当前位置： SCI文献检索 > WORLD JOURNAL OF UROLOGY期刊下所有文献 > NF-κB signaling in prostate cancer: a promising therapeutic target?

NF-κB signaling in prostate cancer: a promising therapeutic target?

Abstract：

:Prostate carcinoma (PCa) displays a wide variety of genetic alterations, versatile expression profiles as well as cell surface markers. Despite this heterogeneity, a common treatment for advanced PCa is androgen deprivation therapy (ADT). ADT targets the androgen receptor-a member of the nuclear receptor superfamily-which is required for development and function of the prostate and critical for PCa growth and survival. After an initial regression of the tumor during ADT, a large fraction of tumors progress to so-called castration-resistant prostate carcinoma (CRPca) which is highly resistant toward chemotherapy. The ensuing high mortality rates illustrate the importance of novel therapeutic targets for CRPCa. The transcription factor NF-κB was recently proposed as such a potential target for therapeutic intervention in CRPCa. Although NF-κB is essential for the regulation of innate and adaptive immunity recent data suggest a role of NF-κB in cancer initiation and progression. However, the exact function of NF-κB signaling in PCa is still a matter of debate. Here, we review known roles of NF-κB signaling in PCa and emphasize the crosstalk of NF-κB and androgen receptor signaling. Finally, we discuss potential therapeutic relevance of blocking NF-κB in PCa.

journal_name

World J Urol

journal_title

World journal of urology

authors

Jain G,Cronauer MV,Schrader M,Möller P,Marienfeld RB

doi

10.1007/s00345-011-0792-y

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

303-10

issue

3

eissn

0724-4983

issn

1433-8726

journal_volume

30

pub_type

杂志文章,评审

相关文献

WORLD JOURNAL OF UROLOGY文献大全
  • Understanding patients' preferences for surgical management of urethral stricture disease.

    abstract：OBJECTIVES:To understand how prioritization of treatment attributes and treatment choice varies by patient characteristics, we sought to specifically determine how demographic variables affect patient treatment preference. PATIENTS AND METHODS:Male patients with urethral stricture disease participated in a choice-base...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-017-2066-9

    authors： Hampson LA,Lin TK,Wilson L,Allen IE,Gaither TW,Breyer BN

    更新日期：2017-11-01 00:00:00

  • The effectiveness of targeted relative to empiric prophylaxis on infectious complications after transrectal ultrasound-guided prostate biopsy: a meta-analysis.

    abstract：PURPOSE:Rectal culture screening for fluoroquinolone (FQ)-resistant Enterobacteriaceae before transrectal ultrasound guided prostate (TRUSPB) biopsy and targeted antibiotic prophylaxis (TAP) may decrease post-TRUSPB infection rates compared to empiric (EAP) regimens. The objective of this study was to evaluate the effe...

    journal_title：World journal of urology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00345-018-2217-7

    authors： Scott S,Harris PN,Williamson DA,Liss MA,Doi SAR,Roberts MJ

    更新日期：2018-07-01 00:00:00

  • Radical retropubic prostatectomy versus brachytherapy for low-risk prostatic cancer: a prospective study.

    abstract：OBJECTIVES:To compare the oncological and functional outcomes reported after radical retropubic prostatectomy (RRP) versus brachytherapy (BT) in the treatment of low-risk prostatic cancer (CaP). METHODS:Between May 1999 and October 2002, 200 patients (mean age 65.3 +/- 8.7) were enrolled and randomized into two groups...

    journal_title：World journal of urology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00345-009-0418-9

    authors： Giberti C,Chiono L,Gallo F,Schenone M,Gastaldi E

    更新日期：2009-10-01 00:00:00

  • Low amplitude rhythmic contraction frequency in human detrusor strips correlates with phasic intravesical pressure waves.

    abstract：PURPOSE:Low amplitude rhythmic contractions (LARC) occur in detrusor smooth muscle and may play a role in storage disorders such as overactive bladder and detrusor overactivity. The purpose of this study was to determine whether LARC frequencies identified in vitro from strips of human urinary bladder tissue correlate ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-016-1994-0

    authors： Colhoun AF,Speich JE,Cooley LF,Bell ED 3rd,Barbee RW,Guruli G,Ratz PH,Klausner AP

    更新日期：2017-08-01 00:00:00

  • Long-term metabolic effects in patients with urinary diversion.

    abstract：:The use of intestinal segments in genitourinary reconstruction could influence vitamin metabolism and affect the skeletal bone and its mineral content in the long term. In 137 patients, serum levels of the vitamins A, B1, B2, B6, B12, D, and E and of folic acid, bile acid, and ammonia as well as levels of intracorpusc...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s003450050069

    authors： Stein R,Lotz J,Andreas J,Fisch M,Prellwitz W,Hohenfellner R,Thüroff JW

    更新日期：1998-01-01 00:00:00

  • Outcome of patients with newly diagnosed prostate cancer with low metastatic burden treated with radical prostatectomy: a comparison to STAMPEDE arm H.

    abstract：PURPOSE:STAMPEDE arm H demonstrated a survival benefit for newly diagnosed prostate cancer (PCa) patients with low metastatic burden (LMB) who additionally received radiotherapy (RT) to the primary. However, it is unknown if radical prostatectomy (RP) may achieve equivalent results, since existing studies did neither i...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02950-0

    authors： Knipper S,Beyer B,Mandel P,Tennstedt P,Tilki D,Steuber T,Graefen M

    更新日期：2020-06-01 00:00:00

  • Comparison of multiparametric and biparametric MRI of the prostate: are gadolinium-based contrast agents needed for routine examinations?

    abstract：PURPOSE:To investigate, if and how omitting gadolinium-based contrast agents (GBCA) and dynamic contrast-enhanced imaging (DCE) influences diagnostic accuracy and tumor detection rates of prostate MRI. METHODS:In this retrospective study, 236 patients were included. The results of biparametric (bpMRI) and multiparamet...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-018-2428-y

    authors： Junker D,Steinkohl F,Fritz V,Bektic J,Tokas T,Aigner F,Herrmann TRW,Rieger M,Nagele U

    更新日期：2019-04-01 00:00:00

  • Comparison of pre-treatment MSKCC and IMDC prognostic risk models in patients with synchronous metastatic renal cell carcinoma treated in the era of targeted therapy.

    abstract：PURPOSE:To compare prognostic performance of MSKCC and IMDC risk models in patients with synchronous mRCC. METHODS:Retrospective analysis of pre-therapeutic MSKCC and IMDC prognostic factors and outcomes in patients with synchronous mRCC treated at a single institute in the targeted therapy era was performed. Cytoredu...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-016-1769-7

    authors： Noe A,de Bruijn RE,Blank C,Horenblas S,Haanen J,Bex A

    更新日期：2016-08-01 00:00:00

  • Scrutiny of cardiovascular risk factors by assessing arterial stiffness in erectile dysfunction patients.

    abstract：PURPOSE:Erectile dysfunction (ED) is an early sign of vascular dysfunction. Studies have reported a correlation between arterial stiffness and cardiovascular events. The objective of this study was to evaluate the association among different criteria for assessing arterial stiffness and cardiovascular risk factors in E...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-009-0486-x

    authors： Chang ST,Chu CM,Hsu JT,Chung CM,Pan KL,Hsiao JF,Lin YS

    更新日期：2010-10-01 00:00:00

  • Adjuvant chemotherapy is ineffective in patients with bladder cancer and variant histology treated with radical cystectomy with curative intent.

    abstract：OBJECTIVES:Adjuvant chemotherapy (ACT) is recommended for non-organ-confined bladder cancer (BCa) after radical cystectomy (RC) and pelvic lymph node dissection (PLND), but there are sparse data regarding its specific efficacy in patients with histological variants. The aim of our study was to evaluate the role of ACT ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-020-03362-1

    authors： Zamboni S,Afferi L,Soria F,Aziz A,Abufaraj M,Poyet C,Necchi A,D'Andrea D,Simone G,Ferriero M,Di Trapani E,Simeone C,Antonelli A,Gallina A,Montorsi F,Briganti A,Colombo R,Gandaglia G,Mattei A,Baumeister P,Mordasini

    更新日期：2020-07-25 00:00:00

  • Differences in histopathological evaluation of standard lymph node dissections result in differences in nodal count but not in survival.

    abstract：OBJECTIVE:To analyse whether the reported differences in nodal yield at pelvic lymph node dissection (PLND) for bladder cancer, between two hospitals, are reflected in the survival rates. PATIENTS AND METHODS:We assessed follow-up data of all 174 patients (mean age: 62.7, median follow-up: 3 years) who underwent PLND ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-012-0916-z

    authors： Mertens LS,Meijer RP,van Werkhoven E,Bex A,van der Poel HG,van Rhijn BW,Meinhardt W,Horenblas S

    更新日期：2013-10-01 00:00:00

  • An antimicrobial prophylaxis protocol using rectal swab cultures for transrectal prostate biopsy.

    abstract：PURPOSE:To evaluate the benefit of an antimicrobial prophylaxis protocol using rectal swab cultures in patients undergoing transrectal ultrasound (TRUS)-guided prostate biopsy in our Veterans Affairs population. METHODS:Between June 1, 2013, and June 1, 2014, we implemented an antimicrobial prophylaxis protocol using ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-015-1571-y

    authors： Summers SJ,Patel DP,Hamilton BD,Presson AP,Fisher MA,Lowrance WT,Southwick AW

    更新日期：2015-12-01 00:00:00

  • PSA-based machine learning model improves prostate cancer risk stratification in a screening population.

    abstract：CONTEXT:The majority of prostate cancer diagnoses are facilitated by testing serum Prostate Specific Antigen (PSA) levels. Despite this, there are limitations to the diagnostic accuracy of PSA. Consideration of patient demographic factors and biochemical adjuncts to PSA may improve prostate cancer risk stratification. ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-020-03392-9

    authors： Perera M,Mirchandani R,Papa N,Breemer G,Effeindzourou A,Smith L,Swindle P,Smith E

    更新日期：2020-08-03 00:00:00

  • Invasive non-urachal adenocarcinoma of the bladder: analysis of the National Cancer Database.

    abstract：PURPOSE:To review the United States National Cancer Database (NCDB) from 2004 to 2015 and analyze survival outcomes of invasive non-urachal adenocarcinoma based on treatment modality. METHODS:The NCDB 2004-2015 bladder dataset was queried for adenocarcinoma histology, excluding urachal variant, and limited to patients...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-018-2411-7

    authors： Davaro F,Schaefer J,May A,Raza J,Siddiqui S,Hamilton Z

    更新日期：2019-03-01 00:00:00

  • Impact of sodium 18F-fluoride PET/CT, 18F-fluorocholine PET/CT and whole-body diffusion-weighted MRI on the management of patients with prostate cancer suspicious for metastasis: a prospective multicentre study.

    abstract：PURPOSE:To compare the impact of 18F-sodium-fluoride (NaF) PET/CT, 18F-fluorocholine (FCH) PET/CT and diffusion-weighted whole-body MRI (DW-MRI) on the management of patients with prostate cancer (PCa) suspicious for distant metastasis. METHODS:Prostate cancer patients were prospectively included between December 2011...

    journal_title：World journal of urology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00345-018-2547-5

    authors： Gauthé M,Aveline C,Lecouvet F,Michaud L,Rousseau C,Tassart M,Cussenot O,Talbot JN,Durand-Zaleski I

    更新日期：2019-08-01 00:00:00

  • The application of ultrasound contrast agents in the characterization of renal tumors.

    abstract：:The aim of this article is to describe the current ultrasound (US) contrast agents employed in the characterization of renal tumors and to report our experience in the use of a contrast-specific ultrasound technique pulse inversion harmonic imaging (PIHI).A total of 23 renal masses were prospectively evaluated by conv...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-004-0410-3

    authors： Siracusano S,Quaia E,Bertolotto M,Ciciliato S,Tiberio A,Belgrano E

    更新日期：2004-11-01 00:00:00

  • 68Ga-labelled PSMA ligand HBED-CC PET/CT imaging in patients with recurrent prostate cancer.

    abstract：BACKGROUND:68Ga-PSMA Positron Emission Tomography/Computerized Tomography (PET/CT) has shown promising results for the detection of recurrent prostate cancer (RPCa). However, the diagnostic value of this method is yet to be validated. The aim of this study was to determine the influence of clinical and biochemical vari...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-018-2460-y

    authors： Akdemir EN,Tuncel M,Akyol F,Bilen CY,Baydar DE,Karabulut E,Ozen H,Caglar M

    更新日期：2019-05-01 00:00:00

  • Does preoperative platelet count and thrombocytosis play a prognostic role in patients undergoing nephrectomy for renal cell carcinoma? Results of a comprehensive retrospective series.

    abstract：PURPOSE:To evaluate the still controversially discussed prognostic role of preoperative platelet level (PPL) and thrombocytosis (TC) in patients who undergo surgery for renal cell carcinoma (RCC) based on the largest patient series reported to date. METHODS:A total of 3,139 patients, who underwent radical or nephron-s...

    journal_title：World journal of urology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00345-012-0931-0

    authors： Brookman-May S,May M,Ficarra V,Kainz MC,Kampel-Kettner K,Kohlschreiber S,Wenzl V,Schneider M,Burger M,Wieland WF,Otto W,Tilki D,Gilfrich C,Hohenfellner M,Pahernik S,Chromecki TF,Stief C,Zigeuner R,Members of the CORON

    更新日期：2013-10-01 00:00:00

  • Safety and efficacy of superior calyceal access versus inferior calyceal access for pelvic and/or lower calyceal renal calculi- a prospective observational comparative study.

    abstract：OBJECTIVE:To compare efficacy and safety between superior calyceal access and inferior calyceal access for pelvic and/or lower calyceal renal stones. METHODS:Consecutive patients presenting with Pelvic and/or inferior calyceal renal calculi were allocated to the superior calyceal access (group 1) or inferior calyceal ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-020-03409-3

    authors： Amaresh M,Hegde P,Chawla A,de la Rosette JJMCH,Laguna MP,Kriplani A

    更新日期：2020-08-31 00:00:00

  • Critical analysis of urethroplasty for male anterior urethral stricture: a single-center experience.

    abstract：PURPOSE:Urethroplasty is the most effective treatment method for anterior urethral strictures, which constitute an important health concern for males. This study aims to investigate factors that may predict treatment failure following urethroplasty for anterior urethral strictures and evaluate outcomes of different ure...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-03014-z

    authors： Yalçınkaya F,Kartal I

    更新日期：2020-09-01 00:00:00

  • Prognostic value of urinary cytology and other biomarkers for recurrence and progression in bladder cancer: a prospective study.

    abstract：PURPOSE:Urinary cytology (C) and cystoscopy remain the gold standard for the detection and screening of bladder cancer (BC). In this prospective study, we analyzed whether baseline C, ImmunoCyt (I), BTA Stat (B), hemoglobin dipstick (H), and NMP22 BladderChek (N) can predict recurrence and progression. METHODS:Urinary...

    journal_title：World journal of urology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00345-016-1795-5

    authors： Bell MD,Yafi FA,Brimo F,Steinberg J,Aprikian AG,Tanguay S,Kassouf W

    更新日期：2016-10-01 00:00:00

  • Histologic characterization of the post-radiation urethral stenosis in men treated for prostate cancer.

    abstract：PURPOSE:To evaluate histological changes in stenotic urethral tissue post-radiation therapy. Treatment of prostate cancer by radiation therapy carries a risk of off-target injury to the membranous urethra causing urethral stenosis. Limited characterization of post-radiation urethral stenosis exists in the literature. W...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-03031-y

    authors： Hughes M,Caza T,Li G,Daugherty M,Blakley S,Nikolavsky D

    更新日期：2020-09-01 00:00:00

  • A single mitochondrial DNA deletion accurately detects significant prostate cancer in men in the PSA 'grey zone'.

    abstract：PURPOSE:To determine the clinical performance of a blood-based test for clinically significant (CS) prostate cancer (PCa) (grade group ≥ 2) intended for use in men with prostate serum antigen levels in the 'grey zone' (PSA < 10 ng/ml). The test quantifies a previously described 3.4 kb mitochondrial DNA (mtDNA) deletion...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-017-2152-z

    authors： Creed J,Klotz L,Harbottle A,Maggrah A,Reguly B,George A,Gnanapragasm V

    更新日期：2018-03-01 00:00:00

  • A prospective risk-stratified follow-up programme for radically treated renal cell carcinoma patients: evaluation after eight years of clinical use.

    abstract：PURPOSE:In mid-2007, we introduced a new risk-stratified follow-up programme (FUP) for surgically treated localized renal cell carcinoma. After inclusion, the patients have been followed prospectively. In this study, we present the results in regard to stratification, completeness of the FUP and recurrences. METHODS:T...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-016-1796-4

    authors： Beisland C,Guðbrandsdottir G,Reisæter LA,Bostad L,Hjelle KM

    更新日期：2016-08-01 00:00:00

  • Inverse stage migration patterns in North American patients undergoing local prostate cancer treatment: a contemporary population-based update in light of the 2012 USPSTF recommendations.

    abstract：PURPOSE:Recent studies demonstrated ongoing inverse stage migration in prostate cancer (PCa) patients towards more advanced and unfavorable tumors. The USPSTF grade D recommendation may impact this trend in North American patients. We assessed contemporary stage migration and treatment trends in a large North American ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-018-2396-2

    authors： Leyh-Bannurah SR,Karakiewicz PI,Pompe RS,Preisser F,Zaffuto E,Dell'Oglio P,Briganti A,Nafez O,Fisch M,Steuber T,Graefen M,Budäus L

    更新日期：2019-03-01 00:00:00

  • Vimentin over-expression and carbonic anhydrase IX under-expression are independent predictors of recurrence, specific and overall survival in non-metastatic clear-cell renal carcinoma: a validation study.

    abstract：PURPOSE:Clinical outcomes prognostic markers are awaited in clear-cell renal carcinoma (ccRCC) to improve patient-tailored management and to assess six different markers' influence on clinical outcomes from ccRCC specimen and their incremental value combined with TNM staging. MATERIALS AND METHODS:This is a retrospect...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-016-1854-y

    authors： Ingels A,Hew M,Algaba F,de Boer OJ,van Moorselaar RJ,Horenblas S,Zondervan P,de la Rosette JJ,Pilar Laguna Pes M

    更新日期：2017-01-01 00:00:00

  • The effects of warm ischaemia time on renal function after laparoscopic partial nephrectomy in patients with normal contralateral kidney.

    abstract：PURPOSE:To assess the effects of warm ischaemia time (WIT) on renal function after laparoscopic partial nephrectomy (LPN) for renal masses in patients with a normal contralateral kidney. METHODS:From October 2006 to December 2008, 53 patients treated with LPN were enrolled in this prospective study. Effective renal pl...

    journal_title：World journal of urology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00345-011-0729-5

    authors： Porpiglia F,Fiori C,Bertolo R,Angusti T,Piccoli GB,Podio V,Russo R

    更新日期：2012-04-01 00:00:00

  • Mediators of the female sexual response: pharmacotherapeutic implications.

    abstract：:A basic understanding of the mediators and related mechanisms involved in the genital physiology of the female sexual response, and, in particular, the physiology of arousal, is paramount for the clinical practitioner whose medical knowledge and practice pertain to female sexual dysfunction. Familiarity with establish...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-002-0271-6

    authors： Burnett AL,Truss MC

    更新日期：2002-06-01 00:00:00

  • Impact of using 29 MHz high-resolution micro-ultrasound in real-time targeting of transrectal prostate biopsies: initial experience.

    abstract：PURPOSE:This report presents our early experience at Cleveland Clinic replacing conventional ultrasound with a novel 29 MHz high-resolution micro-ultrasound system for both systematic sampling and real-time targeting of suspicious regions during prostate biopsy. The added value of micro-ultrasound and MRI over systemat...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02863-y

    authors： Abouassaly R,Klein EA,El-Shefai A,Stephenson A

    更新日期：2020-05-01 00:00:00

  • A quick stone component analysis matters in postoperative fever: a propensity score matching study of 1493 retrograde intrarenal surgery.

    abstract：OBJECTIVE:To evaluate the role of stone components in postoperative fever following RIRS, and to investigate the role of quick stone component analysis during RIRS procedure. PATIENTS AND METHODS:1493 patients with RIRS were retrospectively reviewed. Propensity score matching (PSM) analysis was performed as infection ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-020-03268-y

    authors： Peng L,Xu Z,Wen J,Zhong W,Zeng G

    更新日期：2020-05-24 00:00:00