IL-10 -1082 G>A: a risk for prostate cancer but may be protective against progression of prostate cancer in North Indian cohort.


BACKGROUND:Chronic intraprostatic inflammation is suspected to play a major role in the pathogenesis of prostate cancer (PCa). Polymorphisms in interleukin-10 (IL-10), a key anti-inflammatory cytokine gene can influence immune response and immune evasion of tumor cells. Its role as an anti-metastatic molecule is also well documented. METHODS:Gene promoter polymorphisms in IL-10 (-1082 G>A and -819 C>T) was analyzed in 159 PCa patients and 259 healthy controls to investigate their potential association with susceptibility for PCa. RESULTS:Our results indicated that the heterozygous (GA) and homozygous mutant (AA) genotypes of IL-10 -1082 to be more prevalent among PCa patients in comparison to controls (GA: OR - 2.8, p = 0.011; AA: OR - 2.3, p = 0.037). More patients (92.5%) than controls (82.7%) were positive for the A allele (GA + AA: OR - 2.6, p = 0.015). We observed lower frequency of T(-819)-G(-1082) haplotype in patients without bone metastasis (4.4%, OR - 0.30, p = 0.019) in comparison to PCa patients with bone metastasis (12.6%). CONCLUSION:Our results support the emerging hypothesis that genetically determined immune activity may play a role in the pathophysiology of PCa. Our findings of high producer of IL-10 -1082 variants suggest initiation of PCa. Future studies in large cohort of different ethnicity PCa groups are warranted to establish definite associations with other cytokine gene polymorphisms.


World J Urol


World journal of urology


Kesarwani P,Ahirwar DK,Mandhani A,Singh AN,Dalela D,Srivastava AN,Mittal RD




Has Abstract


2009-06-01 00:00:00












  • Long-term outcome of kidneys with initially poor drainage or no drainage following pyeloplasty.

    abstract::Pyeloplasty for congenital ureteropelvic junction (UPJ) obstruction enjoys a 90-95% success rate. Although treatment of the failed pyeloplasty has been addressed in the literature, management of the poorly draining or nondraining renal unit in the immediate postoperative period has not received any attention. For this...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Miyamoto KK,Mesrobian HG

    更新日期:1996-01-01 00:00:00

  • One-Stop MRI and MRI/transrectal ultrasound fusion-guided biopsy: an expedited pathway for prostate cancer diagnosis.

    abstract:PURPOSE:To assess the feasibility, safety, and outcomes of an expedited One-Stop prostate cancer (PCa) diagnostic pathway. PATIENTS AND METHODS:We identified 370 consecutive patients who underwent multiparametric magnetic resonance imaging (mpMRI) and transrectal ultrasound fusion prostate biopsy (MRI/TRUS-PBx) from o...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Tafuri A,Ashrafi AN,Palmer S,Shakir A,Cacciamani GE,Iwata A,Iwata T,Cai J,Sali A,Gupta C,Medina LG,Stern MC,Duddalwar V,Aron M,Gill IS,Abreu A

    更新日期:2020-04-01 00:00:00

  • Author Correction to: The transgluteal approach to shockwave lithotripsy to treat distal ureter stones: a prospective, randomized, and multicenter study.

    abstract::The funding number was incorrect in the original published article. The correct funding number should read as follows. ...

    journal_title:World journal of urology

    pub_type: 杂志文章,已发布勘误


    authors: Choo MS,Han JH,Kim JK,Shin TY,Lee WK,Lee SK,Lee SH

    更新日期:2018-08-01 00:00:00

  • Salvage high-intensity focused ultrasound versus salvage radical prostatectomy for radiation-recurrent prostate cancer: a comparative study of oncological, functional, and toxicity outcomes.

    abstract:PURPOSE:To compare oncological, functional, and toxicity outcomes of patients with radiation-recurrent prostate cancer (PCa) after external beam radiation therapy (EBRT) or brachytherapy (BT) treated with salvage high-intensity focused ultrasound (S-HIFU) or salvage radical prostatectomy (S-RP). METHODS:This retrospec...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Devos B,Al Hajj Obeid W,Andrianne C,Diamand R,Peltier A,Everaerts W,Van Poppel H,Van Velthoven R,Joniau S

    更新日期:2019-08-01 00:00:00

  • Beyond transrectal ultrasound-guided prostate biopsies: available techniques and approaches.

    abstract:OBJECTIVES:Recent advances have led to the use of magnetic resonance imaging (MRI) alone or with fusion to transrectal ultrasound (TRUS) images for guiding biopsy of the prostate. Our group sought to develop consensus recommendations regarding MRI-guided prostate biopsy based on currently available literature and exper...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


    authors: Warlick C,Futterer J,Maruf M,George AK,Rastinehad AR,Pinto PA,Bosaily AE,Villers A,Moore CM,Mendhiratta N,Taneja SS,Ukimura O,Konety BR

    更新日期:2019-03-01 00:00:00

  • Management of neobladder-vaginal fistula and stress incontinence following radical cystectomy in women: a review.

    abstract::Contemporary literature regarding the management of neobladder-vaginal fistula and stress urinary incontinence following radical cystectomy and neobladder reconstruction in women is reviewed in this article. Neobladder-vaginal fistula is uncommon but mandates meticulous repair. Compared to the native bladder, the wall...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


    authors: Tunuguntla HS,Manoharan M,Gousse AE

    更新日期:2005-09-01 00:00:00

  • Health-related quality-of-life studies in urology: conceptual and methodological considerations.

    abstract::This paper provides an overview of the scientific and practical aspects of assessing health-related quality of life (HRQL). The paper provides a brief overview of developments in the field and then discusses the definition of HRQL. The different types of HRQL measure available to researchers are described, with specif...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


    authors: Browne JP

    更新日期:1999-08-01 00:00:00

  • Optimizing male fertility: oxidative stress and the use of antioxidants.

    abstract:PURPOSE:Management of male infertility is always a difficult task, with pathophysiology and available treatments often poorly understood. The purpose of this review was to summarize current evidence regarding the use of protective agents against reactive oxygen species (ROS), such as antioxidants that may be useful in ...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


    authors: Cardoso JP,Cocuzza M,Elterman D

    更新日期:2019-06-01 00:00:00

  • Circulating sex steroids and prostate cancer: introducing the time-dependency theory.

    abstract:PURPOSE:We sought whether serum total testosterone (tT), estradiol (E2), tT/E2 ratio, and sex hormone-binding globulin (SHBG) significantly fluctuate throughout time in men with prostate cancer (PCa). METHODS:Circulating hormones were measured in a cohort of 631 candidates for radical prostatectomy. Hormone levels wer...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Salonia A,Abdollah F,Capitanio U,Suardi N,Gallina A,Castagna G,Clementi MC,Briganti A,Rigatti P,Montorsi F

    更新日期:2013-04-01 00:00:00

  • Evolution and controversies in the management of low-stage nonseminomatous germ-cell tumors of the testis.

    abstract::The results of changing treatment modalities in 690 consecutive patients with low stages nonseminomatous germ-cell tumors (NSGCT) of the testis were analyzed. Overall, 120 patients (17.4%) suffered relapses, and 25 (3.6%) died of cancer after a follow-up period ranging from 2 to 20 years. The indications for primary (...

    journal_title:World journal of urology

    pub_type: 临床试验,杂志文章


    authors: Pizzocaro G,Nicolai N,Salvioni R

    更新日期:1994-01-01 00:00:00

  • Effects of magnesium citrate and phytin on reducing urinary calcium excretion in rats.

    abstract::The aim of this study was to determine and compare the effects of both magnesium citrate and phytin on reducing urinary calcium excretion under high-calcium-diet conditions during single and combined treatments. An animal experiment was carried out over a period of 4 weeks in 35 male rats. Urinary calcium excretion wa...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Wu N,Thon WF,Krah H,Schlick R,Jonas U

    更新日期:1994-01-01 00:00:00

  • The NF-kappaB/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches?

    abstract::The nuclear factor of kappa beta (NF-kappaB) transcription factor regulates the transcription of numerous genes including that of interleukin 6 (IL-6). The IL-6 acts as an autocrine and paracrine growth factor of androgen-independent prostate cancer. An aberrant expression of the IL-6 gene and an increase in IL-6 expr...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


    authors: Paule B,Terry S,Kheuang L,Soyeux P,Vacherot F,de la Taille A

    更新日期:2007-10-01 00:00:00

  • Dihydrotestosterone and the concept of 5alpha-reductase inhibition in human benign prostatic hyperplasia.

    abstract::The development of human benign prostatic hyperplasia (BPH) clearly requires a combination of testicular androgens and the ageing process. Although the role of androgens as the causative factor for human benign prostatic hyperplasia is debated, they undoubtedly play, at least, a permissive role. The principal prostati...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


    authors: Bartsch G,Rittmaster RS,Klocker H

    更新日期:2002-04-01 00:00:00

  • Inverse stage migration patterns in North American patients undergoing local prostate cancer treatment: a contemporary population-based update in light of the 2012 USPSTF recommendations.

    abstract:PURPOSE:Recent studies demonstrated ongoing inverse stage migration in prostate cancer (PCa) patients towards more advanced and unfavorable tumors. The USPSTF grade D recommendation may impact this trend in North American patients. We assessed contemporary stage migration and treatment trends in a large North American ...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Leyh-Bannurah SR,Karakiewicz PI,Pompe RS,Preisser F,Zaffuto E,Dell'Oglio P,Briganti A,Nafez O,Fisch M,Steuber T,Graefen M,Budäus L

    更新日期:2019-03-01 00:00:00

  • Laparoscopic "single knot-single running" suture vesico-urethral anastomosis with posterior musculofascial reconstruction.

    abstract:PURPOSE:To describe results of a simplified technique to configure the vesicourethral anastomosis and to restore posterior musculofascial plate during laparoscopic radical prostatectomy with a "single knot-single running" suture. METHODS:Between December 2006 and 2009, a conventional Van Velthoven anastomosis (group A...

    journal_title:World journal of urology

    pub_type: 临床试验,杂志文章


    authors: Simone G,Papalia R,Ferriero M,Guaglianone S,Gallucci M

    更新日期:2012-10-01 00:00:00

  • Clinical epidemiology of testicular germ cell tumors.

    abstract::Clinical epidemiology is sometimes called the basic science of clinical medicine. In terms of the pathogenesis of testicular germ cell tumors (GCTs), clinical epidemiology analyzes suspected risk factors. The present review highlights the risk factors established so far and briefly summarizes those factors currently u...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


    authors: Dieckmann KP,Pichlmeier U

    更新日期:2004-04-01 00:00:00

  • XPA-210: a new proliferation marker to characterize tumor biology and progression of renal cell carcinoma.

    abstract:PURPOSE:Recent lung cancer data have shown an association of XPA-210, a key peptide of thymidine kinase, with advanced disease. We thus assessed its proliferation status in primary (M0) and metastatic (M1) renal cell carcinoma (RCC). METHODS:Paraffin slides from 30 patients (mean age: 61.2 years; range: 42-84) with cl...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Gakis G,Hennenlotter J,Scharpf M,Hevler J,Schilling D,Kuehs U,Stenzl A,Schwentner C

    更新日期:2011-12-01 00:00:00

  • Does bipolar energy provide any advantage over monopolar surgery in transurethral resection of non-muscle invasive bladder tumors? A systematic review and meta-analysis.

    abstract:OBJECTIVE:To provide most recent and high quality evidence concerning the comparison between monopolar and bipolar transurethral resection of non-muscle invasive bladder tumors. MATERIALS AND METHODS:Two researchers performed a systematic review of the current literature independently, to identify studies published in...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Tzelves L,Mourmouris P,Skolarikos A

    更新日期:2020-06-26 00:00:00

  • Multiparametric magnetic resonance imaging for prostate cancer-a comparative study including radical prostatectomy specimens.

    abstract:PURPOSE:To evaluate the diagnostic and staging ability of multiparametric MRI (mpMRI) compared to radical prostatectomy (RP) specimens after dissemination of this technology to several centres. mpMRI is an evolving technique aiming to improve upon the diagnostic sensitivity of prostate biopsy for the diagnosis of prost...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Toner L,Papa N,Perera M,Katelaris N,Weerakoon M,Chin K,Harewood L,Bolton DM,Lawrentschuk N

    更新日期:2017-06-01 00:00:00

  • Current controversies in anterior urethral stricture repair: free-graft versus pedicled skin-flap reconstruction.

    abstract::Reconstruction of long anterior urethral strictures that cannot be excised and reanastomosed remains controversial. We critically reviewed the literature on free-graft and pedicled skin-flap urethroplasty to determine the optimal method of repair. Overall, free grafts were successful in 84.3% of cases and flaps, in 85...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审


    authors: Wessells H,McAninch JW

    更新日期:1998-01-01 00:00:00

  • The association between plant-based content in diet and testosterone levels in US adults.

    abstract:PURPOSE:To evaluate the association between the plant-based content of diet and serum testosterone levels in men from the national health and nutrition examination survey (NHANES) database. MATERIALS AND METHODS:Data on demographics, diet, and testosterone levels was acquired from the NHANES database. Using the food f...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Kuchakulla M,Nackeeran S,Blachman-Braun R,Ramasamy R

    更新日期:2020-05-28 00:00:00

  • Dhat syndrome, an emergent condition within urology in Spain.

    abstract:BACKGROUND:Dhat syndrome (DS) consists of vague somatic symptoms and at times sexual dysfunction which the patient falsely attributes to involuntary emissions of semen outside of sexual relations. OBJECTIVE:Describe and analyse the occurrences of DS in patients attending the clinic and clarify the existence of this co...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Menéndez V,Fernández-Suárez A,Placer J,García-Linares M,Tarragon S,Liso E

    更新日期:2013-08-01 00:00:00

  • Low-angle X-ray scattering signatures of urinary calculi.

    abstract::This is the first reported use of low-angle X-ray scattering for the investigation of urinary calculi. Low-angle X-ray scattering (LAXS) measures the diffraction of a broad spectrum of X-rays at a single angle and uses a conventional diagnostic X-ray beam, and could thus be developed for use in vivo. A total of 45 cal...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Dawson C,Horrocks JA,Kwong R,Speller RD,Whitfield HN

    更新日期:1996-01-01 00:00:00

  • Complications of robotic assisted radical prostatectomy.

    abstract:OBJECTIVES:Robotic radical prostatectomy claims optimal oncologic results, minimal morbidity and best outcomes of urinary continence and erection function. Potential benefits concerning side effects and complications compared to open radical prostatectomy are analysed. METHODS:Out of 450 robotic radical prostatectomie...

    journal_title:World journal of urology

    pub_type: 杂志文章,meta分析,多中心研究


    authors: Fischer B,Engel N,Fehr JL,John H

    更新日期:2008-12-01 00:00:00

  • Multiparametric ultrasound-targeted biopsy compares favorably to multiparametric MRI-transrectal ultrasound fusion-targeted biopsy on initial biopsy of men at risk for prostate cancer.

    abstract:PURPOSE:The purpose this study is to evaluate the efficacy of multiparametric ultrasound-targeted biopsies in patients undergoing initial biopsy of the prostate for the suspicion of prostate cancer. MATERIALS AND METHODS:A total of 167 patients who are biopsy naïve underwent multiparametric ultrasound-targeted biopsy ...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Fulgham PF

    更新日期:2018-05-01 00:00:00

  • Multicenter evaluation of the role of UroVysion FISH assay in surveillance of patients with bladder cancer: does FISH positivity anticipate recurrence?

    abstract:BACKGROUND:The significance of a positive UroVysion FISH assay is uncertain in patients with normal cystoscopy. This multicenter study evaluates the clinical significance of a positive FISH assay in patients with no visible tumor and excluding those with a positive cytology. METHODS:A multi-institutional, retrospectiv...

    journal_title:World journal of urology

    pub_type: 杂志文章,多中心研究


    authors: Seideman C,Canter D,Kim P,Cordon B,Weizer A,Oliva I,Rao J,Inman BA,Posch M,Herr H,Lotan Y

    更新日期:2015-09-01 00:00:00

  • Does educational printed material manage to change compliance with prostate cancer screening?

    abstract:BACKGROUND/AIM:The effects of printed educational material on cancer screening in women (Pap test and mammography) are well documented and confirmed by several studies. The aim of our study was to evaluate the impact of similar printed educational material on prostate cancer screening by PSA and DRE. MATERIAL AND METH...

    journal_title:World journal of urology

    pub_type: 杂志文章,随机对照试验


    authors: Stamatiou K,Skolarikos A,Heretis I,Papadimitriou V,Alevizos A,Ilias G,Karanasiou V,Mariolis A,Sofras F

    更新日期:2008-08-01 00:00:00

  • Efficacy of post-nephroureterectomy cisplatin-based adjuvant chemotherapy for locally advanced upper tract urothelial carcinoma: a multi-institutional retrospective study.

    abstract:PURPOSE:To evaluate the efficacy of adjuvant systemic chemotherapy for locally advanced (pT3-4pN0/xM0) upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS:We retrospectively reviewed the medical records of 109 patients with pT3-4pN0/xM0 UTUC who had undergone radical nephroureterectomy between 1996 and 2013...

    journal_title:World journal of urology

    pub_type: 杂志文章


    authors: Nakagawa T,Komemushi Y,Kawai T,Otsuka M,Miyakawa J,Uemura Y,Kanatani A,Taguchi S,Naito A,Suzuki M,Nishimatsu H,Hirano Y,Tanaka Y,Matsumoto A,Miyazaki H,Fujimura T,Fukuhara H,Kume H,Igawa Y,Homma Y

    更新日期:2017-10-01 00:00:00

  • No overt influence of lymphadenectomy on cancer-specific survival in organ-confined versus locally advanced upper urinary tract urothelial carcinoma undergoing radical nephroureterectomy: a retrospective international, multi-institutional study.

    abstract:PURPOSE:Lymph node dissection (LND) is not routinely performed during radical nephroureterectomy (RNU) in upper tract urothelial carcinomas (UTUC), and its clinical relevance is unclear. The purpose of the present study was to evaluate the impact of LND on clinical outcomes in a large multicenter series of RNU for UTUC...

    journal_title:World journal of urology

    pub_type: 杂志文章,多中心研究


    authors: Burger M,Shariat SF,Fritsche HM,Martinez-Salamanca JI,Matsumoto K,Chromecki TF,Ficarra V,Kassouf W,Seitz C,Pycha A,Tritschler S,Walton TJ,Novara G

    更新日期:2011-08-01 00:00:00

  • Improved decision making in intermediate-risk prostate cancer: a multicenter study on pathologic and oncologic outcomes after radical prostatectomy.

    abstract:BACKGROUND:Prognoses for intermediate-risk prostate cancer (PCa) remain heterogeneous. Improved substratification could optimize treatment and monitoring strategies. The objective was to validate this subclassification in a radical prostatectomy (RP) series. METHODS:Between 2000 and 2011, 4038 patients who underwent R...

    journal_title:World journal of urology

    pub_type: 杂志文章,多中心研究


    authors: Beauval JB,Ploussard G,Cabarrou B,Roumiguié M,Ouzzane A,Gas J,Goujon A,Marcq G,Mathieu R,Vincendeau S,Cathelineau X,Mongiat-Artus P,Salomon L,Soulié M,Méjean A,de La Taille A,Rouprêt M,Rozet F,Committee of Cancerology

    更新日期:2017-08-01 00:00:00