Abstract：
INTRODUCTION:Peyronie's disease (PD) is a localized connective tissue disorder of the penile tunica albuginea (TA) with a still obscure etiopathology. Recent studies from our laboratory have demonstrated differences in Smad3 and Smad4 gene expression of PD-fibroblasts and non-PD-fibroblasts after stimulation with recombinant TGF-beta1 for 1 h. In the present study, we investigated gene expression of Smad2-Smad4 and Smad7 up to 6 h after stimulation with TGF-beta1. As a positive control, MCP-1 gene expression was monitored. MATERIALS AND METHODS:Cells with fibroblast characteristics were isolated from seven PD plaques and three TA controls. The cells were incubated with recombinant TGF-beta1 for 2-6 h and expression of Smad2-Smad4, Smad7, and monocyte chemotactic protein-1 (MCP-1) was determined by quantitative real-time PCR. RESULTS:TGF-beta1 treatment resulted in a statistically significant up-regulation of Smad7 and MCP-1 gene expression. Smad7 expression was increased after 2 h (P < 0.001) and was still high after 4 h (P < 0.05). No significant differences between fibroblasts from PD-patients compared to non-PD-patients were observed. MCP-1 peaked after 4 h (P < 0.001) and remained high up to 6 h (P < 0.01). PD-fibroblasts revealed a significantly increased MCP-1 gene expression compared to non-PD-fibroblasts (P = 0.013) after 2 h and remained significantly different also after 6 h (P = 0.038). Gene expression of Smad2-Smad4 did not change during stimulation with TGF-beta1. CONCLUSION:In conclusion, analysis of MCP-1 expression might be a useful marker for Peyronie's disease.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Szardening-Kirchner C,Konrad L,Hauck EW,Haag SM,Eickelberg O,Weidner Wdoi
10.1007/s00345-008-0320-xsubject
Has Abstractpub_date
2009-02-01 00:00:00pages
123-30issue
1eissn
0724-4983issn
1433-8726journal_volume
27pub_type
杂志文章abstract：:Recent investigations have given a clearer insight into the genetic progression of bladder cancer. In this review we identify the clinical courses of bladder cancer, review the basic concepts of carcinogenesis, and focus on the specific cytogenetic and molecular alterations observed in bladder cancer. Progression mode...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00184243
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVES:Nocturia is prevalent and bothersome in men with lower urinary tract symptoms suggestive of BPH (LUTS/BPH). α-Adrenoceptor antagonists without subtype selectivity have inconsistently shown significant effects on nocturia in these patients. We explored the effects of the α1A-adrenoceptor subtype-selective ant...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
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更新日期：2014-10-01 00:00:00
abstract：PURPOSE:To compare prognostic performance of MSKCC and IMDC risk models in patients with synchronous mRCC. METHODS:Retrospective analysis of pre-therapeutic MSKCC and IMDC prognostic factors and outcomes in patients with synchronous mRCC treated at a single institute in the targeted therapy era was performed. Cytoredu...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1769-7
更新日期：2016-08-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-008-0339-z
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journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-018-2374-8
更新日期：2019-03-01 00:00:00
abstract：:Peyronie's disease (PD, induratio penis plastica) is uncommon. Its etiology is unknown and the incidence is stated to be 1%, although more recent data suggest that it is higher. The symptoms are penile deviation and painful erection in association with penile plaques. The diagnosis is performed by palpation of the pen...
journal_title：World journal of urology
pub_type： 杂志文章,评审
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更新日期：2004-11-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-014-1452-9
更新日期：2015-09-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0576-9
更新日期：2011-06-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2389-1
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journal_title：World journal of urology
pub_type： 杂志文章,评审
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更新日期：2010-06-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03133-y
更新日期：2020-12-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF01275152
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2064-y
更新日期：2017-11-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-002-0306-z
更新日期：2003-05-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2032-6
更新日期：2017-10-01 00:00:00
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journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00192265
更新日期：1994-01-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0375-7
更新日期：2004-02-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03141-y
更新日期：2020-12-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0690-3
更新日期：2012-04-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2079-4
更新日期：2017-12-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-013-1094-3
更新日期：2014-02-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03490-8
更新日期：2020-10-20 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2189-7
更新日期：2018-05-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03411-9
更新日期：2020-08-26 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
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更新日期：2009-06-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0238-3
更新日期：2008-04-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
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更新日期：2000-09-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,meta分析
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更新日期：2019-12-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
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更新日期：1998-01-01 00:00:00
abstract：PURPOSE:The effect of living donor kidney allograft size on recipient outcomes is not well understood. In this study, we sought to investigate the relationship between preoperatively measured donor kidney volume and recipient estimated glomerular filtration rate (eGFR) in living donor kidney transplantation (LDKT). ME...
journal_title：World journal of urology
pub_type： 杂志文章
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更新日期：2019-09-01 00:00:00
