Abstract:
:We investigated a possible relationship between brefeldin A (BFA), an antibiotic, and cathepsin D (Cat.D), a lysosomal protease, in prostate cancer proliferation. Effects of BFA (30 ng/ml) were examined on the growth of three human prostatic cancer cell lines, PC-3, DU-145, and LNCaP cells. Its effect on Cat.D in these cancer cells was assessed by Western blots and compared with Cat.D expressed in clinical prostate specimens (n = 55). BFA profoundly (> 70%) inhibited the growth of all three cancer cell lines. Western blots revealed that expression of procathepsin D (Pro.Cat.D) was markedly increased with BFA, whereas actively proliferating (control) cells greatly exhibited mature Cat.D. Analysis of prostate specimens then showed predominant Pro.Cat.D expression in non-cancerous tissues while also showing enhanced expression of mature Cat.D in all cancer specimens. Therefore, BFA-induced growth inhibition in prostatic cancer cells is associated with a blocking of Cat.D maturation (activation), suggesting a possible role of Cat.D in prostate cancer proliferation/development.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Konno S,Cherry JP,Mordente JA,Chapman JR,Choudhury MS,Mallouh C,Tazaki Hdoi
10.1007/pl00007099keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
234-9issue
4eissn
0724-4983issn
1433-8726journal_volume
19pub_type
杂志文章abstract:PURPOSE:Management of prostate cancer following radiation therapy remains challenging, especially for younger men or those with life expectancy greater than 10 years. We outline the efficacy, safety and adequacy of radical prostatectomy for the treatment of radiorecurrent localized prostate cancer. METHODS:A systemati...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-013-1029-z
更新日期:2013-12-01 00:00:00
abstract::We evaluated the quality of micturition in patients with orthotopic neobladder replacement. In the present study, 58 patients who had undergone orthotopic neobladder replacement following cystectomy were enrolled. The quality of micturition was evaluated by means of uroflowmetry, a self-administered questionnaire and ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s003450000156
更新日期:2000-12-01 00:00:00
abstract::Prostate carcinoma (PCa) displays a wide variety of genetic alterations, versatile expression profiles as well as cell surface markers. Despite this heterogeneity, a common treatment for advanced PCa is androgen deprivation therapy (ADT). ADT targets the androgen receptor-a member of the nuclear receptor superfamily-w...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-011-0792-y
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:Assess knowledge and awareness concerning human papillomavirus (HPV) infection, HPV-associated diseases, and the existence of a specific vaccine among non-HPV-screened Caucasian-European adults after the market introduction of HPV vaccines. METHODS:A cohort of 934 consecutive patients seeking their first medic...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1379-1
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:The lack of precedent in transitioning from pediatric to adult care poses a challenge to providers for patients with spina bifida (SB). The purpose of this study was to summarize perceptions about best practices for the care of adult spina bifida patients. MATERIALS AND METHODS:A national survey was electronic...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02635-8
更新日期:2019-04-01 00:00:00
abstract:INTRODUCTION:With low life expectancy rates in hemodialysis patients, the preservation of renal parenchyma must be weighed against the oncological outcomes in considering partial nephrectomy (PN) in solitary kidneys. The main objective of this study was to assess the oncologic and functional outcomes after PN in patien...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-010-0576-9
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:Prostate cancer (PCa) is the most common malignancy in men and the cause for the second most common cancer-related death in the western world. Despite ongoing development of novel approaches such as second generation androgen receptor targeted therapies, metastatic disease is still fatal. In PCa, immunotherapy ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03497-1
更新日期:2020-10-26 00:00:00
abstract::Telemedicine is the use of communication technologies to deliver health care. Telesurgical telementoring represents an advanced form of telemedicine, whereby an experienced surgeon can guide and teach practicing surgeons new operative techniques utilizing current video technology, medical robots, and high-band-width t...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s003450050082
更新日期:1998-01-01 00:00:00
abstract::Transcutaneous application of low-frequency electric current in the treatment of partially or temporarily denervated striated muscles is widely used to prevent or treat muscular atrophy. Due to the high regenerative capacity of smooth-muscle cells, this approach should be beneficial in the treatment of diseases with s...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF00182971
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:Management of male infertility is always a difficult task, with pathophysiology and available treatments often poorly understood. The purpose of this review was to summarize current evidence regarding the use of protective agents against reactive oxygen species (ROS), such as antioxidants that may be useful in ...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-019-02656-3
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:Robotic radical cystectomy (RRC) has become a commonly utilised alternative to open radical cystectomy (ORC). We performed a systematic review and meta-analysis of RRC vs ORC focusing on perioperative outcomes and safety. METHODS:Medline, EMBASE and CENTRAL were searched from January 2000 to April 2020 followi...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-020-03385-8
更新日期:2020-07-30 00:00:00
abstract:PURPOSE:To assess the impact of HA on robotic PN (RPN) outcomes. METHODS:We retrospectively analyzed data from patients who underwent RPN in eight centers between 2009 and 2013. Hemorrhagic complications were defined as the occurrence of a pseudoaneurysm, arteriovenous fistula or hematoma requiring transfusion. Patien...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-015-1537-0
更新日期:2015-11-01 00:00:00
abstract::We prospectively compared, within the same center and during the same period of time, the perioperative parameters as well as the oncological and functional results of both open retropubic (ORP) and laparoscopic radical prostatectomy (LRP). From September 1999 to September 2001, 162 patients with prostate cancer were ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-002-0306-z
更新日期:2003-05-01 00:00:00
abstract::Robotic surgery was started in the Department of Urology, Hospital Kuala Lumpur, in April 2004. We present our experience in developing the program and report the results of our first 50 cases of robotic radical prostatectomy. A three-arm da Vinci robotic system was installed in our hospital in March 2004. Prior to in...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-006-0069-z
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:Although the role of lymph node dissection (LND) is well defined in many urological settings, uncertainty regarding need for LND still exists for patients with renal cell carcinoma (RCC). The aim of the current review is to highlight the rationale for performing or omitting LND at the time of renal surgery. ME...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-016-1886-3
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:Vesico-ureteral reflux (VUR) represents one of the most significant risk factors for acute pyelonephritis in children. Surgery is an important part of its management. Laparoscopic ureteric reimplantation using the Lich-Gregoir technique is an option for VUR. The aim of this study is to assess short- and medium-...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2064-y
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:Bladder cancer (BC) has the highest lifetime treatment costs per patient of all cancers. The high recurrence rate and ongoing invasive monitoring requirement are the key contributors to the economic and human toll of this disease. The purpose of this paper was to utilize the recent literature to identify oppo...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-009-0395-z
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:Cabazitaxel, a semi-synthetic taxane of the third generation, inhibits prostate cancer (PC) cell growth by affecting the microtubule architecture. Since cabazitaxel has also been demonstrated to inhibit androgen receptor (AR) functionality, AR and AR-associated heat shock protein (HSP) expressions in the presen...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2615-x
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:This report presents our early experience at Cleveland Clinic replacing conventional ultrasound with a novel 29 MHz high-resolution micro-ultrasound system for both systematic sampling and real-time targeting of suspicious regions during prostate biopsy. The added value of micro-ultrasound and MRI over systemat...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02863-y
更新日期:2020-05-01 00:00:00
abstract::Oxybutynin is a tertiary amine, which undergoes an extensive first-pass metabolism. It has an active metabolite, N-desethyl oxybutynin, and the effect of oral oxybutynin is to a large extent exerted by this metabolite. Oxybutynin has both an antimuscarinic and a direct muscle relaxant effect, and, in addition, local a...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/pl00007103
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Making healthcare treatment decisions is a complex process involving a broad stakeholder base including patients, their families, health professionals, clinical practice guideline developers and funders of healthcare. METHODS:This paper presents a review of a methodology for the development of urological ca...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-011-0660-9
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:Chronic inflammation has been considered a potential risk factor for prostate cancer. Toll-like receptors (TLRs) are important in the innate immune response to pathogens and in cross talk between innate immunity and adaptive immunity. In this study, sequence variants in the TLR4 gene were investigated to determ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0690-3
更新日期:2012-04-01 00:00:00
abstract::The aim of this study was to determine the long-term clinical efficacy and complications of neuromodulation with a unilateral sacral foramen electrode in 36 patients with chronic voiding dysfunction. Following a positive effect of a percutaneous nerve evaluation test, patients underwent open surgery. A permanent elect...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s003450050074
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:To compare the perioperative relative renal function and determine predictors of deterioration and recovery of separate renal function in patients with renal stones >10 mm and who underwent mini-percutaneous nephrolithotomy or retrograde intra-renal surgery. PATIENTS AND METHODS:A main stone >10 mm or stones g...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1653-x
更新日期:2016-05-01 00:00:00
abstract::This review paper highlights the important health issue of orchialgia and the chronic pelvic pain syndrome. There are a number of specific and non-specific etiologies and different treatment options based on the sub-categorization of orchialgia. The focus of this article is on the specific etiologies of chronic orchia...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-013-1092-5
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:Given that the tumor-promoting inflammation has been previously established in squamous cell carcinoma of the bladder but its contribution to development of urothelial carcinoma (UC) still remains elusive, our aim was to study changes in expression and activity of inflammation-mediating NF-κB and STAT3 transcri...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1237-1
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:The challenges in providing urologic care across borders and in resource-constrained settings are poorly understood. We sought to better characterize the impediments to the delivery of urological care in low- and middle-income countries (LMICs) compared to high-income countries (HICs). METHODS:A 70 question on...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03101-6
更新日期:2020-11-01 00:00:00
abstract::With the advantages of constant availability, minimal loss of bowel, relative simplicity (no mesentery interfering with implantation, high mobility of the tube), minimized risk of stone formation (no use of staples), reliable continence (no leak point) and easy catheterization (longitudinal folds), this straightforwar...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s003450050059
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:To evaluate the perioperative morbidity of PC-RPLND in two intermediate volume centers and to identify predictors of high morbidity. METHODS:Retrospective analysis of 124 patients treated with open PC-RPLND at two tertiary referral centers between 2001 and 2018. Perioperative morbidity was determined by analyz...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03229-5
更新日期:2020-05-05 00:00:00
abstract:OBJECTIVE:To explore efficacy and safety of Botulinum Neurotoxin Type A (BoNT-A) prostatic injection in patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperperplasia. MATERIALS AND METHODS:A phase 3 multicenter open-labeled study randomised patients to receive BoNT-A prostatic injection or o...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00345-018-2193-y
更新日期:2018-06-01 00:00:00