Abstract：
PURPOSE:To evaluate renal function and to identify factors associated with renal dysfunction in the elective indications setting of nephron-sparing surgery (NSS). METHODS:We retrospectively reviewed operative data and glomerular filtration rate (GFR) of 519 patients treated by NSS in an elective indications setting between 1984 and 2006 in eight academic institutions. A GFR decrease under the thresholds of 60 or 45 ml/min at last follow-up was considered a significant renal dysfunction. Univariate and multivariate regression models were used to assess multiple factors of renal function. RESULTS:Median age, tumor size, preoperative, and final GFR were 59.5 years (27-84), 2.7 cm (0.9-11), 79 (45-137), and 69 ml/min (p < 0.0001), respectively, with a median follow-up of 23 months (1-416). Hilar clamping was performed in 375 procedures (72.3 %). Significant GFR decrease was observed in 89 patients (17.1 %). Median operating time, hilar clamping duration, and blood loss were 137 min (55-350), 22 min (0-90), and 150 ml (0-4150), respectively. At univariate analysis, age (p = 0.002), preoperative GFR (p = 0.001), pedicular clamping (p = 0.01), and ischemia time (p = 0.0001) were associated with renal dysfunction. Age (p = 0.004; HR 1.2), pedicular clamping (p = 0.04; HR 1.3), and ischemia time (p = 0.0001; HR 1.8) remained independent risk factors for renal function deterioration in multivariate analysis. CONCLUSION:Non- or time-limited clamping techniques are associated with preservation of renal function in the elective indications setting of NSS.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Bessede T,Bigot P,Bernhard JC,Pignot G,Boulière F,Verhoest G,Crépel M,Salomon L,Mottet N,Bellec L,Soulié M,Ferrière JM,Pfister C,Albouy B,Pouliot F,Dujardin T,Bensalah K,Patard JJdoi
10.1007/s00345-014-1292-7subject
Has Abstractpub_date
2015-01-01 00:00:00pages
11-5issue
1eissn
0724-4983issn
1433-8726journal_volume
33pub_type
杂志文章,多中心研究abstract：:The treatment of clinically locally advanced prostate cancer (cT3-4) is subject to controversies. Patients with lymph node metastases as well as patients with overstaged localized and thus curable disease fall into this category. Radical prostatectomy, external beam radiotherapy and early or deferred hormonal therapy ...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-007-0158-7
更新日期：2007-04-01 00:00:00
abstract：:The surgical complications encountered in 478 patients who underwent primary retroperitoneal lymph-node dissection for clinical stage A and B nonseminomatous testicular cancer during the period ranging from 1982 to 1992 were reviewed. There were 54 complications in 51 patients (10.6%), and there was no surgery-related...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00192272
更新日期：1994-01-01 00:00:00
abstract：INTRODUCTION:Muscle-invasive bladder cancer (MIBC) is an aggressive disease for which treatment strategies are continuously evolving. We characterized trends in treatment modalities for MIBC from 2004 to 2013 (the "pre-immunotherapy era") and identified predictors of receiving the current standard of care treatment: ne...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2371-y
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:To introduce the detailed procedures of two innovative surgical options for pediatric buried penis and prospectively compare their efficacy and safety. METHODS:A single-center, non-randomized, prospective study was conducted at the Zhongnan Hospital of Wuhan University, where patients were operated on using...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2243-5
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:To examine phosphodiesterase type 5 (PDE5) expression in the anterior fibromuscular stroma (AFMS) of the prostate. Although PDE5 expression was identified in the human prostate, differences in PDE5 expression in intra-prostatic regions are unknown. The AFMS in the prostate has peculiar innervations that could c...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03095-1
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:Management of male infertility is always a difficult task, with pathophysiology and available treatments often poorly understood. The purpose of this review was to summarize current evidence regarding the use of protective agents against reactive oxygen species (ROS), such as antioxidants that may be useful in ...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-019-02656-3
更新日期：2019-06-01 00:00:00
abstract：:Non-gonococcal urethritis (NGU) is conventionally treated with oral antibiotics. With this Phase II study, we investigated the action of a locally disinfecting substance, Instillagel, in symptomatic NGU. Instillation treatment was performed twice daily to 32 male patients with symptomatic NGU. To evaluate the therapeu...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-001-0236-1
更新日期：2002-05-01 00:00:00
abstract：PURPOSE:Because there is a lack of evidence, it is not generally recommended to use adjuvant radiotherapy plus chemotherapy to treat lymph node disease in penile cancer. The aim of this study was to determine the benefit of using adjuvant radiotherapy after inguinal surgery for penile cancer. METHODS:Multi-institution...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03179-y
更新日期：2020-04-17 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-007-0175-6
更新日期：2007-10-01 00:00:00
abstract：:During bladder development, undifferentiated mesenchymal and epithelial cells undergo an orderly sequence of differentiation defined by the expression of smooth-muscle (alpha-actin, myosin, vinculin, desmin, vimentin, and laminin) and epithelial (cytokeratins 5, 7, 8, 14, 18 and 19) protein markers. This process requi...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00184602
更新日期：1996-01-01 00:00:00
abstract：:The aim of this cross-sectional study was to compare single with repeated high-intensity focused ultrasound (HIFU) treatment in patients with localized prostate cancer, regarding treatment-related morbidity. A number of 223 consecutive patients with localized prostate cancer were treated with HIFU. Among them, 174 (78...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-006-0107-x
更新日期：2006-11-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0759-z
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:To evaluate the role of adrenergic and nitrergic signaling on ureteric peristaltic frequency and contraction force in vivo using a large animal model. METHODS:Twelve female pigs (72 ± 4 kg) were chronically instrumented with an electronic pressure-monitoring catheter in the right ureter. Nephrostomy, cystostom...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1663-8
更新日期：2016-05-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0358-9
更新日期：2009-02-01 00:00:00
abstract：:Transcutaneous application of low-frequency electric current in the treatment of partially or temporarily denervated striated muscles is widely used to prevent or treat muscular atrophy. Due to the high regenerative capacity of smooth-muscle cells, this approach should be beneficial in the treatment of diseases with s...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00182971
更新日期：1995-01-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2074-9
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:In this study, we investigated the influence of hematuria on the performance of the bladder tumor antigen (BTA) tests in a clinical cohort and in an experimental model. MATERIALS AND METHODS:Urine samples from a cohort of 126 subjects (64 with BCa and 62 controls) were analyzed by ELISA for hemoglobin and B...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0935-9
更新日期：2012-12-01 00:00:00
abstract：INTRODUCTION:The management of the regional lymph nodes in penile cancer patients, particularly when these lymph nodes are impalpable, remains controversial. Prophylactic bilateral inguinal lymphadenectomy is associated with high morbidity and is often unnecessary. However, there is no non-invasive or minimally invasiv...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-008-0288-6
更新日期：2009-04-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-006-0069-z
更新日期：2006-06-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-03001-4
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-007-0204-5
更新日期：2007-12-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
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更新日期：2012-06-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1472-5
更新日期：2015-10-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-018-2421-5
更新日期：2019-01-01 00:00:00
abstract：PURPOSE:Cabazitaxel, a semi-synthetic taxane of the third generation, inhibits prostate cancer (PC) cell growth by affecting the microtubule architecture. Since cabazitaxel has also been demonstrated to inhibit androgen receptor (AR) functionality, AR and AR-associated heat shock protein (HSP) expressions in the presen...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2615-x
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:For the treatment of persistent post-prostatectomy incontinence (PPI), several surgical treatment options including male slings are available. In 2010, the second generation of the retrourethral male sling Advance, AdVanceXP, was introduced. Aim of the study was to examine in a prospective multicentre study the...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-015-1731-0
更新日期：2016-07-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-010-0516-8
更新日期：2010-06-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-009-0395-z
更新日期：2009-06-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-001-0242-3
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:Few studies have been conducted on the serial evaluation of predictors for recovery of urinary continence (RC) after radical prostatectomy (RP) among same cohort. We developed and validated nomograms to predict immediate (≤1), early (≤3), and late (≤12 months) RC from a contemporary series and compared each nom...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1127-y
更新日期：2014-04-01 00:00:00
