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Long-term oncological outcomes in patients with limited nodal disease undergoing radical prostatectomy and pelvic lymph node dissection without adjuvant treatment.

Abstract：

PURPOSE:This study aimed at analysing long-term oncologic outcomes in prostate cancer patients with limited nodal disease (1-2 positive lymph nodes) without adjuvant therapy after radical prostatectomy (RP). METHODS:We retrospectively analysed data of 209 pN1 patients who underwent RP between January 1998 and 2010 with one (160) or two (49) histologically proven positive lymph nodes (LNs) without adjuvant treatment. Biochemical recurrence-free survival, metastasis-free survival and cancer-specific survival (CSS) were reported. In multivariable regression analyses further prognosticators of oncologic outcome in these patients were analysed. RESULTS:Median follow-up was 60.2 months. There was no significant difference in oncologic outcome between patients with one and two positive LNs. 73.1% (76.7%) of patients with one (two) positive LNs had biochemical recurrence during the follow-up period, 20.0% (25.6%) developed metastasis and 8.1% (6.1%) died of their disease. The only factors significantly associated with oncologic outcome in multivariable analysis were Gleason score and pT-stage. CONCLUSIONS:Patients with limited nodal disease (1-2 positive LNs) without adjuvant therapy showed favourable CSS-rates above 94% after 5 years. A subgroup of these patients (37%) remained metastasis-free without need of salvage treatment.

journal_name

World J Urol

journal_title

World journal of urology

authors

Mandel P,Rosenbaum C,Pompe RS,Steuber T,Salomon G,Chun FK,Graefen M,Huland H,Tilki D

doi

10.1007/s00345-017-2079-4

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

1833-1839

issue

12

eissn

0724-4983

issn

1433-8726

pii

10.1007/s00345-017-2079-4

journal_volume

35

pub_type

杂志文章

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