Abstract:
PURPOSE:Radical cystectomy (RC) can be associated with significant blood loss. Allogenic blood transfusion (ABT) may alter disease outcome because of a theoretical immunomodulatory effect. We evaluated the effects of ABT on overall survival (OS) and progression-free survival (PFS) of patients undergoing RC for urothelial carcinoma of the bladder (UCB). MATERIALS AND METHODS:This is a retrospective single-center study of 350 consecutive patients of a university health center with a median follow-up of 70.1 month. All patients underwent RC and pelvic lymph node dissection. The effect of ABT on OS and PFS was analyzed using univariable and multivariable Cox proportional hazards models. RESULTS:The overall ABT rate was 63 % (n = 219), with intraoperative blood transfusion and postoperative blood transfusion being performed in 183 patients (52 %) and 99 patients (28 %), respectively. Preoperative anemia was detected in 156 patients (45 %) with median estimated blood loss of 800 ml (IQR: 500-1,200). ABT was associated with significant decrease of OS and PFS in multivariable analyses (p < 0.001), whereas patients' prognosis worsened the more packed red blood cells (PRBC) were transfused (p < 0.001). The study is limited in part due to its retrospective design. CONCLUSIONS:We found that ABT and the number of PRBC transfused are associated with poor prognosis for UCB patients undergoing RC, whereas preoperative anemia had no influence on survival. This emphasizes the importance of surgeon's awareness for a strict indication for ABT. A prospective study will be necessary to evaluate the independent risks associated with ABT during surgical treatments.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Gierth M,Aziz A,Fritsche HM,Burger M,Otto W,Zeman F,Pawlik MT,Hansen E,May M,Denzinger Sdoi
10.1007/s00345-014-1257-xsubject
Has Abstractpub_date
2014-12-01 00:00:00pages
1447-53issue
6eissn
0724-4983issn
1433-8726journal_volume
32pub_type
杂志文章abstract:PURPOSE:Assess knowledge and awareness concerning human papillomavirus (HPV) infection, HPV-associated diseases, and the existence of a specific vaccine among non-HPV-screened Caucasian-European adults after the market introduction of HPV vaccines. METHODS:A cohort of 934 consecutive patients seeking their first medic...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1379-1
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:Adjuvant chemotherapy (ACT) is recommended for non-organ-confined bladder cancer (BCa) after radical cystectomy (RC) and pelvic lymph node dissection (PLND), but there are sparse data regarding its specific efficacy in patients with histological variants. The aim of our study was to evaluate the role of ACT ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03362-1
更新日期:2020-07-25 00:00:00
abstract::Many human tumors such as bladder carcinoma that are initially responsive to chemotherapy eventually fail to respond to treatment. For most drugs, dose escalation that may be required for a cure cannot be achieved because sensitive tissues such as bone marrow limit cytotoxic therapy. Approaches to prevent or circumven...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/BF00184246
更新日期:1994-01-01 00:00:00
abstract::Our objectives were to ascertain the tolerability and efficacy of trospium chloride in doses of 20 mg twice daily for long-term therapy (52 weeks) in patients with urge syndrome. The trial comprised a total of 358 patients with urge syndrome or urge incontinence. After randomisation in the ratio of 3:1, participants w...
journal_title:World journal of urology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s00345-003-0321-8
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:To explore whether patients undergoing radical prostatectomy at a German Cancer Society (DKG: Deutsche Krebsgesellschaft) certified center (CC) have superior functional and surgical outcomes compared to patients undergoing radical prostatectomy at a non-certified hospital (nCC). METHODS:A retrospective cohort ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03411-9
更新日期:2020-08-26 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-014-1308-3
更新日期:2015-03-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
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更新日期:2018-09-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
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更新日期:2015-09-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,meta分析
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更新日期:2020-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-11-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,meta分析
doi:10.1007/s00345-019-02729-3
更新日期:2019-12-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:2020-05-19 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-011-0822-9
更新日期:2012-04-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/BF00184602
更新日期:1996-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-019-02742-6
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To evaluate the thermal effect of Ho:YAG laser lithotripsy in a standardized in vitro model via real-time temperature measurement. METHODS:Our model comprised a 20 ml test tube simulating the renal pelvis that was immersed in a 37 °C water bath. Two different laser fibers [FlexiFib (15-45 W), RigiFib 1000 (45-...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2303-x
更新日期:2018-09-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-009-0386-0
更新日期:2009-10-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-008-0339-z
更新日期:2009-02-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-008-0332-6
更新日期:2009-04-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1007/s00345-008-0287-7
更新日期:2008-12-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03559-4
更新日期:2021-01-04 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1152-x
更新日期:2014-08-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03229-5
更新日期:2020-05-05 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1099-y
更新日期:2014-06-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-009-0487-9
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Different methods for induction and monitoring of urethral sphincter deficiency were explored in a large animal model. METHODS:Sphincter deficiency was established in female pigs by dilatation and cauterization, and amount and frequencies of voiding were monitored and explored by pad test. Sphincteric closu...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2088-3
更新日期:2017-12-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-008-0320-x
更新日期:2009-02-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03268-y
更新日期:2020-05-24 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-014-1369-3
更新日期:2015-02-01 00:00:00