当前位置： SCI文献检索 > WORLD JOURNAL OF UROLOGY期刊下所有文献 > The NF-kappaB/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches?

The NF-kappaB/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches?

Abstract：

:The nuclear factor of kappa beta (NF-kappaB) transcription factor regulates the transcription of numerous genes including that of interleukin 6 (IL-6). The IL-6 acts as an autocrine and paracrine growth factor of androgen-independent prostate cancer. An aberrant expression of the IL-6 gene and an increase in IL-6 expression are detected in bone metastatic and hormone-refractory prostate cancer. IL-6 has been suggested to have a crucial role in the resistance to chemotherapy or hormonal therapy involving apoptotic cell death. The NF-kappaB/IL-6 dependent pathways promote tumour-cell survival and in most situations protect cells against apoptotic stimuli. These data provide a rational framework for targeting NF-kappaB and IL-6 activity in novel biologically based therapies for aggressive and androgen independent prostate cancers.

journal_name

World J Urol

journal_title

World journal of urology

authors

Paule B,Terry S,Kheuang L,Soyeux P,Vacherot F,de la Taille A

doi

10.1007/s00345-007-0175-6

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

477-89

issue

5

eissn

0724-4983

issn

1433-8726

journal_volume

25

pub_type

杂志文章,评审

相关文献

WORLD JOURNAL OF UROLOGY文献大全
  • Transrectal contrast enhanced ultrasound for diagnosis of prostate cancer.

    abstract：:The diagnosis of prostate cancer is based on histology. Prostate biopsies are obtained based on the triad of prostate specific antigen (PSA), digital rectal examination (DRE) and transrectal ultrasound. Because prostate biopsies still have a large percentage of negative outcomes, patient selection and biopsy direction...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-007-0189-0

    authors： Wink MH,de la Rosette JJ,Grimbergen CA,Wijkstra H

    更新日期：2007-08-01 00:00:00

  • Concomitant carcinoma in situ may not be a prognostic factor for patients with bladder cancer following radical cystectomy: a PRISMA-compliant systematic review and meta-analysis.

    abstract：BACKGROUND:Numerous recent studies have shown that concomitant carcinoma in situ (CIS) can be closely associated with the prognosis of patients with bladder cancer (BCa). However, the prognostic value of CIS in BCa is still not conclusive. Hence, we performed a systematic review and meta-analysis to explore the associa...

    journal_title：World journal of urology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00345-019-02738-2

    authors： Zhang L,Wu B,Zha Z,Zhao H,Yuan J,Jiang Y

    更新日期：2020-01-01 00:00:00

  • PSA-based machine learning model improves prostate cancer risk stratification in a screening population.

    abstract：CONTEXT:The majority of prostate cancer diagnoses are facilitated by testing serum Prostate Specific Antigen (PSA) levels. Despite this, there are limitations to the diagnostic accuracy of PSA. Consideration of patient demographic factors and biochemical adjuncts to PSA may improve prostate cancer risk stratification. ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-020-03392-9

    authors： Perera M,Mirchandani R,Papa N,Breemer G,Effeindzourou A,Smith L,Swindle P,Smith E

    更新日期：2020-08-03 00:00:00

  • Prostatic peripheral nerve distribution may impact the functional outcome of nerve-sparing prostatectomy.

    abstract：PURPOSE:To study microscopic patterns of remaining peripheral nerves (PN) after nerve-sparing (NS) radical prostatectomy (RP) and possible consequences for nerve preparation. METHODS:Specimens from 27 patients (7 = non-NSRP, 20 = unilateral NS) were examined. Sections were investigated for PN content by immunoassaying...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-011-0791-z

    authors： Amend B,Hennenlotter J,Kuehs U,Laible I,Anastasiadis A,Schilling D,Stenzl A,Sievert KD

    更新日期：2013-04-01 00:00:00

  • Perioperative and long-term renal functional outcomes of robotic versus laparoscopic partial nephrectomy: a multicenter matched-pair comparison.

    abstract：PURPOSE:We compared perioperative and long-term renal functional outcomes of robot-assisted partial nephrectomy (RAPN) with laparoscopic partial nephrectomy (LPN) for small renal masses. MATERIALS AND METHODS:A total of 1,032 patients were included for evaluation; propensity score matching was performed to adjust for ...

    journal_title：World journal of urology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00345-015-1488-5

    authors： Kim JH,Park YH,Kim YJ,Kang SH,Byun SS,Kwak C,Hong SH

    更新日期：2015-10-01 00:00:00

  • Standardization of definitions in focal therapy of prostate cancer: report from a Delphi consensus project.

    abstract：PURPOSE:To reach standardized terminology in focal therapy (FT) for prostate cancer (PCa). METHODS:A four-stage modified Delphi consensus project was undertaken among a panel of international experts in the field of FT for PCa. Data on terminology in FT was collected from the panel by three rounds of online questionna...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-016-1782-x

    authors： Postema AW,De Reijke TM,Ukimura O,Van den Bos W,Azzouzi AR,Barret E,Baumunk D,Blana A,Bossi A,Brausi M,Coleman JA,Crouzet S,Dominguez-Escrig J,Eggener S,Ganzer R,Ghai S,Gill IS,Gupta RT,Henkel TO,Hohenfellner M,Jo

    更新日期：2016-10-01 00:00:00

  • Local antiseptic therapy for non-gonococcal urethritis: phase II study with Instillagel.

    abstract：:Non-gonococcal urethritis (NGU) is conventionally treated with oral antibiotics. With this Phase II study, we investigated the action of a locally disinfecting substance, Instillagel, in symptomatic NGU. Instillation treatment was performed twice daily to 32 male patients with symptomatic NGU. To evaluate the therapeu...

    journal_title：World journal of urology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00345-001-0236-1

    authors： Sperling H,Bastian HP,Boeminghau F,Ludwig G,Terhorst B,Rübben H

    更新日期：2002-05-01 00:00:00

  • Can the ice-water test predict the outcome of intradetrusor injections of botulinum toxin in patients with neurogenic bladder dysfunction?

    abstract：:The aim of this project was to evaluate the ice-water test as a predictor of the response to intradetrusor botulinum toxin injection in patients with neurogenic detrusor overactivity. We retrospectively evaluated the urodynamic parameters in 22 patients with neurogenic bladder dysfunction and positive ice-water test. ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-007-0208-1

    authors： Huwyler M,Schurch B,Knapp PA,Reitz A

    更新日期：2007-12-01 00:00:00

  • Update of the International Consultation on Urological Diseases on bladder cancer 2018: non-urothelial cancers of the urinary bladder.

    abstract：PURPOSE:To provide a comprehensive update of the joint consultation of the International Consultation on Urological Diseases (ICUD) for the diagnosis and management of non-urothelial cancer of the urinary bladder. METHODS:A detailed analysis of the literature was conducted reporting on the epidemiology, etiology, diag...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-018-2421-5

    authors： Alanee S,Alvarado-Cabrero I,Murugan P,Kumar R,Nepple KG,Paner GP,Patel MI,Raspollini MR,Lopez-Beltran A,Konety BR

    更新日期：2019-01-01 00:00:00

  • Necessity of differentiating small (

    abstract：PURPOSE:Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) provides reasonable performance in detecting significant cancers. Still, it is unclear about whether all PI-RADS 4 lesions show the same cancer detection rate (CDR) regardless of tumor size. The aim was to compare the CDRs of small (< 10 mm) and l...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02924-2

    authors： Park SY,Park BK

    更新日期：2020-06-01 00:00:00

  • Accelerated Skills Acquisition Protocol (ASAP) in optimizing robotic surgical simulation training: a prospective randomized study.

    abstract：PURPOSE:To assess the efficacy of an accelerated proficiency-based training protocol in robotic simulation practice in delivering durable proficiency compared to conventional training methods. METHODS:Novice medical students (n = 16) were randomized into either the accelerated skills acquisition protocol (ASAP) or con...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02858-9

    authors： Gurung PMS,Campbell T,Wang B,Joseph JV,Ghazi AE

    更新日期：2020-07-01 00:00:00

  • Predictors of admission in patients presenting to the emergency department with urinary tract infection.

    abstract：PURPOSE:Previous studies examining the management of urinary tract infections (UTI) showed marked variability in the economical burden of care, with a tenfold increase in costs when patients require admission to the hospital. We sought to examine the patient and emergency department (ED) characteristics associated with...

    journal_title：World journal of urology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00345-013-1167-3

    authors： Sammon JD,Sharma P,Rahbar H,Roghmann F,Ghani KR,Sukumar S,Karakiewicz PI,Peabody JO,Elder JS,Menon M,Sun M,Trinh QD

    更新日期：2014-06-01 00:00:00

  • The detection of prostatic carcinoma. 4- or 7-MHz transrectal ultrasonography?

    abstract：:In this prospective study a comparison of 4-versus 7-MHz transrectal ultrasonography for the detection of prostatic carcinoma is reported. A total of 150 prostates were biopsied due to suspicion of malignancy arising at either digital rectal examination, 4- and/or 7-MHz transrectal ultrasonography, or elevated serum p...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/BF00182174

    authors： Vleeming R,Noordzij JW,de Reijke TM,Kurth KH

    更新日期：1993-01-01 00:00:00

  • The Urological Dyna-CT: ex vivo feasibility study of interventional cross-sectional imaging in the endourological operation room.

    abstract：BACKGROUND:Imaging of the urinary tract and its surrounding tissue still remains challenging, since standard imaging in the urological operation room consists of fluoroscopy and plain X-rays. The combination of a ceiling-mounted X-ray system and a new urological intervention table now allows cross-sectional imaging and...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-012-0951-9

    authors： Michel MS,Ritter M,Wertz H,Schönberg S,Häcker A,Weisser G

    更新日期：2014-02-01 00:00:00

  • A novel method of surgical instruction: international telementoring.

    abstract：:Telemedicine is the use of communication technologies to deliver health care. Telesurgical telementoring represents an advanced form of telemedicine, whereby an experienced surgeon can guide and teach practicing surgeons new operative techniques utilizing current video technology, medical robots, and high-band-width t...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s003450050082

    authors： Lee BR,Bishoff JT,Janetschek G,Bunyaratevej P,Kamolpronwijit W,Cadeddu JA,Ratchanon S,O'Kelley S,Kavoussi LR

    更新日期：1998-01-01 00:00:00

  • The use of hemostatic agents does not prevent hemorrhagic complications of robotic partial nephrectomy.

    abstract：PURPOSE:To assess the impact of HA on robotic PN (RPN) outcomes. METHODS:We retrospectively analyzed data from patients who underwent RPN in eight centers between 2009 and 2013. Hemorrhagic complications were defined as the occurrence of a pseudoaneurysm, arteriovenous fistula or hematoma requiring transfusion. Patien...

    journal_title：World journal of urology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00345-015-1537-0

    authors： Peyronnet B,Oger E,Khene Z,Verhoest G,Mathieu R,Roumiguié M,Beauval JB,Pradere B,Masson-Lecomte A,Vaessen C,Baumert H,Bernhard JC,Doumerc N,Droupy S,Bruyere F,De La Taille A,Roupret M,Bensalah K

    更新日期：2015-11-01 00:00:00

  • Live surgery in reconstructive urology: evaluation of the surgical outcome and educational benefit of the international meeting on reconstructive urology (IMORU).

    abstract：PURPOSE:The international meeting on reconstructive Urology (IMORU) is a live surgery event (LSE) where expert surgeons perform various reconstructive surgeries. To evaluate patient safety, an extended follow-up of the complications of two subsequent IMORU meetings were gathered. Also, a detailed survey concerning the ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02666-1

    authors： Schuettfort VM,Schoof J,Rosenbaum CM,Ludwig TA,Vetterlein MW,Leyh-Bannurah SR,Maurer V,Meyer CP,Dahlem R,Fisch M,Reiss CP

    更新日期：2019-11-01 00:00:00

  • The prognostic role of preoperative circulating neutrophil-lymphocyte ratio in primary bladder cancer patients undergoing radical cystectomy: a meta-analysis.

    abstract：BACKGROUND:Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of preoperative circulating neutrophil-lymphocyte ratio (NLR) (known as a marker of SIR) in human primary bladder cancer (BC) undergoing radical cystectomy (RC) remains c...

    journal_title：World journal of urology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00345-018-2593-z

    authors： Hu G,Xu F,Zhong K,Wang S,Xu Q,Huang L,Cheng P

    更新日期：2019-09-01 00:00:00

  • First clinical evaluation of a new innovative ureteral access sheath (Re-Trace™): a European study.

    abstract：PURPOSE:The use of a ureteral access sheath (UAS) during flexible retrograde intrarenal surgery (RIRS) has become increasingly popular. Our aim was to evaluate the accessibility of a new UAS device, allowing the transformation of the working guidewire into a safety guidewire. METHODS:A prospective, multicenter study w...

    journal_title：World journal of urology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00345-013-1094-3

    authors： Doizi S,Knoll T,Scoffone CM,Breda A,Brehmer M,Liatsikos E,Cornu JN,Traxer O

    更新日期：2014-02-01 00:00:00

  • Surgical teaching in urology: patient safety and educational value of 'LIVE' and 'SEMI-LIVE' surgical demonstrations.

    abstract：PURPOSE:To evaluate the opinion of urologists and their audience regarding patient safety and educational value of live surgical demonstrations (LSD) and semi-live surgical demonstrations (semi-LSD). METHODS:Following the '2017 Challenges in Endourology' meeting, a survey addressing patient safety and the educational ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-018-2291-x

    authors： Legemate JD,Zanetti SP,Freund JE,Baard J,de la Rosette JJMCH

    更新日期：2018-10-01 00:00:00

  • Surveillance and management of urologic complications after spinal cord injury.

    abstract：PURPOSE:Neurogenic bladder due to spinal cord injury has significant consequences for patients' health and quality of life. Regular surveillance is required to assess the status of the upper and lower urinary lower urinary tracts and prevent their deterioration. In this review, we examine surveillance techniques in neu...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-018-2345-0

    authors： Kreydin E,Welk B,Chung D,Clemens Q,Yang C,Danforth T,Gousse A,Kielb S,Kraus S,Mangera A,Reid S,Szell N,Cruz F,Chartier-Kastler E,Ginsberg DA

    更新日期：2018-10-01 00:00:00

  • One-Stop MRI and MRI/transrectal ultrasound fusion-guided biopsy: an expedited pathway for prostate cancer diagnosis.

    abstract：PURPOSE:To assess the feasibility, safety, and outcomes of an expedited One-Stop prostate cancer (PCa) diagnostic pathway. PATIENTS AND METHODS:We identified 370 consecutive patients who underwent multiparametric magnetic resonance imaging (mpMRI) and transrectal ultrasound fusion prostate biopsy (MRI/TRUS-PBx) from o...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02835-2

    authors： Tafuri A,Ashrafi AN,Palmer S,Shakir A,Cacciamani GE,Iwata A,Iwata T,Cai J,Sali A,Gupta C,Medina LG,Stern MC,Duddalwar V,Aron M,Gill IS,Abreu A

    更新日期：2020-04-01 00:00:00

  • Long-term outcome of kidneys with initially poor drainage or no drainage following pyeloplasty.

    abstract：:Pyeloplasty for congenital ureteropelvic junction (UPJ) obstruction enjoys a 90-95% success rate. Although treatment of the failed pyeloplasty has been addressed in the literature, management of the poorly draining or nondraining renal unit in the immediate postoperative period has not received any attention. For this...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/BF00183119

    authors： Miyamoto KK,Mesrobian HG

    更新日期：1996-01-01 00:00:00

  • The ileal neobladder in female patients with bladder cancer: long-term clinical, functional, and oncological outcome.

    abstract：PURPOSE:To assess long-term clinical and oncological outcome in women undergoing radical cystectomy and ileal neobladder reconstruction for invasive bladder cancer. METHODS:From 1995 to 2010, a total of 121 women with clinically organ-confined urothelial carcinoma underwent radical cystectomy with an orthotopic ileal ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-012-0837-x

    authors： Jentzmik F,Schrader AJ,de Petriconi R,Hefty R,Mueller J,Doetterl J,Eickhoff A,Schrader M

    更新日期：2012-12-01 00:00:00

  • Inferring bladder cancer research prioritization from patient-generated online content.

    abstract：PURPOSE:Patients and their families utilize online resources when dealing with a diagnosis of bladder cancer. Many patients have questions regarding clinical management options. Online research forums may help researchers and providers identify research areas of interest. Our objective was to review online forums and i...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-018-2479-0

    authors： Mossanen M,Chu A,Smith AB,Gore JL

    更新日期：2019-06-01 00:00:00

  • Challenges in urogenital tuberculosis.

    abstract：PURPOSE:For better understanding of urogenital tuberculosis (UGTB), its clinical spectrum and characteristic features need to be evaluated. MATERIALS AND METHODS:One hundred and forty-two cases of UGTB patients were analyzed retrospectively. We considered age, gender, symptoms, and diagnostic procedures. RESULTS:The ...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02767-x

    authors： Kulchavenya E,Kholtobin D,Shevchenko S

    更新日期：2020-01-01 00:00:00

  • Biopsy standards for detection of prostate cancer.

    abstract：:The widespread use of measurement of prostate-specific antigen for prostate cancer screening has led to a dramatic increase in the number of transrectal biopsies. Although transrectal ultrasound-guided prostate biopsy is the gold standard in the diagnosis of prostate cancer, the strategies for initial and repeat biops...

    journal_title：World journal of urology

    pub_type： 杂志文章,评审

    doi：10.1007/s00345-007-0151-1

    authors： Djavan B,Margreiter M

    更新日期：2007-03-01 00:00:00

  • Familial risk of urological cancers: data for clinical counseling.

    abstract：:Familial risks for cancer are important for clinical counseling and understanding cancer etiology. The nationwide Swedish Family-Cancer Database includes all Swedes born in 1932 and later (0 to 68-year-old offspring) with their parents, totaling over 10.2 million individuals. Urological cancer cases were retrieved fro...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-003-0375-7

    authors： Hemminki K,Li X,Czene K

    更新日期：2004-02-01 00:00:00

  • Intra- and inter-resting-state networks abnormalities in overactive bladder syndrome patients: an independent component analysis of resting-state fMRI.

    abstract：PURPOSE:This study aims to determine whether intra-network and inter-network brain connectivities are altered using an independent component analysis (ICA). METHODS:Resting-state functional MRI (rs-fMRI) data were acquired from 26 patients with OAB and 28 healthy controls (HC). Eleven resting-state networks (RSNs) wer...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-019-02838-z

    authors： Zuo L,Chen J,Wang S,Zhou Y,Wang B,Gu H

    更新日期：2020-04-01 00:00:00

  • Advanced ultrasound in the diagnosis of prostate cancer.

    abstract：:The diagnosis of prostate cancer (PCa) can be challenging due to the limited performance of current diagnostic tests, including PSA, digital rectal examination and transrectal conventional US. Multiparametric MRI has improved PCa diagnosis and is recommended prior to biopsy; however, mp-MRI does miss a substantial num...

    journal_title：World journal of urology

    pub_type： 杂志文章

    doi：10.1007/s00345-020-03193-0

    authors： Correas JM,Halpern EJ,Barr RG,Ghai S,Walz J,Bodard S,Dariane C,de la Rosette J

    更新日期：2020-04-18 00:00:00