Abstract：
:The purpose of the present study was to examine the outcome profiles of a large number of patients with locally advanced adenocarcinoma of the prostate following radical perineal prostatectomy (RPP) for clinically organ-confined disease. Of 1662 men who underwent RPP performed by a single surgeon between January 1972 and January 1999, 692 patients (41.6%) aged a median of 66.1 years were found to have extracapsular disease on pathological evaluation. The extent of disease was categorized as either specimen-confined (n = 355) or margin-positive (n = 337). The histological grade of the cancer was characterized using the Gleason score. Time to biochemical failure, defined as a prostate-specific antigen (PSA) level of > or = 0.5 ng/ml, and cancer-associated survival were the end points of our outcome analysis using the Kaplan-Meier product-limit method. The median time to cancer-associated death for patients with specimen-confined and margin-positive disease was 18.5 and 13.1 years, respectively. After 5 years, 37% and 54% of the patients with specimen-confined and margin-positive disease, respectively, had PSA failure. Prostate cancer patients with a Gleason score of 5-6, 7, and 8-10 experienced a median time to cancer-associated death of 19.9, 19.2, and 10.5 years, respectively. A subset of patients undergoing adjunctive radiation therapy (XRT) relapsed biochemically after a median period of approximately 18 months. RPP provides a substantial disease-control benefit in patients with specimen-confined cancer. The time to biochemical failure and the time to cancer-associated death are significantly influenced by the biology of the underlying disease, necessitating long-term follow-up in the outcome analysis of any modality of treatment for prostate cancer. A benefit of early adjunctive XRT for local failure remains to be determined.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Dahm P,Vieweg J,Newhall PM,Robertson JE,Paulson DFdoi
10.1007/s003459900100keywords:
subject
Has Abstractpub_date
2000-06-01 00:00:00pages
173-8issue
3eissn
0724-4983issn
1433-8726journal_volume
18pub_type
杂志文章abstract：PURPOSE:Salvage radiotherapy (SRT) for biochemical recurrence (BCR) following radical prostatectomy (RP) should if possible be added at a prostate-specific antigen (PSA) level of <1-2 ng/mL. The value of positron emission tomography combined with computed tomography (PET/CT) at such low PSA values is not defined. The p...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1547-y
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVES:Recent advances have led to the use of magnetic resonance imaging (MRI) alone or with fusion to transrectal ultrasound (TRUS) images for guiding biopsy of the prostate. Our group sought to develop consensus recommendations regarding MRI-guided prostate biopsy based on currently available literature and exper...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-018-2374-8
更新日期：2019-03-01 00:00:00
abstract：:Urinary bladder cancer (UBC) is a common disease worldwide. At any point in time 2.7 million people have a history of UBC. The incidence of UBC varies over the world with highest rates in developed communities. But the burden of UBC will increase in less developed areas of the world. These changes can be attributed to...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0383-3
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVES:While the coronavirus disease 2019 (COVID-19) pandemic captures healthcare resources worldwide, data on the impact of prioritization strategies in urology during pandemic are absent. We aimed to quantitatively assess the global change in surgical and oncological clinical practice in the early COVID-19 pandem...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03333-6
更新日期：2020-07-04 00:00:00
abstract：PURPOSE:To test the hypothesis that cytoreductive nephrectomy (CN) improves overall survival (OS) of patients with synchronous metastatic renal cell carcinoma (mRCC), who subsequently receive targeted therapies (TT). METHODS:We identified 261 patients who received TT for synchronous mRCC with or without prior CN. To a...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2154-x
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:Patients with end-stage renal disease (ESRD) have an increased risk of developing renal cell carcinoma (RCC). This retrospective study compared clinical and pathological outcomes of RCC occurring in native kidneys of patients with ESRD (whether they underwent kidney transplantation or not) with those of renal t...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1248-y
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:Robotic radical cystectomy (RRC) has become a commonly utilised alternative to open radical cystectomy (ORC). We performed a systematic review and meta-analysis of RRC vs ORC focusing on perioperative outcomes and safety. METHODS:Medline, EMBASE and CENTRAL were searched from January 2000 to April 2020 followi...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-020-03385-8
更新日期：2020-07-30 00:00:00
abstract：INTRODUCTION:With low life expectancy rates in hemodialysis patients, the preservation of renal parenchyma must be weighed against the oncological outcomes in considering partial nephrectomy (PN) in solitary kidneys. The main objective of this study was to assess the oncologic and functional outcomes after PN in patien...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0576-9
更新日期：2011-06-01 00:00:00
abstract：PURPOSE:To investigate the impact of gender differences on treatment success, intraoperative and postoperative complications in patients undergoing ureteroscopy (URS). MATERIALS AND METHODS:A prospectively maintained database of 927 consecutively performed ureteroscopies on solitary ureteral stones in four different c...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-014-1435-x
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:Recent studies demonstrated ongoing inverse stage migration in prostate cancer (PCa) patients towards more advanced and unfavorable tumors. The USPSTF grade D recommendation may impact this trend in North American patients. We assessed contemporary stage migration and treatment trends in a large North American ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2396-2
更新日期：2019-03-01 00:00:00
abstract：:We evaluated the quality of micturition in patients with orthotopic neobladder replacement. In the present study, 58 patients who had undergone orthotopic neobladder replacement following cystectomy were enrolled. The quality of micturition was evaluated by means of uroflowmetry, a self-administered questionnaire and ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s003450000156
更新日期：2000-12-01 00:00:00
abstract：PURPOSE:To compare the efficacy, safety, Patient Global Impression of Improvement (PGI-I), and complications rates after 180-W GreenLight laser (180-W GL laser) standard and anatomical photoselective vaporization (sPVP and aPVP). METHODS:Within a multi-institutional database, we identified patients who underwent sPVP ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2106-5
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:To investigate the spontaneous clearance rates of remnant particles following miniaturized percutaneous nephrolithotomy (mini-PCNL) and retrograde intrarenal surgery (RIRS). METHODS:Among 624 patients who underwent mini-PCNL or RIRS at our institution from 2011 to 2015, we collected data of 247 patients with 2...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1807-5
更新日期：2016-11-01 00:00:00
abstract：PURPOSE:The international meeting on reconstructive Urology (IMORU) is a live surgery event (LSE) where expert surgeons perform various reconstructive surgeries. To evaluate patient safety, an extended follow-up of the complications of two subsequent IMORU meetings were gathered. Also, a detailed survey concerning the ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02666-1
更新日期：2019-11-01 00:00:00
abstract：PURPOSE:To compare the impact of 18F-sodium-fluoride (NaF) PET/CT, 18F-fluorocholine (FCH) PET/CT and diffusion-weighted whole-body MRI (DW-MRI) on the management of patients with prostate cancer (PCa) suspicious for distant metastasis. METHODS:Prostate cancer patients were prospectively included between December 2011...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-018-2547-5
更新日期：2019-08-01 00:00:00
abstract：PURPOSE:Management of prostate cancer following radiation therapy remains challenging, especially for younger men or those with life expectancy greater than 10 years. We outline the efficacy, safety and adequacy of radical prostatectomy for the treatment of radiorecurrent localized prostate cancer. METHODS:A systemati...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-013-1029-z
更新日期：2013-12-01 00:00:00
abstract：:The landscape has dramatically changed for patients seeking treatment for rapid ejaculation. Previously, psychotherapy or behavioral treatment was considered to be the treatment of choice for this troubling sexual dysfunction. Since the early 1990s, an efficacious alternative treatment has emerged-the off-label admini...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-004-0489-6
更新日期：2005-06-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate the factors affecting the lower urinary tract symptoms (LUTS) related quality of life (QoL) score. METHODS:This retrospective study analyzed 29,123 men who underwent health check-ups from January 2007 to July 2011 at a single institution. Those patients who completed th...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2052-2
更新日期：2017-11-01 00:00:00
abstract：:One of the historic landmarks in urology is the first planned nephrectomy performed in 1869 by Gustav Simon of Heidelberg (1824-1877). In the history of medicine the reflections and considerations of the specialized surgeon reveal distinguished analyses of the "case" and, thus, the beginning of a modern scientific dis...
journal_title：World journal of urology
pub_type： 传,历史文章,杂志文章
doi：10.1007/s003450050125
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVE:To provide most recent and high quality evidence concerning the comparison between monopolar and bipolar transurethral resection of non-muscle invasive bladder tumors. MATERIALS AND METHODS:Two researchers performed a systematic review of the current literature independently, to identify studies published in...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03313-w
更新日期：2020-06-26 00:00:00
abstract：PURPOSE:To assess the effects of warm ischaemia time (WIT) on renal function after laparoscopic partial nephrectomy (LPN) for renal masses in patients with a normal contralateral kidney. METHODS:From October 2006 to December 2008, 53 patients treated with LPN were enrolled in this prospective study. Effective renal pl...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-011-0729-5
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To assess treatments and survival of patients with muscle invasive bladder cancer (MIBC) in the Comprehensive Cancer Center Northern Netherlands (CCCN) region. STUDY DESIGN AND SETTING:Retrospective cohort analysis. Data of 548 patients with MIBC diagnosed between 1997 and 2002 were collected from the CCCN c...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0546-2
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:Imaging of the urinary tract and its surrounding tissue still remains challenging, since standard imaging in the urological operation room consists of fluoroscopy and plain X-rays. The combination of a ceiling-mounted X-ray system and a new urological intervention table now allows cross-sectional imaging and...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0951-9
更新日期：2014-02-01 00:00:00
abstract：:Upon feeling the urge to urinate, the urinary bladder contracts, the urethral sphincters relax and urine flows through the urethra. These actions are mediated by the micturition reflex. We investigated the hypothesis that vesical contraction is maintained by positive feedback through continuous flow of urine through t...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0340-5
更新日期：2003-08-01 00:00:00
abstract：:In multivariate analysis, GS of the regular prostatectomy specimen was the only statistically significant parameter for pT2R1 prostate cancer. ...
journal_title：World journal of urology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00345-020-03136-9
更新日期：2020-06-01 00:00:00
abstract：:The orthotopic neobladder has become the preferred method of handling the urinary tract after removal of the bladder in men and women. However, an improved quality of life compared to urinary diversion fails to be realized when voiding dysfunction arises. These difficulties with urination range from retention to incon...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450000146
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:To evaluate the opinion of urologists and their audience regarding patient safety and educational value of live surgical demonstrations (LSD) and semi-live surgical demonstrations (semi-LSD). METHODS:Following the '2017 Challenges in Endourology' meeting, a survey addressing patient safety and the educational ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2291-x
更新日期：2018-10-01 00:00:00
abstract：:This study was designed to evaluate the impact of lower-energy transurethral microwave thermotherapy (TUMT) on quality of life (QoL) and quality of sexual function (QSF) in patients with benign prostatic hyperplasia (BPH). A total of 216 patients with BPH received lower-energy TUMT treatment (Prostasoft 2.0) and were ...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s003450050042
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:It was our aim in this study to develop a technique that is rather simple, overcomes the problems of Devine and Horton glanuloplasty in patients with small glans, and is flexible to be tailored to any hypospadias surgery. METHODS:A total of 11 patients were included in this preliminary report. A triangular ski...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0386-0
更新日期：2009-10-01 00:00:00
abstract：PURPOSE:To evaluate the thermal effect of Ho:YAG laser lithotripsy in a standardized in vitro model via real-time temperature measurement. METHODS:Our model comprised a 20 ml test tube simulating the renal pelvis that was immersed in a 37 °C water bath. Two different laser fibers [FlexiFib (15-45 W), RigiFib 1000 (45-...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2303-x
更新日期：2018-09-01 00:00:00
