Abstract:
PURPOSE:STAMPEDE arm H demonstrated a survival benefit for newly diagnosed prostate cancer (PCa) patients with low metastatic burden (LMB) who additionally received radiotherapy (RT) to the primary. However, it is unknown if radical prostatectomy (RP) may achieve equivalent results, since existing studies did neither include the same selection criteria nor examine comparable endpoints as STAMPEDE arm H. METHODS:We retrospectively analysed 78 RP patients (2008-2018) with LMB (< 4 bone metastases) as defined in the subgroup analysis of STAMPEDE arm H. Like in STAMPEDE, overall (OS), metastatic progression-free (MPFS), and PCa-specific (CSS) survival at 3 years, as well as complication and continence rates were assessed. RESULTS:Median age was 64 years. Median follow-up was 36 months. Median initial prostate-specific antigen was 35 ng/ml. At 3 years, OS was 91%, MPFS was 63%, and CSS was 92%, while 81%, 67%, and 86%, respectively, were reported in the RT subgroup with LMB in STAMPEDE arm H. Clavien-Dindo grade III-IV complications were observed in 16 (21%) patients. Of 38 patients with available continence data, 28 (74%) patients were continent and 2 (5%) patients needed ≥ 3 pads/day at 1 year after RP. CONCLUSIONS:When comparing our RP cohort with the results of STAMPEDE arm H with LMB who received RT, no major disadvantage in OS and CSS may be expected. Since local treatment in patients with LMB might now be considered the new standard, RP should be further explored as local treatment option in these patients.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Knipper S,Beyer B,Mandel P,Tennstedt P,Tilki D,Steuber T,Graefen Mdoi
10.1007/s00345-019-02950-0subject
Has Abstractpub_date
2020-06-01 00:00:00pages
1459-1464issue
6eissn
0724-4983issn
1433-8726pii
10.1007/s00345-019-02950-0journal_volume
38pub_type
杂志文章abstract:PURPOSE:To examine the prevalence of lower urinary tract symptoms (LUTS) and the bother they impose in a population-based sample of adults in Brazil. METHODS:A cross-sectional population-based survey was conducted between September 2006 and January 2007 in the city of Salvador, Brazil. Cluster samples of representativ...
journal_title:World journal of urology
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journal_title:World journal of urology
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更新日期:2013-08-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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