The effect of labor and/or ovariectomy on rodent continence mechanism--the neuronal changes.

Abstract:

:Many women develop stress urinary incontinence (SUI) after childbirth, but the exact neuronal changes are largely unknown. This study is designed to identify the neuronal changes associated with pregnancy, delivery and ovariectomy. A total of 10 virgin and 48 pregnant rats were used. Cystometry and stress/sneeze tests were performed in the virgin once and the pregnant rats at certain time points. Postpartum the rats were equally grouped as follows: group I: delivery, group II: delivery + ballooning, group III: delivery + ovariectomy, group IV: delivery + ballooning + ovariectomy. Tissues from bladder, bladder neck, and urethra were analyzed by immunostaining for PGP 9.5, CGRP, SP, NPY, VIP, TH, n-NOS. We found complex innervation changes in the different tissue samples. Since the bladder neck and the mid-urethra play an important role in the continence mechanism the neuronal changes in these areas contribute to the observed functional changes.

journal_name

World J Urol

journal_title

World journal of urology

authors

Sievert KD,Bakircioglu ME,Tsai T,Nunes L,Lue TF

doi

10.1007/s00345-004-0444-6

keywords:

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

244-50

issue

4

eissn

0724-4983

issn

1433-8726

journal_volume

22

pub_type

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