Abstract：
:A once-daily (o.d.) formulation of alfuzosin has recently been developed in order to improve the convenience of dosing and to provide optimal pharmacokinetic coverage over a 24-h period. The results of two double-blind, placebo-controlled phase III studies of similar design that included 983 patients with LUTS that suggested BPH have confirmed that alfuzosin 10 mg o.d. is a 24-h effective treatment for both symptoms and flow rates, and that there is no additional benefit in using a higher dosage. In addition, alfuzosin is the only α1-blocker that has demonstrated a significant decrease in post-void residual urine, a known risk factor for acute urinary retention, as well as the incidence of acute urinary retention in comparison with a placebo. Administered without an initial dose titration, alfuzosin 10 mg o.d. is well tolerated, with a low incidence of postural hypotension (<1%) and no significant changes in blood pressure compared with a placebo, even in elderly and hypertensive patients. Ejaculation disorders were rarely reported and did not show an evident causal relationship to treatment. Alfuzosin 10 mg o.d. also exhibits an excellent sexual side-effect profile, with no deleterious impact on this important aspect of quality of life for BPH patients.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Höfner K,Jonas Udoi
10.1007/s00345-002-0244-9subject
Has Abstractpub_date
2002-04-01 00:00:00pages
405-412issue
6eissn
0724-4983issn
1433-8726pii
10.1007/s00345-002-0244-9journal_volume
19pub_type
杂志文章abstract：:It has been brought to our attention that the first sentence of the Conclusion in the original publication [1] is incorrect. We have removed this sentence and the correct version can be found in this Erratum. ...
journal_title：World journal of urology
pub_type： 已发布勘误
doi：10.1007/s00345-019-02929-x
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:Urinary cytology (C) and cystoscopy remain the gold standard for the detection and screening of bladder cancer (BC). In this prospective study, we analyzed whether baseline C, ImmunoCyt (I), BTA Stat (B), hemoglobin dipstick (H), and NMP22 BladderChek (N) can predict recurrence and progression. METHODS:Urinary...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-016-1795-5
更新日期：2016-10-01 00:00:00
abstract：INTRODUCTION:Although randomized controlled trials (RCTs) remain the gold standard for determining evidence-based clinical practices, large disease registries that enroll large numbers of patients have become paramount as a relatively cost-effective additional tool. METHODS:We highlight the advantages of disease regis...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0658-3
更新日期：2011-06-01 00:00:00
abstract：PURPOSE:We investigated hemodynamics in patients receiving delta-Aminolevulinic acid (delta-ALA) to visualize tumor margins prior to radical retro pubic prostatectomy. PATIENTS:Twenty patients undergoing elective open radical retro pubic prostatectomy (RRP). METHODS:Cohort observational study. Ten patients receiving ...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-011-0788-7
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:The perioperative and oncological outcomes of laparoscopic radical nephrectomy (LRN) for T1-T2 renal cell carcinoma (RCC) are well established. We aim to determine whether LRN is a comparable alternative to open radical nephrectomy (ORN) in the treatment of T3 RCC using a matched pair analysis study design. ME...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1280-y
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:We aimed to explore the knowledge, attitudes, and practices towards prostate cancer (PCa) risk factors and prevention amongst men living in the southern Italian peninsula. METHODS:We retrospectively reviewed data collected during free preventive visits carried out by the Prevention and Research in Oncology (PR...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2074-9
更新日期：2017-12-01 00:00:00
abstract：:A review of the current literature is conducted to explore the developmental aspects, animal and human experiences and the effects of pharmacological manipulation to explain the role androgens play in sexual function with special emphasis on erectile function and the erectile tissue. This review reveals that androgens...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF01275152
更新日期：1997-01-01 00:00:00
abstract：PURPOSE:Robotic radical cystectomy (RRC) has become a commonly utilised alternative to open radical cystectomy (ORC). We performed a systematic review and meta-analysis of RRC vs ORC focusing on perioperative outcomes and safety. METHODS:Medline, EMBASE and CENTRAL were searched from January 2000 to April 2020 followi...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-020-03385-8
更新日期：2020-07-30 00:00:00
abstract：:Growth and morphogenesis of the prostate involves mesenchymal-epithelial interactions. Transforming growth factor-beta 1 (TGF-beta1) is one growth factor that may play a role in these paracrine interactions. We have localized TGF-beta1 by molecular and immunohistochemical analysis in the developing mouse prostate. Acc...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00191212
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:Although the role of lymph node dissection (LND) is well defined in many urological settings, uncertainty regarding need for LND still exists for patients with renal cell carcinoma (RCC). The aim of the current review is to highlight the rationale for performing or omitting LND at the time of renal surgery. ME...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-016-1886-3
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVES:Objective characterization of renal mass anatomy facilitates treatment selection and prediction of surgical outcomes. We investigated R.E.N.A.L nephrometry score (NS) efficacy in predicting outcomes after minimally invasive nephron-sparing surgery (MINSS). METHODS:A total of 250 patients with 252 renal mass...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0876-3
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:To characterize the clinical and pathologic staging of patients with urothelial carcinoma (UC) in bladder diverticula (BD) after undergoing radical cystectomy (RC) and determine the impact of UCBD on recurrence and survival. METHODS:We reviewed our institutional database of patients who underwent RC for UC (19...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1472-5
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Upper tract urothelial carcinoma (UTUC) is a rare and heterogeneous disease. Several clinical and biological prognostic factors have been identified in multi-institutional collaborative works with the aim of helping decision-making in pursuit of tailored individual patient care. This review provides an overv...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-016-1826-2
更新日期：2017-03-01 00:00:00
abstract：:Although anejaculation is a relatively uncommon occurrence in the general population, over 12,000 new cases are reported annually. Anejaculation may result from spinal cord injury (SCI), retroperitoneal lymph node dissection (RPLND), diabetes mellitis, transverse myelitis, multiple sclerosis, or psychogenic disorders....
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00182035
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:We sought to examine the literature reporting the effect of urinary tract infection (UTI) on non-schistosomiasis-related UBC (UBCNS) through a systematic review and meta-analysis. METHODS:A predefined study protocol was developed according to PRISMA. Medline and Scopus were searched for all studies investigati...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-018-2257-z
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:To investigate transient receptor potential vanilloid 4 (TRPV4) expression and the effects of ruthenium red (RR)-TRPV antagonist-on detrusor overactivity (DO) associated with bladder outlet obstruction (BOO). METHODS:Rats were randomly assigned to 3 groups. The control group (n = 10) included sham-operated rat...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1099-y
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVE:To analyse whether the reported differences in nodal yield at pelvic lymph node dissection (PLND) for bladder cancer, between two hospitals, are reflected in the survival rates. PATIENTS AND METHODS:We assessed follow-up data of all 174 patients (mean age: 62.7, median follow-up: 3 years) who underwent PLND ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0916-z
更新日期：2013-10-01 00:00:00
abstract：:Pyeloplasty for congenital ureteropelvic junction (UPJ) obstruction enjoys a 90-95% success rate. Although treatment of the failed pyeloplasty has been addressed in the literature, management of the poorly draining or nondraining renal unit in the immediate postoperative period has not received any attention. For this...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00183119
更新日期：1996-01-01 00:00:00
abstract：:Successful management of transitional-cell carcinoma of the urinary bladder is greatly dependent upon regular surveillance and early detection of persistent or recurrent carcinoma. The development of a highly sensitive urinary test for the detection of transitional-cell carcinoma of the bladder could have a dramatic i...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF02201981
更新日期：1997-01-01 00:00:00
abstract：:Small-intestinal submucosa (SIS) is a unique biomaterial that has been shown to induce tissue-specific regeneration in numerous organ systems. In the urinary tract, animal studies have demonstrated that SIS promotes functional bladder regeneration. Other preliminary studies have suggested that SIS may also be extremel...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/PL00007071
更新日期：2000-02-01 00:00:00
abstract：OBJECTIVE:The bromodomain and extra-terminal (BET) family of proteins provides a scaffolding platform for the recruitment and tethering of transcription factors to acetylated chromatin, thereby modulating gene expression. In this study, we evaluated the efficacy of the BET-inhibitor PFI-1 to diminish AR/AR-V7 signaling...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2382-8
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:Decreased vitamin D levels have been associated with prostate cancer, but it is unclear whether this association is causal. A functional single-nucleotide polymorphism (SNP) in the group-specific component (GC) gene (T > G, rs2282679) has been associated with 25-hydroxy (25-OH) vitamin D and 1.25 dihydroxy (1.2...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-015-1646-9
更新日期：2016-04-01 00:00:00
abstract：:Due to its unique biological behavior, late relapse (LR) of testicular cancer has recently been described as an own tumor entity. It is currently defined as tumor recurrence more than 2 years after complete remission following primary treatment including chemotherapy. The incidence ranges from 2 to 6%, with a median r...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-004-0397-9
更新日期：2004-04-01 00:00:00
abstract：PURPOSE:To test the association between family history of prostate cancer (FH) and prostate cancer (PCa) risk in a large screening program in Brazil, as no conclusive study has yet investigated this. METHODS:Between 2004 and 2007, 17,569 men were screened in 231 small municipalities using mobile screening units. Posit...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-012-0904-3
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:To compare efficacy and safety between superior calyceal access and inferior calyceal access for pelvic and/or lower calyceal renal stones. METHODS:Consecutive patients presenting with Pelvic and/or inferior calyceal renal calculi were allocated to the superior calyceal access (group 1) or inferior calyceal ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03409-3
更新日期：2020-08-31 00:00:00
abstract：:Our objectives were to ascertain the tolerability and efficacy of trospium chloride in doses of 20 mg twice daily for long-term therapy (52 weeks) in patients with urge syndrome. The trial comprised a total of 358 patients with urge syndrome or urge incontinence. After randomisation in the ratio of 3:1, participants w...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/s00345-003-0321-8
更新日期：2003-05-01 00:00:00
abstract：PURPOSE:Combination therapy of male lower urinary tract symptoms with α(1)-adrenoceptor and muscarinic receptor antagonists attracts increasing interest. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca(2+) channels. Here, we have investigated whether propiverin...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0655-6
更新日期：2011-04-01 00:00:00
abstract：PURPOSE:Prostate cancer (PCa) is the most common malignancy in men and the cause for the second most common cancer-related death in the western world. Despite ongoing development of novel approaches such as second generation androgen receptor targeted therapies, metastatic disease is still fatal. In PCa, immunotherapy ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03497-1
更新日期：2020-10-26 00:00:00
abstract：:The nuclear factor of kappa beta (NF-kappaB) transcription factor regulates the transcription of numerous genes including that of interleukin 6 (IL-6). The IL-6 acts as an autocrine and paracrine growth factor of androgen-independent prostate cancer. An aberrant expression of the IL-6 gene and an increase in IL-6 expr...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-007-0175-6
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the role of stone components in postoperative fever following RIRS, and to investigate the role of quick stone component analysis during RIRS procedure. PATIENTS AND METHODS:1493 patients with RIRS were retrospectively reviewed. Propensity score matching (PSM) analysis was performed as infection ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03268-y
更新日期：2020-05-24 00:00:00
