abstractpub_date
2013-04-01 00:00:00pages
267-73issue
2eissn
0724-4983issn
1433-8726journal_volume
31pub_type
杂志文章abstract::This paper provides an overview of the scientific and practical aspects of assessing health-related quality of life (HRQL). The paper provides a brief overview of developments in the field and then discusses the definition of HRQL. The different types of HRQL measure available to researchers are described, with specif...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s003450050132
更新日期:1999-08-01 00:00:00
abstract:PURPOSE:To study microscopic patterns of remaining peripheral nerves (PN) after nerve-sparing (NS) radical prostatectomy (RP) and possible consequences for nerve preparation. METHODS:Specimens from 27 patients (7 = non-NSRP, 20 = unilateral NS) were examined. Sections were investigated for PN content by immunoassaying...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0791-z
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:To evaluate the diagnostic and staging ability of multiparametric MRI (mpMRI) compared to radical prostatectomy (RP) specimens after dissemination of this technology to several centres. mpMRI is an evolving technique aiming to improve upon the diagnostic sensitivity of prostate biopsy for the diagnosis of prost...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-016-1960-x
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:Digital low-dosage, linear slot scanning radiography (Lodox®) is an imaging modality that can emit down to one-tenth the radiation of conventional X-ray systems. We prospectively evaluated Lodox® as a diagnostic imaging modality in patients with ureterolithiasis. METHODS:Conventional kidney-ureter-bladder (KUB...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02803-w
更新日期:2020-04-01 00:00:00
abstract:INTRODUCTION:The da Vinci Single-Port (SP) platform (Intuitive Surgical Inc, Sunnyvale CA) is a recently approved robotic surgical platform which features several novel modifications from previously available single trocar models including a flexible camera, articulating instruments, and navigator guidance for real-tim...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-019-02898-1
更新日期:2020-04-01 00:00:00
abstract::Vesicoureteral reflux (VUR) represents one of the most significant risk factors for acute pyelonephritis in children. The current indications for the surgical correction of VUR depend on the presence or absence of renal scars. If no scars are present, primary ureteral reimplantation is only indicated in high-grade bil...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-004-0408-x
更新日期:2004-06-01 00:00:00
abstract:PURPOSE:To evaluate the clinical significance of invasive urothelial carcinoma that is ambiguous for muscularis propria invasion on initial transurethral resection of bladder tumor (TURBT). METHODS:All consecutive in-house TURBTs with invasive urothelial carcinoma from 1999 to 2017 that underwent radical cystectomy (R...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02782-y
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:To compare the efficiency and safety of suctioning ureteral access sheath (UAS) and traditional UAS during flexible ureteroscopy (FURS) for treatment of renal stones. METHODS:Between January 2015 and December 2017, 165 patients who had renal stones successfully underwent FURS with suctioning UAS created by con...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2455-8
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To evaluate contemporary international trends in the implementation of minimally invasive adrenalectomy and to assess contemporary outcomes of different minimally invasive techniques performed at urologic centers worldwide. METHODS:A retrospective multinational multicenter study of patients who underwent min...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-016-1791-9
更新日期:2016-10-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of WX-G250, a chimeric monoclonal antibody that binds to carboxy anhydrase IX, combined with low-dose interferon-alpha (LD-IFNα) in patients with progressive metastatic renal cell carcinoma (mRCC). PATIENTS AND METHODS:Thirty-one patients, nephrectomized for the primary tumo...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-010-0570-2
更新日期:2011-02-01 00:00:00
abstract::We report on a 17-year-old white woman with multiple bilateral renal angiomyolipomas (AMLs) in the absence of tuberous sclerosis. Multiple hyperdense lesions were detected in both kidneys by sonography. A computed tomography (CT) scan confirmed mainly fatty tissue. Sparing as much functional tissue as possible, eight ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-001-0242-3
更新日期:2002-09-01 00:00:00
abstract::The purpose of the present study was to examine the outcome profiles of a large number of patients with locally advanced adenocarcinoma of the prostate following radical perineal prostatectomy (RPP) for clinically organ-confined disease. Of 1662 men who underwent RPP performed by a single surgeon between January 1972 ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s003459900100
更新日期:2000-06-01 00:00:00
abstract::Local recurrent prostate cancer after radical treatment is found in the majority of men with a rising PSA. Salvage treatment procedures for recurrent disease, such as radiation therapy and ablative procedures, can provide long-term responses in well-selected cases. Prostate magnetic resonance imaging (MRI) allows diag...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-019-02677-y
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:Taiwan is a highly endemic area for urothelial carcinoma (UC) and chronic kidney disease (CKD). We evaluate the gender effect on the relationship between renal outcome and clinical characteristics of CKD patients with UC. METHODS:The clinical and pathologic records of 404 patients were retrospectively analyzed...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0682-3
更新日期:2011-08-01 00:00:00
abstract::The most important phosphates involved in urinary stone disease are carbonate apatite, brushite, and struvite. Overall, phosphate stones account for 12-20% of all stones, with a downward trend for struvite and an increase in carbonate apatite being observed in the last decade. The physicochemical basis for the formati...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s003450050152
更新日期:1999-10-01 00:00:00
abstract:PURPOSE:To analyze and compare preoperative patient characteristics and postoperative results in men with stress urinary incontinence (SUI) selected for an adjustable male sling system or an artificial urinary sphincter (AUS) in a large, contemporary, multi-institutional patient cohort. METHODS:658 male patients who u...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2523-0
更新日期:2019-07-01 00:00:00
abstract::The aim of this project was to evaluate the ice-water test as a predictor of the response to intradetrusor botulinum toxin injection in patients with neurogenic detrusor overactivity. We retrospectively evaluated the urodynamic parameters in 22 patients with neurogenic bladder dysfunction and positive ice-water test. ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-007-0208-1
更新日期:2007-12-01 00:00:00
abstract::Glycosaminoglycans (GAGs) are potent inhibitors of calcium oxalate growth and aggregation. The synthetic GAG pentosan polysulphate (PPS) was used in the treatment of patients with renal calcium stone disease. Altogether, 121 patients were included in an open trial over a 3-year-period. The average stone episode rate a...
journal_title:World journal of urology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00182052
更新日期:1994-01-01 00:00:00
abstract::This study was designed to evaluate the impact of lower-energy transurethral microwave thermotherapy (TUMT) on quality of life (QoL) and quality of sexual function (QSF) in patients with benign prostatic hyperplasia (BPH). A total of 216 patients with BPH received lower-energy TUMT treatment (Prostasoft 2.0) and were ...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s003450050042
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:This report presents our early experience at Cleveland Clinic replacing conventional ultrasound with a novel 29 MHz high-resolution micro-ultrasound system for both systematic sampling and real-time targeting of suspicious regions during prostate biopsy. The added value of micro-ultrasound and MRI over systemat...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02863-y
更新日期:2020-05-01 00:00:00
abstract::During bladder development, undifferentiated mesenchymal and epithelial cells undergo an orderly sequence of differentiation defined by the expression of smooth-muscle (alpha-actin, myosin, vinculin, desmin, vimentin, and laminin) and epithelial (cytokeratins 5, 7, 8, 14, 18 and 19) protein markers. This process requi...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/BF00184602
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:The purpose of the study is to introduce our experience of a modified single-port minilaparoscopic technique for the treatment of pediatric hydrocele. METHODS:Between June 2008 and May 2012, 279 boys (115 communicating hydrocele and 164 "non-communicating" hydrocele, diagnosis based on preoperative physical ex...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1259-8
更新日期:2014-12-01 00:00:00
abstract:INTRODUCTION:Obesity may be a risk factor for kidney donors to develop reduced renal function. The Framingham heart study suggested that visceral adipose tissue (VAT) confers a more adverse metabolic profile compared with subcutaneous adipose tissue (SAT). Asians tend to have a higher VAT composition and it is unclear ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2566-2
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Recently, the American Urogynecologic Society and Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction released position statements on the use of mid-urethral slings. The statement offers that the polypropylene mesh mid-urethral sling (retropubic and transobturator) is now the recogni...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-015-1600-x
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:To compare efficacy and safety between superior calyceal access and inferior calyceal access for pelvic and/or lower calyceal renal stones. METHODS:Consecutive patients presenting with Pelvic and/or inferior calyceal renal calculi were allocated to the superior calyceal access (group 1) or inferior calyceal ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03409-3
更新日期:2020-08-31 00:00:00
abstract:PURPOSE:To compare the impact of 18F-sodium-fluoride (NaF) PET/CT, 18F-fluorocholine (FCH) PET/CT and diffusion-weighted whole-body MRI (DW-MRI) on the management of patients with prostate cancer (PCa) suspicious for distant metastasis. METHODS:Prostate cancer patients were prospectively included between December 2011...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-018-2547-5
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:We compared perioperative and long-term renal functional outcomes of robot-assisted partial nephrectomy (RAPN) with laparoscopic partial nephrectomy (LPN) for small renal masses. MATERIALS AND METHODS:A total of 1,032 patients were included for evaluation; propensity score matching was performed to adjust for ...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-015-1488-5
更新日期:2015-10-01 00:00:00
abstract:INTRODUCTION:Changes in the management of minimally invasive oncologic renal surgery have introduced ablative therapies as the most recent advancement in minimally invasive technology. METHODS:The current evidence-based medicine on the topic of laparoscopic (LCA) and percutaneous (PCA) renal cryoablation was gathered ...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-010-0552-4
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:Chronic inflammation has been considered a potential risk factor for prostate cancer. Toll-like receptors (TLRs) are important in the innate immune response to pathogens and in cross talk between innate immunity and adaptive immunity. In this study, sequence variants in the TLR4 gene were investigated to determ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0690-3
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:Salvage radiotherapy (SRT) for biochemical recurrence (BCR) following radical prostatectomy (RP) should if possible be added at a prostate-specific antigen (PSA) level of <1-2 ng/mL. The value of positron emission tomography combined with computed tomography (PET/CT) at such low PSA values is not defined. The p...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1547-y
更新日期:2015-11-01 00:00:00