Abstract:
PURPOSE:To assess the association between obstructive sleep apnea (OSA) and Fuhrman grade in patients with clear cell renal cell carcinoma (ccRCC). As secondary endpoints, we studied its association with tumor size, metastasis-free survival (MFS) and cancer-specific survival (CSS). METHODS:We reviewed the databases of two tertiary care centers, identifying 2579 patients who underwent partial or radical nephrectomy for ccRCC between 1991 and 2014. Descriptive statistics were used to compare pathologic variables between patients with and without OSA. Linear and logistic regression models were used to assess the association of OSA with Fuhrman grade and tumor size. A Cox proportional hazards model was used to determine OSA association with MFS and CSS. A pathway analysis was performed on a cohort with available gene expression data. RESULTS:In total, 172 patients (7 %) had self-reported OSA at diagnosis. More patients with OSA had high Fuhrman grade compared to those without OSA [51 vs. 38 %; 13 % risk difference; 95 % confidence interval (CI), 5-20 %; p = 0.003]. On multivariable analysis, the association remained significant (OR 1.41; 95 % CI 1.00-1.99; p = 0.048). OSA was not associated with tumor size (p > 0.5), MFS (p = 0.5) or CSS (p = 0.4). A trend toward vascular endothelial growth factor pathway enrichment was seen in OSA patients (p = 0.08). CONCLUSIONS:OSA is associated with high Fuhrman grade in patients undergoing surgery for ccRCC. Pending validation of this novel finding in further prospective studies, it could help shape future research to better understand etiological mechanisms associated.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Vilaseca A,Nguyen DP,Vertosick EA,Corradi RB,Musquera M,Pérez M,Fossati N,Sjoberg DD,Farré R,Almendros I,Montserrat JM,Benfante NE,Hakimi AA,Skanderup AJ,Russo P,Alcaraz A,Touijer KAdoi
10.1007/s00345-016-1830-6subject
Has Abstractpub_date
2017-01-01 00:00:00pages
51-56issue
1eissn
0724-4983issn
1433-8726pii
10.1007/s00345-016-1830-6journal_volume
35pub_type
杂志文章abstract:PURPOSE:To assess the pathological and the oncologic outcomes of the prostate cancer (PCa) missed by 6- and 12-core biopsy protocols by using a reference 21-core scheme. MATERIALS AND METHODS:Between 2001 and 2009, all patients who had PCa detected in an initial 21-core TRUS biopsy scheme and were treated by a radical...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0800-2
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:To review the recent advances in terms of surgical technique and new robotic platforms applied to radical perineal prostatectomy (RPP). METHODS:A literature review was performed focusing on original articles on perineal prostatectomy searching via Medline/Pubmed and Embase. The entire spectrum was covered such...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-019-03004-1
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:Nephron-sparing surgery (NSS) is the gold standard treatment for resectable renal tumors. In the last decade, laparoscopic partial nephrectomy (LPN) has evolved in technical, surgical and oncological aspects and is an accepted treatment option for local-stage renal tumors. Improvements in not only surgical tech...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1404-4
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:To assess and report the feasibility and efficacy of electronic follow-up in patients after mid-urethral sling (MUS) operation. METHODS:All 235 patients after MUS operation for stress urinary incontinence (SUI) were divided into the WeChat follow-up (WFU) and the outpatient follow-up (OFU) groups. Patients com...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03245-5
更新日期:2020-05-19 00:00:00
abstract:PURPOSE:The primary objective was to evaluate the effect of autologous muscle-derived cell (AMDC) injections on the urethral sphincter morphometry compared to placebo injections. Secondary aims were to explore the reduction of stress incontinence episode frequency (IEF) and factors associated with the efficacy of AMDC....
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03076-4
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:Neurogenic bladder due to spinal cord injury has significant consequences for patients' health and quality of life. Regular surveillance is required to assess the status of the upper and lower urinary lower urinary tracts and prevent their deterioration. In this review, we examine surveillance techniques in neu...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-018-2345-0
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:The efficacy and safety of a novel remotely programmed BetterStim sacral neuromodulation (SNM) system was evaluated in patients with refractory overactive bladder (OAB) in a prospective, controlled, multicenter trial. METHODS:A total of 84 patients referred for SNM therapy from October 2015 to January 2018 wer...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00345-019-02698-7
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:To assess oncologic outcomes after salvage radiotherapy (SRT) without androgen deprivation therapy (ADT) in patients with persistently detectable PSA after radical prostatectomy (RT). METHODS:Two hundred and one patients who failed to achieve an undetectable PSA received SRT without ADT. The primary endpoint w...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-013-1214-0
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To evaluate the detection rate among three different targeted biopsy approaches of robot-assisted MRI/TRUS fusion (RA-TB), mpMRI in-bore (MRGB), cognitive fusion guidance biopsy (COG-TB) for the detection of prostate cancer (PC) and clinically significant PC (csPC). METHODS:Between 2014 and 2016, 156 patients ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2189-7
更新日期:2018-05-01 00:00:00
abstract:PURPOSE:Salvage radiotherapy (SRT) for biochemical recurrence (BCR) following radical prostatectomy (RP) should if possible be added at a prostate-specific antigen (PSA) level of <1-2 ng/mL. The value of positron emission tomography combined with computed tomography (PET/CT) at such low PSA values is not defined. The p...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1547-y
更新日期:2015-11-01 00:00:00
abstract:INTRODUCTION:Peyronie's disease (PD) is a localized connective tissue disorder of the penile tunica albuginea (TA) with a still obscure etiopathology. Recent studies from our laboratory have demonstrated differences in Smad3 and Smad4 gene expression of PD-fibroblasts and non-PD-fibroblasts after stimulation with recom...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-008-0320-x
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Prognoses for intermediate-risk prostate cancer (PCa) remain heterogeneous. Improved substratification could optimize treatment and monitoring strategies. The objective was to validate this subclassification in a radical prostatectomy (RP) series. METHODS:Between 2000 and 2011, 4038 patients who underwent R...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-016-1979-z
更新日期:2017-08-01 00:00:00
abstract::Genital skin loss results from a heterogeneous group of traumatic and infectious processes. Removal of all devitalized tissue is necessary prior to reconstructive surgery; hyperbaric oxygen may help in the management of necrotizing infections. Defect coverage depends more on the remaining genital skin than on the etio...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s003450050115
更新日期:1999-04-01 00:00:00
abstract::Radical cystectomy with pelvic lymph node dissection has been accepted as the standard treatment for muscle-invasive bladder cancer. Radiation therapy and chemotherapy are increasingly being implemented in bladder-preservation protocols to provide an alternative treatment to cystectomy. We review experience with radia...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-002-0276-1
更新日期:2002-08-01 00:00:00
abstract:INTRODUCTION:Changes in the management of minimally invasive oncologic renal surgery have introduced ablative therapies as the most recent advancement in minimally invasive technology. METHODS:The current evidence-based medicine on the topic of laparoscopic (LCA) and percutaneous (PCA) renal cryoablation was gathered ...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-010-0552-4
更新日期:2010-10-01 00:00:00
abstract::Small-intestinal submucosa (SIS) is a unique biomaterial that has been shown to induce tissue-specific regeneration in numerous organ systems. In the urinary tract, animal studies have demonstrated that SIS promotes functional bladder regeneration. Other preliminary studies have suggested that SIS may also be extremel...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/PL00007071
更新日期:2000-02-01 00:00:00
abstract:PURPOSE:Different enhanced recovery after surgery (ERAS) protocols (EP) for radical cystectomy (RC) have been published. Protocols highly differ in number of included items and specific measures. MATERIALS AND METHODS:A systematic review and meta-analysis on EPs in RC were performed using the databases MedLine, Cochra...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03133-y
更新日期:2020-12-01 00:00:00
abstract::The treatment of lower urinary symptoms secondary to benign prostatic hyperplasia (BPH) after failure of medical therapies remains controversial for most urologic surgeons. The complications of traditional surgery are the driving force behind the development of several minimally invasive treatments of symptomatic BPH....
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-006-0063-5
更新日期:2006-09-01 00:00:00
abstract:PURPOSE:XPA-210 is a proliferation marker derived from Thymidine kinase-1. It is of clinical significance in kidney, breast, and bladder cancer. There are no data available for XPA-210 in prostate cancer (PC). Herein, we aim to determine the clinical usefulness of XPA-210 in PC. MATERIALS AND METHODS:In a retrospectiv...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0768-y
更新日期:2012-08-01 00:00:00
abstract::We investigated a possible relationship between brefeldin A (BFA), an antibiotic, and cathepsin D (Cat.D), a lysosomal protease, in prostate cancer proliferation. Effects of BFA (30 ng/ml) were examined on the growth of three human prostatic cancer cell lines, PC-3, DU-145, and LNCaP cells. Its effect on Cat.D in thes...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/pl00007099
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVES:Monopolar transurethral resection of the prostate (TURP) is the gold standard surgical treatment for bothersome moderate to severe lower urinary tract symptoms (LUTS) secondary to benign prostate obstruction. The aim of the study is to compare monopolar versus bipolar TURP focusing on operative and functiona...
journal_title:World journal of urology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00345-017-2023-7
更新日期:2017-10-01 00:00:00
abstract::The prostatitis syndrome is commonly found in urologic practice and is classified according to the NIDDK/NIH, in which bacterial prostatitis (acute and chronic) is distinguished from chronic pelvic pain syndrome (CPPS). In acute bacterial prostatitis (NIH category I), antibiotic treatment is mandatory and successful i...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-003-0333-4
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:Objective characterization of renal mass anatomy facilitates treatment selection and prediction of surgical outcomes. We investigated R.E.N.A.L nephrometry score (NS) efficacy in predicting outcomes after minimally invasive nephron-sparing surgery (MINSS). METHODS:A total of 250 patients with 252 renal mass...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-0876-3
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:To place chemoprevention of prostate cancer in current clinical context. METHODS:Review of recently published updates of large, randomized, controlled trials of primary chemoprevention of prostate cancer. RESULTS:With extended post-intervention follow-up, SELECT demonstrated a 17% increased risk of prostat...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-011-0822-9
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of adjuvant systemic chemotherapy for locally advanced (pT3-4pN0/xM0) upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS:We retrospectively reviewed the medical records of 109 patients with pT3-4pN0/xM0 UTUC who had undergone radical nephroureterectomy between 1996 and 2013...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2032-6
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:To explore the role of prostate biopsy core length on prediction of index tumor clinical significance and localization on radical prostatectomy (RP) and time to recurrence, hypothesizing 10-, 10-12-, or > 12-mm minimum core as potential biopsy quality control. METHODS:Assessed 2424 prostate biopsy cores and co...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2242-6
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:High-quality leadership and chairing skills are vital for good performance in multidisciplinary tumor boards (MTBs), but no instruments currently exist for assessing and improving these skills. OBJECTIVE:To construct and validate a robust instrument for assessment of MTB leading and chairing skills. DESIGN...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2255-1
更新日期:2018-07-01 00:00:00
abstract::Our objectives were to ascertain the tolerability and efficacy of trospium chloride in doses of 20 mg twice daily for long-term therapy (52 weeks) in patients with urge syndrome. The trial comprised a total of 358 patients with urge syndrome or urge incontinence. After randomisation in the ratio of 3:1, participants w...
journal_title:World journal of urology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s00345-003-0321-8
更新日期:2003-05-01 00:00:00
abstract:INTRODUCTION:The conservative management of upper tract urothelial carcinoma (UTUC) has historically been offered to patients with imperative indications. The recent International Consultation on Urologic Diseases (ICUD) publication on UTUC stratified treatment allocations based on high- and low-risk groups. This repor...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-016-1859-6
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:To evaluate the benefit of an antimicrobial prophylaxis protocol using rectal swab cultures in patients undergoing transrectal ultrasound (TRUS)-guided prostate biopsy in our Veterans Affairs population. METHODS:Between June 1, 2013, and June 1, 2014, we implemented an antimicrobial prophylaxis protocol using ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1571-y
更新日期:2015-12-01 00:00:00