Donor kidney volume measured by computed tomography is a strong predictor of recipient eGFR in living donor kidney transplantation.

Abstract:

PURPOSE:The effect of living donor kidney allograft size on recipient outcomes is not well understood. In this study, we sought to investigate the relationship between preoperatively measured donor kidney volume and recipient estimated glomerular filtration rate (eGFR) in living donor kidney transplantation (LDKT). METHODS:We studied computed tomography (CT) donor kidney volumes and recipient outcomes for 438 LDKTs at the Toronto General Hospital between 2007 and 2016. Estimated glomerular filtration rate (eGFR) was calculated at 1, 3, and 6 months and a multivariable linear regression model was fitted to study the effect of donor kidney volume on recipient eGFR. RESULTS:The mean volume and weight of the donated kidneys were 157.3 (± 32.3) cc and 186.7 (± 48.7) g, respectively. Kidney volume was significantly associated with eGFR on multivariable analysis (P < 0.001). Specifically, for every 10 cc increase in kidney volume, there was a 1.68 mL/min, 1.25 mL/min and 0.97 mL/min rise in recipient eGFR at 1, 3, and 6 months, respectively. CONCLUSIONS:Donor kidney volume is a strong independent predictor of recipient eGFR in LDKT, and therefore, may be a valuable addition to predictive models of eGFR after transplant. Further research may determine if the inclusion of donor kidney volume in matching algorithms can improve recipient outcomes.

journal_name

World J Urol

journal_title

World journal of urology

authors

Al-Adra DP,Lambadaris M,Barbas A,Li Y,Selzner M,Singh SK,Famure O,Kim SJ,Ghanekar A

doi

10.1007/s00345-018-2595-x

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

1965-1972

issue

9

eissn

0724-4983

issn

1433-8726

pii

10.1007/s00345-018-2595-x

journal_volume

37

pub_type

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