Association of training level and outcome of software-based image fusion-guided targeted prostate biopsies.


PURPOSE:The aim of this study was to assess the impact of experience on the outcome of image fusion-guided prostate biopsies performed by urologists working at a high-volume medical center. METHODS:The first 210 consecutive fusion biopsies were analyzed following installation of the software-based biopsy platform Artemis™ (Eigen, USA). The impact of training was measured in terms of changes in prostate cancer detection rates and biopsy duration over time. We sought to identify a threshold of experience for urologists, which predicts higher detection rates of targeted biopsies. The influence of various factors on prostate cancer detection rates was evaluated using bi- and multivariate analysis. RESULTS:Twenty-two urologists (n = 9 senior urologists, n = 13 urological residents) performed targeted biopsies followed by systematic 12-core biopsies. Overall, targeted biopsies yielded a positive result in 39.6% of 260 suspicious MRI lesions. A subgroup analysis of the six urologists who performed more than ten biopsies was then conducted, and their level of experience (i.e., performance of more than eight biopsies) was found to be associated with higher detection rates than those with less experience (49.0% and 23.0%, respectively; p < 0.001) in the targeted biopsies. Experience was likewise a significant and independent predictor of a cancer-positive targeted biopsy (p = 0.002). Experienced senior physicians did not outperform residents in their targeted biopsy results. Further, biopsy duration correlated negatively (r = - 0.5931, p < 0.001) with the total number of biopsies performed for all subgroups during the period of assessment. CONCLUSIONS:Experience is an important predictor of the rate of detection in targeted biopsies using software-based biopsy platforms with semi-robotic assistance. Moreover, the performance of just a few procedures appears sufficient to increase biopsy effectiveness significantly. Lastly, supervision by experts is recommended during the training phase.


World J Urol


World journal of urology


Westhoff N,Haumann H,Kriegmair MC,von Hardenberg J,Budjan J,Porubsky S,Michel MS,Honeck P,Ritter M




Has Abstract


2019-10-01 00:00:00














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    abstract:OBJECTIVE:It has been hypothesized that endothelial dysfunction and pelvic atherosclerosis may contribute to lower urinary tract symptoms (LUTS). We assessed the relationship between cardiovascular risk factors and LUTS severity in male patients presented to urology clinic. METHODS:It is a cross-sectional study on pat...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Yee CH,Yip JSY,Cheng NMY,Kwan CH,Li KM,Teoh JYC,Chiu PKF,Wong JH,Chan ESY,Chan CK,Hou SSM,Ng CF

    更新日期:2019-04-01 00:00:00

  • High spatial correlation in brain connectivity between micturition and resting states within bladder-related networks using 7 T MRI in multiple sclerosis women with voiding dysfunction.

    abstract:BACKGROUND:Several studies have reported brain activations and functional connectivity (FC) during micturition using functional magnetic resonance imaging (fMRI) and concurrent urodynamics (UDS) testing. However, due to the invasive nature of UDS procedure, non-invasive resting-state fMRI is being explored as a potenti...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Shi Z,Tran K,Karmonik C,Boone T,Khavari R

    更新日期:2021-01-29 00:00:00

  • Factors predicting inguinal node metastasis in squamous cell cancer of penis.

    abstract:PURPOSE:To identify factors predicting the risk of inguinal metastasis in squamous cell carcinoma of the penis. The therapeutic advantages of early lymphadenectomy in squamous cell carcinoma of the penis must be counterbalanced against its post-operative morbidity. Loss to follow up is a major problem in developing cou...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Bhagat SK,Gopalakrishnan G,Kekre NS,Chacko NK,Kumar S,Manipadam MT,Samuel P

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  • Non-invasive and minimally invasive staging of regional lymph nodes in penile cancer.

    abstract:INTRODUCTION:The management of the regional lymph nodes in penile cancer patients, particularly when these lymph nodes are impalpable, remains controversial. Prophylactic bilateral inguinal lymphadenectomy is associated with high morbidity and is often unnecessary. However, there is no non-invasive or minimally invasiv...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


    authors: Hughes B,Leijte J,Shabbir M,Watkin N,Horenblas S

    更新日期:2009-04-01 00:00:00

  • The use of hemostatic agents does not prevent hemorrhagic complications of robotic partial nephrectomy.

    abstract:PURPOSE:To assess the impact of HA on robotic PN (RPN) outcomes. METHODS:We retrospectively analyzed data from patients who underwent RPN in eight centers between 2009 and 2013. Hemorrhagic complications were defined as the occurrence of a pseudoaneurysm, arteriovenous fistula or hematoma requiring transfusion. Patien...

    journal_title:World journal of urology

    pub_type: 杂志文章,多中心研究


    authors: Peyronnet B,Oger E,Khene Z,Verhoest G,Mathieu R,Roumiguié M,Beauval JB,Pradere B,Masson-Lecomte A,Vaessen C,Baumert H,Bernhard JC,Doumerc N,Droupy S,Bruyere F,De La Taille A,Roupret M,Bensalah K

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  • Long-term oncological outcomes in patients with limited nodal disease undergoing radical prostatectomy and pelvic lymph node dissection without adjuvant treatment.

    abstract:PURPOSE:This study aimed at analysing long-term oncologic outcomes in prostate cancer patients with limited nodal disease (1-2 positive lymph nodes) without adjuvant therapy after radical prostatectomy (RP). METHODS:We retrospectively analysed data of 209 pN1 patients who underwent RP between January 1998 and 2010 wit...

    journal_title:World journal of urology

    pub_type: 杂志文章


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    更新日期:2017-12-01 00:00:00

  • Outcome of patients with newly diagnosed prostate cancer with low metastatic burden treated with radical prostatectomy: a comparison to STAMPEDE arm H.

    abstract:PURPOSE:STAMPEDE arm H demonstrated a survival benefit for newly diagnosed prostate cancer (PCa) patients with low metastatic burden (LMB) who additionally received radiotherapy (RT) to the primary. However, it is unknown if radical prostatectomy (RP) may achieve equivalent results, since existing studies did neither i...

    journal_title:World journal of urology

    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Amaresh M,Hegde P,Chawla A,de la Rosette JJMCH,Laguna MP,Kriplani A

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  • High hospital and surgeon volume and its impact on overall survival after radical cystectomy among patients with bladder cancer in Quebec.

    abstract:INTRODUCTION AND OBJECTIVES:Previous studies reported improved outcomes for bladder cancer patients who had radical cystectomy (RC) performed by surgeons and hospitals with high annual RC volumes. The objective of this study was to determine the effect of high hospital and surgeon volume on overall survival after RC fo...

    journal_title:World journal of urology

    pub_type: 杂志文章,多中心研究


    authors: Santos F,Zakaria AS,Kassouf W,Tanguay S,Aprikian A

    更新日期:2015-09-01 00:00:00

  • Prospective evaluation of a urinary biomarker panel to detect and predict recurrence of non-muscle-invasive bladder cancer.

    abstract:PURPOSE:To perform a feasibility phase study of a panel of putative protein biomarkers and determine whether it can identify and predict tumor recurrence in patients with non-muscle-invasive bladder cancer (NMIBC) on follow-up. METHODS:We prospectively analyzed the urine of 152 patients previously treated for NMIBC. Q...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Srougi V,Reis ST,Viana N,Gallucci FP,Leite KR,Srougi M,Nahas WC

    更新日期:2020-04-06 00:00:00

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    abstract:INTRODUCTION:Erectile dysfunction (ED) and cardiovascular disease (CVD) share a great number of common risk factors. There is growing evidence that aldosterone, an independent CVD risk factor, is associated with ED. AIMS:The purpose of this study was to determine the relationship between plasma aldosterone and erectil...

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    pub_type: 杂志文章


    authors: Wu F,Mao S,Yu T,Jiang H,Ding Q,Xu G

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    abstract::The diagnosis of prostate cancer is based on histology. Prostate biopsies are obtained based on the triad of prostate specific antigen (PSA), digital rectal examination (DRE) and transrectal ultrasound. Because prostate biopsies still have a large percentage of negative outcomes, patient selection and biopsy direction...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


    authors: Wink MH,de la Rosette JJ,Grimbergen CA,Wijkstra H

    更新日期:2007-08-01 00:00:00

  • Multiparametric magnetic resonance imaging for prostate cancer-a comparative study including radical prostatectomy specimens.

    abstract:PURPOSE:To evaluate the diagnostic and staging ability of multiparametric MRI (mpMRI) compared to radical prostatectomy (RP) specimens after dissemination of this technology to several centres. mpMRI is an evolving technique aiming to improve upon the diagnostic sensitivity of prostate biopsy for the diagnosis of prost...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Toner L,Papa N,Perera M,Katelaris N,Weerakoon M,Chin K,Harewood L,Bolton DM,Lawrentschuk N

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  • Ultrastructural study of an antibody-stabilized bladder surface: a new perspective on the elusive glycosaminoglycan layer.

    abstract::The thin mucus or glycosaminoglycan layer of the bladder may be implicated in the pathogenesis of many bladder disease states. We have developed a specific antimucus, antisera stabilization technique to study the ultrastructural morphological appearance of the layer in both normal and abnormal bladders that should pro...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Nickel JC,Cornish J

    更新日期:1994-01-01 00:00:00

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    abstract:INTRODUCTION AND OBJECTIVES:Standardization of hands-on training (HoT) has profoundly impacted the educational field in the last decade. To provide quality training sessions on a global scale, the European School of Urology Training group developed a teaching guide for tutors in 2015. Our study aims to understand wheth...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Veneziano D,Morgia G,Castelli T,Cimino S,Russo G,Privitera S,Goezen A,Van Cleynenbreugel B,Ahmed K,Somani B,Urzì D,ESU-ESUT training Research group.

    更新日期:2020-03-21 00:00:00

  • The effects of testosterone on the cavernous tissue and erectile function.

    abstract::A review of the current literature is conducted to explore the developmental aspects, animal and human experiences and the effects of pharmacological manipulation to explain the role androgens play in sexual function with special emphasis on erectile function and the erectile tissue. This review reveals that androgens...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


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    更新日期:1997-01-01 00:00:00

  • Laparoscopic management of renal cystic disease.

    abstract::Renal cystic disease, ranging from simple cysts to autosomal dominant polycystic kidney disease (ADPKD), can lead to significant complications such as pain, hypertension, infection, upper urinary tract obstruction, and even renal failure. For patients with preserved renal function, laparoscopic ablation of renal cysts...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


    authors: Dunn MD,Clayman RV

    更新日期:2000-09-01 00:00:00

  • Consistent and significant improvement of nighttime voiding frequency (nocturia) with silodosin in men with LUTS suggestive of BPH: pooled analysis of three randomized, placebo-controlled, double-blind phase III studies.

    abstract:OBJECTIVES:Nocturia is prevalent and bothersome in men with lower urinary tract symptoms suggestive of BPH (LUTS/BPH). α-Adrenoceptor antagonists without subtype selectivity have inconsistently shown significant effects on nocturia in these patients. We explored the effects of the α1A-adrenoceptor subtype-selective ant...

    journal_title:World journal of urology

    pub_type: 杂志文章,随机对照试验


    authors: Eisenhardt A,Schneider T,Cruz F,Oelke M

    更新日期:2014-10-01 00:00:00

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    abstract:BACKGROUND:Numerous recent studies have shown that concomitant carcinoma in situ (CIS) can be closely associated with the prognosis of patients with bladder cancer (BCa). However, the prognostic value of CIS in BCa is still not conclusive. Hence, we performed a systematic review and meta-analysis to explore the associa...

    journal_title:World journal of urology

    pub_type: 杂志文章,meta分析


    authors: Zhang L,Wu B,Zha Z,Zhao H,Yuan J,Jiang Y

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    abstract:PURPOSE:To evaluate the diagnostic potential of choline measurements by in vivo magnetic resonance spectroscopy (MR spectroscopy) for diagnosis of renal masses. METHODS:Twenty-eight patients with 29 renal lesions underwent prospectively preoperative 3 T MR spectroscopy of renal masses before diagnostic tissue confirma...

    journal_title:World journal of urology

    pub_type: 杂志文章


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    abstract::This paper provides an overview of the scientific and practical aspects of assessing health-related quality of life (HRQL). The paper provides a brief overview of developments in the field and then discusses the definition of HRQL. The different types of HRQL measure available to researchers are described, with specif...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


    authors: Browne JP

    更新日期:1999-08-01 00:00:00

  • Does partial nephrectomy at an academic institution result in better outcomes?

    abstract:PURPOSE:Partial nephrectomy (PN) outcomes may be better at academic institutions than at non-academic centers. Peer-review, sub-specialized practice profile, higher individual surgeon and institutional caseload may explain this observation. To the best of our knowledge, the role of institutional academic affiliation ha...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Trinh QD,Schmitges J,Sun M,Sammon J,Shariat SF,Sukumar S,Zorn K,Bianchi M,Jeldres C,Perrotte P,Graefen M,Rogers CG,Peabody JO,Menon M,Karakiewicz PI

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  • Clinical outcomes after salvage radiotherapy without androgen deprivation therapy in patients with persistently detectable PSA after radical prostatectomy: results from a national multicentre study.

    abstract:PURPOSE:To assess oncologic outcomes after salvage radiotherapy (SRT) without androgen deprivation therapy (ADT) in patients with persistently detectable PSA after radical prostatectomy (RT). METHODS:Two hundred and one patients who failed to achieve an undetectable PSA received SRT without ADT. The primary endpoint w...

    journal_title:World journal of urology

    pub_type: 杂志文章,多中心研究


    authors: Ploussard G,Staerman F,Pierrevelcin J,Larue S,Villers A,Ouzzane A,Bastide C,Gaschignard N,Buge F,Pfister C,Bonniol R,Rebillard X,Fadli S,Mottet N,Saint F,Saad R,Beauval JB,Roupret M,Audenet F,Peyromaure M,Delongch

    更新日期:2014-10-01 00:00:00

  • The effect of delayed percutaneous nephrolithotomy on the risk of bacteremia and sepsis in patients with neuromuscular disorders.

    abstract:PURPOSE:To determine whether a delayed percutaneous nephrolithotomy (PCNL) reduces the rate of bacteremia/sepsis in patients with neuromuscular disorders. Patients with neuromuscular disorders are at higher risk of developing complications after PCNL. One strategy to reduce the risk of infectious complications is to pl...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Eswara JR,Lee H,Dretler SP,Sacco D

    更新日期:2013-12-01 00:00:00

  • Assessment of the effects of autologous muscle-derived cell injections on urethral sphincter morphometry using 3D/4D ultrasound.

    abstract:PURPOSE:The primary objective was to evaluate the effect of autologous muscle-derived cell (AMDC) injections on the urethral sphincter morphometry compared to placebo injections. Secondary aims were to explore the reduction of stress incontinence episode frequency (IEF) and factors associated with the efficacy of AMDC....

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Ismail S,Morin M,Tu LM

    更新日期:2020-11-01 00:00:00

  • A comparison of prostate cancer detection rates by 12 or 6 core biopsy at different prostate-specific antigen densities in Korean men.

    abstract:OBJECTIVES:To evaluate the diagnostic value of 12 core biopsy versus sextant biopsy at different prostatic-specific antigen densities (PSAD). METHODS:We retrospectively analyzed the records of 1,463 patients who underwent transrectal ultrasound-guided prostate biopsies at our institution. 995 patients underwent 12 cor...

    journal_title:World journal of urology

    pub_type: 杂志文章,多中心研究


    authors: Jeong H,Jeong BC,Kwak C,Lee E,Lee SE,Kim TB

    更新日期:2008-08-01 00:00:00

  • Oncological risk of laparoscopic surgery in urothelial carcinomas.

    abstract:OBJECTIVE:To assess the oncological safety of laparoscopic procedures for the management of urothelial carcinomas of the urinary tract. METHODS:Data on laparoscopic management of urothelial carcinomas in the literature were analysed using MEDLINE and by matching the following keywords: urological malignancies, upper t...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


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  • The role of mycophenolate mofetil in clinical renal transplantation.

    abstract::Mycophenolate mofetil (MM) is the ester derivative of mycophenolic acid (MPA), which exerts immunosuppressive activity by inhibiting de novo purine biosynthesis. Following animal models and pilot studies in human renal allograft recipients that confirmed MM's ability to prevent and half rejection episodes, 3 large mul...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


    authors: Hodge EE

    更新日期:1996-01-01 00:00:00

  • Complications of robotic assisted radical prostatectomy.

    abstract:OBJECTIVES:Robotic radical prostatectomy claims optimal oncologic results, minimal morbidity and best outcomes of urinary continence and erection function. Potential benefits concerning side effects and complications compared to open radical prostatectomy are analysed. METHODS:Out of 450 robotic radical prostatectomie...

    journal_title:World journal of urology

    pub_type: 杂志文章,meta分析,多中心研究


    authors: Fischer B,Engel N,Fehr JL,John H

    更新日期:2008-12-01 00:00:00

  • The application of ultrasound contrast agents in the characterization of renal tumors.

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    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Siracusano S,Quaia E,Bertolotto M,Ciciliato S,Tiberio A,Belgrano E

    更新日期:2004-11-01 00:00:00