Abstract:
PURPOSE:The aim of this study was to assess the impact of experience on the outcome of image fusion-guided prostate biopsies performed by urologists working at a high-volume medical center. METHODS:The first 210 consecutive fusion biopsies were analyzed following installation of the software-based biopsy platform Artemis™ (Eigen, USA). The impact of training was measured in terms of changes in prostate cancer detection rates and biopsy duration over time. We sought to identify a threshold of experience for urologists, which predicts higher detection rates of targeted biopsies. The influence of various factors on prostate cancer detection rates was evaluated using bi- and multivariate analysis. RESULTS:Twenty-two urologists (n = 9 senior urologists, n = 13 urological residents) performed targeted biopsies followed by systematic 12-core biopsies. Overall, targeted biopsies yielded a positive result in 39.6% of 260 suspicious MRI lesions. A subgroup analysis of the six urologists who performed more than ten biopsies was then conducted, and their level of experience (i.e., performance of more than eight biopsies) was found to be associated with higher detection rates than those with less experience (49.0% and 23.0%, respectively; p < 0.001) in the targeted biopsies. Experience was likewise a significant and independent predictor of a cancer-positive targeted biopsy (p = 0.002). Experienced senior physicians did not outperform residents in their targeted biopsy results. Further, biopsy duration correlated negatively (r = - 0.5931, p < 0.001) with the total number of biopsies performed for all subgroups during the period of assessment. CONCLUSIONS:Experience is an important predictor of the rate of detection in targeted biopsies using software-based biopsy platforms with semi-robotic assistance. Moreover, the performance of just a few procedures appears sufficient to increase biopsy effectiveness significantly. Lastly, supervision by experts is recommended during the training phase.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Westhoff N,Haumann H,Kriegmair MC,von Hardenberg J,Budjan J,Porubsky S,Michel MS,Honeck P,Ritter Mdoi
10.1007/s00345-018-2605-zsubject
Has Abstractpub_date
2019-10-01 00:00:00pages
2119-2127issue
10eissn
0724-4983issn
1433-8726pii
10.1007/s00345-018-2605-zjournal_volume
37pub_type
杂志文章abstract:PURPOSE:To evaluate for the first time the prognostic significance of female invasive patterns in stage pT4a urothelial carcinoma of the bladder in a large series of women undergoing anterior pelvic exenteration. PATIENTS AND METHODS:Our series comprised of 92 female patients in total of whom 87 with known invasion pa...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-014-1308-3
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Chronic intraprostatic inflammation is suspected to play a major role in the pathogenesis of prostate cancer (PCa). Polymorphisms in interleukin-10 (IL-10), a key anti-inflammatory cytokine gene can influence immune response and immune evasion of tumor cells. Its role as an anti-metastatic molecule is also w...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-008-0361-1
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:To explore whether patients undergoing radical prostatectomy at a German Cancer Society (DKG: Deutsche Krebsgesellschaft) certified center (CC) have superior functional and surgical outcomes compared to patients undergoing radical prostatectomy at a non-certified hospital (nCC). METHODS:A retrospective cohort ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03411-9
更新日期:2020-08-26 00:00:00
abstract:OBJECTIVES:To place chemoprevention of prostate cancer in current clinical context. METHODS:Review of recently published updates of large, randomized, controlled trials of primary chemoprevention of prostate cancer. RESULTS:With extended post-intervention follow-up, SELECT demonstrated a 17% increased risk of prostat...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-011-0822-9
更新日期:2012-04-01 00:00:00
abstract::The aim of this cross-sectional study was to compare single with repeated high-intensity focused ultrasound (HIFU) treatment in patients with localized prostate cancer, regarding treatment-related morbidity. A number of 223 consecutive patients with localized prostate cancer were treated with HIFU. Among them, 174 (78...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-006-0107-x
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVES:To assess the impact of surgical approaches and clinico-pathological parameters on the prognosis of localized renal cell carcinoma (RCC) after laparoscopic radical nephrectomy (LRN) or open radical nephrectomy (ORN). METHODS:Between 2002 and 2008, 336 patients with localized RCC were treated at our two inst...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-009-0487-9
更新日期:2010-06-01 00:00:00
abstract::The diagnosis of prostate cancer is based on histology. Prostate biopsies are obtained based on the triad of prostate specific antigen (PSA), digital rectal examination (DRE) and transrectal ultrasound. Because prostate biopsies still have a large percentage of negative outcomes, patient selection and biopsy direction...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-007-0189-0
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:To assess treatments and survival of patients with muscle invasive bladder cancer (MIBC) in the Comprehensive Cancer Center Northern Netherlands (CCCN) region. STUDY DESIGN AND SETTING:Retrospective cohort analysis. Data of 548 patients with MIBC diagnosed between 1997 and 2002 were collected from the CCCN c...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-010-0546-2
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:To assess the common practice to transiently place an indwelling transurethral catheter in case of hospitalization of women with febrile urinary tract infections. So far, this intervention has not been scientifically investigated. METHODS:Inclusion criteria were female gender, a leucocyte esterase-positive uri...
journal_title:World journal of urology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00345-018-2474-5
更新日期:2019-05-01 00:00:00
abstract::Animal models are at the centre of laboratory bladder cancer (BC) research and at the same time, the bridge to the clinic. A new and very promising therapeutical approach is to silence abnormally up-regulated genes in cancer, through small interfering RNA (siRNA) molecules. Therapeutic use and success of siRNAs will l...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-009-0374-4
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:Often PIRADS 3 findings are usually followed up with further MRIs of the prostate. Current guidelines do not state an optimal interval between the initial MRI and the follow-up MRI. The aim of this study was to find out if PIRADS 3 lesions evolve over time and to determine how long the optimal interval between ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2135-0
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:In the present study, we aimed to evaluate the sexual function in patients with multiple sclerosis (MS) who were examined in two subgroups and compare the results to the control group with a validated questionnaire. METHODS:A total of 23 consecutive female MS patients divided into groups with relapsing-remitti...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-0891-4
更新日期:2013-08-01 00:00:00
abstract::The aim of this project was to evaluate the ice-water test as a predictor of the response to intradetrusor botulinum toxin injection in patients with neurogenic detrusor overactivity. We retrospectively evaluated the urodynamic parameters in 22 patients with neurogenic bladder dysfunction and positive ice-water test. ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-007-0208-1
更新日期:2007-12-01 00:00:00
abstract:PURPOSE:Data assessing the effectiveness of single-use flexible ureteropyeloscopy (FURS) are limited. This study evaluates and compares single-use FURS with conventional reusable FURS. METHODS:A systematic search using electronic databases (Pubmed and Embase) was performed for studies evaluating single-use FURS in the...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-017-2131-4
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:To determine the clinical performance of a blood-based test for clinically significant (CS) prostate cancer (PCa) (grade group ≥ 2) intended for use in men with prostate serum antigen levels in the 'grey zone' (PSA < 10 ng/ml). The test quantifies a previously described 3.4 kb mitochondrial DNA (mtDNA) deletion...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2152-z
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To present current evidence supporting the vessel sparing technique to reconstruct bulbar urethral strictures via primary anastomosis. METHODS:English literature review of presented series of transecting and non-transecting bulbar urethroplasty from 2000 to 2018. RESULTS:Since its introduction in 2007, vessel...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02867-8
更新日期:2020-12-01 00:00:00
abstract::Noncontrast helical computed tomography (CT) has recently been found to be superior to excretory urography (IVU) in the evaluation of patients with suspected ureterolithiasis. Noncontrast helical CT does not require the use of intravenous contrast material with its associated cost and risk of adverse reactions and can...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s003450050020
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:Psychosocial factors reported by patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) promote greater pain, disability, and ultimately poorer quality of life (QOL). We targeted those parameters in the development of a cognitive-behavioral (CB) program designed specifically for CP/CPPS. M...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-008-0235-6
更新日期:2008-04-01 00:00:00
abstract:PURPOSE:To study microscopic patterns of remaining peripheral nerves (PN) after nerve-sparing (NS) radical prostatectomy (RP) and possible consequences for nerve preparation. METHODS:Specimens from 27 patients (7 = non-NSRP, 20 = unilateral NS) were examined. Sections were investigated for PN content by immunoassaying...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0791-z
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:To provide a comprehensive update of the joint consultation of the International Consultation on Urological Diseases (ICUD) for the diagnosis and management of non-urothelial cancer of the urinary bladder. METHODS:A detailed analysis of the literature was conducted reporting on the epidemiology, etiology, diag...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-018-2421-5
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To evaluate the 6-month effects of the recommended drug and light dosage in focal vascular-targeted photodynamic therapy (VTP) using TOOKAD(®) Soluble in patients with localized prostate cancer (LPCa). METHODS:We performed a pooled analysis of 117 men with LPCa, PSA <10 ng/mL, and Gleason score ≤ 7 (3 + 4), fr...
journal_title:World journal of urology
pub_type: 杂志文章,meta分析
doi:10.1007/s00345-015-1505-8
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:To assess the feasibility, safety, and outcomes of an expedited One-Stop prostate cancer (PCa) diagnostic pathway. PATIENTS AND METHODS:We identified 370 consecutive patients who underwent multiparametric magnetic resonance imaging (mpMRI) and transrectal ultrasound fusion prostate biopsy (MRI/TRUS-PBx) from o...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02835-2
更新日期:2020-04-01 00:00:00
abstract:INTRODUCTION:Although randomized controlled trials (RCTs) remain the gold standard for determining evidence-based clinical practices, large disease registries that enroll large numbers of patients have become paramount as a relatively cost-effective additional tool. METHODS:We highlight the advantages of disease regis...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0658-3
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To assess the impact of prolonged catheterization time on 1-week (short-term), 3-month (intermediate-term) and 1-year (long-term) UC. METHODS:Between 2008 and 2015, 6918 men underwent RP by four high-volume surgeons. Exclusion criteria were baseline urinary incontinence (UI) and radiotherapy prior or within 12...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2274-y
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:In primary prostate cancer (PCa) patients, accurate staging and histologic grading are crucial to guide treatment decisions. 18F-DCFPyL (PSMA)-PET/CT has been successfully introduced for (re)staging PCa, showing high accuracy to localise PCa in lymph nodes and/or osseous structures. The diagnostic performance o...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03490-8
更新日期:2020-10-20 00:00:00
abstract::The cost of urethral catheterisation injury (UCI) is significant, but the true incidence of patient care error is difficult to establish in the absence of specific hospital codes recording difficult urethral catheterisation (DUC) and UCI. For many years urologists are familiar passing a non-traumatic hydrophilic guide...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2499-9
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:The factors affecting spermatogenesis in adulthood in patients with hypospadias (HS) are not clearly understood. In the present study, risk factors affecting post-pubertal high serum follicle-stimulating hormone (FSH) were evaluated in patients with HS. MATERIALS AND METHODS:Among those with a history of HS su...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02687-w
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Individualized risk-adapted algorithms in prostate cancer (PCa) diagnosis using predictive prebiopsy variables in addition to prostate-specific antigen value may result in a considerable reduction of unnecessary systematic biopsies. Multi-parametric magnetic resonance imaging (mpMRI) has emerged ...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-019-02707-9
更新日期:2020-03-01 00:00:00
abstract::Our objectives were to ascertain the tolerability and efficacy of trospium chloride in doses of 20 mg twice daily for long-term therapy (52 weeks) in patients with urge syndrome. The trial comprised a total of 358 patients with urge syndrome or urge incontinence. After randomisation in the ratio of 3:1, participants w...
journal_title:World journal of urology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s00345-003-0321-8
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:To test the hypothesis that cytoreductive nephrectomy (CN) improves overall survival (OS) of patients with synchronous metastatic renal cell carcinoma (mRCC), who subsequently receive targeted therapies (TT). METHODS:We identified 261 patients who received TT for synchronous mRCC with or without prior CN. To a...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2154-x
更新日期:2018-03-01 00:00:00