Abstract:
PURPOSE:To reach standardized terminology in focal therapy (FT) for prostate cancer (PCa). METHODS:A four-stage modified Delphi consensus project was undertaken among a panel of international experts in the field of FT for PCa. Data on terminology in FT was collected from the panel by three rounds of online questionnaires. During a face-to-face meeting on June 21, 2015, attended by 38 experts, all data from the online rounds were reviewed and recommendations for definitions were formulated. RESULTS:Consensus was attained on 23 of 27 topics; Targeted FT was defined as a lesion-based treatment strategy, treating all identified significant cancer foci; FT was generically defined as an anatomy-based (zonal) treatment strategy. Treatment failure due to the ablative energy inadequately destroying treated tissue is defined as ablation failure. In targeting failure the energy is not adequately applied to the tumor spatially and selection failure occurs when a patient was wrongfully selected for FT. No definition of biochemical recurrence can be recommended based on the current data. Important definitions for outcome measures are potency (minimum IIEF-5 score of 21), incontinence (new need for pads or leakage) and deterioration in urinary function (increase in IPSS >5 points). No agreement on the best quality of life tool was established, but UCLA-EPIC and EORTC-QLQ-30 were most commonly supported by the experts. A complete overview of statements is presented in the text. CONCLUSION:Focal therapy is an emerging field of PCa therapeutics. Standardization of definitions helps to create comparable research results and facilitate clear communication in clinical practice.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Postema AW,De Reijke TM,Ukimura O,Van den Bos W,Azzouzi AR,Barret E,Baumunk D,Blana A,Bossi A,Brausi M,Coleman JA,Crouzet S,Dominguez-Escrig J,Eggener S,Ganzer R,Ghai S,Gill IS,Gupta RT,Henkel TO,Hohenfellner M,Jodoi
10.1007/s00345-016-1782-xsubject
Has Abstractpub_date
2016-10-01 00:00:00pages
1373-82issue
10eissn
0724-4983issn
1433-8726pii
10.1007/s00345-016-1782-xjournal_volume
34pub_type
杂志文章,评审abstract:PURPOSE:We sought the association of preoperative serum total testosterone (tT), hypogonadism, 17β estradiol (E2), and sex hormone-binding globulin (SHBG) with early biochemical recurrence (BCR) after radical prostatectomy (RP). METHODS:Sex steroids were assessed the day before surgery (7-11 a.m.) in a cohort of 605 p...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-0856-7
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:To investigate Occult Stress Urinary Incontinence (OSUI) using physical exam (PE) and urodynamics (UDS) in women with advanced pelvic organ prolapse (POP), and compare the two methods. METHODS:This study comprised 105 women with POP stage-III and -IV, according to POP quantification (POP-Q) system, evaluated p...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2366-8
更新日期:2019-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2615-x
更新日期:2019-10-01 00:00:00
abstract::Although immediate radical cystectomy remains the standard of care for invasive bladder cancer, a large body of international experience from single institutions and cooperative groups has accumulated, suggesting favorable results with bladder-sparing approaches in appropriately selected patients. Modern selective bla...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-006-0114-y
更新日期:2006-11-01 00:00:00
abstract:PURPOSE:To compare serial changes of postoperative storage symptoms between PVP and HoLEP, and to identify the predictors influencing postoperative improvement of storage symptoms. METHODS:A total of 486 men (PVP group: 213 cases; HoLEP group: 273 cases), in whom 12-month follow-up data were available, were included i...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1424-0
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abstract::Urinary bladder cancer (UBC) ranks ninth in worldwide cancer incidence. It is more frequent in men than in women. We review the main established/proposed factors, both environmental and genetic, associated with bladder cancer etiology and prognosis. Data were extracted from previous reviews and original articles ident...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-007-0168-5
更新日期:2007-06-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1099-y
更新日期:2014-06-01 00:00:00
abstract::The use of intestinal segments in genitourinary reconstruction could influence vitamin metabolism and affect the skeletal bone and its mineral content in the long term. In 137 patients, serum levels of the vitamins A, B1, B2, B6, B12, D, and E and of folic acid, bile acid, and ammonia as well as levels of intracorpusc...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s003450050069
更新日期:1998-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-021-03599-4
更新日期:2021-01-29 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03229-5
更新日期:2020-05-05 00:00:00
abstract::Urinary tract infection (UTI) remains the most common type of infection contracted by kidney transplant patients. UTI reduces both patient and graft survival. Understanding and managing UTI in transplant patients requires an appreciation of their unique anatomy and physiology. Both the transplant and native urinary sy...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-019-02742-6
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Different methods for induction and monitoring of urethral sphincter deficiency were explored in a large animal model. METHODS:Sphincter deficiency was established in female pigs by dilatation and cauterization, and amount and frequencies of voiding were monitored and explored by pad test. Sphincteric closu...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2088-3
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:Prostate cancer (PCa) is the most common malignancy in men and the cause for the second most common cancer-related death in the western world. Despite ongoing development of novel approaches such as second generation androgen receptor targeted therapies, metastatic disease is still fatal. In PCa, immunotherapy ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03497-1
更新日期:2020-10-26 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2178-x
更新日期:2018-04-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-016-1807-5
更新日期:2016-11-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-0876-3
更新日期:2013-10-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0658-3
更新日期:2011-06-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02814-7
更新日期:2020-03-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02996-0
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-008-0235-6
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF01836343
更新日期:1996-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2353-0
更新日期:2018-12-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-016-1788-4
更新日期:2016-10-01 00:00:00
abstract::The original article can be found online. ...
journal_title:World journal of urology
pub_type: 已发布勘误
doi:10.1007/s00345-020-03495-3
更新日期:2020-10-24 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-0955-5
更新日期:2014-02-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2135-0
更新日期:2018-03-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-018-2547-5
更新日期:2019-08-01 00:00:00
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journal_title:World journal of urology
pub_type: 临床试验,杂志文章
doi:10.1007/s00345-011-0788-7
更新日期:2013-04-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2455-8
更新日期:2019-05-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03490-8
更新日期:2020-10-20 00:00:00