Abstract：
PURPOSE:To test the hypothesis that cytoreductive nephrectomy (CN) improves overall survival (OS) of patients with synchronous metastatic renal cell carcinoma (mRCC), who subsequently receive targeted therapies (TT). METHODS:We identified 261 patients who received TT for synchronous mRCC with or without prior CN. To achieve balance in baseline characteristics between groups, we used the inverse probability of treatment weighting (IPTW) method. We conducted OS analyses, including IPTW-adjusted Kaplan-Meier curves, Cox regression models, interaction term, and landmark and sensitivity analyses. RESULTS:Of the 261 patients, 97 (37.2%) received CN and 164 (62.8%) did not. IPTW-adjusted analyses showed a statistically significant OS benefit for patients treated with CN (HR 0.63, 95% CI 0.46-0.83, P = 0.0015). While there was no statistically significant difference in OS at 3 months (P = 0.97), 6 months (P = 0.67), and 12 months (P = 0.11) from diagnosis, a benefit for the CN group was noted at 18 months (P = 0.005) and 24 months (P = 0.004). On interaction term analyses, the beneficial effect of CN increased with better performance status (P = 0.06), in women (P = 0.03), and in patients with thrombocytosis (P = 0.01). CONCLUSIONS:IPTW-adjusted analysis of our patient cohort suggests that CN improves OS of patients with synchronous mRCC treated with TT. On the whole, the survival difference appears after 12 months. Specific subgroups may particularly benefit from CN, and these subgroups warrant further investigation in prospective trials.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Klatte T,Fife K,Welsh SJ,Sachdeva M,Armitage JN,'Aho T,Riddick AC,Matakidou A,Eisen T,Stewart GDdoi
10.1007/s00345-017-2154-xsubject
Has Abstractpub_date
2018-03-01 00:00:00pages
417-425issue
3eissn
0724-4983issn
1433-8726pii
10.1007/s00345-017-2154-xjournal_volume
36pub_type
杂志文章abstract：PURPOSE:To compare serial changes of postoperative storage symptoms between PVP and HoLEP, and to identify the predictors influencing postoperative improvement of storage symptoms. METHODS:A total of 486 men (PVP group: 213 cases; HoLEP group: 273 cases), in whom 12-month follow-up data were available, were included i...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1424-0
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:To analyse whether the reported differences in nodal yield at pelvic lymph node dissection (PLND) for bladder cancer, between two hospitals, are reflected in the survival rates. PATIENTS AND METHODS:We assessed follow-up data of all 174 patients (mean age: 62.7, median follow-up: 3 years) who underwent PLND ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0916-z
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Making healthcare treatment decisions is a complex process involving a broad stakeholder base including patients, their families, health professionals, clinical practice guideline developers and funders of healthcare. METHODS:This paper presents a review of a methodology for the development of urological ca...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-011-0660-9
更新日期：2011-06-01 00:00:00
abstract：:The present discussion on the natural history, growth rate pathophysiology, morbidity, and possible treatment of benign prostatic hyperplasia (BPH) reinforces the need to objectify mechanical BPH-induced obstruction with pressure-flow study. Different methods for the quantification of BPH-induced obstruction exist and...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00182667
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:To investigate the effects of onabotulinum toxin type A (Onabot/A) intravesical injections on urinary and sexual function in a group of patients affected by multiple sclerosis (MS). METHODS:We enrolled 31 MS female patients with symptoms of overactive bladder and detrusor overactivity. All patients underwent u...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-015-1578-4
更新日期：2015-12-01 00:00:00
abstract：:The orthotopic neobladder has become the preferred method of handling the urinary tract after removal of the bladder in men and women. However, an improved quality of life compared to urinary diversion fails to be realized when voiding dysfunction arises. These difficulties with urination range from retention to incon...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450000146
更新日期：2000-10-01 00:00:00
abstract：:Non-gonococcal urethritis (NGU) is conventionally treated with oral antibiotics. With this Phase II study, we investigated the action of a locally disinfecting substance, Instillagel, in symptomatic NGU. Instillation treatment was performed twice daily to 32 male patients with symptomatic NGU. To evaluate the therapeu...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-001-0236-1
更新日期：2002-05-01 00:00:00
abstract：PURPOSE:Patients and their families utilize online resources when dealing with a diagnosis of bladder cancer. Many patients have questions regarding clinical management options. Online research forums may help researchers and providers identify research areas of interest. Our objective was to review online forums and i...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2479-0
更新日期：2019-06-01 00:00:00
abstract：:Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF alpha) are two closely related peptides that interact with cell-surface epidermal growth factor receptors (EGFR) to induce receptor tyrosine phosphorylation and activation of intracellular signal-transduction pathways. EGF appears to be the predom...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00185972
更新日期：1995-01-01 00:00:00
abstract：:Animal models are at the centre of laboratory bladder cancer (BC) research and at the same time, the bridge to the clinic. A new and very promising therapeutical approach is to silence abnormally up-regulated genes in cancer, through small interfering RNA (siRNA) molecules. Therapeutic use and success of siRNAs will l...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-009-0374-4
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:Digital low-dosage, linear slot scanning radiography (Lodox®) is an imaging modality that can emit down to one-tenth the radiation of conventional X-ray systems. We prospectively evaluated Lodox® as a diagnostic imaging modality in patients with ureterolithiasis. METHODS:Conventional kidney-ureter-bladder (KUB...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02803-w
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:Recent studies demonstrated ongoing inverse stage migration in prostate cancer (PCa) patients towards more advanced and unfavorable tumors. The USPSTF grade D recommendation may impact this trend in North American patients. We assessed contemporary stage migration and treatment trends in a large North American ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2396-2
更新日期：2019-03-01 00:00:00
abstract：PURPOSE:In primary prostate cancer (PCa) patients, accurate staging and histologic grading are crucial to guide treatment decisions. 18F-DCFPyL (PSMA)-PET/CT has been successfully introduced for (re)staging PCa, showing high accuracy to localise PCa in lymph nodes and/or osseous structures. The diagnostic performance o...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03490-8
更新日期：2020-10-20 00:00:00
abstract：:Intratesticular varicocele is a rare condition with a variable clinical and ultrasound presentation. The purpose of this study was to evaluate the grey scale and color Doppler appearances of intratesticular varicocele (ITV). Herein we present seven new cases of intratesticular varicocele. From 2003 to 2005 we evaluate...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-007-0216-1
更新日期：2008-02-01 00:00:00
abstract：PURPOSE:We sought the association of preoperative serum total testosterone (tT), hypogonadism, 17β estradiol (E2), and sex hormone-binding globulin (SHBG) with early biochemical recurrence (BCR) after radical prostatectomy (RP). METHODS:Sex steroids were assessed the day before surgery (7-11 a.m.) in a cohort of 605 p...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0856-7
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:To review the etiology and pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS:A literature review for the years 1985-2012 was performed using the MEDLINE database of the United States National Library of Medicine. RESULTS:The evidence for ongoing infection in men with CP/CPPS ...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-013-1061-z
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVES:Bladder perforation is the second most common complication during transurethral resection of bladder tumours. It is unknown whether perforation affects the natural history of the tumour through cell seeding. The aim of this study was to study the impact of perforation on the oncologic outcomes of bladder car...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1197-x
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:In mid-2007, we introduced a new risk-stratified follow-up programme (FUP) for surgically treated localized renal cell carcinoma. After inclusion, the patients have been followed prospectively. In this study, we present the results in regard to stratification, completeness of the FUP and recurrences. METHODS:T...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1796-4
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:To compare the efficiency and safety of suctioning ureteral access sheath (UAS) and traditional UAS during flexible ureteroscopy (FURS) for treatment of renal stones. METHODS:Between January 2015 and December 2017, 165 patients who had renal stones successfully underwent FURS with suctioning UAS created by con...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2455-8
更新日期：2019-05-01 00:00:00
abstract：PURPOSE:Investigate the short-term effect of sildenafil on microcirculation, especially the velocity, the pattern of the flow and the recruitment of the leukocyte in postcapillaries. METHODS:In male Sprague-Dawley rats, the microcirculatory consequences of 60 min experimental testicular torsion, followed by 240 min of...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2340-5
更新日期：2018-12-01 00:00:00
abstract：INTRODUCTION:Currently, osteoporosis research is rarely undertaken in males but an increase in male life expectancy in the company of hypogonadism suggests the necessity for potential therapeutic options. MATERIALS AND METHODS:In this study, the changes in bone structure under standardized testosterone- (T), raloxifen...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0373-5
更新日期：2009-08-01 00:00:00
abstract：PURPOSE:There are sparse data describing outcomes of bone-only oligometastatic prostate cancer in comparison with lymph node disease treated with stereotactic body radiotherapy (SBRT). The primary aim of this study was to report progression-free survival (PFS) data for patients with bone-only disease. Influence of horm...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02873-w
更新日期：2019-12-01 00:00:00
abstract：:A low-pressure reservoir for urine is created by antimesenteric splitting and side-to-side anastomosis of the rectosigmoid, the expectation being to obtain better continence rates and better protection of the upper tract than are achievable by ureterosigmoidostomy. Between 1990 and August 1993 the procedure was perfor...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00182560
更新日期：1996-01-01 00:00:00
abstract：:Urinary bladder cancer (UBC) ranks ninth in worldwide cancer incidence. It is more frequent in men than in women. We review the main established/proposed factors, both environmental and genetic, associated with bladder cancer etiology and prognosis. Data were extracted from previous reviews and original articles ident...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-007-0168-5
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:Asymptomatic bacteriuria is common in diabetic women. Treatment of asymptomatic bacteriuria is not beneficial, but the natural history of the microbiology of asymptomatic bacteriuria has not been well described. OBJECTIVE:To describe the microbiological outcomes of bacteriuria in diabetic women with untreat...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-005-0042-2
更新日期：2006-02-01 00:00:00
abstract：:The widespread use of measurement of prostate-specific antigen for prostate cancer screening has led to a dramatic increase in the number of transrectal biopsies. Although transrectal ultrasound-guided prostate biopsy is the gold standard in the diagnosis of prostate cancer, the strategies for initial and repeat biops...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-007-0151-1
更新日期：2007-03-01 00:00:00
abstract：:Pyeloplasty for congenital ureteropelvic junction (UPJ) obstruction enjoys a 90-95% success rate. Although treatment of the failed pyeloplasty has been addressed in the literature, management of the poorly draining or nondraining renal unit in the immediate postoperative period has not received any attention. For this...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00183119
更新日期：1996-01-01 00:00:00
abstract：OBJECTIVES:Monopolar transurethral resection of the prostate (TURP) is the gold standard surgical treatment for bothersome moderate to severe lower urinary tract symptoms (LUTS) secondary to benign prostate obstruction. The aim of the study is to compare monopolar versus bipolar TURP focusing on operative and functiona...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-017-2023-7
更新日期：2017-10-01 00:00:00
abstract：PURPOSE:To reach standardized terminology in focal therapy (FT) for prostate cancer (PCa). METHODS:A four-stage modified Delphi consensus project was undertaken among a panel of international experts in the field of FT for PCa. Data on terminology in FT was collected from the panel by three rounds of online questionna...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-016-1782-x
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:Holmium laser enucleation of the prostate (HoLEP) has become a popular alternative to TURP for desobstructive prostate surgery. The prevalence of incidental prostate cancer (iPCa) during surgery varies depending on many preoperative factors. To evaluate whether the surgical procedure itself (HoLEP vs. TURP) inf...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2353-0
更新日期：2018-12-01 00:00:00
