Abstract：
PURPOSE:The perioperative and oncological outcomes of laparoscopic radical nephrectomy (LRN) for T1-T2 renal cell carcinoma (RCC) are well established. We aim to determine whether LRN is a comparable alternative to open radical nephrectomy (ORN) in the treatment of T3 RCC using a matched pair analysis study design. METHODS:A review of a prospectively collected database at the Western General Hospital, Edinburgh, between 2000 and 2011 was conducted. Patient pairs were matched based on age at operation, gender, histological subgroup, maximal tumour diameter, TNM stage and grade. Patient demographics, operative and post-operative outcomes were compared. Overall, cancer-specific and progression-free survival [overall survival, cancer-specific survival (CSS) and progression-free survival (PFS)] were estimated using the Kaplan-Meier method. RESULTS:From 252 patients with T3 disease, 25 pairs were matched. Patients were of median age 66.2 years, 64 % male. Tumours were all clear cell RCC, were stage pT3a (32 %) or pT3b and had maximal tumour diameters of 8.7 cm for LRN and 10.0 cm for ORN. Estimated blood loss (100 ml LRN; 650 ml ORN, p < 0.001) and length of post-operative hospital stay (4 days LRN: 9 days ORN, p < 0.001) were lower in the LRN group. Operation time and post-operative complication rates were comparable. CSS and PFS were comparable with a mean CSS of 91.3 months for LRN and 88.7 months for ORN. CONCLUSION:This study reports the longest median follow-up in a T3 LRN cohort. In matched patients, LRN has been shown to have a superior perioperative profile to ORN for the treatment of pT3a/b RCC, with no adverse effect on midterm oncological outcomes.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Laird A,Choy KC,Delaney H,Cutress ML,O'Connor KM,Tolley DA,McNeill SA,Stewart GD,Riddick ACdoi
10.1007/s00345-014-1280-ysubject
Has Abstractpub_date
2015-01-01 00:00:00pages
25-32issue
1eissn
0724-4983issn
1433-8726journal_volume
33pub_type
杂志文章abstract：PURPOSE:Radical cystectomy (RC) can be associated with significant blood loss. Allogenic blood transfusion (ABT) may alter disease outcome because of a theoretical immunomodulatory effect. We evaluated the effects of ABT on overall survival (OS) and progression-free survival (PFS) of patients undergoing RC for urotheli...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1257-x
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:Several disease characteristics have been identified as potential predictors for pathological node involvement (pN+) following radical cystectomy (RC). However, these have not been assessed in patients treated with neoadjuvant chemotherapy (NAC). We endeavored to assess factors predicting adverse pathology in c...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-015-1667-4
更新日期：2016-05-01 00:00:00
abstract：:The field of tissue engineering has developed in phases: initially researchers searched for "inert" biomaterials to act solely as replacement structures in the body. Then, they explored biodegradable scaffolds--both naturally derived and synthetic--for the temporary support of growing tissues. Now, a third phase of ti...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-008-0273-0
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:Investigate the short-term effect of sildenafil on microcirculation, especially the velocity, the pattern of the flow and the recruitment of the leukocyte in postcapillaries. METHODS:In male Sprague-Dawley rats, the microcirculatory consequences of 60 min experimental testicular torsion, followed by 240 min of...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2340-5
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:To evaluate the benefit of an antimicrobial prophylaxis protocol using rectal swab cultures in patients undergoing transrectal ultrasound (TRUS)-guided prostate biopsy in our Veterans Affairs population. METHODS:Between June 1, 2013, and June 1, 2014, we implemented an antimicrobial prophylaxis protocol using ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1571-y
更新日期：2015-12-01 00:00:00
abstract：:A review of the current literature is conducted to explore the developmental aspects, animal and human experiences and the effects of pharmacological manipulation to explain the role androgens play in sexual function with special emphasis on erectile function and the erectile tissue. This review reveals that androgens...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF01275152
更新日期：1997-01-01 00:00:00
abstract：INTRODUCTION:Changes in the management of minimally invasive oncologic renal surgery have introduced ablative therapies as the most recent advancement in minimally invasive technology. METHODS:The current evidence-based medicine on the topic of laparoscopic (LCA) and percutaneous (PCA) renal cryoablation was gathered ...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-010-0552-4
更新日期：2010-10-01 00:00:00
abstract：:Vesicoureteral reflux (VUR) represents one of the most significant risk factors for acute pyelonephritis in children. The current indications for the surgical correction of VUR depend on the presence or absence of renal scars. If no scars are present, primary ureteral reimplantation is only indicated in high-grade bil...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-004-0408-x
更新日期：2004-06-01 00:00:00
abstract：PURPOSE:To review the etiology and pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS:A literature review for the years 1985-2012 was performed using the MEDLINE database of the United States National Library of Medicine. RESULTS:The evidence for ongoing infection in men with CP/CPPS ...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-013-1061-z
更新日期：2013-08-01 00:00:00
abstract：INTRODUCTION:Natural orifice transluminal endoscopic surgery (NOTES) and laparoendoscopic single-site surgery (LESS) are the next steps in the evolution of laparoscopic surgery, promising reduced morbidity and improved cosmetic result. The inconsistent terminology initially used led to confusion. Understanding the tech...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-012-0899-9
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:Treatment options for antimuscarinic refractory neurogenic detrusor overactivity (NDO) are botulinum toxin type A injections (BTX-A) and augmentation cystoplasty (AC). We estimated initial and cumulative 5-year costs of these treatments. MATERIALS AND METHODS:Base case is an individual with antimuscarinic refr...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0618-3
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate the factors affecting the lower urinary tract symptoms (LUTS) related quality of life (QoL) score. METHODS:This retrospective study analyzed 29,123 men who underwent health check-ups from January 2007 to July 2011 at a single institution. Those patients who completed th...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2052-2
更新日期：2017-11-01 00:00:00
abstract：PURPOSE:Testicular torsion is the most concerning underlying cause of acute scrotal pain that can lead to loss of the affected testicle. Whether a torted testicle can be salvaged surgically is directly affected by prompt presentation and diagnosis. This study aims to evaluate the awareness of testicular torsion amongst...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2269-8
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Making healthcare treatment decisions is a complex process involving a broad stakeholder base including patients, their families, health professionals, clinical practice guideline developers and funders of healthcare. METHODS:This paper presents a review of a methodology for the development of urological ca...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-011-0660-9
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVES:Monopolar transurethral resection of the prostate (TURP) is the gold standard surgical treatment for bothersome moderate to severe lower urinary tract symptoms (LUTS) secondary to benign prostate obstruction. The aim of the study is to compare monopolar versus bipolar TURP focusing on operative and functiona...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-017-2023-7
更新日期：2017-10-01 00:00:00
abstract：:The development of human benign prostatic hyperplasia (BPH) clearly requires a combination of testicular androgens and the ageing process. Although the role of androgens as the causative factor for human benign prostatic hyperplasia is debated, they undoubtedly play, at least, a permissive role. The principal prostati...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-002-0248-5
更新日期：2002-04-01 00:00:00
abstract：OBJECTIVES:Nocturia is prevalent and bothersome in men with lower urinary tract symptoms suggestive of BPH (LUTS/BPH). α-Adrenoceptor antagonists without subtype selectivity have inconsistently shown significant effects on nocturia in these patients. We explored the effects of the α1A-adrenoceptor subtype-selective ant...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-013-1228-7
更新日期：2014-10-01 00:00:00
abstract：OBJECTIVES:Adjuvant chemotherapy (ACT) is recommended for non-organ-confined bladder cancer (BCa) after radical cystectomy (RC) and pelvic lymph node dissection (PLND), but there are sparse data regarding its specific efficacy in patients with histological variants. The aim of our study was to evaluate the role of ACT ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03362-1
更新日期：2020-07-25 00:00:00
abstract：:We are fortunate that our ability to diagnose the specific adrenal entities that mandate a surgical approach is extremely accurate. The combination of analytical methodology to measure the appropriate adrenocortical and medullary hormone production and the radiology techniques for localization are superb. The manageme...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050103
更新日期：1999-02-01 00:00:00
abstract：:The prostatitis syndrome is commonly found in urologic practice and is classified according to the NIDDK/NIH, in which bacterial prostatitis (acute and chronic) is distinguished from chronic pelvic pain syndrome (CPPS). In acute bacterial prostatitis (NIH category I), antibiotic treatment is mandatory and successful i...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-003-0333-4
更新日期：2003-06-01 00:00:00
abstract：PURPOSE:Few studies have been conducted on the serial evaluation of predictors for recovery of urinary continence (RC) after radical prostatectomy (RP) among same cohort. We developed and validated nomograms to predict immediate (≤1), early (≤3), and late (≤12 months) RC from a contemporary series and compared each nom...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1127-y
更新日期：2014-04-01 00:00:00
abstract：:We prospectively compared, within the same center and during the same period of time, the perioperative parameters as well as the oncological and functional results of both open retropubic (ORP) and laparoscopic radical prostatectomy (LRP). From September 1999 to September 2001, 162 patients with prostate cancer were ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-002-0306-z
更新日期：2003-05-01 00:00:00
abstract：PURPOSE:Although the role of lymph node dissection (LND) is well defined in many urological settings, uncertainty regarding need for LND still exists for patients with renal cell carcinoma (RCC). The aim of the current review is to highlight the rationale for performing or omitting LND at the time of renal surgery. ME...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-016-1886-3
更新日期：2017-04-01 00:00:00
abstract：PURPOSE:To analyze and compare preoperative patient characteristics and postoperative results in men with stress urinary incontinence (SUI) selected for an adjustable male sling system or an artificial urinary sphincter (AUS) in a large, contemporary, multi-institutional patient cohort. METHODS:658 male patients who u...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2523-0
更新日期：2019-07-01 00:00:00
abstract：PURPOSE:To evaluate the opinion of urologists and their audience regarding patient safety and educational value of live surgical demonstrations (LSD) and semi-live surgical demonstrations (semi-LSD). METHODS:Following the '2017 Challenges in Endourology' meeting, a survey addressing patient safety and the educational ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2291-x
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:This study aims to determine whether intra-network and inter-network brain connectivities are altered using an independent component analysis (ICA). METHODS:Resting-state functional MRI (rs-fMRI) data were acquired from 26 patients with OAB and 28 healthy controls (HC). Eleven resting-state networks (RSNs) wer...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02838-z
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:To assess the pathological and the oncologic outcomes of the prostate cancer (PCa) missed by 6- and 12-core biopsy protocols by using a reference 21-core scheme. MATERIALS AND METHODS:Between 2001 and 2009, all patients who had PCa detected in an initial 21-core TRUS biopsy scheme and were treated by a radical...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0800-2
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:To investigate the association between overactive bladder (OAB) and coronary artery disease (CAD) as demonstrated on coronary angiography in patients > 65 years. METHODS:The patients who were > 65 years completed an OAB-V8 form before undergoing coronary angiography at a tertiary care hospital. The presence of...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2098-1
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:Bladder cancer (BC) has the highest lifetime treatment costs per patient of all cancers. The high recurrence rate and ongoing invasive monitoring requirement are the key contributors to the economic and human toll of this disease. The purpose of this paper was to utilize the recent literature to identify oppo...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-009-0395-z
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:We sought whether serum total testosterone (tT), estradiol (E2), tT/E2 ratio, and sex hormone-binding globulin (SHBG) significantly fluctuate throughout time in men with prostate cancer (PCa). METHODS:Circulating hormones were measured in a cohort of 631 candidates for radical prostatectomy. Hormone levels wer...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-1009-8
更新日期：2013-04-01 00:00:00
