Abstract：
PURPOSE:The primary objective was to evaluate the effect of autologous muscle-derived cell (AMDC) injections on the urethral sphincter morphometry compared to placebo injections. Secondary aims were to explore the reduction of stress incontinence episode frequency (IEF) and factors associated with the efficacy of AMDC. METHODS:This prospective randomized-controlled study compared the urethral sphincter volumes of participants who had received either an intra-sphincteric injection of 4 cc AMDC in injection media or 4 cc placebo solution, using a transperineal 3D/4D ultrasound at baseline and at 12 months. The reduction of stress IEF on 3-day bladder diary and potential predictors at baseline for response to AMDC were assessed. RESULTS:Fifty-eight participants were included in the study. Compared to baseline, the mean total and external sphincter volumes increased significantly in both groups (respectively, p = 0.001 and p < 0.001 in the AMDC group, p < 0.001 and p = 0.005 in the placebo group) at 12 months. Both groups showed a significant reduction of stress IEF compared to baseline (p = 0.03 and p ≤ 0.001 for AMDC and placebo groups, respectively). There were no between-group differences regarding total and external sphincter volumes and reduction of stress IEF. A longer urethral length (p ≤ 0.001) and a larger external sphincter volume (p ≤ 0.05) were significantly associated with lower stress IEF. CONCLUSION:Significant increases of sphincter volumes as well as reduction of stress IEF occurred among the AMDC and placebo injection groups with no between-group differences at 12 months. A longer urethral length and a larger external sphincter volume at baseline were identified as potential predictors of AMDC injection response.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Ismail S,Morin M,Tu LMdoi
10.1007/s00345-020-03076-4subject
Has Abstractpub_date
2020-11-01 00:00:00pages
2881-2889issue
11eissn
0724-4983issn
1433-8726pii
10.1007/s00345-020-03076-4journal_volume
38pub_type
杂志文章abstract：PURPOSE:To determine whether a delayed percutaneous nephrolithotomy (PCNL) reduces the rate of bacteremia/sepsis in patients with neuromuscular disorders. Patients with neuromuscular disorders are at higher risk of developing complications after PCNL. One strategy to reduce the risk of infectious complications is to pl...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1044-0
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:Digital low-dosage, linear slot scanning radiography (Lodox®) is an imaging modality that can emit down to one-tenth the radiation of conventional X-ray systems. We prospectively evaluated Lodox® as a diagnostic imaging modality in patients with ureterolithiasis. METHODS:Conventional kidney-ureter-bladder (KUB...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02803-w
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abstract：PURPOSE:To assess long-term clinical and oncological outcome in women undergoing radical cystectomy and ileal neobladder reconstruction for invasive bladder cancer. METHODS:From 1995 to 2010, a total of 121 women with clinically organ-confined urothelial carcinoma underwent radical cystectomy with an orthotopic ileal ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0837-x
更新日期：2012-12-01 00:00:00
abstract：:The thin mucus or glycosaminoglycan layer of the bladder may be implicated in the pathogenesis of many bladder disease states. We have developed a specific antimucus, antisera stabilization technique to study the ultrastructural morphological appearance of the layer in both normal and abnormal bladders that should pro...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00182045
更新日期：1994-01-01 00:00:00
abstract：:This paper provides an overview of the scientific and practical aspects of assessing health-related quality of life (HRQL). The paper provides a brief overview of developments in the field and then discusses the definition of HRQL. The different types of HRQL measure available to researchers are described, with specif...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050132
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVES:Androgen receptor (AR) action in benign and malignant tissue is potentiated by a number of co-regulatory proteins that may interact with one or more receptor domains. With improvement of research methodologies, it became possible to detect a number of co-activators whose expression is increased in prostate c...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-011-0797-6
更新日期：2012-06-01 00:00:00
abstract：PURPOSE:Chronic inflammation has been considered a potential risk factor for prostate cancer. Toll-like receptors (TLRs) are important in the innate immune response to pathogens and in cross talk between innate immunity and adaptive immunity. In this study, sequence variants in the TLR4 gene were investigated to determ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0690-3
更新日期：2012-04-01 00:00:00
abstract：:Familial risks for cancer are important for clinical counseling and understanding cancer etiology. The nationwide Swedish Family-Cancer Database includes all Swedes born in 1932 and later (0 to 68-year-old offspring) with their parents, totaling over 10.2 million individuals. Urological cancer cases were retrieved fro...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0375-7
更新日期：2004-02-01 00:00:00
abstract：PURPOSE:Investigate the short-term effect of sildenafil on microcirculation, especially the velocity, the pattern of the flow and the recruitment of the leukocyte in postcapillaries. METHODS:In male Sprague-Dawley rats, the microcirculatory consequences of 60 min experimental testicular torsion, followed by 240 min of...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2340-5
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:Partial nephrectomy (PN) outcomes may be better at academic institutions than at non-academic centers. Peer-review, sub-specialized practice profile, higher individual surgeon and institutional caseload may explain this observation. To the best of our knowledge, the role of institutional academic affiliation ha...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0759-z
更新日期：2012-08-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0682-3
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:Prostate cancer (PCa) is the most common malignancy in men and the cause for the second most common cancer-related death in the western world. Despite ongoing development of novel approaches such as second generation androgen receptor targeted therapies, metastatic disease is still fatal. In PCa, immunotherapy ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03497-1
更新日期：2020-10-26 00:00:00
abstract：OBJECTIVES:It has been reported that apoptosis of penile erectile tissue occurs after penile denervation, castration, and diabetes mellitus in animal studies. Aim of this study was to investigate apoptosis in corpora cavernosa of patients with organic erectile dysfunction (ED). METHODS:Cavernous biopsies were obtained...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0332-6
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:To assess the performance of EAU risk classification in PCa patients according to the biopsy pathway (standard versus MRI guided) and to develop a new, more accurate, targeted biopsy (TB)-based classification. MATERIALS AND METHODS:We included 1345 patients consecutively operated by radical prostatectomy (RP) ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-03053-6
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:To introduce the detailed procedures of two innovative surgical options for pediatric buried penis and prospectively compare their efficacy and safety. METHODS:A single-center, non-randomized, prospective study was conducted at the Zhongnan Hospital of Wuhan University, where patients were operated on using...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2243-5
更新日期：2018-08-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00184246
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:Living donor nephrectomy is a high-stake procedure involving healthy individuals, therefore every effort should be made to define each patient's individualized risk and improve potential donors' information. The aim of this study was to evaluate the interest of the Mayo adhesive probability (MAP) score, an imag...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03513-4
更新日期：2020-11-11 00:00:00
abstract：OBJECTIVE:Radiation for tumors arising in the pelvis has been utilized for over a 100 years. Adverse effects (AEs) of radiotherapy (RT) continue to accumulate with time and are reported to show decades after treatment. The benefit of RT for pelvic tumors is well described as is their acute AEs. Late AEs are less well d...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-010-0603-x
更新日期：2011-02-01 00:00:00
abstract：PURPOSE:Holmium laser enucleation of the prostate (HoLEP) has become a popular alternative to TURP for desobstructive prostate surgery. The prevalence of incidental prostate cancer (iPCa) during surgery varies depending on many preoperative factors. To evaluate whether the surgical procedure itself (HoLEP vs. TURP) inf...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2353-0
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:The perioperative and oncological outcomes of laparoscopic radical nephrectomy (LRN) for T1-T2 renal cell carcinoma (RCC) are well established. We aim to determine whether LRN is a comparable alternative to open radical nephrectomy (ORN) in the treatment of T3 RCC using a matched pair analysis study design. ME...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1280-y
更新日期：2015-01-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-006-0063-5
更新日期：2006-09-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-007-0208-1
更新日期：2007-12-01 00:00:00
abstract：INTRODUCTION:The management of the regional lymph nodes in penile cancer patients, particularly when these lymph nodes are impalpable, remains controversial. Prophylactic bilateral inguinal lymphadenectomy is associated with high morbidity and is often unnecessary. However, there is no non-invasive or minimally invasiv...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-008-0288-6
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:Urethroplasty is the most effective treatment method for anterior urethral strictures, which constitute an important health concern for males. This study aims to investigate factors that may predict treatment failure following urethroplasty for anterior urethral strictures and evaluate outcomes of different ure...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-03014-z
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:Often PIRADS 3 findings are usually followed up with further MRIs of the prostate. Current guidelines do not state an optimal interval between the initial MRI and the follow-up MRI. The aim of this study was to find out if PIRADS 3 lesions evolve over time and to determine how long the optimal interval between ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2135-0
更新日期：2018-03-01 00:00:00
abstract：INTRODUCTION:Currently, osteoporosis research is rarely undertaken in males but an increase in male life expectancy in the company of hypogonadism suggests the necessity for potential therapeutic options. MATERIALS AND METHODS:In this study, the changes in bone structure under standardized testosterone- (T), raloxifen...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0373-5
更新日期：2009-08-01 00:00:00
abstract：:In 90 patients treated with laser prostatectomy using the Urolase (n = 50) or Ultraline (n = 40) laser fiber, the fiber-tip durability was investigated. In general the Urolase fiber tips were less damaged than the Ultraline fiber tips. At visual inspection, 62% of the Urolase fiber tips were graded as minimally damage...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00183619
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVES:To evaluate the impact of age, stone size, location, radiolucency, extraction of stone fragments, size of ureteroscope and presence and degree of hydronephrosis on the efficacy and safety of holmium:YAG (Ho:YAG) laser lithotripsy in the ureteroscopic treatment of ureteral stones in children. METHODS:Between...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1152-x
更新日期：2014-08-01 00:00:00
abstract：:Contemporary literature regarding the management of neobladder-vaginal fistula and stress urinary incontinence following radical cystectomy and neobladder reconstruction in women is reviewed in this article. Neobladder-vaginal fistula is uncommon but mandates meticulous repair. Compared to the native bladder, the wall...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-005-0013-7
更新日期：2005-09-01 00:00:00
abstract：OBJECTIVE:It has been hypothesized that endothelial dysfunction and pelvic atherosclerosis may contribute to lower urinary tract symptoms (LUTS). We assessed the relationship between cardiovascular risk factors and LUTS severity in male patients presented to urology clinic. METHODS:It is a cross-sectional study on pat...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2432-2
更新日期：2019-04-01 00:00:00
