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Experimental animal model and RNA interference: a promising association for bladder cancer research.

Abstract：

:Animal models are at the centre of laboratory bladder cancer (BC) research and at the same time, the bridge to the clinic. A new and very promising therapeutical approach is to silence abnormally up-regulated genes in cancer, through small interfering RNA (siRNA) molecules. Therapeutic use and success of siRNAs will largely depend on their efficient and safe in vivo delivery and on avoiding accidental off-target effects. Intravesical siRNA is a strategy which may be the best deliver option to surperficial BC like intravesical immunotherapy. Its direct action might allow a continuous intracellular exposure to effective siRNA concentrations. While the procedure of transurethral siRNA administration is promising for BC research allowing detection of new targets in BC therapy, the optimal intravesical carrier and the best target(s) to siRNA are to be determined.

journal_name

World J Urol

journal_title

World journal of urology

authors

Reis LO,Pereira TC,Favaro WJ,Cagnon VH,Lopes-Cendes I,Ferreira U

doi

10.1007/s00345-009-0374-4

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

353-61

issue

3

eissn

0724-4983

issn

1433-8726

journal_volume

27

pub_type

杂志文章,评审

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