Visceral obesity in Asian living kidney donors significantly impacts early renal function after donor nephrectomy.

Abstract:

INTRODUCTION:Obesity may be a risk factor for kidney donors to develop reduced renal function. The Framingham heart study suggested that visceral adipose tissue (VAT) confers a more adverse metabolic profile compared with subcutaneous adipose tissue (SAT). Asians tend to have a higher VAT composition and it is unclear if their kidney function is affected differently. We hypothesized that Asian living kidney donors who have visceral obesity are at a higher risk of renal function deterioration 1 year after donation. METHODS:Between 2011 and 2014, we retrospectively evaluated data from 73 consecutive patients (52% male; mean age 44.9 ± 11.7 years) before they underwent donor nephrectomy and at their 1 year routine follow-up. VAT and SAT were measured at the level of the umbilicus on pre-operative computerized tomography (CT). Visceral obesity (VO) was defined as a VAT > 100 cm [2] and patients were then further divided and compared in two subgroups: VAT > 100 and < 100 cm [2]. Estimated glomerular filtration rate (eGFR, mL/min per 1.73 m [2]) was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation pre-operatively and 1 year post-operatively. RESULTS:Both subgroups had similar baseline kidney function (P = NS) pre-operatively. At the 1 year follow-up, patients with VO experienced a more significant decline of renal function (109 ± 9 to 89 ± 8 mL/min per 1.73 m2), compared to those without VO (111 ± 12 to 96 ± 11 mL/min per 1.73 m2, P = 0.013). VO was associated with a body mass index (BMI) > 25 kg/m2 (P < 0.001), male gender (P < 0.001) and older age at the time of donor nephrectomy (48.0 vs 39.5 years, P = 0.01). The presence of hypertension or hyperlipidaemia pre-operatively, choice of surgical approach, and post-operative complication rates, did not differ significantly between the subgroups. CONCLUSIONS:Visceral obesity as defined by VAT > 100 cm2 at the level of the umbilicus on cross-sectional imaging, may have a significant impact on early renal function after donor nephrectomy. Adiposity markers, as measured by cross-sectional CT imaging, may be incorporated into routine pre-operative kidney donor workup.

journal_name

World J Urol

journal_title

World journal of urology

authors

Pek GXW,Ngoh CLY,Teo BW,Vathsala A,Goh BYS,Yong CHR,Raman L,Tiong HY

doi

10.1007/s00345-018-2566-2

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

2231-2236

issue

10

eissn

0724-4983

issn

1433-8726

pii

10.1007/s00345-018-2566-2

journal_volume

37

pub_type

杂志文章
  • Improved decision making in intermediate-risk prostate cancer: a multicenter study on pathologic and oncologic outcomes after radical prostatectomy.

    abstract:BACKGROUND:Prognoses for intermediate-risk prostate cancer (PCa) remain heterogeneous. Improved substratification could optimize treatment and monitoring strategies. The objective was to validate this subclassification in a radical prostatectomy (RP) series. METHODS:Between 2000 and 2011, 4038 patients who underwent R...

    journal_title:World journal of urology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00345-016-1979-z

    authors: Beauval JB,Ploussard G,Cabarrou B,Roumiguié M,Ouzzane A,Gas J,Goujon A,Marcq G,Mathieu R,Vincendeau S,Cathelineau X,Mongiat-Artus P,Salomon L,Soulié M,Méjean A,de La Taille A,Rouprêt M,Rozet F,Committee of Cancerology

    更新日期:2017-08-01 00:00:00

  • Experimental animal model and RNA interference: a promising association for bladder cancer research.

    abstract::Animal models are at the centre of laboratory bladder cancer (BC) research and at the same time, the bridge to the clinic. A new and very promising therapeutical approach is to silence abnormally up-regulated genes in cancer, through small interfering RNA (siRNA) molecules. Therapeutic use and success of siRNAs will l...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审

    doi:10.1007/s00345-009-0374-4

    authors: Reis LO,Pereira TC,Favaro WJ,Cagnon VH,Lopes-Cendes I,Ferreira U

    更新日期:2009-06-01 00:00:00

  • XPA-210: a new proliferation marker determines locally advanced prostate cancer and is a predictor of biochemical recurrence.

    abstract:PURPOSE:XPA-210 is a proliferation marker derived from Thymidine kinase-1. It is of clinical significance in kidney, breast, and bladder cancer. There are no data available for XPA-210 in prostate cancer (PC). Herein, we aim to determine the clinical usefulness of XPA-210 in PC. MATERIALS AND METHODS:In a retrospectiv...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-011-0768-y

    authors: Aufderklamm S,Hennenlotter J,Todenhoefer T,Gakis G,Schilling D,Vogel U,Kuehs U,Dlugosch J,Knapp J,Merseburger A,Gerber V,Ordelheide A,Hevler J,Stenzl A,Schwentner C

    更新日期:2012-08-01 00:00:00

  • Obstructive sleep apnea and Fuhrman grade in patients with clear cell renal cell carcinoma treated surgically.

    abstract:PURPOSE:To assess the association between obstructive sleep apnea (OSA) and Fuhrman grade in patients with clear cell renal cell carcinoma (ccRCC). As secondary endpoints, we studied its association with tumor size, metastasis-free survival (MFS) and cancer-specific survival (CSS). METHODS:We reviewed the databases of...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-016-1830-6

    authors: Vilaseca A,Nguyen DP,Vertosick EA,Corradi RB,Musquera M,Pérez M,Fossati N,Sjoberg DD,Farré R,Almendros I,Montserrat JM,Benfante NE,Hakimi AA,Skanderup AJ,Russo P,Alcaraz A,Touijer KA

    更新日期:2017-01-01 00:00:00

  • Controlled, double-blind, multicentre clinical trial to investigate long-term tolerability and efficacy of trospium chloride in patients with detrusor instability.

    abstract::Our objectives were to ascertain the tolerability and efficacy of trospium chloride in doses of 20 mg twice daily for long-term therapy (52 weeks) in patients with urge syndrome. The trial comprised a total of 358 patients with urge syndrome or urge incontinence. After randomisation in the ratio of 3:1, participants w...

    journal_title:World journal of urology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00345-003-0321-8

    authors: Halaska M,Ralph G,Wiedemann A,Primus G,Ballering-Brühl B,Höfner K,Jonas U

    更新日期:2003-05-01 00:00:00

  • Longer length improvement and more covert incision: a single-center, prospective study of two innovative surgical methods "one stitch" and "four stitch" for pediatric buried penis.

    abstract:BACKGROUND:To introduce the detailed procedures of two innovative surgical options for pediatric buried penis and prospectively compare their efficacy and safety. METHODS:A single-center, non-randomized, prospective study was conducted at the Zhongnan Hospital of Wuhan University, where patients were operated on using...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-018-2243-5

    authors: Lei J,Luo C,Cheng S,Yan W,Wang X,Su X

    更新日期:2018-08-01 00:00:00

  • High NF-κB and STAT3 activity in human urothelial carcinoma: a pilot study.

    abstract:PURPOSE:Given that the tumor-promoting inflammation has been previously established in squamous cell carcinoma of the bladder but its contribution to development of urothelial carcinoma (UC) still remains elusive, our aim was to study changes in expression and activity of inflammation-mediating NF-κB and STAT3 transcri...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-014-1237-1

    authors: Degoricija M,Situm M,Korać J,Miljković A,Matić K,Paradžik M,Marinović Terzić I,Jerončić A,Tomić S,Terzić J

    更新日期:2014-12-01 00:00:00

  • Functional electromyostimulation of the corpus cavernosum penis--preliminary results of a novel therapeutic option for erectile dysfunction.

    abstract::Transcutaneous application of low-frequency electric current in the treatment of partially or temporarily denervated striated muscles is widely used to prevent or treat muscular atrophy. Due to the high regenerative capacity of smooth-muscle cells, this approach should be beneficial in the treatment of diseases with s...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/BF00182971

    authors: Stief CG,Weller E,Noack T,Djamilian M,Meschi M,Truss M,Jonas U

    更新日期:1995-01-01 00:00:00

  • A comparison of prostate cancer detection rates by 12 or 6 core biopsy at different prostate-specific antigen densities in Korean men.

    abstract:OBJECTIVES:To evaluate the diagnostic value of 12 core biopsy versus sextant biopsy at different prostatic-specific antigen densities (PSAD). METHODS:We retrospectively analyzed the records of 1,463 patients who underwent transrectal ultrasound-guided prostate biopsies at our institution. 995 patients underwent 12 cor...

    journal_title:World journal of urology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00345-008-0264-1

    authors: Jeong H,Jeong BC,Kwak C,Lee E,Lee SE,Kim TB

    更新日期:2008-08-01 00:00:00

  • The vacuum cleaner effect in minimally invasive percutaneous nephrolitholapaxy.

    abstract:INTRODUCTION:Percutaneous stone removal increasingly plays an important role among the different approaches of interventional stone therapy, particularly since the development of miniaturized instruments is resulting in lower morbidity for the patients. One major drawback of smaller instruments is the increased difficu...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-015-1541-4

    authors: Nicklas AP,Schilling D,Bader MJ,Herrmann TR,Nagele U,Training and Research in Urological Surgery and Technology (T.R.U.S.T.)-Group.

    更新日期:2015-11-01 00:00:00

  • Comparison of adjustable male slings and artificial urinary sphincter in the treatment of male urinary incontinence: a retrospective analysis of patient selection and postoperative continence status.

    abstract:PURPOSE:To analyze and compare preoperative patient characteristics and postoperative results in men with stress urinary incontinence (SUI) selected for an adjustable male sling system or an artificial urinary sphincter (AUS) in a large, contemporary, multi-institutional patient cohort. METHODS:658 male patients who u...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-018-2523-0

    authors: Grabbert M,Hüsch T,Kretschmer A,Kirschner-Hermanns R,Anding R,Rose A,Friedl A,Obaje A,Heidenreich A,Brehmer B,Naumann CM,Queissert F,Loertzer H,Pfitzenmaier J,Nyarangi-Dix J,Kurosch M,Olianas R,Homberg R,Abdunnur R,

    更新日期:2019-07-01 00:00:00

  • Development of an evidence-based cognitive behavioral treatment program for men with chronic prostatitis/chronic pelvic pain syndrome.

    abstract:OBJECTIVES:Psychosocial factors reported by patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) promote greater pain, disability, and ultimately poorer quality of life (QOL). We targeted those parameters in the development of a cognitive-behavioral (CB) program designed specifically for CP/CPPS. M...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-008-0235-6

    authors: Nickel JC,Mullins C,Tripp DA

    更新日期:2008-04-01 00:00:00

  • Central effects of sildenafil (Viagra) on auditory selective attention and verbal recognition memory in humans: a study with event-related brain potentials.

    abstract::The purpose of this study was to assess possible central side-effects of sildenafil (Viagra) on attention and memory functions. Sildenafil and placebo were administered in young male subjects in a double-blind balanced cross-over design. Behavioral patterns and event-related brain potentials (ERP) were recorded in a s...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/pl00007092

    authors: Schultheiss D,Müller SV,Nager W,Stief CG,Schlote N,Jonas U,Asvestis C,Johannes S,Münte TF

    更新日期:2001-02-01 00:00:00

  • Microcirculatory effects of sildenafil in experimental testicular torsion in rats.

    abstract:PURPOSE:Investigate the short-term effect of sildenafil on microcirculation, especially the velocity, the pattern of the flow and the recruitment of the leukocyte in postcapillaries. METHODS:In male Sprague-Dawley rats, the microcirculatory consequences of 60 min experimental testicular torsion, followed by 240 min of...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-018-2340-5

    authors: Oroszi M,Szabó A,Fehér ÁM,Deák G,Bajory Z

    更新日期:2018-12-01 00:00:00

  • Day-case robotic-assisted partial nephrectomy: feasibility and preliminary results of a prospective evaluation (UroCCR-25 AMBU-REIN study).

    abstract:PURPOSE:Robotic partial nephrectomy (RPN) is a minimally-invasive technique used to treat renal tumors. A clinical pathway and prospective research protocol (AMBU-REIN) were specifically set up to establish and assess the routine use of day-case RPN. METHODS:The AMBU-REIN study was conducted in the framework of the Fr...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-020-03283-z

    authors: Bernhard JC,Robert G,Ricard S,Michiels C,Capon G,Boulenger de Hautecloque A,Bensadoun H,Gay J,Rogier J,Tauzin-Fin P,Gross-Goupil M,Benard A,Nouette K,Roullet S,Ferrière JM

    更新日期:2020-06-08 00:00:00

  • Development of robotic program: an Asian experience.

    abstract::Robotic surgery was started in the Department of Urology, Hospital Kuala Lumpur, in April 2004. We present our experience in developing the program and report the results of our first 50 cases of robotic radical prostatectomy. A three-arm da Vinci robotic system was installed in our hospital in March 2004. Prior to in...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-006-0069-z

    authors: Sahabudin RM,Arni T,Ashani N,Arumuga K,Rajenthran S,Murali S,Patel V,Hemal A,Menon M

    更新日期:2006-06-01 00:00:00

  • Laparoscopic vesico-ureteral reimplantation with Lich-Gregoir approach in children: medium term results of 159 renal units in 117 children.

    abstract:PURPOSE:Vesico-ureteral reflux (VUR) represents one of the most significant risk factors for acute pyelonephritis in children. Surgery is an important part of its management. Laparoscopic ureteric reimplantation using the Lich-Gregoir technique is an option for VUR. The aim of this study is to assess short- and medium-...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-017-2064-y

    authors: Soulier V,Scalabre AL,Lopez M,Li CY,Thach S,Vermersch S,Varlet FO

    更新日期:2017-11-01 00:00:00

  • Inverse stage migration patterns in North American patients undergoing local prostate cancer treatment: a contemporary population-based update in light of the 2012 USPSTF recommendations.

    abstract:PURPOSE:Recent studies demonstrated ongoing inverse stage migration in prostate cancer (PCa) patients towards more advanced and unfavorable tumors. The USPSTF grade D recommendation may impact this trend in North American patients. We assessed contemporary stage migration and treatment trends in a large North American ...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-018-2396-2

    authors: Leyh-Bannurah SR,Karakiewicz PI,Pompe RS,Preisser F,Zaffuto E,Dell'Oglio P,Briganti A,Nafez O,Fisch M,Steuber T,Graefen M,Budäus L

    更新日期:2019-03-01 00:00:00

  • Long-term outcome of kidneys with initially poor drainage or no drainage following pyeloplasty.

    abstract::Pyeloplasty for congenital ureteropelvic junction (UPJ) obstruction enjoys a 90-95% success rate. Although treatment of the failed pyeloplasty has been addressed in the literature, management of the poorly draining or nondraining renal unit in the immediate postoperative period has not received any attention. For this...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/BF00183119

    authors: Miyamoto KK,Mesrobian HG

    更新日期:1996-01-01 00:00:00

  • The sigma rectum pouch (Mainz pouch II).

    abstract::A low-pressure reservoir for urine is created by antimesenteric splitting and side-to-side anastomosis of the rectosigmoid, the expectation being to obtain better continence rates and better protection of the upper tract than are achievable by ureterosigmoidostomy. Between 1990 and August 1993 the procedure was perfor...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/BF00182560

    authors: Fisch M,Wammack R,Hohenfellner R

    更新日期:1996-01-01 00:00:00

  • The impact of time to catheter removal on short-, intermediate- and long-term urinary continence after radical prostatectomy.

    abstract:PURPOSE:To assess the impact of prolonged catheterization time on 1-week (short-term), 3-month (intermediate-term) and 1-year (long-term) UC. METHODS:Between 2008 and 2015, 6918 men underwent RP by four high-volume surgeons. Exclusion criteria were baseline urinary incontinence (UI) and radiotherapy prior or within 12...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-018-2274-y

    authors: Tilki D,Preisser F,Karakiewicz P,Shariat SF,Graefen M,Huland H,Chun FK,Pompe RS

    更新日期:2018-08-01 00:00:00

  • Radical prostatectomy: a prospective comparison of oncological and functional results between open and laparoscopic approaches.

    abstract::We prospectively compared, within the same center and during the same period of time, the perioperative parameters as well as the oncological and functional results of both open retropubic (ORP) and laparoscopic radical prostatectomy (LRP). From September 1999 to September 2001, 162 patients with prostate cancer were ...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-002-0306-z

    authors: Roumeguere T,Bollens R,Vanden Bossche M,Rochet D,Bialek D,Hoffman P,Quackels T,Damoun A,Wespes E,Schulman CC,Zlotta AR

    更新日期:2003-05-01 00:00:00

  • Update of the International Consultation on Urological Diseases on bladder cancer 2018: non-urothelial cancers of the urinary bladder.

    abstract:PURPOSE:To provide a comprehensive update of the joint consultation of the International Consultation on Urological Diseases (ICUD) for the diagnosis and management of non-urothelial cancer of the urinary bladder. METHODS:A detailed analysis of the literature was conducted reporting on the epidemiology, etiology, diag...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审

    doi:10.1007/s00345-018-2421-5

    authors: Alanee S,Alvarado-Cabrero I,Murugan P,Kumar R,Nepple KG,Paner GP,Patel MI,Raspollini MR,Lopez-Beltran A,Konety BR

    更新日期:2019-01-01 00:00:00

  • Robotic extended pyelolithotomy for treatment of renal calculi: a feasibility study.

    abstract::Percutaneous nephrolithotomy (PCNL) remains the treatment of choice for staghorn renal calculi. Many reports suggest that laparoscopy can be an alternative treatment for large renal stones. We wished to evaluate the role and feasibility of laparoscopic extended pyelolithotomy (REP) for treatment of staghorn calculi. T...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-006-0099-6

    authors: Badani KK,Hemal AK,Fumo M,Kaul S,Shrivastava A,Rajendram AK,Yusoff NA,Sundram M,Woo S,Peabody JO,Mohamed SR,Menon M

    更新日期:2006-06-01 00:00:00

  • Higher expression of phosphodiesterase type 5 in the anterior fibromuscular stroma of the human prostate.

    abstract:PURPOSE:To examine phosphodiesterase type 5 (PDE5) expression in the anterior fibromuscular stroma (AFMS) of the prostate. Although PDE5 expression was identified in the human prostate, differences in PDE5 expression in intra-prostatic regions are unknown. The AFMS in the prostate has peculiar innervations that could c...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-020-03095-1

    authors: Iwata T,Fujihara A,Shiraishi T,Yamada Y,Hongo F,Ukimura O

    更新日期:2020-11-01 00:00:00

  • Critical analysis of urethroplasty for male anterior urethral stricture: a single-center experience.

    abstract:PURPOSE:Urethroplasty is the most effective treatment method for anterior urethral strictures, which constitute an important health concern for males. This study aims to investigate factors that may predict treatment failure following urethroplasty for anterior urethral strictures and evaluate outcomes of different ure...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-019-03014-z

    authors: Yalçınkaya F,Kartal I

    更新日期:2020-09-01 00:00:00

  • High spatial correlation in brain connectivity between micturition and resting states within bladder-related networks using 7 T MRI in multiple sclerosis women with voiding dysfunction.

    abstract:BACKGROUND:Several studies have reported brain activations and functional connectivity (FC) during micturition using functional magnetic resonance imaging (fMRI) and concurrent urodynamics (UDS) testing. However, due to the invasive nature of UDS procedure, non-invasive resting-state fMRI is being explored as a potenti...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-021-03599-4

    authors: Shi Z,Tran K,Karmonik C,Boone T,Khavari R

    更新日期:2021-01-29 00:00:00

  • Noncontrast helical CT for ureteral stones.

    abstract::Noncontrast helical computed tomography (CT) has recently been found to be superior to excretory urography (IVU) in the evaluation of patients with suspected ureterolithiasis. Noncontrast helical CT does not require the use of intravenous contrast material with its associated cost and risk of adverse reactions and can...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审

    doi:10.1007/s003450050020

    authors: Boridy IC,Nikolaidis P,Kawashima A,Sandler CM,Goldman SM

    更新日期:1998-01-01 00:00:00

  • Comparison of suctioning and traditional ureteral access sheath during flexible ureteroscopy in the treatment of renal stones.

    abstract:PURPOSE:To compare the efficiency and safety of suctioning ureteral access sheath (UAS) and traditional UAS during flexible ureteroscopy (FURS) for treatment of renal stones. METHODS:Between January 2015 and December 2017, 165 patients who had renal stones successfully underwent FURS with suctioning UAS created by con...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-018-2455-8

    authors: Zhu Z,Cui Y,Zeng F,Li Y,Chen Z,Hequn C

    更新日期:2019-05-01 00:00:00

  • Continuous monitoring of intrapelvic pressure during flexible ureteroscopy using a sensor wire: a pilot study.

    abstract:PURPOSE:To evaluate the feasibility of measuring the intrapelvic pressure (IPP) during f-URS with a wire including a pressure sensor and to assess IPP profiles during the procedure. METHODS:Patients undergoing f-URS for stone disease were recruited. A wire with pressure sensor was placed in the renal cavities to measu...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-020-03216-w

    authors: Doizi S,Letendre J,Cloutier J,Ploumidis A,Traxer O

    更新日期:2020-05-07 00:00:00