Abstract:
INTRODUCTION AND OBJECTIVES:Reactive oxygen species (ROS) are produced during the interaction between oxalate/calcium oxalate monohydrate (COM) crystals and renal epithelial cells and are responsible for the various cellular responses through the activation of NADPH oxidase (Nox). Ox and COM also activate the renin-angiotensin-aldosterone system (RAAS). Aldosterone stimulates ROS production through activation of Nox with the involvement of mineralocorticoid receptor (MR), Rac1 and mitogen-activated protein kinases (MAPK). We investigated RAAS pathways in vivo in an animal model of hyperoxaluria and in vitro by exposing renal epithelial cells to COM crystals. METHODS:Hyperoxaluria was induced in male SD rats by administering ethylene glycol. One group of rats was additionally given spironolactone. Total RNA was extracted and subjected to genomic microarrays to obtain global transcriptome data. Normal rat kidney cell line (NRK-52E) was incubated with aldosterone(10(-7) M) and COM(67 μg/cm(2)) with or without spironolactone(10(-5) M), a selective inhibitor of SRC family of kinases; protein phosphatase 2(pp2) (10(-5) M) and Nox inhibitor; diphenylene iodonium (DPI) (10(-5) M). RESULTS:Relative expression of genes encoding for AGT, angiotensin receptors 1b and 2, Renin 1, Cyp11b, HSD11B2, Nr3c2, NOx4 and Rac1 was upregulated in the kidneys of rats with hyperoxaluria. Treatment with spironolactone reversed the effect of hyperoxaluria. Both aldosterone and COM crystals activated Nox and Rac1 expression in NRK52E, while spironolactone inhibited Nox and Rac1 expression. Increased Rac1 expression was significantly attenuated by treatment with PP2 and spironolactone. CONCLUSIONS:Results indicate that hyperoxaluria-induced production of ROS, injury and inflammation are in part associated with the activation of Nox through renin-angiotensin-aldosterone pathway.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Tsuji H,Wang W,Sunil J,Shimizu N,Yoshimura K,Uemura H,Peck AB,Khan SRdoi
10.1007/s00345-015-1563-ysubject
Has Abstractpub_date
2016-01-01 00:00:00pages
89-95issue
1eissn
0724-4983issn
1433-8726pii
10.1007/s00345-015-1563-yjournal_volume
34pub_type
杂志文章abstract:PURPOSE:To assess the common practice to transiently place an indwelling transurethral catheter in case of hospitalization of women with febrile urinary tract infections. So far, this intervention has not been scientifically investigated. METHODS:Inclusion criteria were female gender, a leucocyte esterase-positive uri...
journal_title:World journal of urology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00345-018-2474-5
更新日期:2019-05-01 00:00:00
abstract::A low-pressure reservoir for urine is created by antimesenteric splitting and side-to-side anastomosis of the rectosigmoid, the expectation being to obtain better continence rates and better protection of the upper tract than are achievable by ureterosigmoidostomy. Between 1990 and August 1993 the procedure was perfor...
journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:World journal of urology
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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journal_title:World journal of urology
pub_type: 杂志文章
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journal_title:World journal of urology
pub_type: 杂志文章,随机对照试验
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更新日期:2016-04-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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journal_title:World journal of urology
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journal_title:World journal of urology
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pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-03-23 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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更新日期:1999-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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pub_type: 历史文章,杂志文章
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更新日期:2000-02-01 00:00:00
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更新日期:2020-07-21 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,meta分析
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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