Abstract:
OBJECTIVES:Adjuvant chemotherapy (ACT) is recommended for non-organ-confined bladder cancer (BCa) after radical cystectomy (RC) and pelvic lymph node dissection (PLND), but there are sparse data regarding its specific efficacy in patients with histological variants. The aim of our study was to evaluate the role of ACT on survival outcomes in patients with variant histology in a large multicenter cohort. MATERIALS AND METHODS:We retrospectively evaluated data of 3963 patients with BCa treated with RC and bilateral PLND with curative intent at several institutions between 1999 and 2018. The histological type was classified into six groups: pure urothelial carcinoma (PUC) or squamous, sarcomatoid, micropapillary, glandular and neuroendocrine differentiation. Multivariable competing risk analysis was applied to assess the role of ACT on recurrence and cancer-specific mortality (CSM) in each histological subtype. RESULTS:Of the 3963 patients included in the study, 23% had variant histology at RC specimen and 723 (18%) patients received ACT. ACT was found to be significantly associated with reduced risk of recurrence (sub-hazard ratio [SHR]: 0.55, confidence interval [CI] 0.42-0.71, p < 0.001) and CSM (SHR: 0.58, CI 0.44-0.78, p < 0.001) in the PUC only, while no histological subtype received a significant benefit on survival outcomes (all p > 0.05) from administration of ACT. The limitation of the study includes the retrospective design, the lack of a central pathology review and the number of ACT cycles. CONCLUSION:In our study, the administration of ACT was associated with improved survival outcomes in PUC only. No histological subtype found a benefit in overall recurrence and CSM from ACT.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Zamboni S,Afferi L,Soria F,Aziz A,Abufaraj M,Poyet C,Necchi A,D'Andrea D,Simone G,Ferriero M,Di Trapani E,Simeone C,Antonelli A,Gallina A,Montorsi F,Briganti A,Colombo R,Gandaglia G,Mattei A,Baumeister P,Mordasinidoi
10.1007/s00345-020-03362-1subject
Has Abstractpub_date
2020-07-25 00:00:00eissn
0724-4983issn
1433-8726pii
10.1007/s00345-020-03362-1pub_type
杂志文章abstract:PURPOSE:Urethroplasty is the most effective treatment method for anterior urethral strictures, which constitute an important health concern for males. This study aims to investigate factors that may predict treatment failure following urethroplasty for anterior urethral strictures and evaluate outcomes of different ure...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-03014-z
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:Management of male infertility is always a difficult task, with pathophysiology and available treatments often poorly understood. The purpose of this review was to summarize current evidence regarding the use of protective agents against reactive oxygen species (ROS), such as antioxidants that may be useful in ...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-019-02656-3
更新日期:2019-06-01 00:00:00
abstract::The physiological role of dehydroepiandrosterone (DHEA) and DHEA sulphate (DHEAS) is poorly understood. It depends in a large part on their transformation into testosterone and estradiol. The capacity of DHEA as a neurosteroid, the recent discovery of putative specific DHEA receptors on endothelial and vascular smooth...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-003-0367-7
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:To investigate the association between overactive bladder (OAB) and coronary artery disease (CAD) as demonstrated on coronary angiography in patients > 65 years. METHODS:The patients who were > 65 years completed an OAB-V8 form before undergoing coronary angiography at a tertiary care hospital. The presence of...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2098-1
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To assess the performance of EAU risk classification in PCa patients according to the biopsy pathway (standard versus MRI guided) and to develop a new, more accurate, targeted biopsy (TB)-based classification. MATERIALS AND METHODS:We included 1345 patients consecutively operated by radical prostatectomy (RP) ...
journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2106-5
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Oxidative stress is believed to be one of the important etiologies in carcinogenesis that has not been systemically investigated in urothelial carcinoma (UC). Through data mining from a published transcriptomic database of UC of urinary bladders (UBUCs) (GSE31684), glutathione peroxidase 2 (GPX2) was identified...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1522-7
更新日期:2015-11-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1127-y
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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abstract:PURPOSE:To investigate Occult Stress Urinary Incontinence (OSUI) using physical exam (PE) and urodynamics (UDS) in women with advanced pelvic organ prolapse (POP), and compare the two methods. METHODS:This study comprised 105 women with POP stage-III and -IV, according to POP quantification (POP-Q) system, evaluated p...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2366-8
更新日期:2019-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-008-0361-1
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:Patients with end-stage renal disease (ESRD) have an increased risk of developing renal cell carcinoma (RCC). This retrospective study compared clinical and pathological outcomes of RCC occurring in native kidneys of patients with ESRD (whether they underwent kidney transplantation or not) with those of renal t...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1248-y
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:We aim to evaluate prostate-specific antigen (PSA) trends in post-primary focal cryotherapy (PFC) patients. MATERIALS AND METHODS:This was an institutional review board-approved retrospective study of PFC patients from 2010 to 2015. Patients with at least one post-PFC PSA were included in the study. Biochemica...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2130-5
更新日期:2018-02-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-016-1850-2
更新日期:2017-01-01 00:00:00
abstract::Telemedicine is the use of communication technologies to deliver health care. Telesurgical telementoring represents an advanced form of telemedicine, whereby an experienced surgeon can guide and teach practicing surgeons new operative techniques utilizing current video technology, medical robots, and high-band-width t...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s003450050082
更新日期:1998-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03133-y
更新日期:2020-12-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2479-0
更新日期:2019-06-01 00:00:00
abstract::The 30-45% failure rate after radical cystoprostatectomy mandates that we explore and optimize multimodal therapy to achieve better disease control in these patients. Cisplatin-based multi-agent combination chemotherapy has been used with success in metastatic disease and has therefore also been introduced in patients...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-006-0113-z
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2052-2
更新日期:2017-11-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/BF00184243
更新日期:1994-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-007-0206-3
更新日期:2007-10-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2405-5
更新日期:2019-03-01 00:00:00
abstract:INTRODUCTION:The management of the regional lymph nodes in penile cancer patients, particularly when these lymph nodes are impalpable, remains controversial. Prophylactic bilateral inguinal lymphadenectomy is associated with high morbidity and is often unnecessary. However, there is no non-invasive or minimally invasiv...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-008-0288-6
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:To evaluate for the first time the prognostic significance of female invasive patterns in stage pT4a urothelial carcinoma of the bladder in a large series of women undergoing anterior pelvic exenteration. PATIENTS AND METHODS:Our series comprised of 92 female patients in total of whom 87 with known invasion pa...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-014-1308-3
更新日期:2015-03-01 00:00:00
abstract::This is the first reported use of low-angle X-ray scattering for the investigation of urinary calculi. Low-angle X-ray scattering (LAXS) measures the diffraction of a broad spectrum of X-rays at a single angle and uses a conventional diagnostic X-ray beam, and could thus be developed for use in vivo. A total of 45 cal...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF00182064
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:Urinary cytology (C) and cystoscopy remain the gold standard for the detection and screening of bladder cancer (BC). In this prospective study, we analyzed whether baseline C, ImmunoCyt (I), BTA Stat (B), hemoglobin dipstick (H), and NMP22 BladderChek (N) can predict recurrence and progression. METHODS:Urinary...
journal_title:World journal of urology
pub_type: 临床试验,杂志文章
doi:10.1007/s00345-016-1795-5
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:To compare prospectively early outcome and complications of catheter removal after robot-assisted radical prostatectomy (RARP) on the 4th or 7th day with a standardized running barbed suture technique. INTRODUCTION:The time point of removing the indwelling catheter after RARP mainly depends on institute's/su...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-03001-4
更新日期:2020-09-01 00:00:00