Abstract:
:We report on 208 patients with locally advanced renal-cell carcinoma who received a surgical adjuvant vaccination with autologous, Newcastle disease virus (NDV)-modified, and lethally irradiated tumor cells in combination with low-dose recombinant interleukin-2 and interferon-alpha. The pathological stage was defined as pT2-3a, N1-2, MO (n = 107); pT3b-4 NO, MO (n = 68); and pT3b-4, N1-2, MO (n = 23). The follow-up of 203 evaluable patients showed a median disease-free survival of 21+ months (range, 2-64+ months). In all, 18 relapses (9%) occurred in spite of initial vaccination therapy. Those patients presented with local relapse (n = 3), lymph node metastases (n = 10), and/or distant organ metastases (n = 9). All patients relapsing during the first 6 months after the onset of treatment had primary lymph node involvement of the disease. An analysis of the patient subgroup with a follow-up of more than 22 months showed 10 relapses among 56 patients (18%) along with a median follow-up of 39 months (range, 23-64 months). Toxicity was very mild, manifesting as flu-like symptoms and fevers of up to 38 degrees C. At 8 and 24 weeks after the start of vaccination, anti-NDV serum antibodies were detectable in 70% and 100% of the patients tested, respectively. In comparison with historical data based on the natural course of patients with locally advanced renal-cell cancer, our results demonstrate an improvement of the disease-free survival after surgical adjuvant treatment with autologous, NDV-modified tumor vaccines in combination with low-dose cytokines.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Kirchner HH,Anton P,Atzpodien Jdoi
10.1007/BF00184874subject
Has Abstractpub_date
1995-01-01 00:00:00pages
171-3issue
3eissn
0724-4983issn
1433-8726journal_volume
13pub_type
临床试验,杂志文章abstract:PURPOSE:The aim of the study is to evaluate the impact of having a nadir and persistently detectable ultrasensitive prostate-specific antigen (uPSA) between 0.01 and 0.1 ng/ml post-robot-assisted radical prostatectomy (RARP), on future biochemical recurrence (BCR). METHODS:We conducted a retrospective analysis of a pr...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03367-w
更新日期:2020-07-21 00:00:00
abstract:PURPOSE:This report presents our early experience at Cleveland Clinic replacing conventional ultrasound with a novel 29 MHz high-resolution micro-ultrasound system for both systematic sampling and real-time targeting of suspicious regions during prostate biopsy. The added value of micro-ultrasound and MRI over systemat...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02863-y
更新日期:2020-05-01 00:00:00
abstract::We report on a 17-year-old white woman with multiple bilateral renal angiomyolipomas (AMLs) in the absence of tuberous sclerosis. Multiple hyperdense lesions were detected in both kidneys by sonography. A computed tomography (CT) scan confirmed mainly fatty tissue. Sparing as much functional tissue as possible, eight ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-001-0242-3
更新日期:2002-09-01 00:00:00
abstract::The aim of this project was to evaluate the ice-water test as a predictor of the response to intradetrusor botulinum toxin injection in patients with neurogenic detrusor overactivity. We retrospectively evaluated the urodynamic parameters in 22 patients with neurogenic bladder dysfunction and positive ice-water test. ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-007-0208-1
更新日期:2007-12-01 00:00:00
abstract::The postnatal management of prenatally detected hydronephrosis mainly involves a close follow-up with ultrasound, renal isotopic scan and URO-MRI. In some cases, there is an indication for either a pyeloplasty or, more exceptionally, nephrectomy of a non-functioning obstructed kidney. In this chapter, we review the in...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-004-0458-0
更新日期:2004-12-01 00:00:00
abstract:PURPOSE:During rejection, leukocytes are recruited from the peripheral circulation into the graft leading to the damage of endothelial cells, capillary perfusion failure and graft loss. Chemokines play a pivotal role in the recruitment of leukocytes to the endothelium. Viral macrophage inflammatory protein-II (vMIP-II)...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-010-0556-0
更新日期:2010-08-01 00:00:00
abstract::Noncontrast helical computed tomography (CT) has recently been found to be superior to excretory urography (IVU) in the evaluation of patients with suspected ureterolithiasis. Noncontrast helical CT does not require the use of intravenous contrast material with its associated cost and risk of adverse reactions and can...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s003450050020
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:To assess the performance of EAU risk classification in PCa patients according to the biopsy pathway (standard versus MRI guided) and to develop a new, more accurate, targeted biopsy (TB)-based classification. MATERIALS AND METHODS:We included 1345 patients consecutively operated by radical prostatectomy (RP) ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-03053-6
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To prospectively compare short-term functional outcomes achieved by laparoscopic or robot-assisted sacrocolpopexy for pelvic organ prolapse. MATERIALS AND METHODS:We prospectively collected clinical and operative data over 24 months for female patients who underwent either pure laparoscopic sacrocolpopexy (L...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0748-2
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate the safety and efficiency of multiple-tract percutaneous nephrolithotomy (PCNL) as a day surgery for the treatment of complex renal stones. PATIENTS AND METHODS: A mature protocol for day surgery was implemented. Forty-six patients who underwent planned day-surgery PCNL...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03260-6
更新日期:2020-05-23 00:00:00
abstract:PURPOSE:To assess the impact of prolonged catheterization time on 1-week (short-term), 3-month (intermediate-term) and 1-year (long-term) UC. METHODS:Between 2008 and 2015, 6918 men underwent RP by four high-volume surgeons. Exclusion criteria were baseline urinary incontinence (UI) and radiotherapy prior or within 12...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2274-y
更新日期:2018-08-01 00:00:00
abstract::It has been brought to our attention that the first sentence of the Conclusion in the original publication [1] is incorrect. We have removed this sentence and the correct version can be found in this Erratum. ...
journal_title:World journal of urology
pub_type: 已发布勘误
doi:10.1007/s00345-019-02929-x
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:For better understanding of urogenital tuberculosis (UGTB), its clinical spectrum and characteristic features need to be evaluated. MATERIALS AND METHODS:One hundred and forty-two cases of UGTB patients were analyzed retrospectively. We considered age, gender, symptoms, and diagnostic procedures. RESULTS:The ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02767-x
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Obesity may be a risk factor for kidney donors to develop reduced renal function. The Framingham heart study suggested that visceral adipose tissue (VAT) confers a more adverse metabolic profile compared with subcutaneous adipose tissue (SAT). Asians tend to have a higher VAT composition and it is unclear ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2566-2
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:Treatment options for antimuscarinic refractory neurogenic detrusor overactivity (NDO) are botulinum toxin type A injections (BTX-A) and augmentation cystoplasty (AC). We estimated initial and cumulative 5-year costs of these treatments. MATERIALS AND METHODS:Base case is an individual with antimuscarinic refr...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-010-0618-3
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:To evaluate the perioperative morbidity of PC-RPLND in two intermediate volume centers and to identify predictors of high morbidity. METHODS:Retrospective analysis of 124 patients treated with open PC-RPLND at two tertiary referral centers between 2001 and 2018. Perioperative morbidity was determined by analyz...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03229-5
更新日期:2020-05-05 00:00:00
abstract::The most important phosphates involved in urinary stone disease are carbonate apatite, brushite, and struvite. Overall, phosphate stones account for 12-20% of all stones, with a downward trend for struvite and an increase in carbonate apatite being observed in the last decade. The physicochemical basis for the formati...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s003450050152
更新日期:1999-10-01 00:00:00
abstract:PURPOSE:To evaluate for the first time the prognostic significance of female invasive patterns in stage pT4a urothelial carcinoma of the bladder in a large series of women undergoing anterior pelvic exenteration. PATIENTS AND METHODS:Our series comprised of 92 female patients in total of whom 87 with known invasion pa...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-014-1308-3
更新日期:2015-03-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:The possibility of performing remote-surgery has been the goal to achieve, since the early development of the first surgical robotic platforms. This systematic review aims to analyse the state of the art in the field and to provide an overview of the possible growth of this technology. METH...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02996-0
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:To investigate pathological and oncological outcomes of obese patients who underwent robot-assisted radical prostatectomy (RARP) compared with laparoscopic radical prostatectomy (LRP) or open retropubic radical prostatectomy (RRP) since limited comparative data exist with regard to oncological and survival o...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-014-1326-1
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:To evaluate renal function and to identify factors associated with renal dysfunction in the elective indications setting of nephron-sparing surgery (NSS). METHODS:We retrospectively reviewed operative data and glomerular filtration rate (GFR) of 519 patients treated by NSS in an elective indications setting be...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-014-1292-7
更新日期:2015-01-01 00:00:00
abstract::Many women develop stress urinary incontinence (SUI) after childbirth, but the exact neuronal changes are largely unknown. This study is designed to identify the neuronal changes associated with pregnancy, delivery and ovariectomy. A total of 10 virgin and 48 pregnant rats were used. Cystometry and stress/sneeze tests...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-004-0444-6
更新日期:2004-10-01 00:00:00
abstract:PURPOSE:Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) provides reasonable performance in detecting significant cancers. Still, it is unclear about whether all PI-RADS 4 lesions show the same cancer detection rate (CDR) regardless of tumor size. The aim was to compare the CDRs of small (< 10 mm) and l...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02924-2
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:68Ga-PSMA Positron Emission Tomography/Computerized Tomography (PET/CT) has shown promising results for the detection of recurrent prostate cancer (RPCa). However, the diagnostic value of this method is yet to be validated. The aim of this study was to determine the influence of clinical and biochemical vari...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2460-y
更新日期:2019-05-01 00:00:00
abstract::In 90 patients treated with laser prostatectomy using the Urolase (n = 50) or Ultraline (n = 40) laser fiber, the fiber-tip durability was investigated. In general the Urolase fiber tips were less damaged than the Ultraline fiber tips. At visual inspection, 62% of the Urolase fiber tips were graded as minimally damage...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF00183619
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:The bromodomain and extra-terminal (BET) family of proteins provides a scaffolding platform for the recruitment and tethering of transcription factors to acetylated chromatin, thereby modulating gene expression. In this study, we evaluated the efficacy of the BET-inhibitor PFI-1 to diminish AR/AR-V7 signaling...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2382-8
更新日期:2019-02-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Reactive oxygen species (ROS) are produced during the interaction between oxalate/calcium oxalate monohydrate (COM) crystals and renal epithelial cells and are responsible for the various cellular responses through the activation of NADPH oxidase (Nox). Ox and COM also activate the renin-ang...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1563-y
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Standardization of hands-on training (HoT) has profoundly impacted the educational field in the last decade. To provide quality training sessions on a global scale, the European School of Urology Training group developed a teaching guide for tutors in 2015. Our study aims to understand wheth...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03161-8
更新日期:2020-03-21 00:00:00
abstract:PURPOSE:To explore the role of prostate biopsy core length on prediction of index tumor clinical significance and localization on radical prostatectomy (RP) and time to recurrence, hypothesizing 10-, 10-12-, or > 12-mm minimum core as potential biopsy quality control. METHODS:Assessed 2424 prostate biopsy cores and co...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2242-6
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:To compare the range of reach of our newly designed omni-directional ureteroscope (URF-Y0016), compared to the commonly used URF-P6, FlexX2s, and LithoVue™ scopes, in the upper, middle, and lower calyces in an ex-vivo pyelocaliceal model. METHODS:We fabricated a three-dimensional pyelocaliceal model of the upp...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03151-w
更新日期:2020-03-14 00:00:00