Abstract：
PURPOSE:To review the etiology and pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS:A literature review for the years 1985-2012 was performed using the MEDLINE database of the United States National Library of Medicine. RESULTS:The evidence for ongoing infection in men with CP/CPPS is lacking. However, men with CP/CPPS are twice as likely to have had a sexually transmitted disease (STD), and bacteria from men with CP/CPPS may be phenotypically different from those that cause cystitis or acute prostatitis. Evidence continues to support an alteration in both the afferent and efferent autonomic nervous systems. Functional brain imaging suggests changes in the gray matter as well as the importance of the anterior insula and anterior cingulated gyrus in pain processing. Neural function can be modulated by immune and endocrine factors. Alterations in cytokine function and autoimmunity appear to play a role in the immune dysfunction. Alterations in the hypothalamic-pituitary-adrenal axis can mediate the endocrine effects, similar to many other chronic pain conditions. Genetics may play a role in who may develop chronic pain after an initial insult. Finally, any biological changes must then be processed through the psychosocial environment, including the tendency to catastrophize, and degree of spousal support, to produce a given individual patient's pain experience. CONCLUSIONS:Infection with atypical bacteria or sequelae of an STD may lead to CP/CPPS in some men. Such a biological insult in the context of alterations in psychoimmunoneurendocrine factors produces the chronic pain experience.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Pontari MAdoi
10.1007/s00345-013-1061-zsubject
Has Abstractpub_date
2013-08-01 00:00:00pages
725-32issue
4eissn
0724-4983issn
1433-8726journal_volume
31pub_type
杂志文章,评审abstract：PURPOSE:To test the hypothesis that cytoreductive nephrectomy (CN) improves overall survival (OS) of patients with synchronous metastatic renal cell carcinoma (mRCC), who subsequently receive targeted therapies (TT). METHODS:We identified 261 patients who received TT for synchronous mRCC with or without prior CN. To a...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2154-x
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:The significance of a positive UroVysion FISH assay is uncertain in patients with normal cystoscopy. This multicenter study evaluates the clinical significance of a positive FISH assay in patients with no visible tumor and excluding those with a positive cytology. METHODS:A multi-institutional, retrospectiv...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-014-1452-9
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:To characterize the clinical and pathologic staging of patients with urothelial carcinoma (UC) in bladder diverticula (BD) after undergoing radical cystectomy (RC) and determine the impact of UCBD on recurrence and survival. METHODS:We reviewed our institutional database of patients who underwent RC for UC (19...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1472-5
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVES:Bladder perforation is the second most common complication during transurethral resection of bladder tumours. It is unknown whether perforation affects the natural history of the tumour through cell seeding. The aim of this study was to study the impact of perforation on the oncologic outcomes of bladder car...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1197-x
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:To compare serial changes of postoperative storage symptoms between PVP and HoLEP, and to identify the predictors influencing postoperative improvement of storage symptoms. METHODS:A total of 486 men (PVP group: 213 cases; HoLEP group: 273 cases), in whom 12-month follow-up data were available, were included i...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1424-0
更新日期：2015-08-01 00:00:00
abstract：:In this prospective study a comparison of 4-versus 7-MHz transrectal ultrasonography for the detection of prostatic carcinoma is reported. A total of 150 prostates were biopsied due to suspicion of malignancy arising at either digital rectal examination, 4- and/or 7-MHz transrectal ultrasonography, or elevated serum p...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00182174
更新日期：1993-01-01 00:00:00
abstract：:Successful management of transitional-cell carcinoma of the urinary bladder is greatly dependent upon regular surveillance and early detection of persistent or recurrent carcinoma. The development of a highly sensitive urinary test for the detection of transitional-cell carcinoma of the bladder could have a dramatic i...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF02201981
更新日期：1997-01-01 00:00:00
abstract：:Radical cystectomy with pelvic lymph node dissection has been accepted as the standard treatment for muscle-invasive bladder cancer. Radiation therapy and chemotherapy are increasingly being implemented in bladder-preservation protocols to provide an alternative treatment to cystectomy. We review experience with radia...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-002-0276-1
更新日期：2002-08-01 00:00:00
abstract：PURPOSE:Neurogenic bladder due to spinal cord injury has significant consequences for patients' health and quality of life. Regular surveillance is required to assess the status of the upper and lower urinary lower urinary tracts and prevent their deterioration. In this review, we examine surveillance techniques in neu...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-018-2345-0
更新日期：2018-10-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-003-0367-7
更新日期：2003-11-01 00:00:00
abstract：OBJECTIVES:Objective characterization of renal mass anatomy facilitates treatment selection and prediction of surgical outcomes. We investigated R.E.N.A.L nephrometry score (NS) efficacy in predicting outcomes after minimally invasive nephron-sparing surgery (MINSS). METHODS:A total of 250 patients with 252 renal mass...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0876-3
更新日期：2013-10-01 00:00:00
abstract：:We report on 208 patients with locally advanced renal-cell carcinoma who received a surgical adjuvant vaccination with autologous, Newcastle disease virus (NDV)-modified, and lethally irradiated tumor cells in combination with low-dose recombinant interleukin-2 and interferon-alpha. The pathological stage was defined ...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00184874
更新日期：1995-01-01 00:00:00
abstract：:Urinary tract infection (UTI) remains the most common type of infection contracted by kidney transplant patients. UTI reduces both patient and graft survival. Understanding and managing UTI in transplant patients requires an appreciation of their unique anatomy and physiology. Both the transplant and native urinary sy...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-019-02742-6
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:It has been reported that apoptosis of penile erectile tissue occurs after penile denervation, castration, and diabetes mellitus in animal studies. Aim of this study was to investigate apoptosis in corpora cavernosa of patients with organic erectile dysfunction (ED). METHODS:Cavernous biopsies were obtained...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0332-6
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:To report survival outcomes of patients treated surgically for sarcomatoid-variant renal cell carcinomas (sRCC) and to assess whether the underlying histologic subtype is an independent predictor of outcome. METHODS:One hundred and fifty-one patients underwent surgery at a referral center between 1991 and 2014...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1644-y
更新日期：2016-04-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-020-03385-8
更新日期：2020-07-30 00:00:00
abstract：OBJECTIVES:Androgen receptor (AR) action in benign and malignant tissue is potentiated by a number of co-regulatory proteins that may interact with one or more receptor domains. With improvement of research methodologies, it became possible to detect a number of co-activators whose expression is increased in prostate c...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-011-0797-6
更新日期：2012-06-01 00:00:00
abstract：:Can urolithiasis start as an intratubular event? Under severe hyperoxaluric conditions in animal models at least crystal formation can. Recently models have been presented that assess the chances of crystal formation under more normal conditions. These models describe changes in fluid composition as this passes throug...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF01367659
更新日期：1997-01-01 00:00:00
abstract：PURPOSE:The aim of the study is to evaluate the impact of having a nadir and persistently detectable ultrasensitive prostate-specific antigen (uPSA) between 0.01 and 0.1 ng/ml post-robot-assisted radical prostatectomy (RARP), on future biochemical recurrence (BCR). METHODS:We conducted a retrospective analysis of a pr...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03367-w
更新日期：2020-07-21 00:00:00
abstract：BACKGROUND:The anti-androgen withdrawal syndrome (AAWS) can be seen in one-third of patients after discontinuation of first-generation non-steroidal anti-androgen therapy. With the introduction of new agents for anti-androgen therapy as well as alternate mechanisms of action, new therapeutic options before and after do...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-014-1288-3
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:The aim of this study was to assess the impact of experience on the outcome of image fusion-guided prostate biopsies performed by urologists working at a high-volume medical center. METHODS:The first 210 consecutive fusion biopsies were analyzed following installation of the software-based biopsy platform Arte...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2605-z
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Asymptomatic bacteriuria is common in diabetic women. Treatment of asymptomatic bacteriuria is not beneficial, but the natural history of the microbiology of asymptomatic bacteriuria has not been well described. OBJECTIVE:To describe the microbiological outcomes of bacteriuria in diabetic women with untreat...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-005-0042-2
更新日期：2006-02-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-012-0904-3
更新日期：2013-10-01 00:00:00
abstract：:Animal models are at the centre of laboratory bladder cancer (BC) research and at the same time, the bridge to the clinic. A new and very promising therapeutical approach is to silence abnormally up-regulated genes in cancer, through small interfering RNA (siRNA) molecules. Therapeutic use and success of siRNAs will l...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-009-0374-4
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVES:To report the surgical outcomes of laparoscopic radical cystectomy (LRC) with extracorporeal orthotopic ileal neobladder (OIN) in patients with muscle-invasive urothelial carcinoma of the bladder (UCB). MATERIALS AND METHODS:Between October 2009 and December 2011, 37 patients with muscle-invasive UCB underw...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1122-3
更新日期：2014-04-01 00:00:00
abstract：:In 90 patients treated with laser prostatectomy using the Urolase (n = 50) or Ultraline (n = 40) laser fiber, the fiber-tip durability was investigated. In general the Urolase fiber tips were less damaged than the Ultraline fiber tips. At visual inspection, 62% of the Urolase fiber tips were graded as minimally damage...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00183619
更新日期：1995-01-01 00:00:00
abstract：INTRODUCTION:Herein, current developments in open and minimally invasive renal surgery are presented. MATERIALS AND METHODS:This also includes considerations on the appropriate indication for the two surgical procedures in small renal tumours, locally advanced disease (>pT2), complicated renal tumours as well as cytor...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0238-3
更新日期：2008-04-01 00:00:00
abstract：PURPOSE:To compare oncological, functional, and toxicity outcomes of patients with radiation-recurrent prostate cancer (PCa) after external beam radiation therapy (EBRT) or brachytherapy (BT) treated with salvage high-intensity focused ultrasound (S-HIFU) or salvage radical prostatectomy (S-RP). METHODS:This retrospec...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02640-x
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:To evaluate the role of multiparametric magnetic resonance imaging (mpMRI) in Gleason score (GS) 3 + 4 prostate cancer (PCa) and evaluate independent factors in mpMRI that can predict GS upgrading, we compared the outcomes of GS upgrading group and GS non-upgrading group. PATIENTS AND METHODS:We analyzed th...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03421-7
更新日期：2020-08-31 00:00:00
abstract：:The orthotopic neobladder has become the preferred method of handling the urinary tract after removal of the bladder in men and women. However, an improved quality of life compared to urinary diversion fails to be realized when voiding dysfunction arises. These difficulties with urination range from retention to incon...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450000146
更新日期：2000-10-01 00:00:00
