Abstract:
:Radical cystectomy with pelvic lymph node dissection has been accepted as the standard treatment for muscle-invasive bladder cancer. Radiation therapy and chemotherapy are increasingly being implemented in bladder-preservation protocols to provide an alternative treatment to cystectomy. We review experience with radiation and chemotherapy in treating bladder cancer and their use in bladder-preservation protocols. Multimodality organ-sparing treatment strategies offer overall survival rates comparable to radical cystectomy and pelvic lymph node dissection in selected cases. However, bladder-preservation techniques risk local recurrence of potentially aggressive tumors whose long-term effect on cancer-specific survival has not been fully characterized. No improvement in quality of life has clearly been demonstrated with bladder-preservation regimens. Bladder-preservation protocols are costly and require precise coordination of multiple specialists as well as strict, life-long patient compliance. Bladder-preservation protocols should only be performed at tertiary care centers with experience in their administration and be limited to patients desiring an alternative cystectomy or who are not surgical candidates.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Bradley BA,Wajsman Zdoi
10.1007/s00345-002-0276-1keywords:
subject
Has Abstractpub_date
2002-08-01 00:00:00pages
167-74issue
3eissn
0724-4983issn
1433-8726journal_volume
20pub_type
杂志文章,评审abstract::It is well established that transmitters of the nonadrenergic-noncholinergic (NANC) system are involved in the control of sexual arousal and penile erection in healthy males. The proerectile activity of dopamine D1/D2 receptor agonist apomorphine-HCl (IXENSE, UPRIMA) involves oxytocinergic pathways descending from the...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-002-0300-5
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:Assess knowledge and awareness concerning human papillomavirus (HPV) infection, HPV-associated diseases, and the existence of a specific vaccine among non-HPV-screened Caucasian-European adults after the market introduction of HPV vaccines. METHODS:A cohort of 934 consecutive patients seeking their first medic...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1379-1
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:Adjuvant chemotherapy (ACT) is recommended for non-organ-confined bladder cancer (BCa) after radical cystectomy (RC) and pelvic lymph node dissection (PLND), but there are sparse data regarding its specific efficacy in patients with histological variants. The aim of our study was to evaluate the role of ACT ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03362-1
更新日期:2020-07-25 00:00:00
abstract::This study examined subjective continence status and use of subsequent alternative therapeutic procedures at long-term follow-up after collagen injection for stress incontinence (SI) in women. Seventy women who underwent collagen injection for SI were identified by retrospective chart review and surveyed by mail quest...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-007-0193-4
更新日期:2007-08-01 00:00:00
abstract:PURPOSE:To examine the prevalence of lower urinary tract symptoms (LUTS) and the bother they impose in a population-based sample of adults in Brazil. METHODS:A cross-sectional population-based survey was conducted between September 2006 and January 2007 in the city of Salvador, Brazil. Cluster samples of representativ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1057-8
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of WX-G250, a chimeric monoclonal antibody that binds to carboxy anhydrase IX, combined with low-dose interferon-alpha (LD-IFNα) in patients with progressive metastatic renal cell carcinoma (mRCC). PATIENTS AND METHODS:Thirty-one patients, nephrectomized for the primary tumo...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-010-0570-2
更新日期:2011-02-01 00:00:00
abstract::Familial risks for cancer are important for clinical counseling and understanding cancer etiology. The nationwide Swedish Family-Cancer Database includes all Swedes born in 1932 and later (0 to 68-year-old offspring) with their parents, totaling over 10.2 million individuals. Urological cancer cases were retrieved fro...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-003-0375-7
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:Prognoses for intermediate-risk prostate cancer (PCa) remain heterogeneous. Improved substratification could optimize treatment and monitoring strategies. The objective was to validate this subclassification in a radical prostatectomy (RP) series. METHODS:Between 2000 and 2011, 4038 patients who underwent R...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-016-1979-z
更新日期:2017-08-01 00:00:00
abstract::The aim of this cross-sectional study was to compare single with repeated high-intensity focused ultrasound (HIFU) treatment in patients with localized prostate cancer, regarding treatment-related morbidity. A number of 223 consecutive patients with localized prostate cancer were treated with HIFU. Among them, 174 (78...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-006-0107-x
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVES:To report the surgical outcomes of laparoscopic radical cystectomy (LRC) with extracorporeal orthotopic ileal neobladder (OIN) in patients with muscle-invasive urothelial carcinoma of the bladder (UCB). MATERIALS AND METHODS:Between October 2009 and December 2011, 37 patients with muscle-invasive UCB underw...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1122-3
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:Treatment options for antimuscarinic refractory neurogenic detrusor overactivity (NDO) are botulinum toxin type A injections (BTX-A) and augmentation cystoplasty (AC). We estimated initial and cumulative 5-year costs of these treatments. MATERIALS AND METHODS:Base case is an individual with antimuscarinic refr...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-010-0618-3
更新日期:2011-02-01 00:00:00
abstract:INTRODUCTION:The management of the regional lymph nodes in penile cancer patients, particularly when these lymph nodes are impalpable, remains controversial. Prophylactic bilateral inguinal lymphadenectomy is associated with high morbidity and is often unnecessary. However, there is no non-invasive or minimally invasiv...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-008-0288-6
更新日期:2009-04-01 00:00:00
abstract::Recent investigations have given a clearer insight into the genetic progression of bladder cancer. In this review we identify the clinical courses of bladder cancer, review the basic concepts of carcinogenesis, and focus on the specific cytogenetic and molecular alterations observed in bladder cancer. Progression mode...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/BF00184243
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Reactive oxygen species (ROS) are produced during the interaction between oxalate/calcium oxalate monohydrate (COM) crystals and renal epithelial cells and are responsible for the various cellular responses through the activation of NADPH oxidase (Nox). Ox and COM also activate the renin-ang...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1563-y
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To assess treatments and survival of patients with muscle invasive bladder cancer (MIBC) in the Comprehensive Cancer Center Northern Netherlands (CCCN) region. STUDY DESIGN AND SETTING:Retrospective cohort analysis. Data of 548 patients with MIBC diagnosed between 1997 and 2002 were collected from the CCCN c...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-010-0546-2
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:Patients presenting with prostate gland sizes greater than 200 cc pose a unique surgical challenge to both patients and surgeons. The objective of this study is to critically assess the efficacy and risks associated with performing holmium laser enucleation of the prostate (HoLEP) on glands ≥ 200 cc. MATERIALS...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03156-5
更新日期:2020-03-23 00:00:00
abstract:PURPOSE:We compared perioperative and long-term renal functional outcomes of robot-assisted partial nephrectomy (RAPN) with laparoscopic partial nephrectomy (LPN) for small renal masses. MATERIALS AND METHODS:A total of 1,032 patients were included for evaluation; propensity score matching was performed to adjust for ...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-015-1488-5
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:To study microscopic patterns of remaining peripheral nerves (PN) after nerve-sparing (NS) radical prostatectomy (RP) and possible consequences for nerve preparation. METHODS:Specimens from 27 patients (7 = non-NSRP, 20 = unilateral NS) were examined. Sections were investigated for PN content by immunoassaying...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0791-z
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the impact of age, stone size, location, radiolucency, extraction of stone fragments, size of ureteroscope and presence and degree of hydronephrosis on the efficacy and safety of holmium:YAG (Ho:YAG) laser lithotripsy in the ureteroscopic treatment of ureteral stones in children. METHODS:Between...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1152-x
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess the impact of experience on the outcome of image fusion-guided prostate biopsies performed by urologists working at a high-volume medical center. METHODS:The first 210 consecutive fusion biopsies were analyzed following installation of the software-based biopsy platform Arte...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2605-z
更新日期:2019-10-01 00:00:00
abstract:PURPOSES:To describe the differential tissue expression of tumor-associated trypsin inhibitor (TATI) in normal bladder urothelium, primary urothelial carcinoma of the bladder (UCB) and metastatic UCB and to assess the association of TATI expression with molecular markers commonly altered in UCB and clinical outcomes af...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0727-7
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:This study aimed at analysing long-term oncologic outcomes in prostate cancer patients with limited nodal disease (1-2 positive lymph nodes) without adjuvant therapy after radical prostatectomy (RP). METHODS:We retrospectively analysed data of 209 pN1 patients who underwent RP between January 1998 and 2010 wit...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2079-4
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:The aim of the study is to evaluate the impact of having a nadir and persistently detectable ultrasensitive prostate-specific antigen (uPSA) between 0.01 and 0.1 ng/ml post-robot-assisted radical prostatectomy (RARP), on future biochemical recurrence (BCR). METHODS:We conducted a retrospective analysis of a pr...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03367-w
更新日期:2020-07-21 00:00:00
abstract:PURPOSE:To assess the pathological and the oncologic outcomes of the prostate cancer (PCa) missed by 6- and 12-core biopsy protocols by using a reference 21-core scheme. MATERIALS AND METHODS:Between 2001 and 2009, all patients who had PCa detected in an initial 21-core TRUS biopsy scheme and were treated by a radical...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0800-2
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:To evaluate histological changes in stenotic urethral tissue post-radiation therapy. Treatment of prostate cancer by radiation therapy carries a risk of off-target injury to the membranous urethra causing urethral stenosis. Limited characterization of post-radiation urethral stenosis exists in the literature. W...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-03031-y
更新日期:2020-09-01 00:00:00
abstract:INTRODUCTION:The survival of patients with metastatic urothelial cancer (mUC) is poor. During the last 40 years, chemotherapy was the predominant treatment modality for mUC. The discovery of the immune checkpoint inhibitors (ICI), especially the inhibitors of the programmed cell death 1 and its ligand (PD-1/PD-L1), has...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-018-2538-6
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:To evaluate whether stone dust can be obtained from all prevailing stone composition types using the thulium fiber laser (TFL) for lithotripsy. Where applicable, stone dust was further characterized by morpho-constitutional analysis. METHODS:Human urinary stones were submitted to in vitro lithotripsy using a F...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03217-9
更新日期:2020-05-03 00:00:00
abstract:PURPOSE:To identify factors predicting the risk of inguinal metastasis in squamous cell carcinoma of the penis. The therapeutic advantages of early lymphadenectomy in squamous cell carcinoma of the penis must be counterbalanced against its post-operative morbidity. Loss to follow up is a major problem in developing cou...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-009-0421-1
更新日期:2010-02-01 00:00:00
abstract:PURPOSE:Robotic-assisted laparoscopic (RAL) surgery has gained momentum in pediatric urology. Technological adaptations such as the development of 5 mm instruments have led to robotic procedures being performed on younger children and those having smaller body habitus, with improved cosmesis. However, concerns have bee...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02765-z
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To assess the oncological safety of laparoscopic procedures for the management of urothelial carcinomas of the urinary tract. METHODS:Data on laparoscopic management of urothelial carcinomas in the literature were analysed using MEDLINE and by matching the following keywords: urological malignancies, upper t...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-008-0349-x
更新日期:2009-02-01 00:00:00